JP4491616B2 - ラマン分光分析に用いる分析用基板及び分析用基板組合体 - Google Patents
ラマン分光分析に用いる分析用基板及び分析用基板組合体 Download PDFInfo
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- JP4491616B2 JP4491616B2 JP2007542322A JP2007542322A JP4491616B2 JP 4491616 B2 JP4491616 B2 JP 4491616B2 JP 2007542322 A JP2007542322 A JP 2007542322A JP 2007542322 A JP2007542322 A JP 2007542322A JP 4491616 B2 JP4491616 B2 JP 4491616B2
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
- G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
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Description
3 ガラス基板
5 金粒子
7 密集領域
9 分散領域
21 分析用基板組合体
23 円筒状ガラス基板
25a 金粒子
25b 板状ガラス基板
31 分析用ガラス基板
33 金粒子
35 円筒状ガラス基板
41 分析用基板組合体
43 円筒状分析用基板
45 板状分析用基板
51 分析用基板組合体
53 円筒状分析用基板(大直径)
55 円筒状分析用基板(小直径)
61 分析用基板組合体
63 板状分析用基板
71 分析用基板組合体
73 板状分析用基板
75 容器
81 分析用基板組合体
101 分析用基板組合体
103 分析用基板
105 分析用基板
111 分析用基板組合体
113 分析用基板
115 分析用基板
121 分析用基板組合体
123 分析用基板
125 分析用基板
127 分析用基板
L レーザ光
R ラマン散乱
S 測定分子
T 試料
−〔ラマンシフト1013cm-1ピーク両端の散乱強度の平均値〕
その結果、ピーク強度の増加に伴う、濃度の増加が認められ、定量性の存在が確認された。そこで、それぞれの増強および多重増強回数において検出限界濃度と検出感度増強度を算出した。検出限界濃度はS/N(signal to noise ratio)=3におけるピリジン水溶液の濃度として計算を行った。ノイズ値は、ラマンスペクトルにおいてピークが何も認められない2300−2350cm-1における二乗平均平方根(RMS)を用いた。得られた検出限界シグナル値は図18の検量線と照らし合わせて検出限界濃度を計算した。検出限界増強度は増強回数0回における検出限界濃度を1と設定し算出した。その結果を図16および図17に示す。その結果、通常のラマン測定(増強回数0回)では検出限界が220ppmであるのに対し、SERS(増強回数1回)では129ppbとなり、検出感度増強度は1,700倍となった(図16参照)。一方、MERS(多重増強回数5回)では0.96ppbとなり、通常のラマン測定に対して検出感度増強度は209,900倍となった(図17参照)。つまり、MERSを用いることにより通常のラマン分光計による検出感度に対して10,000倍を超えるラマン散乱の増強が確認された。
Claims (10)
- ラマン分光分析に用いる分析用基板であって、所定の透明基板と、この透明基板の表面に不均一に付着した金属粒子とからなり、
前記金属粒子は、前記透明基板上の所定の領域ではナノオーダーの間隔で密集し、それ以外の領域ではマイクロオーダーの間隔で分散していることを特徴とする分析用基板。 - 前記金属粒子は金、銀、銅、白金、パラジウム、アルミニウム、チタン又はコバルトからなることを特徴とする請求項1に記載の分析用基板。
- 前記透明基板は、板状であることを特徴とする請求項1又は2に記載の分析用基板。
- 前記透明基板は、円筒状であることを特徴とする請求項1又は2に記載の分析用基板。
- 前記透明基板は、直方体状であることを特徴とする請求項1又は2に記載の分析用基板。
- 少なくとも2枚の上記請求項3に記載の板状の分析用基板を相互に平行に配列したことを特徴とする分析用基板組合体。
- 上記請求項4に記載の円筒状の分析用基板と、この円筒状の分析用基板の内部に挿入される少なくとも1枚の上記請求項3に記載の板状の分析用基板とからなることを特徴とする分析用基板組合体。
- 直径の異なる少なくとも2つの上記請求項4に記載の円筒状の分析用基板を備え、直径の大きな分析用基板の内部に直径の小さな分析用基板を配置したことを特徴とする分析用基板組合体。
- 上記請求項5に記載の直方体状の分析用基板と、この直方体状の分析用基板の内部に挿入される少なくとも1枚の上記請求項3に記載の板状の分析用基板とからなることを特徴とする分析用基板組合体。
- 前記複数の分析用基板には、相互に異なる金属粒子が付着されていることを特徴とする請求項6〜9の何れか一項に記載の分析用基板組合体。
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JP2005309337 | 2005-10-25 | ||
JP2005309337 | 2005-10-25 | ||
PCT/JP2006/320703 WO2007049487A1 (ja) | 2005-10-25 | 2006-10-18 | ラマン分光分析に用いる分析用基板及び分析用基板組合体 |
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JPWO2007049487A1 JPWO2007049487A1 (ja) | 2009-04-30 |
JP4491616B2 true JP4491616B2 (ja) | 2010-06-30 |
