JP4410992B2 - 細菌株、処理された植物抽出物、それらを含有する組成物、その調製方法、ならびにその治療的応用および産業的応用 - Google Patents
細菌株、処理された植物抽出物、それらを含有する組成物、その調製方法、ならびにその治療的応用および産業的応用 Download PDFInfo
- Publication number
- JP4410992B2 JP4410992B2 JP2002545628A JP2002545628A JP4410992B2 JP 4410992 B2 JP4410992 B2 JP 4410992B2 JP 2002545628 A JP2002545628 A JP 2002545628A JP 2002545628 A JP2002545628 A JP 2002545628A JP 4410992 B2 JP4410992 B2 JP 4410992B2
- Authority
- JP
- Japan
- Prior art keywords
- plant extract
- coli
- probiotic composition
- volatile fraction
- probiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 158
- 238000000034 method Methods 0.000 title claims abstract description 52
- 239000000419 plant extract Substances 0.000 title claims description 52
- 230000001225 therapeutic effect Effects 0.000 title abstract description 17
- 230000001580 bacterial effect Effects 0.000 title description 13
- 238000002360 preparation method Methods 0.000 title description 10
- 239000006041 probiotic Substances 0.000 claims abstract description 103
- 235000018291 probiotics Nutrition 0.000 claims abstract description 103
- 230000000529 probiotic effect Effects 0.000 claims abstract description 98
- 238000009472 formulation Methods 0.000 claims abstract description 75
- 230000001717 pathogenic effect Effects 0.000 claims abstract description 14
- 238000004519 manufacturing process Methods 0.000 claims abstract description 12
- 230000008569 process Effects 0.000 claims abstract description 9
- 239000000284 extract Substances 0.000 claims abstract description 8
- 241000588724 Escherichia coli Species 0.000 claims description 58
- 206010012735 Diarrhoea Diseases 0.000 claims description 34
- 241000196324 Embryophyta Species 0.000 claims description 31
- 241000894006 Bacteria Species 0.000 claims description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- 230000035899 viability Effects 0.000 claims description 24
- 230000002496 gastric effect Effects 0.000 claims description 21
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 21
- 241000125205 Anethum Species 0.000 claims description 20
- 235000016068 Berberis vulgaris Nutrition 0.000 claims description 20
- 241000335053 Beta vulgaris Species 0.000 claims description 20
- 235000013305 food Nutrition 0.000 claims description 18
- 235000010469 Glycine max Nutrition 0.000 claims description 15
- 238000001256 steam distillation Methods 0.000 claims description 15
- 235000017587 Medicago sativa ssp. sativa Nutrition 0.000 claims description 14
- 206010017964 Gastrointestinal infection Diseases 0.000 claims description 13
- 244000068988 Glycine max Species 0.000 claims description 13
- 239000012153 distilled water Substances 0.000 claims description 13
- 235000006679 Mentha X verticillata Nutrition 0.000 claims description 12
- 235000002899 Mentha suaveolens Nutrition 0.000 claims description 12
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims description 12
- 241000208317 Petroselinum Species 0.000 claims description 12
- 230000000813 microbial effect Effects 0.000 claims description 12
- 235000011197 perejil Nutrition 0.000 claims description 12
- 230000003115 biocidal effect Effects 0.000 claims description 11
- 238000000855 fermentation Methods 0.000 claims description 11
- 239000007858 starting material Substances 0.000 claims description 11
- 235000013311 vegetables Nutrition 0.000 claims description 11
- 241000589516 Pseudomonas Species 0.000 claims description 10
- 230000004151 fermentation Effects 0.000 claims description 10
- 244000052769 pathogen Species 0.000 claims description 10
- 230000005856 abnormality Effects 0.000 claims description 9
- 240000007124 Brassica oleracea Species 0.000 claims description 8
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 claims description 8
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 claims description 8
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 claims description 8
- 208000001848 dysentery Diseases 0.000 claims description 8
- 206010012742 Diarrhoea infectious Diseases 0.000 claims description 7
