JP4549985B2 - Spr検出能力を有するマイクロ流体デバイス - Google Patents
Spr検出能力を有するマイクロ流体デバイス Download PDFInfo
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- JP4549985B2 JP4549985B2 JP2006046266A JP2006046266A JP4549985B2 JP 4549985 B2 JP4549985 B2 JP 4549985B2 JP 2006046266 A JP2006046266 A JP 2006046266A JP 2006046266 A JP2006046266 A JP 2006046266A JP 4549985 B2 JP4549985 B2 JP 4549985B2
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- Prior art keywords
- sensor chip
- channel
- surface plasmon
- spr
- thin film
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
- G01N21/553—Attenuated total reflection and using surface plasmons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0654—Lenses; Optical fibres
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0622—Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Optical Measuring Cells (AREA)
Description
12 ポンピングテーブル
14 センサチップ
16 光検出器
18 ロータ
20 チャネル
22 チャネル
24 廃棄物ライン
26 表面プラズモン生成薄膜
28 注入口
30 排出口
32,34 結合カバー
36 ステータ
55 クロマトグラフ媒体
Claims (7)
- 少なくとも一部に表面プラズモン生成薄膜を含む基板を備えるSPRセンサチップであって、前記SPRセンサチップは、所定の波長を有する赤外線放射光を通過させて前記表面プラズモン生成薄膜に達することができるようにポリイミド材料により少なくとも部分的に形成され、前記ポリイミド材料は、可視光に対して透過性ではないが、不可視波長範囲の少なくとも一部における所定の波長を有する赤外線放射光に対して透過性である、SPRセンサチップ。
- 前記基板は少なくとも1つのチャネルを備え、前記表面プラズモン生成薄膜は前記チャネル内に、又は該チャネルに隣接して配置される、請求項1に記載のSPRセンサチップ。
- 前記表面プラズモン生成薄膜に隣接した少なくとも1つのチャネルにおいて、クロマトグラフ分離媒体をさらに備える、請求項2に記載のSPRセンサチップ。
- 前記表面プラズモン生成薄膜に結合される親和性媒体をさらに備える、請求項1、2又は3に記載のSPRセンサチップ。
- 請求項1〜4のいずれか1項に記載のSPRセンサチップと、
前記所定の波長の不可視放射を生成し、前記SPRセンサチップに向かって該不可視放射を誘導するように構成された光検出器と
を備える、SPRシステム。 - 前記光検出器は、前記不可視放射が前記表面プラズモン生成薄膜から反射された後に、前記不可視放射を検出するように構成された検出器をさらに備える、請求項5に記載のSPRシステム。
- 請求項1〜4のいずれか1項に記載のSPRセンサチップを提供するステップと、
対象となる溶液を前記チャネルに通すステップと、
前記表面プラズモン生成薄膜に向けて、不可視放射を前記SPRセンサチップの前記基板に通すステップとを含む、方法。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/064,575 US8178046B2 (en) | 2005-02-23 | 2005-02-23 | Microfluidic devices with SPR sensing capabilities |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2006234817A JP2006234817A (ja) | 2006-09-07 |
JP2006234817A5 JP2006234817A5 (ja) | 2009-04-09 |
JP4549985B2 true JP4549985B2 (ja) | 2010-09-22 |
Family
ID=36177667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2006046266A Active JP4549985B2 (ja) | 2005-02-23 | 2006-02-23 | Spr検出能力を有するマイクロ流体デバイス |
Country Status (3)
Country | Link |
---|---|
US (1) | US8178046B2 (ja) |
EP (1) | EP1696225A1 (ja) |
JP (1) | JP4549985B2 (ja) |
Families Citing this family (22)
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US20070176728A1 (en) * | 2006-01-31 | 2007-08-02 | Ranganath Tirumala R | Tiled periodic metal film sensors |
US20080318334A1 (en) * | 2007-06-20 | 2008-12-25 | Robotti Karla M | Microfluidic devices comprising fluid flow paths having a monolithic chromatographic material |
WO2009022985A1 (en) * | 2007-08-14 | 2009-02-19 | Agency For Science, Technology And Research | Sensor chip for use in optical spectroscopy |
