JP4462818B2 - 生体接着性薬物送達系 - Google Patents
生体接着性薬物送達系 Download PDFInfo
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- JP4462818B2 JP4462818B2 JP2002266381A JP2002266381A JP4462818B2 JP 4462818 B2 JP4462818 B2 JP 4462818B2 JP 2002266381 A JP2002266381 A JP 2002266381A JP 2002266381 A JP2002266381 A JP 2002266381A JP 4462818 B2 JP4462818 B2 JP 4462818B2
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- JP
- Japan
- Prior art keywords
- delivery system
- drug
- drug delivery
- therapeutically effective
- vaginal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
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- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- AIDS & HIV (AREA)
- Diabetes (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/101,014 US6899890B2 (en) | 2002-03-20 | 2002-03-20 | Bioadhesive drug delivery system |
| US10/101014 | 2002-03-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003286193A JP2003286193A (ja) | 2003-10-07 |
| JP4462818B2 true JP4462818B2 (ja) | 2010-05-12 |
Family
ID=22282669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002266381A Expired - Fee Related JP4462818B2 (ja) | 2002-03-20 | 2002-09-12 | 生体接着性薬物送達系 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6899890B2 (hu) |
| EP (1) | EP1494630A4 (hu) |
| JP (1) | JP4462818B2 (hu) |
| KR (2) | KR20030076159A (hu) |
| CN (3) | CN1444926A (hu) |
| AR (1) | AR039037A1 (hu) |
| AU (2) | AU2002300175B2 (hu) |
| BR (1) | BR0202767A (hu) |
| CA (1) | CA2392473C (hu) |
| FR (1) | FR2837389A1 (hu) |
| HU (1) | HUP0203102A3 (hu) |
| IT (1) | ITMI20021660A1 (hu) |
| MX (1) | MXPA02006943A (hu) |
| PT (1) | PT102854B (hu) |
| RU (1) | RU2320322C2 (hu) |
| WO (1) | WO2003079981A2 (hu) |
| ZA (1) | ZA200407535B (hu) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7060732B2 (en) * | 2000-12-12 | 2006-06-13 | Imaginative Research Associates, Inc. | Antibiotic/benzoyl peroxide dispenser |
| US20060189552A1 (en) * | 2000-12-12 | 2006-08-24 | Mohan Vishnupad | Dispenser for dispensing three or more actives |
| US6899890B2 (en) * | 2002-03-20 | 2005-05-31 | Kv Pharmaceutical Company | Bioadhesive drug delivery system |
| US20060083759A1 (en) * | 2002-07-17 | 2006-04-20 | Aleksander Resman | Stabilization of the profile of release of active substances from a formulation |
| WO2004105662A1 (en) * | 2003-05-23 | 2004-12-09 | Program For Appropriate Technology In Health | Microbicidal compositions and methods of use |
| ITTO20030404A1 (it) * | 2003-05-30 | 2004-11-30 | Rottapharm S R L | Composizione per il ripristino dell'ecosistema vaginale |
| GB0315671D0 (en) * | 2003-07-04 | 2003-08-13 | Chelsea And Westminster Nhs Tr | Improvements in or relating to organic compounds |
| BRPI0414500A (pt) | 2003-09-19 | 2006-11-07 | Drugtech Corp | formulação farmacêutica composição para tratar uma infecção vaginal, e, métodos para tratar uma infecção vaginal, para estabilizar uma formulação de clindamicina, para tratar ou prevenir uma recorrência de uma infecção vaginal em uma paciente e para tratar condições vaginais |
| US20060140990A1 (en) | 2003-09-19 | 2006-06-29 | Drugtech Corporation | Composition for topical treatment of mixed vaginal infections |