- 241000241413 Propolis Species 0.000 claims description 7
- 229940069949 propolis Drugs 0.000 claims description 7
- 240000002234 Allium sativum Species 0.000 claims description 6
- 241000607142 Salmonella Species 0.000 claims description 6
- 241000607768 Shigella Species 0.000 claims description 6
- 235000013399 edible fruits Nutrition 0.000 claims description 6
- 235000004611 garlic Nutrition 0.000 claims description 6
- 235000013336 milk Nutrition 0.000 claims description 6
- 239000008267 milk Substances 0.000 claims description 6
- 210000004080 milk Anatomy 0.000 claims description 6
- 238000005507 spraying Methods 0.000 claims description 6
- 238000002512 chemotherapy Methods 0.000 claims description 5
- 244000000021 enteric pathogen Species 0.000 claims description 5
- 238000001959 radiotherapy Methods 0.000 claims description 5
- 240000004658 Medicago sativa Species 0.000 claims description 4
- 208000019902 chronic diarrheal disease Diseases 0.000 claims description 4
- 235000008216 herbs Nutrition 0.000 claims description 4
- 244000005706 microflora Species 0.000 claims description 4
- 210000000056 organ Anatomy 0.000 claims description 4
- 241000589876 Campylobacter Species 0.000 claims description 3
- 240000000560 Citrus x paradisi Species 0.000 claims description 3
- 241000193403 Clostridium Species 0.000 claims description 3
- 241000588769 Proteus <enterobacteria> Species 0.000 claims description 3
- 206010039438 Salmonella Infections Diseases 0.000 claims description 3
- 230000000443 biocontrol Effects 0.000 claims description 3
- 238000011109 contamination Methods 0.000 claims description 3
- 230000003287 optical effect Effects 0.000 claims description 3
- 206010039447 salmonellosis Diseases 0.000 claims description 3
- 238000002560 therapeutic procedure Methods 0.000 claims description 3
- 235000013351 cheese Nutrition 0.000 claims description 2
- 208000019836 digestive system infectious disease Diseases 0.000 claims description 2
- 239000000796 flavoring agent Substances 0.000 claims description 2
- 235000013355 food flavoring agent Nutrition 0.000 claims description 2
- 238000012423 maintenance Methods 0.000 claims description 2
- 230000001766 physiological effect Effects 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 235000013618 yogurt Nutrition 0.000 claims description 2
- 238000003809 water extraction Methods 0.000 claims 3
- 238000000605 extraction Methods 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 244000005700 microbiome Species 0.000 abstract description 83
- 239000000463 material Substances 0.000 abstract description 10
- 239000007864 aqueous solution Substances 0.000 abstract description 4
- 239000003674 animal food additive Substances 0.000 description 41
- 239000002778 food additive Substances 0.000 description 20
- 235000015872 dietary supplement Nutrition 0.000 description 17
- 230000002829 reductive effect Effects 0.000 description 15
- 239000000047 product Substances 0.000 description 13
- 208000024891 symptom Diseases 0.000 description 12
- 241000219823 Medicago Species 0.000 description 10
- 241000283903 Ovis aries Species 0.000 description 10
- 239000003242 anti bacterial agent Substances 0.000 description 10
- 229940088710 antibiotic agent Drugs 0.000 description 10
- 230000004584 weight gain Effects 0.000 description 10
- 235000019786 weight gain Nutrition 0.000 description 10
- 239000002028 Biomass Substances 0.000 description 9
- 230000009286 beneficial effect Effects 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 9
- 235000013373 food additive Nutrition 0.000 description 9
- 241000736262 Microbiota Species 0.000 description 8
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 244000309466 calf Species 0.000 description 7
- 239000007789 gas Substances 0.000 description 7
- 244000005709 gut microbiome Species 0.000 description 7
- 241000271566 Aves Species 0.000 description 6
- 241000186000 Bifidobacterium Species 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000002609 medium Substances 0.000 description 6
- 229920001817 Agar Polymers 0.000 description 5
