JP4308732B2 - マイクロ流体滴定装置 - Google Patents
マイクロ流体滴定装置 Download PDFInfo
- Publication number
- JP4308732B2 JP4308732B2 JP2004234314A JP2004234314A JP4308732B2 JP 4308732 B2 JP4308732 B2 JP 4308732B2 JP 2004234314 A JP2004234314 A JP 2004234314A JP 2004234314 A JP2004234314 A JP 2004234314A JP 4308732 B2 JP4308732 B2 JP 4308732B2
- Authority
- JP
- Japan
- Prior art keywords
- titration
- chamber
- titrant
- chambers
- fluid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
- G01N21/79—Photometric titration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N37/00—Details not covered by any other group of this subclass
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Plasma & Fusion (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Description
16 流体試料入口ポート
20 空気管理ポート
22 滴定チャンバ
32 マイクロ流体チャネル
34 滴定剤
Claims (10)
- 本体への流体試料入口ポート(16)を画定する第1のオリフィスと、
その各々が第1の端部において前記試料入口ポート(16)と関連している複数のマイクロ流体チャネル(32)と、
その各々が前記マイクロ流体チャネル(32)及び空気管理ポート(20)と流体連通している複数の滴定チャンバ(22)と、
を有する本体部材(10)からなり、
前記複数の滴定チャンバ(22)の各々が滴定剤(34)を含み、前記複数の滴定チャンバ(22)のうちの任意の1つの滴定チャンバ(22)内の滴定剤(34)濃度が、他の滴定チャンバ(22)内の滴定剤(34)濃度と異なる、滴定装置。 - 前記滴定剤(34)が、所定の属性に関して試料を滴定するように構成されており、且つ緩衝剤及び指示薬を含む、請求項1に記載の装置。
- 前記複数の滴定チャンバ(22)が、滴定チャンバT1〜Tnとして定義され、滴定チャンバT1内の滴定剤(34)濃度が、滴定チャンバTn内の滴定剤(34)濃度よりも低い、請求項1に記載の装置。
- 前記複数の滴定チャンバ(22)が、滴定チャンバT1、T2、...Tnとして定義され、滴定チャンバT2内の滴定剤(34)濃度が、滴定チャンバT1内の滴定剤(34)濃度よりも所定の増分量だけ高い、請求項3に記載の装置。
- 隣接する前記滴定チャンバ(22)間の滴定剤(34)の濃度差が、T1からTnまで線形的に増加する、請求項4に記載の装置。
- 隣接する前記滴定チャンバ(22)間の滴定剤(34)の濃度差が、T1からTnまで対数的に増加する、請求項4による装置。
- 所定の化学的属性に関して流体を滴定する方法であって、
(a)所定の化学的属性に関して流体を滴定するための既知濃度の滴定剤(34)をそれぞれ含む複数の滴定チャンバ(22)を有し、且つ前記複数の滴定チャンバ(22)が前記滴定剤(34)の累進的な濃度範囲を画定するように、マイクロ流体チップ(10)を設けるステップと、
(b)前記チップ(10)の入口(16)に流体を導入するステップと、
(c)その各々が滴定チャンバ(22)と連通している、前記チップ内の複数の流体経路(32)中に、毛管作用によって前記入口(16)からの流体の流れを誘導し、各滴定チャンバ(22)に流体を充填させるステップと、
(d)前記流体を各滴定チャンバ(22)内の滴定剤(34)と反応させるステップと、
(e)前記滴定チャンバ(22)を観察し、変色の起こった滴定チャンバ(20)と、変色の起おこらなかった滴定チャンバ(22)を識別するステップと、
を包含する方法。 - 前記滴定の終点が、変色の起こった滴定チャンバ(22)と、変色の起こらなかった滴定チャンバ(22)とを識別することによって決定される、請求項7に記載の方法。
- 前記ステップ(c)が、前記経路(32)及び前記滴定チャンバ(22)から押し出された空気を、前記滴定チャンバ(22)から放出させるステップを含む、請求項7に記載の方法。
- 滴定の終点を判定する方法であって、
(a)請求項1に記載の滴定装置において、各滴定チャンバ(22)に試料流体を導入し、各滴定チャンバ内で前記試料流体を滴定剤(34)と反応させて、前記滴定チャンバ(22)の各々において個別の滴定を実施するステップを包含する、方法。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/640,697 US20050037508A1 (en) | 2003-08-12 | 2003-08-12 | Microfluidic titration apparatus |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005062186A JP2005062186A (ja) | 2005-03-10 |
JP4308732B2 true JP4308732B2 (ja) | 2009-08-05 |
Family
ID=33565266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004234314A Expired - Fee Related JP4308732B2 (ja) | 2003-08-12 | 2004-08-11 | マイクロ流体滴定装置 |
Country Status (5)
Country | Link |
---|---|
US (1) | US20050037508A1 (ja) |
EP (1) | EP1506813A1 (ja) |
JP (1) | JP4308732B2 (ja) |
