JP4371179B2 - 系列限定ニューロン前駆体 - Google Patents
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- JP4371179B2 JP4371179B2 JP50743099A JP50743099A JP4371179B2 JP 4371179 B2 JP4371179 B2 JP 4371179B2 JP 50743099 A JP50743099 A JP 50743099A JP 50743099 A JP50743099 A JP 50743099A JP 4371179 B2 JP4371179 B2 JP 4371179B2
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/909,435 US6734015B1 (en) | 1997-07-04 | 1997-07-04 | Isolation of lineage-restricted neuronal precursors |
| US08/909,435 | 1997-07-04 | ||
| US09/109,858 US6787353B1 (en) | 1997-07-04 | 1998-07-02 | Lineage-restricted neuronal precursors and methods of isolation |
| US09/109,858 | 1998-07-02 | ||
| PCT/US1998/013875 WO1999001159A1 (en) | 1997-07-04 | 1998-07-03 | Lineage-restricted neuronal precursors |
Publications (3)
| Publication Number | Publication Date |
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| JP2002515071A JP2002515071A (ja) | 2002-05-21 |
| JP2002515071A5 JP2002515071A5 (enExample) | 2006-01-05 |
| JP4371179B2 true JP4371179B2 (ja) | 2009-11-25 |
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| EP (1) | EP1011732A4 (enExample) |
| JP (1) | JP4371179B2 (enExample) |
| KR (1) | KR20060002033A (enExample) |
| AU (1) | AU755657B2 (enExample) |
| CA (1) | CA2294737A1 (enExample) |
| IL (1) | IL133799A0 (enExample) |
| WO (1) | WO1999001159A1 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6150328A (en) | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| US6291206B1 (en) | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
| EP0733109B9 (en) | 1993-12-07 | 2006-07-05 | Genetics Institute, LLC | Bmp-12, bmp-13 and tendon-inducing compositions thereof |
| US7544511B2 (en) | 1996-09-25 | 2009-06-09 | Neuralstem Biopharmaceuticals Ltd. | Stable neural stem cell line methods |
| US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
| US7410798B2 (en) | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
| US6727224B1 (en) | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
| DE60044655D1 (de) * | 1999-02-12 | 2010-08-19 | Stemcells California Inc | Angereicherte Zellpopulationen des zentralen Nervensystems |
| DE60026512D1 (de) * | 1999-05-07 | 2006-05-04 | Univ Utah Res Found | Auf eine zellinie beschränkte vorläuferzellen aus dem neuralrohr der maus und aus embryonalen stammzellen der maus |
| DE19928210B4 (de) * | 1999-06-19 | 2005-08-18 | Neuroprogen Gmbh Leipzig | Neuronales Zellmaterial und Verfahren zu dessen Herstellung |
| EP1762244A1 (en) * | 1999-09-08 | 2007-03-14 | Genetics Institute, LLC | Bmp-9 compositions for inducing differentiation of cholinergic neurons |
| AU7355500A (en) * | 1999-09-08 | 2001-04-10 | Genetics Institute Inc. | Bmp-9 compositions and methods for inducing differentiation of cholinergic neurons |
| EP1223990B1 (en) | 1999-10-15 | 2004-07-28 | Genetics Institute, LLC | Formulations of hyaluronic acid for delivery of osteogenic proteins |
| US20050042749A1 (en) | 2001-05-16 | 2005-02-24 | Carpenter Melissa K. | Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease |
| EP1287116A2 (en) | 2000-05-17 | 2003-03-05 | Geron Corporation | Neural progenitor cell populations |
| US7250294B2 (en) * | 2000-05-17 | 2007-07-31 | Geron Corporation | Screening small molecule drugs using neural cells differentiated from human embryonic stem cells |
| CA2424062A1 (en) | 2000-09-29 | 2002-04-04 | Derek Van Der Kooy | Primitive neural stem cells and method for differentiation of stem cells to neural cells |
| US7226587B2 (en) | 2001-06-01 | 2007-06-05 | Wyeth | Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins |
| TWI267378B (en) | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
| CN101029302B (zh) * | 2001-06-21 | 2011-03-30 | 杰龙公司 | 用于治疗帕金森病的多巴胺能神经元和具有增殖能力的前体细胞 |
| US20050101014A1 (en) | 2002-07-11 | 2005-05-12 | Keirstead Hans S. | Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury |
| US7285415B2 (en) | 2002-07-11 | 2007-10-23 | The Regents Of The University Of California | Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury |
| US8293488B2 (en) | 2002-12-09 | 2012-10-23 | Neuralstem, Inc. | Method for screening neurogenic agents |
| US20040185429A1 (en) | 2002-12-09 | 2004-09-23 | Judith Kelleher-Andersson | Method for discovering neurogenic agents |
