AU750295B2 - Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging - Google Patents
Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging Download PDFInfo
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- AU750295B2 AU750295B2 AU72758/98A AU7275898A AU750295B2 AU 750295 B2 AU750295 B2 AU 750295B2 AU 72758/98 A AU72758/98 A AU 72758/98A AU 7275898 A AU7275898 A AU 7275898A AU 750295 B2 AU750295 B2 AU 750295B2
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4536497P | 1997-05-02 | 1997-05-02 | |
| US60/045364 | 1997-05-02 | ||
| US5798697P | 1997-09-05 | 1997-09-05 | |
| US60/057986 | 1997-09-05 | ||
| PCT/US1998/008861 WO1998050430A2 (en) | 1997-05-02 | 1998-05-01 | Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU7275898A AU7275898A (en) | 1998-11-27 |
| AU750295B2 true AU750295B2 (en) | 2002-07-11 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU72758/98A Ceased AU750295B2 (en) | 1997-05-02 | 1998-05-01 | Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6455676B1 (enExample) |
| EP (1) | EP0979279B1 (enExample) |
| JP (2) | JP4512673B2 (enExample) |
| AU (1) | AU750295B2 (enExample) |
| CA (1) | CA2299049C (enExample) |
| DE (1) | DE69839263T2 (enExample) |
| WO (1) | WO1998050430A2 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6670323B1 (en) | 1999-11-12 | 2003-12-30 | Baxter International, Inc. | Reduced side-effect hemoglobin compositions |
| WO2003049593A2 (en) * | 2001-12-06 | 2003-06-19 | Duke University | Prevention of flap necrosis in plastic surgery |
| DE10224750A1 (de) | 2002-06-04 | 2003-12-24 | Fresenius Medical Care De Gmbh | Vorrichtung zur Behandlung einer medizinischen Flüssigkeit |
| US7642233B2 (en) * | 2004-09-15 | 2010-01-05 | William Marsh Rice University | Enhancing recombinant hemoglobin production by co-expression with alpha hemoglobin stabilizing protein |
| WO2006031993A2 (en) * | 2004-09-15 | 2006-03-23 | William Marsh Rice University | Enhancing recombinant hemoglobin production by co-expression with alpha hemoglobin stabilizing protein |
| US20070166792A1 (en) * | 2004-09-15 | 2007-07-19 | Olson John S | Increasing hemoglobin and other heme protein production in bacteria by co-expression of heme transport genes |
| US7935074B2 (en) | 2005-02-28 | 2011-05-03 | Fresenius Medical Care Holdings, Inc. | Cassette system for peritoneal dialysis machine |
| US20060195064A1 (en) * | 2005-02-28 | 2006-08-31 | Fresenius Medical Care Holdings, Inc. | Portable apparatus for peritoneal dialysis therapy |
| US8197231B2 (en) | 2005-07-13 | 2012-06-12 | Purity Solutions Llc | Diaphragm pump and related methods |
| EP2007744B1 (en) * | 2006-04-03 | 2017-05-17 | Pharmatherm Chemicals Inc. | Thermal extraction method for producing a taxane extract |
| DK2463297T3 (en) | 2006-05-22 | 2017-01-09 | Univ California | Oxygen Compositions and Methods |
| US7905990B2 (en) | 2007-11-20 | 2011-03-15 | Ensyn Renewables, Inc. | Rapid thermal conversion of biomass |
| US8192401B2 (en) | 2009-03-20 | 2012-06-05 | Fresenius Medical Care Holdings, Inc. | Medical fluid pump systems and related components and methods |
| EP2453946B1 (en) | 2009-07-15 | 2013-02-13 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassettes and related systems |
| US8720913B2 (en) * | 2009-08-11 | 2014-05-13 | Fresenius Medical Care Holdings, Inc. | Portable peritoneal dialysis carts and related systems |
| US8499702B2 (en) | 2010-07-15 | 2013-08-06 | Ensyn Renewables, Inc. | Char-handling processes in a pyrolysis system |
| DE102010053973A1 (de) | 2010-12-09 | 2012-06-14 | Fresenius Medical Care Deutschland Gmbh | Medizinisches Gerät mit einer Heizung |
| US9694125B2 (en) | 2010-12-20 | 2017-07-04 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassettes and related systems and methods |
| US9624915B2 (en) | 2011-03-09 | 2017-04-18 | Fresenius Medical Care Holdings, Inc. | Medical fluid delivery sets and related systems and methods |
| CN103648540B (zh) | 2011-04-21 | 2016-06-01 | 弗雷塞尼斯医疗保健控股公司 | 医疗流体泵送系统及相关装置和方法 |
| US9186449B2 (en) | 2011-11-01 | 2015-11-17 | Fresenius Medical Care Holdings, Inc. | Dialysis machine support assemblies and related systems and methods |
| JP6389125B2 (ja) * | 2011-11-07 | 2018-09-12 | ザ ジェネラル ホスピタル コーポレイション | 赤血球の処理法 |
| US9109177B2 (en) | 2011-12-12 | 2015-08-18 | Ensyn Renewables, Inc. | Systems and methods for renewable fuel |
| US9610392B2 (en) | 2012-06-08 | 2017-04-04 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassettes and related systems and methods |