- 208000005577 Gastroenteritis Diseases 0.000 description 5
- 241000186660 Lactobacillus Species 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 5
- 239000008272 agar Substances 0.000 description 5
- 238000009341 apiculture Methods 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 5
- 238000002350 laparotomy Methods 0.000 description 5
- 235000012054 meals Nutrition 0.000 description 5
- 230000007246 mechanism Effects 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 238000010606 normalization Methods 0.000 description 5
- 235000015097 nutrients Nutrition 0.000 description 5
- 241000283707 Capra Species 0.000 description 4
- 241000617624 Escherichia coli M17 Species 0.000 description 4
- 241000282412 Homo Species 0.000 description 4
- 241000194036 Lactococcus Species 0.000 description 4
- 241000124008 Mammalia Species 0.000 description 4
- 241000605122 Nitrosomonas Species 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 230000003247 decreasing effect Effects 0.000 description 4
- 230000000593 degrading effect Effects 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 235000012907 honey Nutrition 0.000 description 4
- 230000001965 increasing effect Effects 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 235000014655 lactic acid Nutrition 0.000 description 4
- 239000004310 lactic acid Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 230000000638 stimulation Effects 0.000 description 4
- 241000588986 Alcaligenes Species 0.000 description 3
- 241000186063 Arthrobacter Species 0.000 description 3
- 241000588722 Escherichia Species 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 108010047620 Phytohemagglutinins Proteins 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 3
- 108010038854 colibacterin Proteins 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000010924 continuous production Methods 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 210000000987 immune system Anatomy 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 229940039696 lactobacillus Drugs 0.000 description 3
- 230000000670 limiting effect Effects 0.000 description 3
- 230000001885 phytohemagglutinin Effects 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 210000004989 spleen cell Anatomy 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- 230000001629 suppression Effects 0.000 description 3
- 239000003039 volatile agent Substances 0.000 description 3
- 208000030507 AIDS Diseases 0.000 description 2
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 208000004232 Enteritis Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000192125 Firmicutes Species 0.000 description 2
- 201000010538 Lactose Intolerance Diseases 0.000 description 2
- 244000070406 Malus silvestris Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 230000003042 antagnostic effect Effects 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 238000010923 batch production Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 229940041514 candida albicans extract Drugs 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 235000020971 citrus fruits Nutrition 0.000 description 2
- 230000001332 colony forming effect Effects 0.000 description 2
- 239000012228 culture supernatant Substances 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000003754 fetus Anatomy 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 230000009931 harmful effect Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000002949 hemolytic effect Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000006916 nutrient agar Substances 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 239000012138 yeast extract Substances 0.000 description 2
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 241001037861 Arthrobacter bacterium Species 0.000 description 1
- 206010003497 Asphyxia Diseases 0.000 description 1
- 229920002498 Beta-glucan Polymers 0.000 description 1
- 241000186015 Bifidobacterium longum subsp. infantis Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 244000000626 Daucus carota Species 0.000 description 1