| EA010885B1 (ru) | 2003-12-08 | 2008-12-30 | Бентли Фармасьютикалз, Инк. | Фармацевтические композиции и способы лечения инсулином |
| US8057433B2 (en) | 2004-07-08 | 2011-11-15 | Drugtech Corporation | Delivery system |
| UA93354C2 (ru) | 2004-07-09 | 2011-02-10 | Гилиад Сайенсиз, Инк. | Местный противовирусный препарат |
| US20060093675A1 (en) * | 2004-10-29 | 2006-05-04 | Mathew Ebmeier | Intravaginal treatment of vaginal infections with metronidazole compositions |
| US7619008B2 (en) * | 2004-11-12 | 2009-11-17 | Kimberly-Clark Worldwide, Inc. | Xylitol for treatment of vaginal infections |
| US20060217443A1 (en) * | 2005-03-28 | 2006-09-28 | Kimberly-Clark Worldwide, Inc. | Method for preventing and/or treating vaginal and vulval infections |
| BRPI0612968A2 (pt) | 2005-04-27 | 2010-12-14 | Shenzhen Phlora Biotechnology Ltd | uso do Ácido benzàico e/ou seu sal de sàdio em combinaÇço com sacarÍdeos, composiÇço vaginal e mÉtodo para modular a flora vaginal e a acidez vaginal |
| WO2006121429A1 (en) * | 2005-05-06 | 2006-11-16 | Imaginative Research Associates, Inc. | Clindamycin compositions and delivery system therefor |
| US20070110805A1 (en) * | 2005-05-09 | 2007-05-17 | Levinson R S | Modified-release pharmaceutical compositions |
| US7786176B2 (en) * | 2005-07-29 | 2010-08-31 | Kimberly-Clark Worldwide, Inc. | Vaginal treatment composition containing xylitol |
| WO2007021964A2 (en) | 2005-08-11 | 2007-02-22 | Massachusetts Institute Of Technology | Intravesical drug delivery device and method |
| AR056453A1 (es) * | 2005-08-12 | 2007-10-10 | Drug Tech Corp | Composiciones con estrogeno y metodos terapeuticos para su uso |
| AU2006332518A1 (en) * | 2006-01-05 | 2007-07-12 | Drugtech Corporation | Composition and method of use thereof |
| EP1968544A2 (en) * | 2006-01-05 | 2008-09-17 | Drugtech Corporation | Drug delivery system for bioadhesion to a vulvovaginal surface |
| US20070202050A1 (en) * | 2006-02-09 | 2007-08-30 | Julianne Berry | Pharmaceutical Formulations |
| EP1872775A1 (en) * | 2006-06-29 | 2008-01-02 | Polichem S.A. | Use of a hydrophilic matrix comprising a polyacrylic acid derivative, a cellulose ether and a disintegrant for the manufacture of a medicament for treating female genital disorders |
| US20080003262A1 (en) * | 2006-06-30 | 2008-01-03 | Drugtech Corporation | Compositions and therapeutic methods of use |
| US20080085877A1 (en) * | 2006-08-10 | 2008-04-10 | Drugtech Corporation | Therapeutic methods of using estrogen compositions |
| US20080268022A1 (en) * | 2007-02-23 | 2008-10-30 | Mccabe R Tyler | Mehtods for treating and preventing ailments caused by human papillomavirus |
| WO2008144143A1 (en) * | 2007-05-14 | 2008-11-27 | Drugtech Corporation | Endometriosis treatment |
| EP1994938A1 (en) * | 2007-05-21 | 2008-11-26 | Combinature Biopharm AG | New lipoglycodepsipeptide compositions |
| BRPI0820800B8 (pt) * | 2007-12-11 | 2021-06-22 | Massachusetts Inst Technology | dispositivo médico implantável para liberação controlada de droga |
| US20090238867A1 (en) * | 2007-12-13 | 2009-09-24 | Scott Jenkins | Nanoparticulate Anidulafungin Compositions and Methods for Making the Same |
