HUP0100336A3 - Vla-4 antagonists, pharmaceutical compositions comprising them and process for preparing them - Google Patents
Vla-4 antagonists, pharmaceutical compositions comprising them and process for preparing themInfo
- Publication number
- HUP0100336A3 HUP0100336A3 HU0100336A HUP0100336A HUP0100336A3 HU P0100336 A3 HUP0100336 A3 HU P0100336A3 HU 0100336 A HU0100336 A HU 0100336A HU P0100336 A HUP0100336 A HU P0100336A HU P0100336 A3 HUP0100336 A3 HU P0100336A3
- Authority
- HU
- Hungary
- Prior art keywords
- vla
- antagonists
- preparing
- pharmaceutical compositions
- pharmaceutical
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1233698A | 1998-01-23 | 1998-01-23 | |
| US11072398P | 1998-12-03 | 1998-12-03 | |
| PCT/EP1999/000384 WO1999037605A1 (en) | 1998-01-23 | 1999-01-21 | Vla-4 antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0100336A2 HUP0100336A2 (hu) | 2001-07-30 |
| HUP0100336A3 true HUP0100336A3 (en) | 2002-11-28 |
Family
ID=26683440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0100336A HUP0100336A3 (en) | 1998-01-23 | 1999-01-21 | Vla-4 antagonists, pharmaceutical compositions comprising them and process for preparing them |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1049665A1 (de) |
| JP (1) | JP4564654B2 (de) |
| KR (1) | KR20010034317A (de) |
| CN (1) | CN1294576A (de) |
| AU (1) | AU746174B2 (de) |
| BR (1) | BR9907733A (de) |
| CA (1) | CA2318639A1 (de) |
| EE (1) | EE200000428A (de) |
| HU (1) | HUP0100336A3 (de) |
| ID (1) | ID26665A (de) |
| IL (1) | IL137329A0 (de) |
| NO (1) | NO20003694L (de) |
| WO (1) | WO1999037605A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2339738T3 (es) | 1999-01-22 | 2010-05-25 | Elan Pharmaceuticals, Inc. | Derivados de acilo los cuales tratan trastornos relacionados con vla-4. |
| WO2000043369A1 (en) * | 1999-01-22 | 2000-07-27 | Elan Pharmaceuticals, Inc. | Compounds which inhibit leukocyte adhesion mediated by vla-4 |
| US6436904B1 (en) | 1999-01-25 | 2002-08-20 | Elan Pharmaceuticals, Inc. | Compounds which inhibit leukocyte adhesion mediated by VLA-4 |
| CA2361162A1 (en) | 1999-03-01 | 2000-09-08 | Elan Pharmaceuticals, Inc. | Alpha-aminoacetic acid derivatives useful as alpha 4 beta 7-receptor antagonists |
| AU3006401A (en) * | 1999-12-07 | 2001-06-18 | Novartis Ag | Vla-4 integrin antagonists |
| BR0016818A (pt) * | 1999-12-28 | 2002-10-01 | Pfizer Prod Inc | Inibidores não-peptidila de adesão celular dependente de vla-4 úteis no tratamento de doenças inflamatórias, auto-imunes e respiratórias |
| DE10019755A1 (de) * | 2000-04-20 | 2001-11-08 | Bayer Ag | Neue Aminoaryl/cycloalkylcarbonsäuren als Integrinantagonisten |
| GB2367816A (en) | 2000-10-09 | 2002-04-17 | Bayer Ag | Urea- and thiourea-containing derivatives of beta-amino acids |
| GB2369357A (en) * | 2000-10-09 | 2002-05-29 | Bayer Ag | Aliphatic, cyclic amino carboxylic acids as integrin antagonists |
| GB2377933A (en) | 2001-07-06 | 2003-01-29 | Bayer Ag | Succinic acid derivatives useful as integrin antagonists |
| TW200307671A (en) | 2002-05-24 | 2003-12-16 | Elan Pharm Inc | Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins |
| TWI281470B (en) | 2002-05-24 | 2007-05-21 | Elan Pharm Inc | Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins |
| TW200610754A (en) * | 2004-06-14 | 2006-04-01 | Daiichi Seiyaku Co | Vla-4 inhibitor |
| GB0523576D0 (en) * | 2005-11-18 | 2005-12-28 | Theradeas Ltd | Drug composition and its use in therapy |
| AU2008219007A1 (en) | 2007-02-20 | 2008-08-28 | Merrimack Pharmaceuticals, Inc. | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
| CA2721093A1 (en) | 2008-04-11 | 2009-10-15 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and conjugates thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
| WO1999033789A1 (en) * | 1997-12-23 | 1999-07-08 | Aventis Pharma Limited | SUBSTITUTED β-ALANINES |
-
1999
- 1999-01-21 JP JP2000528529A patent/JP4564654B2/ja not_active Expired - Fee Related
- 1999-01-21 EP EP99908811A patent/EP1049665A1/de not_active Withdrawn
- 1999-01-21 BR BR9907733-7A patent/BR9907733A/pt not_active IP Right Cessation
- 1999-01-21 AU AU28292/99A patent/AU746174B2/en not_active Ceased
- 1999-01-21 HU HU0100336A patent/HUP0100336A3/hu unknown
- 1999-01-21 IL IL13732999A patent/IL137329A0/xx unknown
- 1999-01-21 ID IDW20001404A patent/ID26665A/id unknown
- 1999-01-21 EE EEP200000428A patent/EE200000428A/xx unknown
- 1999-01-21 WO PCT/EP1999/000384 patent/WO1999037605A1/en not_active Application Discontinuation
- 1999-01-21 CN CN99803780A patent/CN1294576A/zh active Pending
- 1999-01-21 KR KR1020007008039A patent/KR20010034317A/ko not_active Application Discontinuation
- 1999-01-21 CA CA002318639A patent/CA2318639A1/en not_active Abandoned
-
2000
- 2000-07-19 NO NO20003694A patent/NO20003694L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20003694L (no) | 2000-09-20 |
| HUP0100336A2 (hu) | 2001-07-30 |
| WO1999037605A1 (en) | 1999-07-29 |
| KR20010034317A (ko) | 2001-04-25 |
| JP4564654B2 (ja) | 2010-10-20 |
| IL137329A0 (en) | 2001-07-24 |
| AU2829299A (en) | 1999-08-09 |
| EP1049665A1 (de) | 2000-11-08 |
| EE200000428A (et) | 2001-12-17 |
| ID26665A (id) | 2001-01-25 |
| CA2318639A1 (en) | 1999-07-29 |
| NO20003694D0 (no) | 2000-07-19 |
| CN1294576A (zh) | 2001-05-09 |
| JP2002501039A (ja) | 2002-01-15 |
| AU746174B2 (en) | 2002-04-18 |
| BR9907733A (pt) | 2000-10-17 |
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