JP4512673B2 - 増大した可溶性発現および／または低下した一酸化窒素の排出を伴うヘモグロビン変異体 - Google Patents

増大した可溶性発現および／または低下した一酸化窒素の排出を伴うヘモグロビン変異体 Download PDF

Info

Publication number
JP4512673B2
JP4512673B2 JP54825298A JP54825298A JP4512673B2 JP 4512673 B2 JP4512673 B2 JP 4512673B2 JP 54825298 A JP54825298 A JP 54825298A JP 54825298 A JP54825298 A JP 54825298A JP 4512673 B2 JP4512673 B2 JP 4512673B2
Authority
JP
Japan
Prior art keywords
leu
hemoglobin
trp
soluble
val
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP54825298A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002507115A (ja
JP2002507115A5 (enExample
Inventor
ジェイ． ウェイカート，マイケル
ビー． グラスコック，クリストファー
ジェイ． マシューズ，アントニー
ディー． レモン，ダグラス
エイチ． ドハーティー，ダニエル
エス． オルソン，ジョン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
William Marsh Rice University
Original Assignee
William Marsh Rice University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by William Marsh Rice University filed Critical William Marsh Rice University
Publication of JP2002507115A publication Critical patent/JP2002507115A/ja
Publication of JP2002507115A5 publication Critical patent/JP2002507115A5/ja
Application granted granted Critical
Publication of JP4512673B2 publication Critical patent/JP4512673B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP54825298A 1997-05-02 1998-05-01 増大した可溶性発現および／または低下した一酸化窒素の排出を伴うヘモグロビン変異体 Expired - Fee Related JP4512673B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4536497P 1997-05-02 1997-05-02
US60/045,364 1997-05-02
US5798697P 1997-09-05 1997-09-05
US60/057,986 1997-09-05
PCT/US1998/008861 WO1998050430A2 (en) 1997-05-02 1998-05-01 Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008094054A Division JP4399634B2 (ja) 1997-05-02 2008-03-31 増大した可溶性発現および／または低下した一酸化窒素の排出を伴うヘモグロビン変異体

Publications (3)

Publication Number Publication Date
JP2002507115A JP2002507115A (ja) 2002-03-05
JP2002507115A5 JP2002507115A5 (enExample) 2006-03-02
JP4512673B2 true JP4512673B2 (ja) 2010-07-28

Family

ID=26722688

Family Applications (2)

Application Number Title Priority Date Filing Date
JP54825298A Expired - Fee Related JP4512673B2 (ja) 1997-05-02 1998-05-01 増大した可溶性発現および／または低下した一酸化窒素の排出を伴うヘモグロビン変異体
JP2008094054A Expired - Fee Related JP4399634B2 (ja) 1997-05-02 2008-03-31 増大した可溶性発現および／または低下した一酸化窒素の排出を伴うヘモグロビン変異体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008094054A Expired - Fee Related JP4399634B2 (ja) 1997-05-02 2008-03-31 増大した可溶性発現および／または低下した一酸化窒素の排出を伴うヘモグロビン変異体

Country Status (7)