| WO2010019507A2 (en) * | 2008-08-09 | 2010-02-18 | Massachusetts Institute Of Technology | Implantable drug delivery device and methods of treating male genitourinary and surrounding tissues |
| US8758730B2 (en) * | 2009-02-26 | 2014-06-24 | B.R.A.I.N. Biotechnology Research And Information Network Ag | Compositions, use and method for the use of surface active proteins in topical drug delivery across keratin |
| CA2765734C (en) | 2009-06-26 | 2016-12-13 | Taris Biomedical, Inc. | Implantable drug delivery devices and methods of making the same |
| US20110008469A1 (en) * | 2009-07-09 | 2011-01-13 | Florida Gulf Coast University | Antimicrobial composition and methods and apparatus for use thereof |
| US9017312B2 (en) | 2009-09-10 | 2015-04-28 | Taris Biomedical Llc | Implantable device for controlled drug delivery |
| RU2479305C2 (ru) * | 2010-12-06 | 2013-04-20 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Фармацевтическая композиция для лечения инфекционных воспалительных заболеваний в гинекологии и способ ее получения |
| WO2012096985A1 (en) | 2011-01-10 | 2012-07-19 | Taris Biomedical, Inc. | Lidocaine regimen for the use of sustained treatment of bladder pain and irritative voiding |
| BR112013019410A2 (pt) | 2011-02-04 | 2019-09-24 | Taris Biomedical Inc | dispositivo implantável para liberação controlada de fármaco de solubilidade baixa |
| US9327037B2 (en) | 2011-02-08 | 2016-05-03 | The Johns Hopkins University | Mucus penetrating gene carriers |
| PL2694033T3 (pl) | 2011-04-04 | 2017-06-30 | Environ Skin Care (Pty) Ltd | Leczenie zakażeń wirusowych |
| CA2839790A1 (en) | 2011-05-02 | 2012-11-08 | Aptalis Pharmatech, Inc. | Rapid dissolve tablet compositions for vaginal administration |
| JP6047576B2 (ja) * | 2011-09-19 | 2016-12-21 | オムニアクティブ ヘルス テクノロジーズ リミテッド | 食用のリコピン含有オレオレジンおよびリコピン結晶の調製のための効率的な方法 |
| US9180094B2 (en) | 2011-10-12 | 2015-11-10 | The Texas A&M University System | High porosity materials, scaffolds, and method of making |
| AU2013209452B2 (en) * | 2012-01-19 | 2015-11-05 | The Johns Hopkins University | Nanoparticle formulations with enhanced mucosal penetration |
| US9822257B2 (en) | 2012-07-23 | 2017-11-21 | Crayola Llc | Dissolvable films and methods of using the same |
| RU2538703C2 (ru) * | 2013-03-12 | 2015-01-10 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Фармацевтическая композиция для лечения вагинального кандидоза и способ ее получения |
| US10315019B2 (en) | 2013-03-15 | 2019-06-11 | Taris Biomedical Llc | Drug delivery devices with drug-permeable component and methods |
| WO2014192791A1 (ja) * | 2013-05-30 | 2014-12-04 | 大正製薬株式会社 | 坐剤 |
| EP4234036A3 (en) | 2013-08-19 | 2023-11-01 | TARIS Biomedical LLC | Multi-unit drug delivery devices |
| US10363215B2 (en) | 2013-11-08 | 2019-07-30 | The Texas A&M University System | Porous microparticles with high loading efficiencies |
| US20150238549A1 (en) * | 2014-02-27 | 2015-08-27 | Mak Wood, Inc. | Probiotic dosage units |
| EP3113824B1 (en) | 2014-03-03 | 2021-04-14 | Cook Medical Technologies LLC | Mechanical dilator |
| US10335500B2 (en) | 2014-05-12 | 2019-07-02 | The Johns Hopkins University | Highly stable biodegradable gene vector platforms for overcoming biological barriers |