| US9500188B2 (en) | 2012-06-11 | 2016-11-22 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassettes and related systems and methods |
| FR3002146B1 (fr) * | 2013-02-15 | 2016-03-04 | Hemarina | Utilisation d'hemoglobine d'annelides pour traiter les cancers |
| US9561323B2 (en) | 2013-03-14 | 2017-02-07 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassette leak detection methods and devices |
| US10117985B2 (en) | 2013-08-21 | 2018-11-06 | Fresenius Medical Care Holdings, Inc. | Determining a volume of medical fluid pumped into or out of a medical fluid cassette |
| US10752672B1 (en) * | 2019-02-01 | 2020-08-25 | Cheer Global Limited | Recombinant hemoglobins and methods of preparation and use thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5028588A (en) * | 1987-05-16 | 1991-07-02 | Somatogenetics International, Inc. | Blood substitutes |
| WO1997004110A1 (en) * | 1995-07-14 | 1997-02-06 | Somatogen, Inc. | Methods for increasing protein expression |
| WO1997015591A1 (en) * | 1995-10-23 | 1997-05-01 | Rice University | Hemoglobin mutants that reduce heme loss |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6022849A (en) * | 1987-05-16 | 2000-02-08 | Baxter Biotech Technology Saarl | Mutant recombinant hemoglobins containing heme pocket mutations |
| US5449759A (en) | 1987-05-16 | 1995-09-12 | Somatogen, Inc. | Hemoglobins with intersubunit desulfide bonds |
| US5599907A (en) | 1989-05-10 | 1997-02-04 | Somatogen, Inc. | Production and use of multimeric hemoglobins |
| US5545727A (en) | 1989-05-10 | 1996-08-13 | Somatogen, Inc. | DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin |
| US5844090A (en) | 1994-05-09 | 1998-12-01 | Somatogen, Inc. | Modified hemoglobin-like compounds |
| US5173426A (en) * | 1989-10-06 | 1992-12-22 | Yale University | DNAs encoding genetically engineered low oxygen affinity mutants of human hemoglobin |
| CA2170638A1 (en) | 1993-09-14 | 1995-03-23 | Noboru Komiyama | Improvements in or relating to haemoglobin |
| US5665869A (en) | 1993-11-15 | 1997-09-09 | Somatogen, Inc. | Method for the rapid removal of protoporphyrin from protoporphyrin IX-containing solutions of hemoglobin |
| US5843888A (en) * | 1995-05-01 | 1998-12-01 | Carnegie Mellon University | Low oxygen affinity mutant hemoglobin |
| WO1997023631A2 (en) * | 1995-12-22 | 1997-07-03 | Somatogen, Inc. | Globins containing binding domains |
-
1998
- 1998-05-01 WO PCT/US1998/008861 patent/WO1998050430A2/en not_active Ceased
- 1998-05-01 DE DE69839263T patent/DE69839263T2/de not_active Expired - Lifetime
- 1998-05-01 US US09/403,208 patent/US6455676B1/en not_active Expired - Fee Related
- 1998-05-01 EP EP98920113A patent/EP0979279B1/en not_active Expired - Lifetime
- 1998-05-01 AU AU72758/98A patent/AU750295B2/en not_active Ceased
- 1998-05-01 CA CA002299049A patent/CA2299049C/en not_active Expired - Fee Related
- 1998-05-01 JP JP54825298A patent/JP4512673B2/ja not_active Expired - Fee Related
-
2002
- 2002-03-27 US US10/107,871 patent/US7049406B2/en not_active Expired - Fee Related
-
2008
- 2008-03-31 JP JP2008094054A patent/JP4399634B2/ja not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5028588A (en) * | 1987-05-16 | 1991-07-02 | Somatogenetics International, Inc. | Blood substitutes |
| WO1997004110A1 (en) * | 1995-07-14 | 1997-02-06 | Somatogen, Inc. | Methods for increasing protein expression |
| WO1997015591A1 (en) * | 1995-10-23 | 1997-05-01 | Rice University | Hemoglobin mutants that reduce heme loss |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002507115A (ja) | 2002-03-05 |
| AU7275898A (en) | 1998-11-27 |
| US6455676B1 (en) | 2002-09-24 |
| DE69839263T2 (de) | 2009-04-30 |
| US20030017537A1 (en) | 2003-01-23 |
| EP0979279A2 (en) | 2000-02-16 |
| DE69839263D1 (de) | 2008-04-30 |
| EP0979279B1 (en) | 2008-03-19 |
| US7049406B2 (en) | 2006-05-23 |
| JP2008194051A (ja) | 2008-08-28 |
| CA2299049C (en) | 2008-07-15 |
| WO1998050430A3 (en) | 1999-04-01 |
| JP4512673B2 (ja) | 2010-07-28 |
| JP4399634B2 (ja) | 2010-01-20 |
| CA2299049A1 (en) | 1998-11-12 |
| WO1998050430A2 (en) | 1998-11-12 |
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| PC1 | Assignment before grant (sect. 113) |
Free format text: BAXTER BIOTECH TECHNOLOGY SARL; WILLIAM MARSH RICE UNIVERSITY |
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| FGA | Letters patent sealed or granted (standard patent) |