JP4571236B2 - ミューオピオイド作用薬およびカッパ−２オピオイド作用薬のサブ鎮痛用量共同投与による鎮痛性相乗作用を惹起する鎮痛組成物およびその製造方法 - Google Patents

ミューオピオイド作用薬およびカッパ−２オピオイド作用薬のサブ鎮痛用量共同投与による鎮痛性相乗作用を惹起する鎮痛組成物およびその製造方法 Download PDF

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JP4571236B2
JP4571236B2 JP51535797A JP51535797A JP4571236B2 JP 4571236 B2 JP4571236 B2 JP 4571236B2 JP 51535797 A JP51535797 A JP 51535797A JP 51535797 A JP51535797 A JP 51535797A JP 4571236 B2 JP4571236 B2 JP 4571236B2
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analgesic
oxycodone
morphine
dose
composition according
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JP2000511158A (ja
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スミス，マリー
ロス，フレイザー
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ザ ユニバーシティ オブ クィーンズランド
ザ リンクス プロジェクト リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
JP51535797A 1995-10-19 1996-10-21 ミューオピオイド作用薬およびカッパ−２オピオイド作用薬のサブ鎮痛用量共同投与による鎮痛性相乗作用を惹起する鎮痛組成物およびその製造方法 Expired - Fee Related JP4571236B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU6038 1995-10-19
AUPN6038A AUPN603895A0 (en) 1995-10-19 1995-10-19 Production of analgesic synergy by co-administration of sub-analgesic doses of two strong opioids
PCT/AU1996/000656 WO1997014438A1 (en) 1995-10-19 1996-10-21 Production of analgesic synergy by co-administration of sub-analgesic doses of a mu opioid agonist and a kappa-2 opioid agonist

Publications (2)

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JP2000511158A JP2000511158A (ja) 2000-08-29
JP4571236B2 true JP4571236B2 (ja) 2010-10-27

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JP51535797A Expired - Fee Related JP4571236B2 (ja) 1995-10-19 1996-10-21 ミューオピオイド作用薬およびカッパ−２オピオイド作用薬のサブ鎮痛用量共同投与による鎮痛性相乗作用を惹起する鎮痛組成物およびその製造方法

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US (1) US6310072B1 (zh)
EP (1) EP0871488B1 (zh)
JP (1) JP4571236B2 (zh)
CN (1) CN1104910C (zh)
AT (1) ATE292982T1 (zh)
AU (2) AUPN603895A0 (zh)
CA (1) CA2235375C (zh)
DE (1) DE69634609T2 (zh)
DK (1) DK0871488T3 (zh)
ES (1) ES2241003T3 (zh)
NZ (1) NZ319531A (zh)
WO (1) WO1997014438A1 (zh)
ZA (1) ZA968808B (zh)

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Also Published As

Publication number Publication date
CN1204264A (zh) 1999-01-06
EP0871488B1 (en) 2005-04-13
DE69634609T2 (de) 2006-02-02
NZ319531A (en) 1999-11-29
CA2235375A1 (en) 1997-04-24
CA2235375C (en) 2008-01-08
EP0871488A1 (en) 1998-10-21
US6310072B1 (en) 2001-10-30
EP0871488A4 (en) 2001-04-04
DK0871488T3 (da) 2005-08-15
AU706691B2 (en) 1999-06-24
ES2241003T3 (es) 2005-10-16
ZA968808B (en) 1997-05-27
CN1104910C (zh) 2003-04-09
JP2000511158A (ja) 2000-08-29
WO1997014438A1 (en) 1997-04-24
DE69634609D1 (de) 2005-05-19
ATE292982T1 (de) 2005-04-15
AUPN603895A0 (en) 1995-11-09
AU7207696A (en) 1997-05-07

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