| JP7425534B2 (ja) | 2015-04-23 | 2024-01-31 | タリス バイオメディカル エルエルシー | 薬物透過性構成要素を有する薬物送達デバイス及び方法 |
| CN107847434A (zh) | 2015-05-29 | 2018-03-27 | Eve制药有限公司 | Ph依赖型阴道组合物和治疗阴道病症的方法 |
| EP3355893A4 (en) | 2015-09-29 | 2019-06-12 | Kimberly-Clark Worldwide, Inc. | SYNERGISTIC COMPOSITION FOR MAINTAINING A HEALTHY BALANCE OF THE MICROFLORE |
| KR101880179B1 (ko) * | 2016-11-03 | 2018-07-20 | 한국생명공학연구원 | 미카펀진(micafungin) 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 함유하는 항바이러스용 약학적 조성물 |
| CN110799198A (zh) * | 2016-11-30 | 2020-02-14 | 普罗生物瑞士股份公司 | 用于稳定阴道液的酸度和氧化还原状态的基于合适的生化组合物的泌尿生殖器医疗设备制剂 |
| US20220047651A1 (en) * | 2018-12-19 | 2022-02-17 | Healthy Cow Corporation | Ready-to-use probiotic compositions and uses thereof |
| US11529346B2 (en) * | 2020-06-18 | 2022-12-20 | National Medical Supply, LLC | Vaginal gel |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3988508A (en) | 1973-03-08 | 1976-10-26 | Petrolite Corporation | High internal phase ratio emulsion polymers |
| DE3321043A1 (de) * | 1983-06-10 | 1984-12-13 | Bayer Ag, 5090 Leverkusen | Antimykotische mittel fuer einmalige gynaekologische behandlung |
| US4551148A (en) | 1982-09-07 | 1985-11-05 | Kv Pharmaceutical Company | Vaginal delivery systems and their methods of preparation and use |
| US5266329A (en) | 1985-10-31 | 1993-11-30 | Kv Pharmaceutical Company | Vaginal delivery system |
| US5536743A (en) | 1988-01-15 | 1996-07-16 | Curatek Pharmaceuticals Limited Partnership | Intravaginal treatment of vaginal infections with buffered metronidazole compositions |
| US4895452A (en) | 1988-03-03 | 1990-01-23 | Micro-Pak, Inc. | Method and apparatus for producing lipid vesicles |
| US5055303A (en) | 1989-01-31 | 1991-10-08 | Kv Pharmaceutical Company | Solid controlled release bioadherent emulsions |
| CA1337279C (en) | 1989-06-06 | 1995-10-10 | Robert J. Borgman | Intravaginal treatment of vaginal infections with buffered metronidazole compositions |
| US5298246A (en) | 1991-01-09 | 1994-03-29 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Stable pharmaceutical composition and method for its production |
| ATE154241T1 (de) | 1991-10-01 | 1997-06-15 | Takeda Chemical Industries Ltd | Mikropartikeln-zusammenfassung zur verlängerten freigabe und herstellung derselbe |
| US5189070A (en) | 1992-05-29 | 1993-02-23 | Shell Oil Company | Process for preparing low density porous crosslinked polymeric materials |
| US6191105B1 (en) | 1993-05-10 | 2001-02-20 | Protein Delivery, Inc. | Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin |
| US5576016A (en) | 1993-05-18 | 1996-11-19 | Pharmos Corporation | Solid fat nanoemulsions as drug delivery vehicles |
| US5744155A (en) | 1993-08-13 | 1998-04-28 | Friedman; Doron | Bioadhesive emulsion preparations for enhanced drug delivery |
| US5470885A (en) | 1993-09-29 | 1995-11-28 | The Research Foundation Of The State University Of New York | Fluorocarbons as anti-inflammatory agents |
| TW438601B (en) | 1994-05-18 | 2001-06-07 | Janssen Pharmaceutica Nv | New mucoadhesive emulsion compositions and a process for the preparation thereof |