US20090084166A1 (en) * | 2007-09-27 | 2009-04-02 | Robotti Karla M | Sensors comprising a chelated metal ion linker layer |
CN101868711B (zh) * | 2007-11-22 | 2013-09-18 | 皇家飞利浦电子股份有限公司 | 组合的光学和电学传感器盒 |
JP4806699B2 (ja) * | 2008-08-01 | 2011-11-02 | 日本電信電話株式会社 | マイクロチップ及び該マイクロチップを用いた抗体固定化方法 |
CN101650370B (zh) * | 2008-08-13 | 2013-05-01 | 中国科学院电子学研究所 | 一种集成微流控传感芯片及其对微流体进行检测方法 |
US8110148B2 (en) * | 2008-11-06 | 2012-02-07 | Siemens Medical Solutions Usa, Inc. | Apparatus and method using rotary flow distribution mechanisms |
US8696991B1 (en) | 2010-01-04 | 2014-04-15 | Harold W. Howe | Field deployable surface plasmon resonance based biosensor |
JP5796333B2 (ja) * | 2011-04-26 | 2015-10-21 | Jfeエンジニアリング株式会社 | マイクロチップユニット及びマイクロチップユニットを用いた化合物の合成装置 |
US9417186B2 (en) * | 2012-08-30 | 2016-08-16 | Infineon Technologies Ag | Opto-electronic sensor |
MX362545B (es) * | 2013-02-18 | 2019-01-24 | Theranos Ip Co Llc | Analisis de imagen y medicion de muestras biologicas. |
US9757726B2 (en) * | 2013-03-14 | 2017-09-12 | Inguran, Llc | System for high throughput sperm sorting |
KR101759894B1 (ko) * | 2014-04-09 | 2017-07-31 | (주)플렉센스 | 랩온어칩 및 이의 제조 방법 |
ES2701832T3 (es) * | 2014-05-27 | 2019-02-26 | Academia Sinica | Dispositivo de detección, y sistema de detección y método de detección que usan el mismo |
WO2016132625A1 (ja) * | 2015-02-18 | 2016-08-25 | シャープ株式会社 | 試料容器、計測方法、および試料容器の製造方法 |
US10859493B2 (en) | 2015-06-12 | 2020-12-08 | Lacrisciences, Llc | Miniature, field portable, surface plasmon resonance apparatus and its applications in the detection of chemical and biological agents |
EP3353531A2 (en) | 2015-09-24 | 2018-08-01 | LacriSciences LLC | Optical sensors, systems and methods of using same |
CA3005050A1 (en) | 2015-11-10 | 2017-05-18 | Lacriscience, Llc | Systems and methods for determining sample osmolarity |
CN105609588B (zh) * | 2016-01-22 | 2018-01-05 | 南京理工大学 | Au纳米颗粒增强的高性能无机钙钛矿CsPbX3纳米晶可见光探测器 |
DE102017105113B4 (de) | 2017-03-10 | 2021-09-30 | Leibniz-Institut für Photonische Technologien e.V. (Engl.Leibniz Institute of Photonic Technology) | Anordnung und Verfahren für die Erfassung von Änderungen der optischen Weglänge in einem Nano-Kapillarkanal |
CN108931503A (zh) * | 2018-04-19 | 2018-12-04 | 中山大学 | 一种基于局域表面等离子体共振传感的多指标检测器件 |
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- 2006-02-23 JP JP2006046266A patent/JP4549985B2/ja active Active
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Also Published As
Publication number | Publication date |
---|---|
EP1696225A1 (en) | 2006-08-30 |
US8178046B2 (en) | 2012-05-15 |
US20060188401A1 (en) | 2006-08-24 |
JP2006234817A (ja) | 2006-09-07 |
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Free format text: JAPANESE INTERMEDIATE CODE: R250 |
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Free format text: JAPANESE INTERMEDIATE CODE: R250 |
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Free format text: JAPANESE INTERMEDIATE CODE: R250 |