KR (1) | KR20050019049A (ja) |
TW (1) | TWI234655B (ja) |
Families Citing this family (19)
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WO2006089252A2 (en) * | 2005-02-16 | 2006-08-24 | Mcneely Michael R | Liquid valving using reactive or responsive materials |
KR100667651B1 (ko) * | 2005-04-29 | 2007-01-12 | 이형춘 | 휘발성염기질소 분석에서 피씨카메라를 이용한자동적정방법 |
JP2006346626A (ja) * | 2005-06-17 | 2006-12-28 | Toppan Printing Co Ltd | 反応チップ |
JP2008145243A (ja) * | 2006-12-08 | 2008-06-26 | Canon Inc | プローブ・アレイ作製装置用の液体吐出ユニットとその製造方法 |
US7977660B2 (en) * | 2007-08-14 | 2011-07-12 | General Electric Company | Article, device, and method |
JP5309312B2 (ja) | 2007-11-01 | 2013-10-09 | Jfeテクノス株式会社 | マイクロチップ、マイクロチップデバイス及びマイクロチップを用いた蒸発操作方法 |
KR100955773B1 (ko) * | 2008-01-08 | 2010-04-30 | 이형춘 | 피씨 카메라를 이용한 산도 자동 적정 방법 |
KR100955774B1 (ko) * | 2008-01-11 | 2010-04-30 | 이형춘 | 피씨 카메라를 이용한 과망간산칼륨소비량 자동 적정 방법 |
DE102008050092A1 (de) * | 2008-10-06 | 2010-04-08 | Hach Lange Gmbh | Mobile Wasser-Analyseanordnung |
JP5431764B2 (ja) * | 2009-03-30 | 2014-03-05 | Jfeテクノス株式会社 | マイクロチップを用いたフッ素f−18標識化合物の製造方法及び装置 |
EP2596347B1 (en) * | 2010-07-22 | 2017-09-06 | Hach Company | Alkalinity analysis using a lab-on-a-chip |
WO2012160941A1 (ja) * | 2011-05-20 | 2012-11-29 | 国立大学法人筑波大学 | 滴定装置、これを用いた米検査方法 |
DE102014006317B3 (de) * | 2014-04-30 | 2015-05-07 | Gebrüder Heyl Analysentechnik GmbH & Co KG | Verfahren zur Erweiterung des Messbereiches von fotometrischen Systemen |
TWI582427B (zh) * | 2016-03-29 | 2017-05-11 | 光寶電子(廣州)有限公司 | 流體檢測裝置 |
CN107238573A (zh) * | 2016-03-29 | 2017-10-10 | 光宝电子(广州)有限公司 | 流体检测装置 |
US9700888B1 (en) * | 2016-04-13 | 2017-07-11 | Ipmd Inc. | Point of care medical device for detecting infectious diseases |
CA3096538A1 (en) * | 2018-04-09 | 2019-10-17 | Ecolab Usa Inc. | Methods for colorimetric endpoint detection and multiple analyte titration systems |
JP7316898B2 (ja) * | 2019-10-04 | 2023-07-28 | 三菱重工業株式会社 | 監視システムおよび監視方法 |
WO2022231608A1 (en) * | 2021-04-30 | 2022-11-03 | Hewlett-Packard Development Company, L.P. | Microfluidic device |
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2003
- 2003-08-12 US US10/640,697 patent/US20050037508A1/en not_active Abandoned
-
2004
- 2004-02-12 TW TW093103320A patent/TWI234655B/zh not_active IP Right Cessation
- 2004-02-25 EP EP04004238A patent/EP1506813A1/en not_active Withdrawn
- 2004-08-11 JP JP2004234314A patent/JP4308732B2/ja not_active Expired - Fee Related
- 2004-08-11 KR KR1020040063105A patent/KR20050019049A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2005062186A (ja) | 2005-03-10 |
US20050037508A1 (en) | 2005-02-17 |
TWI234655B (en) | 2005-06-21 |
EP1506813A1 (en) | 2005-02-16 |
KR20050019049A (ko) | 2005-02-28 |
TW200506363A (en) | 2005-02-16 |
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