- 235000002767 Daucus carota Nutrition 0.000 description 1
- 241000194033 Enterococcus Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 206010017916 Gastroenteritis staphylococcal Diseases 0.000 description 1
- 206010064147 Gastrointestinal inflammation Diseases 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 1
- 241000186604 Lactobacillus reuteri Species 0.000 description 1
- 244000235131 Mahonia repens Species 0.000 description 1
- 235000011430 Malus pumila Nutrition 0.000 description 1
- 235000015103 Malus silvestris Nutrition 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010033645 Pancreatitis Diseases 0.000 description 1
- 208000008469 Peptic Ulcer Diseases 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 241000286209 Phasianidae Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 241000588767 Proteus vulgaris Species 0.000 description 1
- 241000589776 Pseudomonas putida Species 0.000 description 1
- 239000012979 RPMI medium Substances 0.000 description 1
- 241000702670 Rotavirus Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
- 241000295644 Staphylococcaceae Species 0.000 description 1
- 208000008582 Staphylococcal Food Poisoning Diseases 0.000 description 1
- 206010041925 Staphylococcal infections Diseases 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 208000002495 Uterine Neoplasms Diseases 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 210000003815 abdominal wall Anatomy 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 102000019997 adhesion receptor Human genes 0.000 description 1
- 108010013985 adhesion receptor Proteins 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 238000010564 aerobic fermentation Methods 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 235000019730 animal feed additive Nutrition 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 235000021016 apples Nutrition 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 229940004120 bifidobacterium infantis Drugs 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- HXCILVUBKWANLN-UHFFFAOYSA-N brilliant green cation Chemical class C1=CC(N(CC)CC)=CC=C1C(C=1C=CC=CC=1)=C1C=CC(=[N+](CC)CC)C=C1 HXCILVUBKWANLN-UHFFFAOYSA-N 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 206010009887 colitis Diseases 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- AIUDWMLXCFRVDR-UHFFFAOYSA-N dimethyl 2-(3-ethyl-3-methylpentyl)propanedioate Chemical compound CCC(C)(CC)CCC(C(=O)OC)C(=O)OC AIUDWMLXCFRVDR-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 230000005584 early death Effects 0.000 description 1
- 230000009982 effect on human Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 244000144993 groups of animals Species 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 230000009390 immune abnormality Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 229960001438 immunostimulant agent Drugs 0.000 description 1
- 239000003022 immunostimulating agent Substances 0.000 description 1
- 230000003308 immunostimulating effect Effects 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000012678 infectious agent Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 1
- 229940001882 lactobacillus reuteri Drugs 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000012931 lyophilized formulation Substances 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000007269 microbial metabolism Effects 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 230000001459 mortal effect Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 239000003305 oil spill Substances 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 208000011906 peptic ulcer disease Diseases 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 235000013406 prebiotics Nutrition 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000009290 primary effect Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 229940007042 proteus vulgaris Drugs 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000011272 standard treatment Methods 0.000 description 1