| WO2006055685A2 (en) | 2004-11-17 | 2006-05-26 | Neuralstem, Inc. | Transplantation of human neural cells for treatment of neurodegenerative conditions |
| WO2008020815A1 (en) | 2006-08-15 | 2008-02-21 | Agency For Science, Technology And Research | Mesenchymal stem cell conditioned medium |
| US20100119493A1 (en) * | 2007-04-17 | 2010-05-13 | University Of Rochester | Telencephalic Glial-Restricted Cell Populations and Related Compositions and Methods |
| EP2014768A1 (en) * | 2007-07-10 | 2009-01-14 | Innovalor AG | Neurons and methods for preparing them |
| CN101939362A (zh) | 2008-01-30 | 2011-01-05 | 杰龙公司 | 用于培养干细胞衍生的少突胶质细胞前体细胞的合成表面 |
| WO2009116951A2 (en) | 2008-03-17 | 2009-09-24 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
| WO2010008486A2 (en) | 2008-06-24 | 2010-01-21 | Parkinsons Institute | Pluripotent cell lines and methods of use thereof |
| SG10201404280XA (en) | 2009-07-21 | 2014-10-30 | Abt Holding Co | Use of stem cells to reduce leukocyte extravasation |
| AU2010276264B2 (en) | 2009-07-21 | 2013-09-19 | Abt Holding Company | Use of stem cells to reduce leukocyte extravasation |
| DK2539436T3 (da) | 2010-02-25 | 2021-10-18 | Abt Holding Co | Modulering af makrofagaktivering |
| SG187226A1 (en) | 2010-07-28 | 2013-03-28 | Neuralstem Inc | Methods for treating and/or reversing neurodegenerative diseases and/or disorders |
| US9725689B2 (en) | 2010-10-08 | 2017-08-08 | Terumo Bct, Inc. | Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
| WO2012168295A1 (en) | 2011-06-06 | 2012-12-13 | ReGenesys BVBA | Expansion of stem cells in hollow fiber bioreactors |
| KR102057601B1 (ko) | 2013-03-15 | 2019-12-19 | 웨이크 포리스트 유니버시티 헬스 사이언시즈 | 신경 전구 세포 분화 |
| KR102161726B1 (ko) | 2013-04-12 | 2020-10-06 | 사베리오 라프란체스카 | 이식용 장기의 개선 |
| EP2992088B1 (en) | 2013-04-30 | 2019-08-21 | Katholieke Universiteit Leuven | Cell therapy for myelodysplastic syndromes |
| EP3068867B1 (en) | 2013-11-16 | 2018-04-18 | Terumo BCT, Inc. | Expanding cells in a bioreactor |
| CN107148275A (zh) | 2014-10-20 | 2017-09-08 | 神经干细胞公司 | 包含编码生长因子的外源多核苷酸的稳定的神经干细胞及其使用方法 |
| EP3266040A1 (en) * | 2015-03-03 | 2018-01-10 | Lutz Rebstock | Inspection system |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5087570A (en) * | 1988-05-10 | 1992-02-11 | Weissman Irving L | Homogeneous mammalian hematopoietic stem cell composition |
| US5411883A (en) * | 1989-12-26 | 1995-05-02 | Somatix Therapy Corporation | Proliferated neuron progenitor cell product and process |
| FI935929L (fi) * | 1991-07-08 | 1994-02-02 | Neurospheres Ltd | Ny vaext regulerande faktor i stamcellen som foermaor foeroeka in vitro |
| US5175103A (en) * | 1991-10-21 | 1992-12-29 | Trustees Of University Of Pennsylvania | Preparation of pure cultures of post-mitotic human neurons |
| US5589376A (en) * | 1992-07-27 | 1996-12-31 | California Institute Of Technology | Mammalian neural crest stem cells |
| ATE483795T1 (de) * | 1992-10-28 | 2010-10-15 | Neurospheres Holdings Ltd | Biologische faktoren und neuronale stammzellen |
| US5753505A (en) * | 1995-07-06 | 1998-05-19 | Emory University | Neuronal progenitor cells and uses thereof |
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1998
- 1998-07-03 CA CA002294737A patent/CA2294737A1/en not_active Abandoned
- 1998-07-03 EP EP98934255A patent/EP1011732A4/en not_active Withdrawn
- 1998-07-03 IL IL13379998A patent/IL133799A0/xx active IP Right Grant
- 1998-07-03 JP JP50743099A patent/JP4371179B2/ja not_active Expired - Fee Related
- 1998-07-03 WO PCT/US1998/013875 patent/WO1999001159A1/en not_active Ceased
- 1998-07-03 KR KR1020057024112A patent/KR20060002033A/ko not_active Ceased
- 1998-07-03 AU AU83823/98A patent/AU755657B2/en not_active Ceased
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2004
- 2004-08-04 US US10/911,374 patent/US20050003531A1/en not_active Abandoned
Also Published As
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| US20050003531A1 (en) | 2005-01-06 |
| CA2294737A1 (en) | 1999-01-14 |
| AU8382398A (en) | 1999-01-25 |
| IL133799A0 (en) | 2001-04-30 |
| JP2002515071A (ja) | 2002-05-21 |
| WO1999001159A1 (en) | 1999-01-14 |
| AU755657B2 (en) | 2002-12-19 |
| KR20060002033A (ko) | 2006-01-06 |
| EP1011732A4 (en) | 2002-10-23 |
| EP1011732A1 (en) | 2000-06-28 |
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