| US5980936A (en) | 1997-08-07 | 1999-11-09 | Alliance Pharmaceutical Corp. | Multiple emulsions comprising a hydrophobic continuous phase |
| US5877216A (en) | 1997-10-28 | 1999-03-02 | Vivus, Incorporated | Treatment of female sexual dysfunction |
| AU740758B2 (en) | 1997-10-28 | 2001-11-15 | Vivus, Inc. | Treatment of female sexual dysfunction |
| US6899890B2 (en) * | 2002-03-20 | 2005-05-31 | Kv Pharmaceutical Company | Bioadhesive drug delivery system |
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- 2002-06-28 CA CA002392473A patent/CA2392473C/en not_active Expired - Lifetime
- 2002-07-10 KR KR1020020039940A patent/KR20030076159A/ko not_active Application Discontinuation
- 2002-07-15 MX MXPA02006943A patent/MXPA02006943A/es active IP Right Grant
- 2002-07-15 AU AU2002300175A patent/AU2002300175B2/en not_active Ceased
- 2002-07-18 BR BR0202767-4A patent/BR0202767A/pt not_active IP Right Cessation
- 2002-07-26 IT IT2002MI001660A patent/ITMI20021660A1/it unknown
- 2002-07-29 CN CN02127087A patent/CN1444926A/zh active Pending
- 2002-07-29 CN CN2010105156408A patent/CN102048689A/zh active Pending
- 2002-07-29 CN CNA2007101048008A patent/CN101045034A/zh active Pending
- 2002-09-12 JP JP2002266381A patent/JP4462818B2/ja not_active Expired - Fee Related
- 2002-09-18 HU HU0203102A patent/HUP0203102A3/hu unknown
- 2002-10-15 PT PT102854A patent/PT102854B/pt not_active IP Right Cessation
- 2002-11-27 FR FR0214858A patent/FR2837389A1/fr active Pending
-
2003
- 2003-03-19 WO PCT/US2003/008266 patent/WO2003079981A2/en not_active Application Discontinuation
- 2003-03-19 RU RU2004130870/15A patent/RU2320322C2/ru not_active IP Right Cessation
- 2003-03-19 EP EP03714226A patent/EP1494630A4/en not_active Ceased
- 2003-03-19 AU AU2003218233A patent/AU2003218233A1/en not_active Abandoned
- 2003-03-20 AR ARP030100979A patent/AR039037A1/es unknown
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2004
- 2004-09-17 ZA ZA200407535A patent/ZA200407535B/en unknown
-
2008
- 2008-10-29 KR KR1020080106637A patent/KR20080098576A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2004130870A (ru) | 2005-06-10 |
| US20030180366A1 (en) | 2003-09-25 |
| PT102854A (pt) | 2003-09-30 |
| HUP0203102A2 (hu) | 2004-05-28 |
| HU0203102D0 (hu) | 2002-11-28 |
| AU2002300175A1 (en) | 2003-10-09 |
| AU2003218233A8 (en) | 2003-10-08 |
| WO2003079981A2 (en) | 2003-10-02 |
| PT102854B (pt) | 2004-02-27 |
| AU2002300175B2 (en) | 2004-04-22 |
| AU2003218233A1 (en) | 2003-10-08 |
| WO2003079981A3 (en) | 2003-11-06 |
| US6899890B2 (en) | 2005-05-31 |
| CA2392473A1 (en) | 2003-09-20 |
| CN102048689A (zh) | 2011-05-11 |
| JP2003286193A (ja) | 2003-10-07 |
| ZA200407535B (en) | 2006-06-28 |
| AR039037A1 (es) | 2005-02-02 |
| BR0202767A (pt) | 2004-05-25 |
| CA2392473C (en) | 2007-09-18 |
| ITMI20021660A1 (it) | 2004-01-26 |
| KR20080098576A (ko) | 2008-11-11 |
| MXPA02006943A (es) | 2004-12-13 |
| KR20030076159A (ko) | 2003-09-26 |
| EP1494630A2 (en) | 2005-01-12 |
| FR2837389A1 (fr) | 2003-09-26 |
| HUP0203102A3 (en) | 2004-06-28 |
| EP1494630A4 (en) | 2007-03-14 |
| RU2320322C2 (ru) | 2008-03-27 |
| CN101045034A (zh) | 2007-10-03 |
| CN1444926A (zh) | 2003-10-01 |
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