JP4299666B2 - Ｄｎａプロテインキナーゼ阻害剤としてのチオピラン−４−オン類 - Google Patents

Ｄｎａプロテインキナーゼ阻害剤としてのチオピラン−４−オン類 Download PDF

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Publication number
JP4299666B2
JP4299666B2 JP2003520749A JP2003520749A JP4299666B2 JP 4299666 B2 JP4299666 B2 JP 4299666B2 JP 2003520749 A JP2003520749 A JP 2003520749A JP 2003520749 A JP2003520749 A JP 2003520749A JP 4299666 B2 JP4299666 B2 JP 4299666B2
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Japan
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group
dna
aryl
compound
compound according
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Expired - Fee Related
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JP2003520749A
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English (en)
Japanese (ja)
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JP2005502656A5 (https=
JP2005502656A (ja
Inventor
グリフィン，ロジャー，ジョン
ゴルディング，バーナード，トーマス
ニューウェル，デイヴィッド，リチャード
カルヴァート，ヒラリー，アラン
カーティン，ニコラ，ジェーン
ハードキャッスル，イアン，ロバート
マーティン，ニオール，モリソン，バール
スミス，グレーム，キャメロン，ミューレイ
リゴロー，ローラン，ジャン，マルタン
ワークマン，ポール
レノー，フロランス，イレーン
ナトレイ，バーナード，ポール
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Cancer Research Technology Ltd
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Cancer Research Technology Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
JP2003520749A 2001-08-14 2002-08-14 Ｄｎａプロテインキナーゼ阻害剤としてのチオピラン−４−オン類 Expired - Fee Related JP4299666B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0119863.9A GB0119863D0 (en) 2001-08-14 2001-08-14 DNA-PK inhibitors
PCT/GB2002/003740 WO2003015790A1 (en) 2001-08-14 2002-08-14 Thiopyrane-4-ones as dna protein kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2005502656A JP2005502656A (ja) 2005-01-27
JP2005502656A5 JP2005502656A5 (https=) 2005-12-22
JP4299666B2 true JP4299666B2 (ja) 2009-07-22

Family

ID=9920418

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003520749A Expired - Fee Related JP4299666B2 (ja) 2001-08-14 2002-08-14 Ｄｎａプロテインキナーゼ阻害剤としてのチオピラン−４−オン類

Country Status (8)

Country Link
US (1) US7105518B2 (https=)
EP (1) EP1416936B1 (https=)
JP (1) JP4299666B2 (https=)
AT (1) ATE296633T1 (https=)
DE (1) DE60204468T2 (https=)
ES (1) ES2243750T3 (https=)
GB (1) GB0119863D0 (https=)
WO (1) WO2003015790A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0119865D0 (en) * 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
GB0209891D0 (en) * 2002-04-30 2002-06-05 Glaxo Group Ltd Novel compounds
AU2004265149A1 (en) * 2003-08-13 2005-02-24 Kudos Pharmaceuticals Limited Aminopyrones and their use as ATM inhibitors
BRPI0515498A (pt) * 2004-09-20 2008-07-29 Kudos Pharm Ltd inibidores de dna-pk
EP1848712A1 (en) * 2005-02-09 2007-10-31 Kudos Pharmaceuticals Ltd Atm inhibitors
AR053358A1 (es) * 2005-04-15 2007-05-02 Cancer Rec Tech Ltd Inhibidores de adn - pk
US20090035394A1 (en) * 2005-05-26 2009-02-05 Graeme Cameron Murray Smith Use of dna-pk inhibition to sensitise atm deficient cancers to dna-damaging cancer therapies
UY31232A1 (es) * 2007-07-19 2009-03-02 Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones
CN112566905B (zh) * 2019-05-10 2024-07-30 上海海雁医药科技有限公司 取代的苯基丙烯基吡啶类衍生物，其制法与医药上的用途