- 201000002190 staphyloenterotoxemia Diseases 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 230000003319 supportive effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
- A23L21/20—Products from apiculture, e.g. royal jelly or pollen; Substitutes therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/84—Flavour masking or reducing agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/065—Microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/04—Preserving or maintaining viable microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/185—Escherichia
- C12R2001/19—Escherichia coli
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Food Science & Technology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Nutrition Science (AREA)
- General Engineering & Computer Science (AREA)
- Animal Husbandry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Insects & Arthropods (AREA)
- Physiology (AREA)
- Oncology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/725,846 US6500423B2 (en) | 1999-06-03 | 2000-11-30 | Bacterial strain, processed plant extracts, compositions containing same, processes for their preparation and their therapeutic and industrial applications |
PCT/IL2001/001088 WO2002043649A2 (fr) | 2000-11-30 | 2001-11-27 | Souche bacterienne, extraits de plantes traites, compositions a base de ces elements, procedes relatifs a leur elaboration, et leurs applications therapeutiques et industrielles |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2004534512A JP2004534512A (ja) | 2004-11-18 |
JP2004534512A5 JP2004534512A5 (fr) | 2005-12-22 |
JP4410992B2 true JP4410992B2 (ja) | 2010-02-10 |
Family
ID=24916190
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002545628A Expired - Fee Related JP4410992B2 (ja) | 2000-11-30 | 2001-11-27 | 細菌株、処理された植物抽出物、それらを含有する組成物、その調製方法、ならびにその治療的応用および産業的応用 |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP1343370A4 (fr) |
JP (1) | JP4410992B2 (fr) |
KR (1) | KR20030082549A (fr) |
CN (1) | CN1294253C (fr) |
AU (2) | AU2100402A (fr) |
BR (1) | BR0116178A (fr) |
CA (1) | CA2430292A1 (fr) |
IL (1) | IL156213A0 (fr) |
MX (1) | MXPA03004851A (fr) |
NZ (1) | NZ526748A (fr) |
PL (1) | PL366363A1 (fr) |
RU (1) | RU2281326C2 (fr) |
WO (1) | WO2002043649A2 (fr) |
ZA (1) | ZA200304747B (fr) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0212975D0 (en) * | 2002-06-06 | 2002-07-17 | Mars Uk Ltd | Mammalian animal composition |
IL152127A0 (en) | 2002-10-06 | 2003-05-29 | Bio Balance Corp | Probiotic compositions for the treatment of inflammatory bowel disease |
CN1867258A (zh) * | 2003-08-18 | 2006-11-22 | 生物平衡公司 | 一种稳定的液体益生组合物、其制备和应用 |
MY143693A (en) | 2004-03-24 | 2011-06-30 | Nestec Sa | Shelf stable product wih living micro-organisms |
US20090252708A1 (en) * | 2006-05-18 | 2009-10-08 | Biobalance Llc | Biotherapeutic compositions comprising probiotic escherichia coli and uses thereof |
RU2453320C2 (ru) * | 2008-08-05 | 2012-06-20 | Виктор Владимирович Чалов | Композиция для перорального применения, содержащая непатогенные микроорганизмы, обладающая способностью нормализовать микрофлору кишечника (варианты) |
KR101127171B1 (ko) * | 2009-07-24 | 2012-03-20 | (주)애드바이오텍 | 오리의 급만성 전염질병을 유발하는 병원체에 대한 항체를 지닌 난황을 함유하는 오리 사료 첨가용 조성물 |
EP2463382A1 (fr) | 2010-12-07 | 2012-06-13 | Enterologics, Inc. | Procédé d'identification de E. Coli M-17 |
RU2458527C1 (ru) * | 2010-12-30 | 2012-08-20 | Общество с ограниченной ответственностью "БИОТРОФ" | Способ получения препарата для кормления сельскохозяйственных животных и птицы и способ приготовления корма на его основе |
JP6278960B2 (ja) | 2012-07-20 | 2018-02-14 | プレヴテック マイクロビア インコーポレイテッド | 非病原性f18e.coli株及びその使用 |
WO2014049023A1 (fr) | 2012-09-25 | 2014-04-03 | Aquilon Cyl Sanidad Animal | Compositions probiotiques et prébiotiques |
US8906668B2 (en) | 2012-11-23 | 2014-12-09 | Seres Health, Inc. | Synergistic bacterial compositions and methods of production and use thereof |
JP6506173B2 (ja) * | 2012-11-23 | 2019-04-24 | セレス セラピューティクス インコーポレイテッド | 相乗的細菌組成物並びにその生成及び使用の方法 |
BR112015018625A2 (pt) | 2013-02-04 | 2017-09-19 | Seres Therapeutics Inc | composições e métodos |
