JP4391597B2 - 抗糖尿病性、低脂質性及び抗高血圧性を有するチアゾリンジオンとオキサゾリジンジオン誘導体 - Google Patents
抗糖尿病性、低脂質性及び抗高血圧性を有するチアゾリンジオンとオキサゾリジンジオン誘導体 Download PDFInfo
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- JP4391597B2 JP4391597B2 JP54317398A JP54317398A JP4391597B2 JP 4391597 B2 JP4391597 B2 JP 4391597B2 JP 54317398 A JP54317398 A JP 54317398A JP 54317398 A JP54317398 A JP 54317398A JP 4391597 B2 JP4391597 B2 JP 4391597B2
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- 239000003472 antidiabetic agent Substances 0.000 title abstract description 5
- 230000003178 anti-diabetic effect Effects 0.000 title abstract description 4
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- 125000001639 phenylmethylene group Chemical group [H]C(=*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims description 6
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 4
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- COWNFYYYZFRNOY-UHFFFAOYSA-N oxazolidinedione Chemical compound O=C1COC(=O)N1 COWNFYYYZFRNOY-UHFFFAOYSA-N 0.000 claims description 4
- DOJMKGYWVKQRNI-UHFFFAOYSA-N 5-[[4-[(3-methyl-4-oxophthalazin-1-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione Chemical compound C12=CC=CC=C2C(=O)N(C)N=C1COC(C=C1)=CC=C1CC1SC(=O)NC1=O DOJMKGYWVKQRNI-UHFFFAOYSA-N 0.000 claims description 3
- AZQBBQQYUFIZDL-UHFFFAOYSA-N 5-[[4-[(3-methyl-4-oxophthalazin-1-yl)methoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione Chemical compound C12=CC=CC=C2C(=O)N(C)N=C1COC(C=C1)=CC=C1C=C1SC(=O)NC1=O AZQBBQQYUFIZDL-UHFFFAOYSA-N 0.000 claims description 3
- SQXKUKDJRRMGDV-UHFFFAOYSA-N 5-[[4-[2-(1,4-dioxo-3h-phthalazin-2-yl)ethoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione Chemical compound O=C1C2=CC=CC=C2C(O)=NN1CCOC(C=C1)=CC=C1C=C1SC(=O)NC1=O SQXKUKDJRRMGDV-UHFFFAOYSA-N 0.000 claims description 3
- ZOEGSOBAHONJKF-UHFFFAOYSA-N 5-[[4-[2-(1-oxo-4-phenylphthalazin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione Chemical compound S1C(=O)NC(=O)C1CC(C=C1)=CC=C1OCCN1C(=O)C2=CC=CC=C2C(C=2C=CC=CC=2)=N1 ZOEGSOBAHONJKF-UHFFFAOYSA-N 0.000 claims description 3
- SSOWJXNHFJYAIY-UHFFFAOYSA-N 5-[[4-[2-(1-oxo-4-phenylphthalazin-2-yl)ethoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione Chemical compound S1C(=O)NC(=O)C1=CC(C=C1)=CC=C1OCCN1C(=O)C2=CC=CC=C2C(C=2C=CC=CC=2)=N1 SSOWJXNHFJYAIY-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
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- Organic Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
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- Animal Behavior & Ethology (AREA)
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- Diabetes (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/982,962 | 1997-12-02 | ||
| US08/982,962 US6011036A (en) | 1997-04-15 | 1997-12-02 | Heterocyclic compounds having antidiabetic hypolipidemic antihypertensive properties process for their preparation and pharmaceutical compositions containing them |
| PCT/US1998/007285 WO1998045292A1 (en) | 1997-12-02 | 1998-04-10 | Thiazolidinedione and oxazolidinedione derivatives having antidiabetic, hypolipidaemic and antihypertensive properties |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002508745A JP2002508745A (ja) | 2002-03-19 |
