JP4371179B2 - 系列限定ニューロン前駆体 - Google Patents
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- JP4371179B2 JP4371179B2 JP50743099A JP50743099A JP4371179B2 JP 4371179 B2 JP4371179 B2 JP 4371179B2 JP 50743099 A JP50743099 A JP 50743099A JP 50743099 A JP50743099 A JP 50743099A JP 4371179 B2 JP4371179 B2 JP 4371179B2
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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| US08/909,435 | 1997-07-04 | ||
| US08/909,435 US6734015B1 (en) | 1997-07-04 | 1997-07-04 | Isolation of lineage-restricted neuronal precursors |
| US09/109,858 US6787353B1 (en) | 1997-07-04 | 1998-07-02 | Lineage-restricted neuronal precursors and methods of isolation |
| US09/109,858 | 1998-07-02 | ||
| PCT/US1998/013875 WO1999001159A1 (en) | 1997-07-04 | 1998-07-03 | Lineage-restricted neuronal precursors |
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| CA (1) | CA2294737A1 (enExample) |
| IL (1) | IL133799A0 (enExample) |
| WO (1) | WO1999001159A1 (enExample) |
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| US6150328A (en) | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| US6291206B1 (en) | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
| DK0733109T3 (da) | 1993-12-07 | 2006-07-03 | Genetics Inst Llc | BMP-12, BMP-13 og seneinducerende præparater dermed |
| US7544511B2 (en) | 1996-09-25 | 2009-06-09 | Neuralstem Biopharmaceuticals Ltd. | Stable neural stem cell line methods |
| US7410798B2 (en) | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
| US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
| US6727224B1 (en) | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
| ES2295012T3 (es) * | 1999-02-12 | 2008-04-16 | Stemcells California, Inc. | Poblaciones enriquecidas de celulas del sistema nervioso central. |
| EP1179046B1 (en) * | 1999-05-07 | 2006-03-08 | University Of Utah Research Foundation | Lineage-restricted precursor cells isolated from mouse neural tube and mouse embryonic stem cells |
| DE19928210B4 (de) * | 1999-06-19 | 2005-08-18 | Neuroprogen Gmbh Leipzig | Neuronales Zellmaterial und Verfahren zu dessen Herstellung |
| WO2001017547A2 (en) * | 1999-09-08 | 2001-03-15 | Genetics Institute, Inc. | Bmp-9 compositions and methods for inducing differentiation of cholinergic neurons |
| EP1762244A1 (en) * | 1999-09-08 | 2007-03-14 | Genetics Institute, LLC | Bmp-9 compositions for inducing differentiation of cholinergic neurons |
| US7189392B1 (en) | 1999-10-15 | 2007-03-13 | Genetics Institute, Llc | Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins |
| US20050042749A1 (en) | 2001-05-16 | 2005-02-24 | Carpenter Melissa K. | Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease |
| AU2001263199B2 (en) | 2000-05-17 | 2004-09-16 | Asterias Biotherapeutics, Inc. | Neural progenitor cell populations |
| US7250294B2 (en) | 2000-05-17 | 2007-07-31 | Geron Corporation | Screening small molecule drugs using neural cells differentiated from human embryonic stem cells |
| AU2001293586A1 (en) | 2000-09-29 | 2002-04-08 | Vincent Tropepe | Primitive neural stem cells and method for differentiation of stem cells to neural cells |
| CA2449008A1 (en) | 2001-06-01 | 2002-12-12 | Wyeth | Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins |
| TWI267378B (en) | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
| CN101029302B (zh) * | 2001-06-21 | 2011-03-30 | 杰龙公司 | 用于治疗帕金森病的多巴胺能神经元和具有增殖能力的前体细胞 |
| US20050101014A1 (en) | 2002-07-11 | 2005-05-12 | Keirstead Hans S. | Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury |
| US7285415B2 (en) | 2002-07-11 | 2007-10-23 | The Regents Of The University Of California | Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury |
| US8293488B2 (en) | 2002-12-09 | 2012-10-23 | Neuralstem, Inc. | Method for screening neurogenic agents |
| AU2003293409A1 (en) | 2002-12-09 | 2004-06-30 | Karl K. Johe | Method for discovering neurogenic agents |
| WO2006055685A2 (en) | 2004-11-17 | 2006-05-26 | Neuralstem, Inc. | Transplantation of human neural cells for treatment of neurodegenerative conditions |
| EP2054506A1 (en) | 2006-08-15 | 2009-05-06 | Agency for Science, Technology and Research | Mesenchymal stem cell conditioned medium |
