JP4425632B2 - ４−（ピペリジル）（２−ピリジル）メタノン−（ｅ）−ｏ−メチルオキシムおよびその塩の合成 - Google Patents

４−（ピペリジル）（２−ピリジル）メタノン−（ｅ）−ｏ−メチルオキシムおよびその塩の合成 Download PDF

Info

Publication number
JP4425632B2
JP4425632B2 JP2003536228A JP2003536228A JP4425632B2 JP 4425632 B2 JP4425632 B2 JP 4425632B2 JP 2003536228 A JP2003536228 A JP 2003536228A JP 2003536228 A JP2003536228 A JP 2003536228A JP 4425632 B2 JP4425632 B2 JP 4425632B2
Authority
JP
Japan
Prior art keywords
formula
compound
solvent
acid
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2003536228A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005506357A (ja
JP2005506357A5 (de
Inventor
ウェンシュ ウ，
ホンビアオ リアオ，
デビット ジェイ． エス． ツァイ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of JP2005506357A publication Critical patent/JP2005506357A/ja
Publication of JP2005506357A5 publication Critical patent/JP2005506357A5/ja
Application granted granted Critical
Publication of JP4425632B2 publication Critical patent/JP4425632B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2003536228A 2001-10-15 2002-10-15 ４−（ピペリジル）（２−ピリジル）メタノン−（ｅ）−ｏ−メチルオキシムおよびその塩の合成 Expired - Fee Related JP4425632B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32956101P 2001-10-15 2001-10-15
PCT/US2002/033118 WO2003033488A1 (en) 2001-10-15 2002-10-15 Synthesis of 4-(piperidyl) (2-pyridyl)methanone-(e)-o-methyloxime and its salts

Publications (3)

Publication Number Publication Date
JP2005506357A JP2005506357A (ja) 2005-03-03
JP2005506357A5 JP2005506357A5 (de) 2009-08-20
JP4425632B2 true JP4425632B2 (ja) 2010-03-03

Family

ID=23285979

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003536228A Expired - Fee Related JP4425632B2 (ja) 2001-10-15 2002-10-15 ４−（ピペリジル）（２−ピリジル）メタノン−（ｅ）−ｏ−メチルオキシムおよびその塩の合成

Country Status (14)

Country Link
EP (1) EP1436282B1 (de)
JP (1) JP4425632B2 (de)
CN (2) CN101157685A (de)
AR (1) AR036881A1 (de)
AT (1) ATE298333T1 (de)
CA (1) CA2463510A1 (de)
DE (1) DE60204791T2 (de)
DK (1) DK1436282T3 (de)
ES (1) ES2240839T3 (de)
HK (1) HK1062683A1 (de)
MX (1) MXPA04003477A (de)
PT (1) PT1436282E (de)
WO (1) WO2003033488A1 (de)
ZA (1) ZA200402070B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2008008340A (es) * 2005-12-21 2008-09-03 Schering Corp Tratamiento de enfermedad de higado graso no alcoholica usando agentes reductores de colesterol y/o antagonista/agonista inverso de receptor de histamina 3.
FR2938534B1 (fr) 2008-11-14 2012-10-26 Sanofi Aventis Procede de preparation de l'hemifumarate d'eplivanserine
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
CN109996793B (zh) * 2017-02-08 2022-02-25 日产化学株式会社 肟基化合物的几何异构体的制造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20020507A1 (es) * 2000-10-17 2002-06-25 Schering Corp Compuestos no-imidazoles como antagonistas del receptor histamina h3

Also Published As

Publication number Publication date
ATE298333T1 (de) 2005-07-15
PT1436282E (pt) 2005-10-31
AR036881A1 (es) 2004-10-13
JP2005506357A (ja) 2005-03-03
ES2240839T3 (es) 2005-10-16
CA2463510A1 (en) 2003-04-24
DE60204791T2 (de) 2006-05-18
CN101157685A (zh) 2008-04-09
DE60204791D1 (de) 2005-07-28
EP1436282B1 (de) 2005-06-22
CN1678605A (zh) 2005-10-05
CN100360520C (zh) 2008-01-09
DK1436282T3 (da) 2005-07-11
ZA200402070B (en) 2005-04-29
HK1062683A1 (en) 2004-11-19
MXPA04003477A (es) 2004-07-30
EP1436282A1 (de) 2004-07-14
WO2003033488A1 (en) 2003-04-24

Similar Documents

Publication Publication Date Title
WO2008005423A1 (en) Improved method of making sufentanil
JP3066083B2 (ja) １―ベンジル―４―（（５，６―ジメトキシ―１―インダノン）―２―イル）メチルピペリジンを調製する方法及びそのための中間物質
JP2009515945A (ja) 塩酸ドネペジルの調製に有用な中間体およびその新規な多形の改善された合成および調製
JP4425632B2 (ja) ４−（ピペリジル）（２−ピリジル）メタノン−（ｅ）−ｏ−メチルオキシムおよびその塩の合成
US20040087795A1 (en) Novel processes for the preparation of 4-phenylpiperidine derivatives
JP2005506357A5 (de)
JPH11116570A (ja) ジヒドロピリジン誘導体の製造法
US6642385B2 (en) Synthesis of 4-(piperidyl)(2-pyridyl)methanone-(E)-O-methyloxime and salts
JPH07116116B2 (ja) ３−アミノアクリル酸エステルの製造法
JPH04288096A (ja) ３−オキソ−４−アザ−アンドロスト−１−エン　１７β−ケトンの新製造方法
WO2006134606A1 (en) A novel process for the preparation of lercanidipine
WO2002053537A1 (en) Process for preparing (±) trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidine
JP2004528380A (ja) ゾルピデムの製造方法
JP2005501056A (ja) ５−置換イソベンゾフランの製造方法
JP2009173688A (ja) （４−ブロモフェニル）（４−ピペリジル）メタノン−（ｚ）−ｏ−エチルオキシムおよび塩の合成
JP2003515600A (ja) ｛２−［４−（α−フェニル−ｐ−クロロベンジル）ピペラジン−１−イル］エトキシ｝酢酸の製法及びそのための新規な中間体
KR100374405B1 (ko) 암로디핀 베실레이트의 제조방법
JPH05508633A (ja) デフェロキサミンの調製に用いる中間体
JP4441260B2 (ja) ４−アミノ−４−フェニルピペリジン類の製造方法
EP2938595B1 (de) Verfahren zur synthese eines hydrazin zur behandlung des papillomavirus
KR100354806B1 (ko) 암로디핀 베실레이트의 신규 중간체 및 그의 제조방법
JP2009510017A (ja) （３−クロロ−４−フルオロフェニル）−（４−フルオロ−４−｛［（５−メチル−ピリミジン−２−イルメチル）−アミノ］−メチル｝−ピペリジン−１−イル）−メタノンの製造方法および新規な中間体ピリミジン誘導体
JPS6341907B2 (de)
JPS6327349B2 (de)
JPH08217749A (ja) 塩酸ニカルジピンの新規製造法及び新規合成中間体

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050908

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050908

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20090204

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090210

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090508

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090515

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090609

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090616

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20090702

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090731

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091023

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20091117

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20091209

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20121218

Year of fee payment: 3

LAPS Cancellation because of no payment of annual fees