JP4596915B2 - チエノピロリルおよびフラノピロリル化合物並びにヒスタミンｈ４受容体リガンドとしてのそれらの使用 - Google Patents
チエノピロリルおよびフラノピロリル化合物並びにヒスタミンｈ４受容体リガンドとしてのそれらの使用 Download PDFInfo
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- JP4596915B2 JP4596915B2 JP2004534722A JP2004534722A JP4596915B2 JP 4596915 B2 JP4596915 B2 JP 4596915B2 JP 2004534722 A JP2004534722 A JP 2004534722A JP 2004534722 A JP2004534722 A JP 2004534722A JP 4596915 B2 JP4596915 B2 JP 4596915B2
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- alkyl
- cycloalkyl
- independently
- phenyl
- alkoxy
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40872302P | 2002-09-06 | 2002-09-06 | |
| PCT/US2003/028017 WO2004022537A2 (en) | 2002-09-06 | 2003-09-05 | Thienopyrrolyl and furanopyrrolyl compounds and their use as histamine h4 receptor ligands |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006500394A JP2006500394A (ja) | 2006-01-05 |
| JP2006500394A5 JP2006500394A5 (OSRAM) | 2006-10-19 |
| JP4596915B2 true JP4596915B2 (ja) | 2010-12-15 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004534722A Expired - Fee Related JP4596915B2 (ja) | 2002-09-06 | 2003-09-05 | チエノピロリルおよびフラノピロリル化合物並びにヒスタミンｈ４受容体リガンドとしてのそれらの使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7226938B2 (OSRAM) |
| EP (1) | EP1543011B1 (OSRAM) |
| JP (1) | JP4596915B2 (OSRAM) |
| AT (1) | ATE325125T1 (OSRAM) |
| AU (1) | AU2003272285A1 (OSRAM) |
| CA (1) | CA2497868C (OSRAM) |
| CY (1) | CY1105080T1 (OSRAM) |
| DE (1) | DE60305052T2 (OSRAM) |
| DK (1) | DK1543011T3 (OSRAM) |
| ES (1) | ES2264534T3 (OSRAM) |
| PT (1) | PT1543011E (OSRAM) |
| WO (1) | WO2004022537A2 (OSRAM) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2264534T3 (es) * | 2002-09-06 | 2007-01-01 | Janssen Pharmaceutica N.V. | Compuestos de tienopirrolilo y furanopirrolilo y su utilizacion como ligandos del receptor histaminico h4. |
| GB0222912D0 (en) * | 2002-10-03 | 2002-11-13 | Astrazeneca Ab | Novel process and intermediates |
| GB0222909D0 (en) * | 2002-10-03 | 2002-11-13 | Astrazeneca Ab | Novel process and intermediates |
| CA2540260A1 (en) * | 2003-09-26 | 2005-04-07 | Janssen Pharmaceutica N.V. | Analyzing histamine h4 receptor-mediated effects in whole blood |
| AU2004312530A1 (en) * | 2003-12-29 | 2005-07-21 | Sepracor Inc. | Pyrrole and pyrazole DAAO inhibitors |
| WO2005123673A1 (en) | 2004-06-18 | 2005-12-29 | Biolipox Ab | Indoles useful in the treatment of inflammation |
| EP1776982A1 (en) * | 2005-10-18 | 2007-04-25 | Argenta Discovery Limited | Pyrimidine compounds as histamine modulators |
| AU2005303893A1 (en) * | 2004-11-11 | 2006-05-18 | Argenta Discovery Ltd | Pyrimidine compounds as histamine modulators |
| EP1671972A1 (en) * | 2004-11-24 | 2006-06-21 | Pfizer Limited | Octahydropyrrolo[3,4-c]pyrrole derivatives |
| EP1846409A1 (en) * | 2004-11-24 | 2007-10-24 | Pfizer Limited | Octahydropyrrolo[3,4-c]pyrrole derivatives |
| KR20070114123A (ko) | 2005-01-19 | 2007-11-29 | 바이올리폭스 에이비 | 염증 치료에 유용한 인돌 |
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| FR2571723B1 (fr) * | 1984-10-12 | 1988-08-26 | Lipha | Derives de thieno et furo-(2,3-c) pyrroles, procedes de preparation et medicaments les contenant |
| NZ223654A (en) * | 1987-03-09 | 1990-03-27 | Janssen Pharmaceutica Nv | 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions |
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2003
- 2003-09-05 ES ES03754461T patent/ES2264534T3/es not_active Expired - Lifetime
- 2003-09-05 EP EP03754461A patent/EP1543011B1/en not_active Expired - Lifetime
- 2003-09-05 DE DE60305052T patent/DE60305052T2/de not_active Expired - Lifetime
- 2003-09-05 AU AU2003272285A patent/AU2003272285A1/en not_active Abandoned
- 2003-09-05 JP JP2004534722A patent/JP4596915B2/ja not_active Expired - Fee Related
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- 2003-09-05 DK DK03754461T patent/DK1543011T3/da active
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Also Published As
| Publication number | Publication date |
|---|---|
| DE60305052D1 (de) | 2006-06-08 |
| US7645758B2 (en) | 2010-01-12 |
| WO2004022537A3 (en) | 2004-05-06 |
| AU2003272285A8 (en) | 2004-03-29 |
| ATE325125T1 (de) | 2006-06-15 |
| DE60305052T2 (de) | 2006-12-21 |
| US7226938B2 (en) | 2007-06-05 |
| CY1105080T1 (el) | 2009-11-04 |
| US20070185131A1 (en) | 2007-08-09 |
| PT1543011E (pt) | 2006-08-31 |
| CA2497868A1 (en) | 2004-03-18 |
| AU2003272285A1 (en) | 2004-03-29 |
| DK1543011T3 (da) | 2006-08-07 |
| CA2497868C (en) | 2010-11-30 |
| WO2004022537A2 (en) | 2004-03-18 |
| EP1543011A2 (en) | 2005-06-22 |
| JP2006500394A (ja) | 2006-01-05 |
| ES2264534T3 (es) | 2007-01-01 |
| EP1543011B1 (en) | 2006-05-03 |
| US20040048878A1 (en) | 2004-03-11 |
| US20070185120A1 (en) | 2007-08-09 |
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