Country Link
US (2) US6455676B1 (enExample)
EP (1) EP0979279B1 (enExample)
JP (2) JP4512673B2 (enExample)
AU (1) AU750295B2 (enExample)
CA (1) CA2299049C (enExample)
DE (1) DE69839263T2 (enExample)
WO (1) WO1998050430A2 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6670323B1 (en) 1999-11-12 2003-12-30 Baxter International, Inc. Reduced side-effect hemoglobin compositions
WO2003049593A2 (en) * 2001-12-06 2003-06-19 Duke University Prevention of flap necrosis in plastic surgery
DE10224750A1 (de) 2002-06-04 2003-12-24 Fresenius Medical Care De Gmbh Vorrichtung zur Behandlung einer medizinischen Flüssigkeit
US7642233B2 (en) * 2004-09-15 2010-01-05 William Marsh Rice University Enhancing recombinant hemoglobin production by co-expression with alpha hemoglobin stabilizing protein
WO2006031993A2 (en) * 2004-09-15 2006-03-23 William Marsh Rice University Enhancing recombinant hemoglobin production by co-expression with alpha hemoglobin stabilizing protein
US20070166792A1 (en) * 2004-09-15 2007-07-19 Olson John S Increasing hemoglobin and other heme protein production in bacteria by co-expression of heme transport genes
US7935074B2 (en) 2005-02-28 2011-05-03 Fresenius Medical Care Holdings, Inc. Cassette system for peritoneal dialysis machine
US20060195064A1 (en) * 2005-02-28 2006-08-31 Fresenius Medical Care Holdings, Inc. Portable apparatus for peritoneal dialysis therapy
US8197231B2 (en) 2005-07-13 2012-06-12 Purity Solutions Llc Diaphragm pump and related methods
EP2007744B1 (en) * 2006-04-03 2017-05-17 Pharmatherm Chemicals Inc. Thermal extraction method for producing a taxane extract
DK2463297T3 (en) 2006-05-22 2017-01-09 Univ California Oxygen Compositions and Methods
US7905990B2 (en) 2007-11-20 2011-03-15 Ensyn Renewables, Inc. Rapid thermal conversion of biomass
US8192401B2 (en) 2009-03-20 2012-06-05 Fresenius Medical Care Holdings, Inc. Medical fluid pump systems and related components and methods
EP2453946B1 (en) 2009-07-15 2013-02-13 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems
US8720913B2 (en) * 2009-08-11 2014-05-13 Fresenius Medical Care Holdings, Inc. Portable peritoneal dialysis carts and related systems
US8499702B2 (en) 2010-07-15 2013-08-06 Ensyn Renewables, Inc. Char-handling processes in a pyrolysis system
DE102010053973A1 (de) 2010-12-09 2012-06-14 Fresenius Medical Care Deutschland Gmbh Medizinisches Gerät mit einer Heizung
US9694125B2 (en) 2010-12-20 2017-07-04 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
US9624915B2 (en) 2011-03-09 2017-04-18 Fresenius Medical Care Holdings, Inc. Medical fluid delivery sets and related systems and methods
CN103648540B (zh) 2011-04-21 2016-06-01 弗雷塞尼斯医疗保健控股公司 医疗流体泵送系统及相关装置和方法
US9186449B2 (en) 2011-11-01 2015-11-17 Fresenius Medical Care Holdings, Inc. Dialysis machine support assemblies and related systems and methods
JP6389125B2 (ja) * 2011-11-07 2018-09-12 ザ ジェネラル ホスピタル コーポレイション 赤血球の処理法
US9109177B2 (en) 2011-12-12 2015-08-18 Ensyn Renewables, Inc. Systems and methods for renewable fuel
US9610392B2 (en) 2012-06-08 2017-04-04 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
US9500188B2 (en) 2012-06-11 2016-11-22 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
FR3002146B1 (fr) * 2013-02-15 2016-03-04 Hemarina Utilisation d'hemoglobine d'annelides pour traiter les cancers
US9561323B2 (en) 2013-03-14 2017-02-07 Fresenius Medical Care Holdings, Inc. Medical fluid cassette leak detection methods and devices
US10117985B2 (en) 2013-08-21 2018-11-06 Fresenius Medical Care Holdings, Inc. Determining a volume of medical fluid pumped into or out of a medical fluid cassette
US10752672B1 (en) * 2019-02-01 2020-08-25 Cheer Global Limited Recombinant hemoglobins and methods of preparation and use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6022849A (en) * 1987-05-16 2000-02-08 Baxter Biotech Technology Saarl Mutant recombinant hemoglobins containing heme pocket mutations
GB8711614D0 (en) * 1987-05-16 1987-06-24 Medical Res Council Proteins
US5449759A (en) 1987-05-16 1995-09-12 Somatogen, Inc. Hemoglobins with intersubunit desulfide bonds
US5599907A (en) 1989-05-10 1997-02-04 Somatogen, Inc. Production and use of multimeric hemoglobins
US5545727A (en) 1989-05-10 1996-08-13 Somatogen, Inc. DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
US5844090A (en) 1994-05-09 1998-12-01 Somatogen, Inc. Modified hemoglobin-like compounds
US5173426A (en) * 1989-10-06 1992-12-22 Yale University DNAs encoding genetically engineered low oxygen affinity mutants of human hemoglobin
CA2170638A1 (en) 1993-09-14 1995-03-23 Noboru Komiyama Improvements in or relating to haemoglobin
US5665869A (en) 1993-11-15 1997-09-09 Somatogen, Inc. Method for the rapid removal of protoporphyrin from protoporphyrin IX-containing solutions of hemoglobin
US5843888A (en) * 1995-05-01 1998-12-01 Carnegie Mellon University Low oxygen affinity mutant hemoglobin
AU6489996A (en) * 1995-07-14 1997-02-18 Somatogen, Inc. Methods for increasing protein expression
EP0859789A1 (en) * 1995-10-23 1998-08-26 Rice University Hemoglobin mutants that reduce heme loss
WO1997023631A2 (en) * 1995-12-22 1997-07-03 Somatogen, Inc. Globins containing binding domains

