JP4564654B2 - Ｖｌａ−４アンタゴニスト - Google Patents
Ｖｌａ−４アンタゴニスト Download PDFInfo
- Publication number
- JP4564654B2 JP4564654B2 JP2000528529A JP2000528529A JP4564654B2 JP 4564654 B2 JP4564654 B2 JP 4564654B2 JP 2000528529 A JP2000528529 A JP 2000528529A JP 2000528529 A JP2000528529 A JP 2000528529A JP 4564654 B2 JP4564654 B2 JP 4564654B2
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- mixture
- aryl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C*C*(C)(*)N Chemical compound C*C*(C)(*)N 0.000 description 1
- JLQUEGAVLHIIBF-JTQLQIEISA-N COC(C[C@@H](c(cc1)ccc1OC)N)=O Chemical compound COC(C[C@@H](c(cc1)ccc1OC)N)=O JLQUEGAVLHIIBF-JTQLQIEISA-N 0.000 description 1
- ARFATOIPZCSLEI-LJAQVGFWSA-N Cc(cccc1)c1NC(Nc1ccc(CC(N(CCCOC)CC(N[C@@H](CC(OC)=O)c(cc2)ccc2OC)=O)=O)cc1)=O Chemical compound Cc(cccc1)c1NC(Nc1ccc(CC(N(CCCOC)CC(N[C@@H](CC(OC)=O)c(cc2)ccc2OC)=O)=O)cc1)=O ARFATOIPZCSLEI-LJAQVGFWSA-N 0.000 description 1
- RNVCVTLRINQCPJ-UHFFFAOYSA-N Cc1ccccc1N Chemical compound Cc1ccccc1N RNVCVTLRINQCPJ-UHFFFAOYSA-N 0.000 description 1
- CSEWAUGPAQPMDC-UHFFFAOYSA-N Nc1ccc(CC(O)=O)cc1 Chemical compound Nc1ccc(CC(O)=O)cc1 CSEWAUGPAQPMDC-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1233698A | 1998-01-23 | 1998-01-23 | |
| US09/012,336 | 1998-01-23 | ||
| US11072398P | 1998-12-03 | 1998-12-03 | |
| US60/110,723 | 1998-12-03 | ||
| PCT/EP1999/000384 WO1999037605A1 (en) | 1998-01-23 | 1999-01-21 | Vla-4 antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002501039A JP2002501039A (ja) | 2002-01-15 |
| JP2002501039A5 JP2002501039A5 (de) | 2006-03-02 |
| JP4564654B2 true JP4564654B2 (ja) | 2010-10-20 |
Family
ID=26683440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000528529A Expired - Fee Related JP4564654B2 (ja) | 1998-01-23 | 1999-01-21 | Ｖｌａ−４アンタゴニスト |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1049665A1 (de) |
| JP (1) | JP4564654B2 (de) |
| KR (1) | KR20010034317A (de) |
| CN (1) | CN1294576A (de) |
| AU (1) | AU746174B2 (de) |
| BR (1) | BR9907733A (de) |
| CA (1) | CA2318639A1 (de) |
| EE (1) | EE200000428A (de) |
| HU (1) | HUP0100336A3 (de) |
| ID (1) | ID26665A (de) |
| IL (1) | IL137329A0 (de) |
| NO (1) | NO20003694L (de) |
| WO (1) | WO1999037605A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2623900A (en) * | 1999-01-22 | 2000-08-07 | American Home Products Corporation | Compounds which inhibit leukocyte adhesion mediated by vla-4 |
| NZ529822A (en) | 1999-01-22 | 2005-11-25 | Elan Pharm Inc | Acyl derivatives which treat VLA-4 related disorders |
| US6436904B1 (en) | 1999-01-25 | 2002-08-20 | Elan Pharmaceuticals, Inc. | Compounds which inhibit leukocyte adhesion mediated by VLA-4 |
| ATE264298T1 (de) | 1999-03-01 | 2004-04-15 | Elan Pharm Inc | Alpha-aminoessigsäure derivate als alpha 4 beta 7-rezeptor antagonisten |
| WO2001042192A2 (en) * | 1999-12-07 | 2001-06-14 | Novartis Ag | Vla-4 integrin antagonists |
| OA12126A (en) * | 1999-12-28 | 2006-05-05 | Pfizer Prod Inc | Non-peptidyl inhibitors of VLA-4 dependent cell binding useful in treating inflammatory, autoimmune,and respiratory diseases. |
| DE10019755A1 (de) * | 2000-04-20 | 2001-11-08 | Bayer Ag | Neue Aminoaryl/cycloalkylcarbonsäuren als Integrinantagonisten |
| GB2369357A (en) * | 2000-10-09 | 2002-05-29 | Bayer Ag | Aliphatic, cyclic amino carboxylic acids as integrin antagonists |
| GB2367816A (en) * | 2000-10-09 | 2002-04-17 | Bayer Ag | Urea- and thiourea-containing derivatives of beta-amino acids |
| GB2377933A (en) | 2001-07-06 | 2003-01-29 | Bayer Ag | Succinic acid derivatives useful as integrin antagonists |
| TW200307671A (en) | 2002-05-24 | 2003-12-16 | Elan Pharm Inc | Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins |
| TWI281470B (en) | 2002-05-24 | 2007-05-21 | Elan Pharm Inc | Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins |
| TW200610754A (en) * | 2004-06-14 | 2006-04-01 | Daiichi Seiyaku Co | Vla-4 inhibitor |
| GB0523576D0 (en) * | 2005-11-18 | 2005-12-28 | Theradeas Ltd | Drug composition and its use in therapy |
| WO2008103378A2 (en) | 2007-02-20 | 2008-08-28 | Merrimack Pharmaceuticals, Inc. | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
| JP5639039B2 (ja) | 2008-04-11 | 2014-12-10 | メリマック ファーマシューティカルズ インコーポレーティッド | ヒト血清アルブミンリンカーおよびそのコンジュゲート |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
| BR9814376A (pt) * | 1997-12-23 | 2000-10-10 | Aventis Pharma Ltd | Composto ou um pró-medicamento correspondente, ou um sal farmaceuticamente aceitável ou solvato de um tal composto ou um pró-medicamento deste, uso destes, composição farmacêutica, processo para o tratamento de um paciente humano ou animal não humano sofrendo de, ou sujeito a, condições que podem ser melhoradas pela admnistração de um inibidor da adesão celular mediada por &4ß1, e, resina |
-
1999
- 1999-01-21 AU AU28292/99A patent/AU746174B2/en not_active Ceased
- 1999-01-21 HU HU0100336A patent/HUP0100336A3/hu unknown
- 1999-01-21 WO PCT/EP1999/000384 patent/WO1999037605A1/en not_active Application Discontinuation
- 1999-01-21 JP JP2000528529A patent/JP4564654B2/ja not_active Expired - Fee Related
- 1999-01-21 EP EP99908811A patent/EP1049665A1/de not_active Withdrawn
- 1999-01-21 BR BR9907733-7A patent/BR9907733A/pt not_active IP Right Cessation
- 1999-01-21 EE EEP200000428A patent/EE200000428A/xx unknown
- 1999-01-21 IL IL13732999A patent/IL137329A0/xx unknown
- 1999-01-21 CA CA002318639A patent/CA2318639A1/en not_active Abandoned
- 1999-01-21 KR KR1020007008039A patent/KR20010034317A/ko not_active Application Discontinuation
- 1999-01-21 ID IDW20001404A patent/ID26665A/id unknown
- 1999-01-21 CN CN99803780A patent/CN1294576A/zh active Pending
-
2000
- 2000-07-19 NO NO20003694A patent/NO20003694L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0100336A2 (hu) | 2001-07-30 |
| CN1294576A (zh) | 2001-05-09 |
| NO20003694L (no) | 2000-09-20 |
| CA2318639A1 (en) | 1999-07-29 |
| KR20010034317A (ko) | 2001-04-25 |
| EP1049665A1 (de) | 2000-11-08 |
| WO1999037605A1 (en) | 1999-07-29 |
| AU2829299A (en) | 1999-08-09 |
| HUP0100336A3 (en) | 2002-11-28 |
| JP2002501039A (ja) | 2002-01-15 |
| IL137329A0 (en) | 2001-07-24 |
| ID26665A (id) | 2001-01-25 |
| NO20003694D0 (no) | 2000-07-19 |
| AU746174B2 (en) | 2002-04-18 |
| EE200000428A (et) | 2001-12-17 |
| BR9907733A (pt) | 2000-10-17 |
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|---|---|---|---|
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