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JP2007542322A Active JP4491616B2 (ja) | 2005-10-25 | 2006-10-18 | ラマン分光分析に用いる分析用基板及び分析用基板組合体 |
Country Status (6)
Country | Link |
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US (1) | US20090097021A1 (ja) |
EP (1) | EP1950556A4 (ja) |
JP (1) | JP4491616B2 (ja) |
CN (1) | CN101351700B (ja) |
TW (1) | TW200728706A (ja) |
WO (1) | WO2007049487A1 (ja) |
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WO2007108360A1 (ja) * | 2006-03-17 | 2007-09-27 | Intellectual Property Bank Corp. | 細径盲管を用いた表面増強ラマン散乱による物質検知方法および物質検知装置、複数物質検知デバイス、盲管 |
CN102483379A (zh) * | 2009-07-30 | 2012-05-30 | 惠普开发有限公司 | 用于进行拉曼光谱学的纳米线集光器 |
JP5292326B2 (ja) * | 2010-01-29 | 2013-09-18 | 株式会社日立ハイテクノロジーズ | 標準試料作成方法、および標準試料 |
US9019494B2 (en) | 2011-08-14 | 2015-04-28 | Industrial Technology Research Institute | Surface-enhanced Raman scattering substrate and a trace detection method of a biological and chemical analyte using the same |
TWI485388B (zh) * | 2011-08-14 | 2015-05-21 | Ind Tech Res Inst | 拉曼散射增強基板、利用上述基板之微量生化感測方法 |
US9212997B2 (en) | 2012-07-29 | 2015-12-15 | Hewlett-Packard Development Company, L.P. | Scattering spectroscopy nanosensor |
JP6151948B2 (ja) | 2013-03-29 | 2017-06-21 | 浜松ホトニクス株式会社 | 表面増強ラマン散乱ユニット及びラマン分光分析方法 |
CN104508466B (zh) | 2012-08-10 | 2018-07-17 | 浜松光子学株式会社 | 表面增强拉曼散射元件 |
JP6230250B2 (ja) | 2013-03-29 | 2017-11-15 | 浜松ホトニクス株式会社 | 表面増強ラマン散乱ユニット、及びラマン分光分析方法 |
WO2014025037A1 (ja) | 2012-08-10 | 2014-02-13 | 浜松ホトニクス株式会社 | 表面増強ラマン散乱素子及びその製造方法 |
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CN103196887B (zh) * | 2013-03-27 | 2015-01-28 | 中国科学院重庆绿色智能技术研究院 | 一种有机农药检测用高通量微流控装置及其水样检测方法 |
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KR20210058883A (ko) * | 2018-10-11 | 2021-05-24 | 휴렛-팩커드 디벨롭먼트 컴퍼니, 엘.피. | 분석 칩들 상의 분석물들을 갖는 마이크로도트들의 퇴적 |
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-
2006
- 2006-10-18 WO PCT/JP2006/320703 patent/WO2007049487A1/ja active Application Filing
- 2006-10-18 EP EP06821905.4A patent/EP1950556A4/en not_active Withdrawn
- 2006-10-18 JP JP2007542322A patent/JP4491616B2/ja active Active
- 2006-10-18 US US12/084,062 patent/US20090097021A1/en not_active Abandoned
- 2006-10-18 CN CN2006800491295A patent/CN101351700B/zh not_active Expired - Fee Related
- 2006-10-23 TW TW095139030A patent/TW200728706A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
JPWO2007049487A1 (ja) | 2009-04-30 |
US20090097021A1 (en) | 2009-04-16 |
WO2007049487A1 (ja) | 2007-05-03 |
CN101351700B (zh) | 2012-07-04 |
CN101351700A (zh) | 2009-01-21 |
EP1950556A1 (en) | 2008-07-30 |
EP1950556A4 (en) | 2014-07-02 |
TW200728706A (en) | 2007-08-01 |
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