| JP2002508745A5 JP2002508745A5 (enExample) | 2005-11-24 |
| JP4391597B2 true JP4391597B2 (ja) | 2009-12-24 |
Family
ID=25529696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54317398A Expired - Fee Related JP4391597B2 (ja) | 1997-12-02 | 1998-04-10 | 抗糖尿病性、低脂質性及び抗高血圧性を有するチアゾリンジオンとオキサゾリジンジオン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0971917B1 (enExample) |
| JP (1) | JP4391597B2 (enExample) |
| AT (1) | ATE212991T1 (enExample) |
| AU (1) | AU6966498A (enExample) |
| DE (1) | DE69803750T2 (enExample) |
| WO (1) | WO1998045292A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19921567A1 (de) * | 1999-05-11 | 2000-11-16 | Basf Ag | Verwendung von Phthalazine-Derivaten |
| WO2001066135A1 (en) | 2000-03-08 | 2001-09-13 | Novo Nordisk A/S | Lowering serum lipids |
| EP1444219A1 (en) | 2001-10-12 | 2004-08-11 | Novo Nordisk A/S | Substituted piperidines and their use for the treatment of diseases related to the histamine h3 receptor |
| EP1458382A1 (en) | 2001-12-21 | 2004-09-22 | Novo Nordisk A/S | Amide derivatives as gk activators |
| EP1501822B1 (en) * | 2002-04-30 | 2010-12-15 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| CA2488642C (en) | 2002-06-27 | 2011-09-06 | Dharma Rao Polisetti | Aryl carbonyl derivatives as glucokinase activators |
| KR20060089874A (ko) | 2003-09-30 | 2006-08-09 | 노보 노르디스크 에이/에스 | 신규 멜라노코르틴 수용체 작용제 |
| WO2005056036A2 (en) | 2003-12-09 | 2005-06-23 | Novo Nordisk A/S | Regulation of food preference using glp-1 agonists |
| PL1723128T3 (pl) | 2004-01-06 | 2013-04-30 | Novo Nordisk As | Pochodne heteroarylowe mocznika oraz ich zastosowanie jako aktywatory glukokinazy |
| JP2007536344A (ja) | 2004-05-04 | 2007-12-13 | ノボ ノルディスク アクティーゼルスカブ | 新規のインドール誘導体 |
| US8410047B2 (en) | 2004-06-11 | 2013-04-02 | Novo Nordisk A/S | Counteracting drug-induced obesity using GLP-1 agonists |
| CN101060856B (zh) | 2004-11-22 | 2011-01-19 | 诺和诺德公司 | 可溶、稳定的含胰岛素制剂 |
| JP2008521864A (ja) | 2004-12-03 | 2008-06-26 | トランステック・ファーマ、インコーポレイテッド | ヘテロ芳香族グルコキナーゼ活性化剤 |
| BRPI0613564A2 (pt) | 2005-07-04 | 2011-01-18 | Novo Nordisk As | compostos, seus usos na preparação de composições farmacêuticas e composições farmacêuticas compreendendo os mesmos |
| MX2008000255A (es) | 2005-07-14 | 2008-04-02 | Novo Nordisk As | Activadores de urea glucocinasa. |
| ES2426345T3 (es) | 2005-07-20 | 2013-10-22 | Eli Lilly And Company | Compuesto unidos en posición 1-amino |
| EP1951658B1 (en) | 2005-11-17 | 2012-09-26 | Eli Lilly & Company | Glucagon receptor antagonists, preparation and therapeutic uses |
| KR101280333B1 (ko) | 2006-03-28 | 2013-07-02 | 하이 포인트 파마슈티칼스, 엘엘씨 | 히스타민 ｈ３ 수용체 활성을 갖는 벤조티아졸 |
| AU2007267197B2 (en) | 2006-05-29 | 2011-12-01 | High Point Pharmaceuticals, Llc | 3- (1, 3-Benzodioxol-5-yl) -6- (4-cyclopropylpiperazin-1-yl) -pyridazine, its salts and solvates and its use as histamine H3 receptor antagonist |
| EP2097388B1 (en) | 2006-11-15 | 2011-09-07 | High Point Pharmaceuticals, LLC | Novel 2-(2-hydroxyphenyl)benzimidazoles useful for treating obesity and diabetes |
