JP4581110B2 - ヘモグロビンの精製方法 - Google Patents
ヘモグロビンの精製方法 Download PDFInfo
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- JP4581110B2 JP4581110B2 JP2000559150A JP2000559150A JP4581110B2 JP 4581110 B2 JP4581110 B2 JP 4581110B2 JP 2000559150 A JP2000559150 A JP 2000559150A JP 2000559150 A JP2000559150 A JP 2000559150A JP 4581110 B2 JP4581110 B2 JP 4581110B2
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- JJAHTWIKCUJRDK-UHFFFAOYSA-N succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate Chemical compound C1CC(CN2C(C=CC2=O)=O)CCC1C(=O)ON1C(=O)CCC1=O JJAHTWIKCUJRDK-UHFFFAOYSA-N 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002889 sympathetic effect Effects 0.000 description 1
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 239000000304 virulence factor Substances 0.000 description 1
- 230000007923 virulence factor Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/113,953 US6150507A (en) | 1995-03-23 | 1998-07-10 | Method for producing a purified hemoglobin product |
| US09/113,953 | 1998-07-10 | ||
| PCT/US1999/013922 WO2000002921A1 (en) | 1998-07-10 | 1999-06-21 | Method for purifying hemoglobin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002520338A JP2002520338A (ja) | 2002-07-09 |
| JP2002520338A5 JP2002520338A5 (https=) | 2006-08-10 |
| JP4581110B2 true JP4581110B2 (ja) | 2010-11-17 |
Family
ID=22352497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000559150A Expired - Fee Related JP4581110B2 (ja) | 1998-07-10 | 1999-06-21 | ヘモグロビンの精製方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6150507A (https=) |
| EP (1) | EP1097171B1 (https=) |
| JP (1) | JP4581110B2 (https=) |
| CN (1) | CN1166689C (https=) |
| AT (1) | ATE347564T1 (https=) |
| AU (1) | AU755280B2 (https=) |
| CA (1) | CA2336808C (https=) |
| DE (1) | DE69934312T2 (https=) |
| DK (1) | DK1097171T3 (https=) |
| ES (1) | ES2278450T3 (https=) |
| NZ (1) | NZ509257A (https=) |
| WO (1) | WO2000002921A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001076507A2 (en) | 2000-04-11 | 2001-10-18 | The University Of Miami | Use of oxygen carriers to improve grafted cell survival in neural transplantation |
| FR2824568B1 (fr) * | 2001-05-11 | 2004-04-09 | Lab Francais Du Fractionnement | Procede de preparation de concentres d'immunoglobulines humaines a usage therapeutique |
| US7038016B2 (en) | 2001-08-21 | 2006-05-02 | Apex Bioscience, Inc. | Methods for purification of an activated PEG solution and for the synthesis of a modified hemoglobin solution |
| SI1543038T2 (sl) | 2002-09-11 | 2020-12-31 | Genentech, Inc. | Čiščenje proteinov |
| RU2325924C2 (ru) * | 2002-10-03 | 2008-06-10 | Нортфилд Лэборэтериз, Инк. | Способ лечения пациентов с массивной потерей крови |
| NZ541340A (en) * | 2003-01-29 | 2008-04-30 | Northfield Lab | Polymerized hemoglobin solutions having reduced amount of tetramer and method for preparing |
| US20070123698A1 (en) * | 2003-12-26 | 2007-05-31 | Oxygenix Co., Ltd. | Process for purification of hemoglobin |
| US20090117207A1 (en) * | 2005-11-29 | 2009-05-07 | Zoltani Csaba K | Methods and compositions for treatment of poison-caused pathology |
| US20090004159A1 (en) * | 2006-01-24 | 2009-01-01 | The Board Of Trustees Of The University Of Illinoi | Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells |
| JP2009524436A (ja) * | 2006-01-24 | 2009-07-02 | ノースフィールド ラボラトリーズ、インコーポレイテッド | 重合したヘモグロビンの培地、並びに島細胞の単離及び移植におけるその使用 |
| JP2010500042A (ja) * | 2006-08-15 | 2010-01-07 | ビーエーエスエフ ソシエタス・ヨーロピア | 産生細胞からのタンパク質単離方法 |
| JP2011207853A (ja) * | 2010-03-30 | 2011-10-20 | Terumo Corp | 人工酸素運搬体製造に用いるヘモグロビン原料中間生成物 |
| JP6786917B2 (ja) * | 2016-07-08 | 2020-11-18 | 東ソー株式会社 | ヘモグロビン調製液及びヘモグロビン類測定液体クロマトグラフィー法 |
| CN111989568B (zh) | 2018-04-18 | 2024-05-28 | 积水医疗株式会社 | 血红蛋白分析方法 |
| CN110128531B (zh) * | 2019-05-17 | 2022-03-08 | 润方（北京）生物医药研究院有限公司 | 一种无碳酸酐酶血红蛋白的制备方法 |
| CN110563836A (zh) * | 2019-09-09 | 2019-12-13 | 润方（北京）生物医药研究院有限公司 | 交联血红蛋白的制备方法及包含该血红蛋白的器官灌注液 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2449885C3 (de) * | 1974-10-21 | 1980-04-30 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Verfahren zur Herstellung von chemisch modifizierten haltbaren Hämoglobinpräparaten sowie das nach diesem Verfahren hergestellte modifizierte Hämoglobinpräparat |
| US4059512A (en) * | 1974-12-27 | 1977-11-22 | Preventive Systems, Inc. | Process for removing endotoxin from biological fluids |
| US3959128A (en) * | 1974-12-27 | 1976-05-25 | Preventive Systems, Inc | Process for removing endotoxin from biological fluids |
