JP4408603B2 - 有機無機複合生体材料およびその製造方法 - Google Patents

有機無機複合生体材料およびその製造方法 Download PDF

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Publication number
JP4408603B2
JP4408603B2 JP2002065778A JP2002065778A JP4408603B2 JP 4408603 B2 JP4408603 B2 JP 4408603B2 JP 2002065778 A JP2002065778 A JP 2002065778A JP 2002065778 A JP2002065778 A JP 2002065778A JP 4408603 B2 JP4408603 B2 JP 4408603B2
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Japan
Prior art keywords
collagen
organic
inorganic composite
reaction
biomaterial
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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JP2002065778A
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English (en)
Japanese (ja)
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JP2003190271A (ja
JP2003190271A5 (enExample
Inventor
順三 田中
正紀 菊池
典一 伊藤
佳宣 萬代
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Science and Technology Agency
Nitta Gelatin Inc
National Institute for Materials Science
National Institute of Japan Science and Technology Agency
Original Assignee
Japan Science and Technology Agency
Nitta Gelatin Inc
National Institute for Materials Science
National Institute of Japan Science and Technology Agency
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Application filed by Japan Science and Technology Agency, Nitta Gelatin Inc, National Institute for Materials Science, National Institute of Japan Science and Technology Agency filed Critical Japan Science and Technology Agency
Priority to JP2002065778A priority Critical patent/JP4408603B2/ja
Priority to PCT/JP2002/009592 priority patent/WO2003035127A1/ja
Priority to US10/492,937 priority patent/US8168151B2/en
Priority to EP02765594A priority patent/EP1437148B1/en
Publication of JP2003190271A publication Critical patent/JP2003190271A/ja
Publication of JP2003190271A5 publication Critical patent/JP2003190271A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/915—Method or apparatus for preparing biological material
    • Y10S623/919—Bone

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Composite Materials (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
JP2002065778A 2001-10-19 2002-03-11 有機無機複合生体材料およびその製造方法 Expired - Lifetime JP4408603B2 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2002065778A JP4408603B2 (ja) 2001-10-19 2002-03-11 有機無機複合生体材料およびその製造方法
PCT/JP2002/009592 WO2003035127A1 (en) 2001-10-19 2002-09-19 Organic/inorganic composite biomaterials and processes for producing the same
US10/492,937 US8168151B2 (en) 2001-10-19 2002-09-19 Organic/inorganic composite biomaterials and process for producing the same
EP02765594A EP1437148B1 (en) 2001-10-19 2002-09-19 Organic/inorganic composite biomaterials and processes for producing the same

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001-322255 2001-10-19
JP2001322255 2001-10-19
JP2002065778A JP4408603B2 (ja) 2001-10-19 2002-03-11 有機無機複合生体材料およびその製造方法

Publications (3)

Publication Number Publication Date
JP2003190271A JP2003190271A (ja) 2003-07-08
JP2003190271A5 JP2003190271A5 (enExample) 2005-07-14
JP4408603B2 true JP4408603B2 (ja) 2010-02-03

Family

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Family Applications (1)

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JP2002065778A Expired - Lifetime JP4408603B2 (ja) 2001-10-19 2002-03-11 有機無機複合生体材料およびその製造方法

Country Status (4)

Country Link
US (1) US8168151B2 (enExample)
EP (1) EP1437148B1 (enExample)
JP (1) JP4408603B2 (enExample)
WO (1) WO2003035127A1 (enExample)