| US8022066B2 (en) | 2006-11-15 | 2011-09-20 | High Point Pharmaceuticals, Llc | 2-(2-hydroxyphenyl) benzothiadiazines useful for treating obesity and diabetes |
| JP5226008B2 (ja) | 2007-01-11 | 2013-07-03 | ノボ・ノルデイスク・エー／エス | ウレアグルコキナーゼアクチベーター |
| WO2011104378A1 (en) | 2010-02-26 | 2011-09-01 | Novo Nordisk A/S | Peptides for treatment of obesity |
| BR112012021231A2 (pt) | 2010-02-26 | 2015-09-08 | Basf Plant Science Co Gmbh | método para acentuar o rendimento em plantas, planta, construto, uso de um construto, método para a produção de uma planta transgênica, partes coletáveis de uma planta, produtos derivados de uma planta, uso de um ácido nucleíco e método para a produção de um produto |
| BR112012024379A2 (pt) | 2010-03-26 | 2017-01-10 | Novo Nordisk As | "peptídeos glucagon, seu uso, bem como composição farmacêutica" |
| EP2670368A4 (en) | 2011-02-03 | 2015-04-15 | Pharmedica Ltd | NEW ORAL DISSOLUTION FILMS FOR INSULIN DELIVERY FOR THE TREATMENT OF DIABETES |
| MX2013011175A (es) | 2011-03-28 | 2013-11-01 | Novo Nordisk As | Analogos de glucagon novedosos. |
| WO2013041678A1 (en) | 2011-09-23 | 2013-03-28 | Novo Nordisk A/S | Novel glucagon analogues |
| RU2683039C2 (ru) | 2013-04-18 | 2019-03-26 | Ново Нордиск А/С | Стабильные совместные агонисты рецептора глюкагоноподобного пептида-1/глюкагона пролонгированного действия для медицинского применения |
| JP2017525656A (ja) | 2014-06-04 | 2017-09-07 | ノヴォ ノルディスク アー／エス | 医療用のｇｌｐ−１／グルカゴン受容体コアゴニスト |
| WO2018167194A1 (en) | 2017-03-15 | 2018-09-20 | Novo Nordisk A/S | Bicyclic compounds capable of binding to melanocortin 4 receptor |
| US20210221867A1 (en) | 2018-05-15 | 2021-07-22 | Novo Nordisk A/S | Compounds Capable of Binding to Melanocortin 4 Receptor |
| WO2020053414A1 (en) | 2018-09-14 | 2020-03-19 | Novo Nordisk A/S | Bicyclic compounds capable of acting as melanocortin 4 receptor agonists |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0306228B1 (en) * | 1987-09-04 | 1999-11-17 | Beecham Group Plc | Substituted thiazolidinedione derivatives |
| GB8820389D0 (en) * | 1988-08-26 | 1988-09-28 | Beecham Group Plc | Novel compounds |
| GB8919417D0 (en) * | 1989-08-25 | 1989-10-11 | Beecham Group Plc | Novel compounds |
| GB9023583D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
| GB9023585D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
-
1998
- 1998-04-10 JP JP54317398A patent/JP4391597B2/ja not_active Expired - Fee Related
- 1998-04-10 DE DE69803750T patent/DE69803750T2/de not_active Expired - Fee Related
- 1998-04-10 EP EP98915492A patent/EP0971917B1/en not_active Expired - Lifetime
- 1998-04-10 AT AT98915492T patent/ATE212991T1/de active
- 1998-04-10 WO PCT/US1998/007285 patent/WO1998045292A1/en not_active Ceased
- 1998-04-10 AU AU69664/98A patent/AU6966498A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU6966498A (en) | 1998-10-30 |
| DE69803750T2 (de) | 2002-09-12 |
| EP0971917A1 (en) | 2000-01-19 |
| ATE212991T1 (de) | 2002-02-15 |
| EP0971917B1 (en) | 2002-02-06 |
| WO1998045292A1 (en) | 1998-10-15 |
| DE69803750D1 (de) | 2002-03-21 |
| JP2002508745A (ja) | 2002-03-19 |
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