| DK144800C (da) * | 1980-04-21 | 1982-10-25 | Forenede Bryggerier As | Fremgangsmaade til udvinding af enzymer,fortrinsvis cu,zn-superoxid-dismutase (sod),catalase og carbonsyreanhydrase,fra blod |
| US4381239A (en) * | 1981-02-10 | 1983-04-26 | Tanabe Seiyaku Co., Ltd. | Method for reducing the pyrogen content of or removing pyrogens from substances contaminated therewith |
| US4473647A (en) * | 1981-02-27 | 1984-09-25 | Amf Inc. | Tissue culture medium |
| US4468330A (en) * | 1981-04-27 | 1984-08-28 | Sekisui Kagaku Kogyo Kabushiki Kaisha | Filler for liquid chromatography useful for separating a hemoglobin variant in blood |
| US4584130A (en) * | 1985-03-29 | 1986-04-22 | University Of Maryland | Intramolecularly cross-linked hemoglobin and method of preparation |
| CA1244349A (en) * | 1985-06-26 | 1988-11-08 | Jen-Chang Hsia | Purification of hemoglobin and modified hemoglobin by affinity chromatography |
| GB8600582D0 (en) * | 1986-01-10 | 1986-02-19 | Ca Minister Nat Defence | Purifying biological materials |
| CA1312009C (en) * | 1986-11-10 | 1992-12-29 | Carl W. Rausch | Extra pure semi-synthetic blood substitute |
| US5084558A (en) * | 1987-10-13 | 1992-01-28 | Biopure Corporation | Extra pure semi-synthetic blood substitute |
| DE3778006D1 (de) * | 1986-11-10 | 1992-05-07 | Biopure Corp | Hochreines, halbsynthetisches blutsurrogat. |
| JP2592973B2 (ja) * | 1988-06-15 | 1997-03-19 | バクスター インターナショナル インコーポレーテッド | 架橋ヘモグロビンの精製方法 |
| CA1338244C (en) * | 1988-08-17 | 1996-04-09 | Xiang-Fu Wu | Purification of hemoglobin and methemoglobin by bioselective elution |
| US5128452A (en) * | 1989-04-19 | 1992-07-07 | Baxter International Inc. | Process for the production of crosslinked hemoglobin in the presence of sodium tripolyphosphate |
| US5234903A (en) * | 1989-11-22 | 1993-08-10 | Enzon, Inc. | Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute |
| SK54993A3 (en) * | 1990-11-29 | 1993-10-06 | Upjohn Co | Imidoester cross-linked hemoglobin compositions |
| US5250665A (en) * | 1991-05-31 | 1993-10-05 | The University Of Toronto Innovations Foundation | Specifically β-β cross-linked hemoglobins and method of preparation |
| US5264555A (en) * | 1992-07-14 | 1993-11-23 | Enzon, Inc. | Process for hemoglobin extraction and purification |
| US5578564A (en) * | 1993-07-23 | 1996-11-26 | Somatogen, Inc. | Nickel-free hemoglobin and methods for producing such hemoglobin |
| US5840851A (en) * | 1993-07-23 | 1998-11-24 | Plomer; J. Jeffrey | Purification of hemoglobin |
| US5665869A (en) * | 1993-11-15 | 1997-09-09 | Somatogen, Inc. | Method for the rapid removal of protoporphyrin from protoporphyrin IX-containing solutions of hemoglobin |
| ES2179188T3 (es) * | 1995-03-23 | 2003-01-16 | Biopure Corp | Sustituto de la sangre a base de hemoglobina polimerizada estable. |
-
1998
- 1998-07-10 US US09/113,953 patent/US6150507A/en not_active Expired - Lifetime
-
1999
- 1999-06-21 NZ NZ509257A patent/NZ509257A/xx not_active IP Right Cessation
- 1999-06-21 ES ES99930467T patent/ES2278450T3/es not_active Expired - Lifetime
- 1999-06-21 DE DE69934312T patent/DE69934312T2/de not_active Expired - Lifetime
- 1999-06-21 CA CA002336808A patent/CA2336808C/en not_active Expired - Fee Related
- 1999-06-21 AU AU47003/99A patent/AU755280B2/en not_active Ceased
- 1999-06-21 EP EP99930467A patent/EP1097171B1/en not_active Expired - Lifetime
- 1999-06-21 WO PCT/US1999/013922 patent/WO2000002921A1/en not_active Ceased
- 1999-06-21 CN CNB998082864A patent/CN1166689C/zh not_active Expired - Fee Related
- 1999-06-21 JP JP2000559150A patent/JP4581110B2/ja not_active Expired - Fee Related
- 1999-06-21 AT AT99930467T patent/ATE347564T1/de not_active IP Right Cessation
- 1999-06-21 DK DK99930467T patent/DK1097171T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| CN1166689C (zh) | 2004-09-15 |
| JP2002520338A (ja) | 2002-07-09 |
| ES2278450T3 (es) | 2007-08-01 |
| WO2000002921A1 (en) | 2000-01-20 |
| CN1308636A (zh) | 2001-08-15 |
| DK1097171T3 (da) | 2007-04-10 |
| HK1037643A1 (en) | 2002-02-15 |
| NZ509257A (en) | 2003-03-28 |
| EP1097171A1 (en) | 2001-05-09 |
| CA2336808C (en) | 2008-08-19 |
| EP1097171B1 (en) | 2006-12-06 |
| US6150507A (en) | 2000-11-21 |
| DE69934312T2 (de) | 2007-07-12 |
| AU4700399A (en) | 2000-02-01 |
| AU755280B2 (en) | 2002-12-05 |
| ATE347564T1 (de) | 2006-12-15 |
| DE69934312D1 (de) | 2007-01-18 |
| CA2336808A1 (en) | 2000-01-20 |
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