US10973861B2 (en) | 2013-02-04 | 2021-04-13 | Seres Therapeutics, Inc. | Compositions and methods |
US9717726B2 (en) | 2013-03-14 | 2017-08-01 | Maregade Rx, LLC | Product and method for treating diarrhea |
AU2014232370B2 (en) | 2013-03-15 | 2018-11-01 | Seres Therapeutics, Inc. | Network-based microbial compositions and methods |
EP3074027A1 (fr) | 2013-11-25 | 2016-10-05 | Seres Therapeutics, Inc. | Compositions bactériennes synergiques et leurs procédés de production et d'utilisation |
EP3082431A4 (fr) | 2013-12-16 | 2017-11-15 | Seres Therapeutics, Inc. | Compositions bactériennes et leurs méthodes d'utilisation pour traiter des troubles du système immunitaire |
RU2660355C2 (ru) * | 2016-04-01 | 2018-07-05 | Акционерное общество "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" | Антибактериальная фармацевтическая композиция для перорального применения, содержащая бактериофаги |
EP3468382A4 (fr) * | 2016-06-14 | 2020-01-22 | Prevtec Microbia Inc | Granules d'alimentaire pour animaux comprenant un additif alimentaire, procédé pour les fabriquer et les utiliser |
RU2639544C1 (ru) * | 2016-12-16 | 2017-12-21 | Общество с ограниченной ответственностью "БИОРЕАКТОР" | Средство для лечения и профилактики заболеваний желудочно-кишечного тракта птицы |
ES2953520T3 (es) | 2016-12-23 | 2023-11-14 | Maregade Rx Llc | Producto a baja dosis y método para el tratamiento de la diarrea |
CN107319103A (zh) * | 2017-08-01 | 2017-11-07 | 河南牧业经济学院 | 促进畜禽生长和肠道发育的饲料添加剂及其制备方法和应用 |
AU2018318132A1 (en) | 2017-08-14 | 2020-02-27 | Seres Therapeutics, Inc. | Compositions and methods for treating cholestatic disease |
KR101939080B1 (ko) * | 2017-10-23 | 2019-01-16 | 고려대학교 산학협력단 | 슈도모나스 베로니 균주 kacc 81051bp 및 이를 포함하는 조성물 |
CN109260235A (zh) * | 2018-10-23 | 2019-01-25 | 上海市第十人民医院 | 一种组合物在制备防治便秘药物或保健品中的应用 |
CN110004072B (zh) * | 2018-11-12 | 2021-08-13 | 西安交通大学 | 一株益生性粪肠球菌分离株a3-1及其应用 |
CN113652340A (zh) * | 2021-08-24 | 2021-11-16 | 江苏江大源生态生物科技股份有限公司 | 一种益生菌制剂、菌种筛选装置及筛选方法 |
CN113616715B (zh) * | 2021-08-31 | 2022-05-06 | 昆明理工大学 | 治疗仔猪腹泻及改善其肠道菌群的发酵中药口服液 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3908028A (en) * | 1973-04-19 | 1975-09-23 | Procter & Gamble | Soft drink composition containing paramethoxycinnamaldehyde as a flavoring agent and sweetner |
GB1501098A (en) * | 1974-06-11 | 1978-02-15 | Brewing Patents Ltd | Preparation of hop oil |
US4986985A (en) * | 1987-11-02 | 1991-01-22 | Bar Ilan University | Method of treating skin virus infections |
CH675685A5 (fr) * | 1988-06-24 | 1990-10-31 | Flachsmann Ag Emil | |
US5443826A (en) * | 1988-08-02 | 1995-08-22 | Borody; Thomas J. | Treatment of gastro-intestinal disorders with a fecal composition or a composition of bacteroides and E. Coli |
US5082489A (en) * | 1990-02-06 | 1992-01-21 | The Royal Institution For The Advancement Of Learning (Mcgill University) | Composition for biocontrol of wild buckwheat |
US5478557A (en) * | 1992-07-29 | 1995-12-26 | The United States Of America, As Represented By The Secretary Of Agriculture | Probiotic for control of salmonella |
US5486367A (en) * | 1992-10-13 | 1996-01-23 | Kansas State University Research Foundation | Enzymatic method for accelerating fermentation of comestible products |
US5376374A (en) * | 1993-05-24 | 1994-12-27 | Zelaya; Luz M. | Oral rinse composition |
US5733774A (en) * | 1995-02-02 | 1998-03-31 | Ecoscience Corporation | Method and composition for producing stable bacteria and bacterial formulations |
AU714310B2 (en) * | 1995-05-12 | 1999-12-23 | Japan Pharmaceutical Development Co., Ltd | Plant extract |
DK0828502T3 (da) * | 1995-05-26 | 2002-04-15 | D & W Trading B V | Farmaceutiske sammensætninger, der er baseret på æteriske olier, som er opnået fra planter, til anvendelse inden for det human- og veterinærmedicinske område |
US5679364A (en) * | 1995-06-07 | 1997-10-21 | Lee County Mosquito Control District | Compositions and methods for reducing the amount of contaminants in aquatic and terrestrial environments |
GB2303799B (en) * | 1995-07-29 | 1999-03-10 | Siemens Plc | Improvements in or relating to aqueous sample testing apparatus |