| WO2008131004A1 (en) * | 2007-04-17 | 2008-10-30 | University Of Rochester | Telencephalic glial-restricted cell populations and related compositions and methods |
| EP2014768A1 (en) * | 2007-07-10 | 2009-01-14 | Innovalor AG | Neurons and methods for preparing them |
| EP2240536B1 (en) | 2008-01-30 | 2019-09-04 | Asterias Biotherapeutics, Inc. | Synthetic surfaces for culturing stem cell derived oligodendrocyte progenitor cells |
| JP2011514169A (ja) | 2008-03-17 | 2011-05-06 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | 幹細胞培養のためのマイクロキャリア |
| US8669048B2 (en) | 2008-06-24 | 2014-03-11 | Parkinson's Institute | Pluripotent cell lines and methods of use thereof |
| AU2010276201B2 (en) | 2009-07-21 | 2013-10-17 | Healios K.K. | Use of stem cells to reduce leukocyte extravasation |
| SG10201404281YA (en) | 2009-07-21 | 2014-09-26 | Abt Holding Co | Use of stem cells to reduce leukocyte extravasation |
| SG10201501402UA (en) | 2010-02-25 | 2015-04-29 | Abt Holding Co | Modulation of macrophage activation |
| RU2013108868A (ru) | 2010-07-28 | 2014-09-10 | Ньюралстем, Инк. | Способы лечения и/или реверсии нейродегенеративных заболеваний и/или расстройств |
| WO2012048298A2 (en) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
| KR102073530B1 (ko) | 2011-06-06 | 2020-02-04 | 리제네시스 비브이비에이 | 중공 섬유 생물 반응기에서의 줄기 세포의 확장 |
| CA2907327C (en) | 2013-03-15 | 2020-04-07 | Wake Forest University Health Sciences | Neural progenitor cell differentiation |
| AU2014250761B2 (en) | 2013-04-12 | 2019-02-28 | Robert J. Deans | Improving organs for transplantation |
| AU2014266935B2 (en) | 2013-04-30 | 2020-06-11 | Katholieke Universiteit Leuven | Cell therapy for myelodysplastic syndromes |
| WO2015073918A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
| EP3209306B1 (en) | 2014-10-20 | 2024-04-24 | Neuralstem, Inc. | Stable neural stem cells comprising an exogenous polynucleotide coding for a growth factor and methods of use thereof |
| JP6942634B2 (ja) * | 2015-03-03 | 2021-09-29 | レブストック，ルッツ | 点検システム |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5087570A (en) * | 1988-05-10 | 1992-02-11 | Weissman Irving L | Homogeneous mammalian hematopoietic stem cell composition |
| US5411883A (en) * | 1989-12-26 | 1995-05-02 | Somatix Therapy Corporation | Proliferated neuron progenitor cell product and process |
| JP4416837B2 (ja) * | 1991-07-08 | 2010-02-17 | ニューロスフィアーズ ホウルディングス リミテッド | 試験管内で増殖し得る新規な成長因子応答性の前駆細胞 |
| US5175103A (en) * | 1991-10-21 | 1992-12-29 | Trustees Of University Of Pennsylvania | Preparation of pure cultures of post-mitotic human neurons |
| US5589376A (en) * | 1992-07-27 | 1996-12-31 | California Institute Of Technology | Mammalian neural crest stem cells |
| ATE234353T1 (de) * | 1992-10-28 | 2003-03-15 | Neurospheres Holdings Ltd | Biologische faktoren und neuronale stammzellen |
| US5753505A (en) * | 1995-07-06 | 1998-05-19 | Emory University | Neuronal progenitor cells and uses thereof |
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1998
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- 1998-07-03 WO PCT/US1998/013875 patent/WO1999001159A1/en not_active Ceased
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- 1998-07-03 IL IL13379998A patent/IL133799A0/xx active IP Right Grant
- 1998-07-03 AU AU83823/98A patent/AU755657B2/en not_active Ceased
- 1998-07-03 KR KR1020057024112A patent/KR20060002033A/ko not_active Ceased
- 1998-07-03 JP JP50743099A patent/JP4371179B2/ja not_active Expired - Fee Related
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2004
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Also Published As
| Publication number | Publication date |
|---|---|
| AU8382398A (en) | 1999-01-25 |
| JP2002515071A (ja) | 2002-05-21 |
| KR20060002033A (ko) | 2006-01-06 |
| EP1011732A1 (en) | 2000-06-28 |
| IL133799A0 (en) | 2001-04-30 |
| WO1999001159A1 (en) | 1999-01-14 |
| EP1011732A4 (en) | 2002-10-23 |
| US20050003531A1 (en) | 2005-01-06 |
| CA2294737A1 (en) | 1999-01-14 |
| AU755657B2 (en) | 2002-12-19 |
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