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1303724A (https=) 1969-05-14 1973-01-17
JPH0753725B2 (ja) 1987-10-08 1995-06-07 富山化学工業株式会社 ４ｈ―１―ベンゾピラン―４―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤
US5284856A (en) 1988-10-28 1994-02-08 Hoechst Aktiengesellschaft Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives
AU634994B2 (en) 1988-12-21 1993-03-11 Pharmacia & Upjohn Company Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
US5703075A (en) 1988-12-21 1997-12-30 Pharmacia & Upjohn Company Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
JPH03215423A (ja) 1990-01-18 1991-09-20 Kyowa Hakko Kogyo Co Ltd 血管拡張剤
EP0525123B1 (en) 1990-06-20 1997-09-17 PHARMACIA & UPJOHN COMPANY Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
ATE128128T1 (de) 1990-06-29 1995-10-15 Upjohn Co Antiatherosclerotische und antithrombotische 2- amino-6-phenyl-4h-pyran-4-one.
US5302613A (en) 1990-06-29 1994-04-12 The Upjohn Company Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
US5252735A (en) 1990-06-29 1993-10-12 The Upjohn Company Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
JP3215423B2 (ja) 1992-01-18 2001-10-09 ザ・ユニバーシティ・オブ・ニューキャッスル・アポン・タイン 導電性ポリマーの製法
WO1994005283A1 (fr) 1992-09-02 1994-03-17 Kyowa Hakko Kogyo Co., Ltd. Medicament anti-vih
EP0695547B1 (en) 1993-04-09 2001-08-08 Toyama Chemical Co., Ltd. Immunomodulator, cell adhesion inhibitor, and agent for treating and preventing autoimmune diseases
US5378725A (en) 1993-07-19 1995-01-03 The Arizona Board Of Regents Inhibition of phosphatidylinositol 3-kinase with wortmannin and analogs thereof
US5441947A (en) 1993-08-25 1995-08-15 Eli Lilly And Company Methods of inhibiting vascular restenosis
US5504103A (en) 1993-08-25 1996-04-02 Eli Lilly And Company Inhibition of phosphatidylinositol 3-kinase with 17 β-hydroxywortmannin and analogs thereof
US5468773A (en) 1993-08-25 1995-11-21 Eli Lilly And Company Methods for inhibiting bone loss and cartilage degradation using wortmannin and its analogs
CA2133815A1 (en) 1993-10-12 1995-04-13 Jeffrey Alan Dodge Inhibition of phosphatidylinositol 3-kinase with viridin, demethoxyviridin, viridiol, demethoxyviridiol, virone, wortmannolone, and analogs thereof
US6632789B1 (en) 1994-04-29 2003-10-14 The United States Of America As Represented By The Secretary Of The Navy Methods for modulating T cell responses by manipulating intracellular signal transduction
US5480906A (en) 1994-07-01 1996-01-02 Eli Lilly And Company Stereochemical Wortmannin derivatives
GB9521987D0 (en) 1995-10-26 1996-01-03 Ludwig Inst Cancer Res Phosphoinositide 3-kinase modulators
US5733920A (en) 1995-10-31 1998-03-31 Mitotix, Inc. Inhibitors of cyclin dependent kinases
AU1461197A (en) 1995-11-16 1997-06-05 Icos Corporation Cell cycle checkpoint pik-related kinase materials and methods
GB2302021A (en) 1996-10-16 1997-01-08 Lilly Co Eli Inhibiting bone loss or resorption
WO1998055602A1 (en) 1997-06-06 1998-12-10 Mayo Foundation For Medical Education And Research Screening for phosphatidylinositol related-kinase inhibitors
WO1998056391A1 (en) 1997-06-13 1998-12-17 President And Fellows Of Harvard College Methods for treating human cancers
FR2776291B1 (fr) 1998-03-18 2000-06-16 Pf Medicament Nouveaux derives bis-benzamides, leur procede de fabrication, les compositions pharmaceutiques les contenant et leur utilisation comme medicament
US6348311B1 (en) 1999-02-10 2002-02-19 St. Jude Childre's Research Hospital ATM kinase modulation for screening and therapies
US6387640B1 (en) 1999-02-10 2002-05-14 St. Jude Children's Research Hospital ATM kinase modulation for screening and therapies
CN1891693A (zh) 2000-01-24 2007-01-10 基纳西亚股份有限公司 用于治疗的吗啉代基取代的化合物
WO2002020500A2 (en) 2000-09-01 2002-03-14 Icos Corporation Materials and methods to potentiate cancer treatment
DE60203260T2 (de) 2001-01-16 2006-02-02 Glaxo Group Ltd., Greenford Pharmazeutische kombination, die ein 4-chinazolinamin und paclitaxel, carboplatin oder vinorelbin enthält, zur behandlung von krebs
GB0119865D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
WO2003035618A2 (en) 2001-10-24 2003-05-01 Iconix Pharmaceuticals, Inc. Modulators of phosphoinositide 3-kinase
AU2002357667A1 (en) 2001-10-24 2003-05-06 Iconix Pharmaceuticals, Inc. Modulators of phosphoinositide 3-kinase
BR0307944A (pt) 2002-02-25 2005-02-01 Kudos Pharm Ltd Piranonas úteis como inibidores de atm
US7049313B2 (en) 2002-02-25 2006-05-23 Kudos Pharmaceuticals Ltd. ATM inhibitors
DE60335359D1 (de) 2002-04-30 2011-01-27 Kudos Pharm Ltd Phthalazinonderivate

Also Published As

Publication number Publication date
US20050107367A1 (en) 2005-05-19
WO2003015790A1 (en) 2003-02-27
DE60204468T2 (de) 2006-04-27
ES2243750T3 (es) 2005-12-01
DE60204468D1 (de) 2005-07-07
JP2005502656A (ja) 2005-01-27
EP1416936A1 (en) 2004-05-12
GB0119863D0 (en) 2001-10-10
EP1416936B1 (en) 2005-06-01
ATE296633T1 (de) 2005-06-15
US7105518B2 (en) 2006-09-12

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