US5888395A (en) * | 1996-08-30 | 1999-03-30 | The Regents Of The University Of California | Method for enhanced longevity of in situ microbial filter used for bioremediation |
US5773075A (en) * | 1996-12-13 | 1998-06-30 | Kalamazoo Holdings, Inc. | High temperature countercurrent solvent extraction of Capsicum solids |
US5965128A (en) * | 1997-08-13 | 1999-10-12 | University Of Georgia Research Foundation Inc. | Control of enterohemorrhagic E. coli 0157:H7 in cattle by probiotic bacteria and specific strains of E. coli |
IL130303A0 (en) * | 1999-06-03 | 2000-06-01 | M G Novobiotech Ltd | A bacterial strain processed plant extracts and probiotic compositions for human and veterinary use |
-
2001
- 2001-11-27 AU AU2100402A patent/AU2100402A/xx active Pending
- 2001-11-27 EP EP01998302A patent/EP1343370A4/fr not_active Ceased
- 2001-11-27 JP JP2002545628A patent/JP4410992B2/ja not_active Expired - Fee Related
- 2001-11-27 PL PL01366363A patent/PL366363A1/xx unknown
- 2001-11-27 AU AU2002221004A patent/AU2002221004B2/en not_active Ceased
- 2001-11-27 KR KR10-2003-7007337A patent/KR20030082549A/ko not_active Application Discontinuation
- 2001-11-27 WO PCT/IL2001/001088 patent/WO2002043649A2/fr active Application Filing
- 2001-11-27 CA CA002430292A patent/CA2430292A1/fr not_active Abandoned
- 2001-11-27 MX MXPA03004851A patent/MXPA03004851A/es not_active Application Discontinuation
- 2001-11-27 BR BR0116178-4A patent/BR0116178A/pt not_active IP Right Cessation
- 2001-11-27 CN CNB018214851A patent/CN1294253C/zh not_active Expired - Fee Related
- 2001-11-27 IL IL15621301A patent/IL156213A0/xx unknown
- 2001-11-27 NZ NZ526748A patent/NZ526748A/xx unknown
- 2001-11-27 RU RU2003119151/13A patent/RU2281326C2/ru not_active IP Right Cessation
-
2003
- 2003-06-19 ZA ZA200304747A patent/ZA200304747B/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2002043649A8 (fr) | 2004-04-29 |
KR20030082549A (ko) | 2003-10-22 |
RU2281326C2 (ru) | 2006-08-10 |
JP2004534512A (ja) | 2004-11-18 |
CA2430292A1 (fr) | 2002-06-06 |
CN1294253C (zh) | 2007-01-10 |
AU2002221004B2 (en) | 2007-01-25 |
IL156213A0 (en) | 2003-12-23 |
MXPA03004851A (es) | 2004-05-04 |
AU2100402A (en) | 2002-06-11 |
BR0116178A (pt) | 2003-10-14 |
CN1494374A (zh) | 2004-05-05 |
EP1343370A4 (fr) | 2004-02-11 |
ZA200304747B (en) | 2004-09-03 |
NZ526748A (en) | 2006-03-31 |
EP1343370A2 (fr) | 2003-09-17 |
PL366363A1 (en) | 2005-01-24 |
WO2002043649A2 (fr) | 2002-06-06 |
WO2002043649A3 (fr) | 2002-08-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP4410992B2 (ja) | 細菌株、処理された植物抽出物、それらを含有する組成物、その調製方法、ならびにその治療的応用および産業的応用 | |
JP4623896B2 (ja) | ヒトおよび動物に使用される細菌株、加工された植物抽出物およびプロバイオティック組成物 | |
AU2002221004A1 (en) | Preparation of compositions comprising bacterial strains and volatile plant extracts and therapeutic and industrial applications thereof | |
US7504251B2 (en) | Bacterial strain, processed plant extracts, compositions containing same, processes for their preparation and their therapeutic and industrial applications | |
AU2007201690A1 (en) | Preparation of Compositions Comprising Bacterial Strains and Volatile Plant Extracts and Therapeutic and Industrial Applications Thereof | |
NZ544366A (en) | Bacterial strain, processed plant extracts, compositions containing same, processes for their preparation and their therapeutic and industrial applications |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20041126 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20041126 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20070914 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20071212 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20080929 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20081219 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20091027 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20091116 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20121120 Year of fee payment: 3 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20131120 Year of fee payment: 4 |
|
LAPS | Cancellation because of no payment of annual fees |