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US20040081704A1 (en) 1998-02-13 2004-04-29 Centerpulse Biologics Inc. Implantable putty material
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
US7514248B2 (en) 2002-04-18 2009-04-07 University Of Florida Research Foundation, Inc. Process for making organic/inorganic composites
US7455854B2 (en) 2002-04-18 2008-11-25 University Of Florida Research Foundation, Inc. Method for producing a mineral fiber
US7514249B2 (en) 2002-04-18 2009-04-07 The University Of Florida Research Foundation, Inc. Biomimetic organic/inorganic composites
CN100372579C (zh) 2002-11-06 2008-03-05 独立行政法人物质·材料研究机构 含有自体组织化磷灰石-胶原复合体的交联磷灰石-胶原多孔体及其制备方法
JP4643166B2 (ja) 2004-03-30 2011-03-02 独立行政法人物質・材料研究機構 アパタイト／コラーゲン複合体繊維を含む多孔体の平均気孔径制御方法
EP1588724A3 (en) * 2004-04-22 2006-12-06 Ngk Spark Plug Co., Ltd Composite material comprising fibrous organic material and fibrous calcium phosphate
JP4806166B2 (ja) * 2004-05-07 2011-11-02 独立行政法人科学技術振興機構 無機化合物複合体、および、その製造方法、並びに、医療用材料
EP1908828A1 (en) 2005-07-22 2008-04-09 PHG Corporation Novel polypeptide and method for producing the same
US9763788B2 (en) 2005-09-09 2017-09-19 Board Of Trustees Of The University Of Arkansas Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same
WO2007030752A2 (en) * 2005-09-09 2007-03-15 University Of Arkansas At Little Rock System and method for tissue generation and bone regeneration
US8936805B2 (en) 2005-09-09 2015-01-20 Board Of Trustees Of The University Of Arkansas Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same
CN100341588C (zh) * 2005-10-10 2007-10-10 胡庆柳 多孔胶原复合纳米羟基磷灰石人工骨的制备方法
US20070112115A1 (en) * 2005-11-15 2007-05-17 Shalaby Shalaby W Inorganic-organic hybrid micro-/nanofibers
JP4968639B2 (ja) * 2005-12-15 2012-07-04 独立行政法人物質・材料研究機構 リン酸カルシウム及びアパタイト／コラーゲン複合物からなる複合体
CA2667213C (en) 2006-10-23 2015-12-29 Eth Zurich Fibrous pharmaceutical and implant materials
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
EP1964583A1 (en) * 2007-02-09 2008-09-03 Royal College of Surgeons in Ireland Process for producing a collagen/hydroxyapatite composite scaffold
WO2011019724A1 (en) * 2009-08-10 2011-02-17 Osseous Technologies Of America Self-supporting collagen tunnel for guided tissue regeneration and method of using same
US8962896B2 (en) 2009-09-11 2015-02-24 E I Du Pont De Nemours And Company Conversion of ethanol to a reaction product comprising 1-butanol using hydroxyapatite catalysts
JP2012065742A (ja) * 2010-09-22 2012-04-05 Atree Co Ltd コラーゲン／アパタイト配向性材料、及びコラーゲン／アパタイト配向性材料の製造方法
JP2013542837A (ja) 2010-11-15 2013-11-28 ジンマー オーソバイオロジクス，インコーポレイティド 骨空隙充填剤
US8431753B2 (en) * 2011-03-09 2013-04-30 E I Du Pont De Nemours And Company Conversion of butanol to a reaction product comprising 2-ethylhexanol using hydroxyapatite catalysts
CN102755668A (zh) * 2011-04-29 2012-10-31 天津市赛宁生物工程技术有限公司 可塑型医用骨泥
WO2013005778A1 (ja) * 2011-07-04 2013-01-10 国立大学法人東京工業大学 生体吸収性の傾斜した多孔質複合体及びそれを用いた人工骨、並びにそれらの製造方法
CN104093429B (zh) 2011-12-05 2016-05-18 日立化成株式会社 骨/组织再生诱导用膜及其制造方法
CN103127556A (zh) * 2011-12-05 2013-06-05 贵州金玖生物技术有限公司 一种可吸收复合人工骨
US20130303363A1 (en) 2012-03-01 2013-11-14 E I Du Pont De Nemours And Company Conversion of ethanol to a reaction product comprising 1-butanol using hydroxyapatite catalysts
WO2013157638A1 (ja) 2012-04-19 2013-10-24 独立行政法人物質・材料研究機構 HAp/Col複合体によって被覆された生体材料
CN103285428B (zh) * 2013-04-26 2015-01-28 珠海市红旌发展有限公司 一种人工骨材料及其制备方法
US20150045885A1 (en) 2013-08-06 2015-02-12 University Of Limerick Seedless group iv nanowires, and methods for the production thereof
US11234747B2 (en) 2015-02-25 2022-02-01 National University Corporation Tokyo Medical And Dental University Medical device, device structures for dentistry, for head and neck surgery and for orthopedic surgery, and method for bonding medical device to bone
GB201516179D0 (en) * 2015-09-14 2015-10-28 Fujifilm Mfg Europe Bv Bone void filling composite
CN113913961B (zh) * 2021-11-16 2023-05-16 清华大学 一种活性元素掺杂的矿化胶原纳米纤维及其制备方法
CN114159622B (zh) * 2021-12-03 2023-05-30 清华大学 一种活性元素掺杂的矿化胶原纳米颗粒及其制备方法

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US6311690B1 (en) * 1986-03-27 2001-11-06 Gensci Orthobiologics, Inc. Bone repair material and delayed drug delivery system
JPS6434372A (en) * 1987-07-31 1989-02-03 Toa Nenryo Kogyo Kk Filler for bone depleted part and void part
US5231169A (en) * 1990-10-17 1993-07-27 Norian Corporation Mineralized collagen
JP3028375B2 (ja) 1990-11-20 2000-04-04 三菱マテリアル株式会社 アパタイトウィスカー及びその製造方法
DK0573491T3 (da) 1991-12-30 2002-05-21 Norian Corp Mineraliseret kollagen
US5532217A (en) * 1992-04-24 1996-07-02 Silver; Frederick H. Process for the mineralization of collagen fibers, product produced thereby and use thereof to repair bone
US5607590A (en) * 1993-08-06 1997-03-04 Shimizu; Yasuhiko Material for medical use and process for preparing same
JP2775386B2 (ja) * 1993-10-04 1998-07-16 科学技術庁無機材質研究所長 アパタイト・有機物複合体とその製造法
JP2869528B2 (ja) * 1996-10-28 1999-03-10 工業技術院長 コラーゲン繊維−リン酸カルシウム化合物複合材料及びその製造法
JP3592920B2 (ja) 1998-01-19 2004-11-24 独立行政法人物質・材料研究機構 有機無機配向性複合材料の製造方法
DE19812714A1 (de) 1998-03-24 1999-09-30 Merck Patent Gmbh Verfahren zur Herstellung von mineralisierten Kollagenfibrillen und deren Verwendung als Knochenersatzwerkstoff
US6395036B1 (en) * 1998-04-06 2002-05-28 Isis Innovation Limited Composite material and methods of making the same
JP4349596B2 (ja) 1998-06-17 2009-10-21 独立行政法人物質・材料研究機構 アパタイトコーティング有機材料の製造方法

Also Published As

Publication number Publication date
WO2003035127A1 (en) 2003-05-01
JP2003190271A (ja) 2003-07-08
EP1437148A1 (en) 2004-07-14
US20050053638A1 (en) 2005-03-10
US8168151B2 (en) 2012-05-01
EP1437148B1 (en) 2012-06-13
EP1437148A4 (en) 2008-07-02

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