Also Published As

Publication number Publication date
JP2002507115A (ja) 2002-03-05
AU7275898A (en) 1998-11-27
US6455676B1 (en) 2002-09-24
DE69839263T2 (de) 2009-04-30
US20030017537A1 (en) 2003-01-23
EP0979279A2 (en) 2000-02-16
DE69839263D1 (de) 2008-04-30
EP0979279B1 (en) 2008-03-19
US7049406B2 (en) 2006-05-23
JP2008194051A (ja) 2008-08-28
CA2299049C (en) 2008-07-15
WO1998050430A3 (en) 1999-04-01
JP4399634B2 (ja) 2010-01-20
CA2299049A1 (en) 1998-11-12
WO1998050430A2 (en) 1998-11-12
AU750295B2 (en) 2002-07-11

Similar Documents

Publication Publication Date Title
JP4399634B2 (ja) 増大した可溶性発現および／または低下した一酸化窒素の排出を伴うヘモグロビン変異体
US6184356B1 (en) Production and use of multimeric hemoglobins
AU672960B2 (en) Production and use of multimeric hemoglobins
AU784195B2 (en) Reduced side-effect hemoglobin compositions
NO315568B1 (no) Fremgangsmåte til fremstilling av hemoglobinliknende protein
US6218513B1 (en) Globins containing binding domains
JP3991057B2 (ja) 改変ヘモグロビン化合物およびその精製方法
JPH09500639A (ja) ニッケルを含まないヘモグロビンおよびこのようなヘモグロビンを生産するための方法
EP1950298A2 (en) Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging
EP0784983A2 (en) Use of extracellular hemoglobin
US6171826B1 (en) Methods of controlling beta dimer formation in hemoglobin
WO1997023631A2 (en) Globins containing binding domains
CA2618690A1 (en) Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging
WO1991013158A1 (en) Protein production in yeast
WO1998008954A2 (en) Production of heme and recombinant hemoproteins
Olson et al. Hemoglobin mutants that reduce heme loss

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050215

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050927

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20071030

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080129

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080310

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080228

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080414

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080331

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080520

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080813

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080929

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080919

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20081111

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090206

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20090414

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20090514

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20090513

A72 Notification of change in name of applicant

Free format text: JAPANESE INTERMEDIATE CODE: A721

Effective date: 20090513

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130521

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130521

Year of fee payment: 3

R370 Written measure of declining of transfer procedure

Free format text: JAPANESE INTERMEDIATE CODE: R370

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130521

Year of fee payment: 3

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313117

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130521

Year of fee payment: 3

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees