JP4317224B2 - 膜拡散を測定するシステム、キットおよび方法 - Google Patents
膜拡散を測定するシステム、キットおよび方法 Download PDFInfo
- Publication number
- JP4317224B2 JP4317224B2 JP2006527975A JP2006527975A JP4317224B2 JP 4317224 B2 JP4317224 B2 JP 4317224B2 JP 2006527975 A JP2006527975 A JP 2006527975A JP 2006527975 A JP2006527975 A JP 2006527975A JP 4317224 B2 JP4317224 B2 JP 4317224B2
- Authority
- JP
- Japan
- Prior art keywords
- base
- cavity
- opening
- membrane
- hollow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000012528 membrane Substances 0.000 title claims description 56
- 238000009792 diffusion process Methods 0.000 title claims description 14
- 238000000034 method Methods 0.000 title description 8
- 239000000203 mixture Substances 0.000 claims description 13
- 150000001875 compounds Chemical class 0.000 claims description 11
- 239000012530 fluid Substances 0.000 claims description 8
- 238000004891 communication Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 description 11
- 229940079593 drug Drugs 0.000 description 11
- 210000004027 cell Anatomy 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 238000005259 measurement Methods 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- LPLLVINFLBSFRP-UHFFFAOYSA-N 2-methylamino-1-phenylpropan-1-one Chemical compound CNC(C)C(=O)C1=CC=CC=C1 LPLLVINFLBSFRP-UHFFFAOYSA-N 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 240000003023 Cosmos bipinnatus Species 0.000 description 1
- 235000005956 Cosmos caudatus Nutrition 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- -1 for example Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 210000002287 horizontal cell Anatomy 0.000 description 1
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- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920005597 polymer membrane Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 231100000245 skin permeability Toxicity 0.000 description 1
- 229910000679 solder Inorganic materials 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- 229920001059 synthetic polymer Polymers 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
- G01N2013/003—Diffusion; diffusivity between liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
- G01N2015/086—Investigating permeability, pore-volume, or surface area of porous materials of films, membranes or pellicules
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Clinical Laboratory Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/669,276 US7635452B2 (en) | 2003-09-24 | 2003-09-24 | System, kit, and method for measuring membrane diffusion |
| PCT/US2004/024487 WO2005036138A1 (en) | 2003-09-24 | 2004-07-28 | System, kit, and method for measuring membrane diffusion |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007506970A JP2007506970A (ja) | 2007-03-22 |
| JP2007506970A5 JP2007506970A5 (enExample) | 2007-09-13 |
| JP4317224B2 true JP4317224B2 (ja) | 2009-08-19 |
Family
ID=34313693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006527975A Expired - Fee Related JP4317224B2 (ja) | 2003-09-24 | 2004-07-28 | 膜拡散を測定するシステム、キットおよび方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US7635452B2 (enExample) |
| EP (1) | EP1664733A1 (enExample) |
| JP (1) | JP4317224B2 (enExample) |
| WO (1) | WO2005036138A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060154378A1 (en) * | 2005-01-13 | 2006-07-13 | Yabin Lei | Method for measuring the leaching of encapsulated material into application media |
| DE102005057031B4 (de) * | 2005-11-25 | 2011-04-21 | Innovent E.V. Technologieentwicklung | Vorrichtung für Permeations-oder Stoffdurchgangsuntersuchungen |
| FR2951089B1 (fr) * | 2009-10-09 | 2013-07-05 | Univ Franche Comte | Insert de diffusion pour l'analyse de membrane, kit-cellule-unite et procede de diffusion |
| DE102009052673A1 (de) * | 2009-11-12 | 2011-05-19 | Nanoanalytics Gmbh | Vorrichtung zur Bestimmung der Impedanz von Zellschichten |
| CN102183444B (zh) * | 2011-01-27 | 2013-09-25 | 中国商用飞机有限责任公司 | 在铺层面内方向上测试气体渗透率的测试装置及其方法 |
| CN102141504B (zh) * | 2011-01-27 | 2013-06-12 | 中国商用飞机有限责任公司 | 在铺层厚度方向上测试气体渗透率的测试装置及其方法 |
| FR2981156B1 (fr) | 2011-10-10 | 2014-05-30 | Univ Claude Bernard Lyon | Dispositif d'etude de la permeabilite de membranes biologiques, artificielles ou synthetiques |
| ITRM20130163A1 (it) * | 2013-03-18 | 2014-09-19 | Univ Roma | Dispositivi e metodo per testare film sottili e strisce |
| CN103308564A (zh) * | 2013-06-03 | 2013-09-18 | 拉芳家化股份有限公司 | 一种化妆品活性成分经皮吸收效率的检测方法 |
| JP6418711B2 (ja) * | 2014-05-19 | 2018-12-05 | 株式会社イントロテック | 透過性試験装置 |
| WO2016020438A1 (en) * | 2014-08-06 | 2016-02-11 | Hexal Ag | Method and device for determining the disintegration time of film-shaped pharmaceutical dosage forms |
| US10705004B2 (en) | 2015-10-01 | 2020-07-07 | Galderma Research & Development | Diffusion cell and uses for evaluating the diffusion of a compound through a membrane |
| FR3042037A1 (fr) * | 2015-10-01 | 2017-04-07 | Galderma Res & Dev | Cellule de diffusion et utilisations pour evaluer la diffusion d'un compose a travers une membrane |
| US10613011B2 (en) * | 2016-03-14 | 2020-04-07 | Creighton University | Diffusion cells and related methods |
| FR3054144B1 (fr) * | 2016-07-20 | 2021-01-01 | Inst De Radioprotection Et De Surete Nucleaire | Dispositif de gradient de diffusion en couche mince et appareil de mise au point d’un tel dispositif |
| US10883978B2 (en) * | 2017-01-31 | 2021-01-05 | Agilent Technologies, Inc. | Method and device for calibration of biological flux |
| GB2559991A (en) * | 2017-02-23 | 2018-08-29 | Medherant Ltd | Diffusion test system |
| CN107389523B (zh) * | 2017-07-06 | 2020-02-18 | 中国农业科学院农业资源与农业区划研究所 | 一种包膜肥料控释膜最大孔径的测定方法和测定系统 |
| US11596919B2 (en) * | 2018-08-17 | 2023-03-07 | Sierra Biosystems, Inc. | Row-independent oligonucleotide synthesis |
| US11181460B1 (en) * | 2019-06-20 | 2021-11-23 | The United States Of America As Represented By The Secretary Of The Army | Apparatus and method for measuring permeation of contaminants through a complex protective material swatch |
| US12038433B2 (en) * | 2019-09-09 | 2024-07-16 | Board Of Regents, The University Of Texas System | Methods and apparatus for high-throughput screening for testing permeability and retention of compounds across biological barriers |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4511534A (en) * | 1982-05-26 | 1985-04-16 | John T. Bennett | Liquid transfer device |
| US5591636A (en) * | 1993-10-18 | 1997-01-07 | Precision Instrument Design | Membrane holder |
| US5490415A (en) | 1994-04-15 | 1996-02-13 | Pharmetrix Corporation | Diffusion test apparatus and method |
| US5962250A (en) | 1997-10-28 | 1999-10-05 | Glaxo Group Limited | Split multi-well plate and methods |
| US6521191B1 (en) | 1999-07-07 | 2003-02-18 | Novosis Ag | Permeation cell for in vitro determination of skin permeation of pharmaceutical drugs |
| US6439036B1 (en) | 2000-06-13 | 2002-08-27 | Symyx Technologics, Inc. | Method for evaluating a test fluid |
| US6455007B1 (en) | 2000-06-13 | 2002-09-24 | Symyx Technologies, Inc. | Apparatus and method for testing compositions in contact with a porous medium |
| ATE342959T1 (de) | 2000-07-14 | 2006-11-15 | Transform Pharmaceuticals Inc | System und verfahren zum optimieren des gewebebarrieretransfers von verbindungen |
| WO2002016941A2 (en) | 2000-08-23 | 2002-02-28 | The Regents Of The University Of California | A combinatorial method for rapid screening of drug delivery formulations |
-
2003
- 2003-09-24 US US10/669,276 patent/US7635452B2/en not_active Expired - Fee Related
-
2004
- 2004-07-28 WO PCT/US2004/024487 patent/WO2005036138A1/en not_active Ceased
- 2004-07-28 JP JP2006527975A patent/JP4317224B2/ja not_active Expired - Fee Related
- 2004-07-28 EP EP04757380A patent/EP1664733A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007506970A (ja) | 2007-03-22 |
| US7635452B2 (en) | 2009-12-22 |
| EP1664733A1 (en) | 2006-06-07 |
| US20050063862A1 (en) | 2005-03-24 |
| WO2005036138A1 (en) | 2005-04-21 |
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