JP2005502656A5 - - Google Patents

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Publication number
JP2005502656A5
JP2005502656A5 JP2003520749A JP2003520749A JP2005502656A5 JP 2005502656 A5 JP2005502656 A5 JP 2005502656A5 JP 2003520749 A JP2003520749 A JP 2003520749A JP 2003520749 A JP2003520749 A JP 2003520749A JP 2005502656 A5 JP2005502656 A5 JP 2005502656A5
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JP
Japan
Prior art keywords
compound according
group
nitrogen atom
heterocycle
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2003520749A
Other languages
English (en)
Japanese (ja)
Other versions
JP4299666B2 (ja
JP2005502656A (ja
Filing date
Publication date
Priority claimed from GBGB0119863.9A external-priority patent/GB0119863D0/en
Application filed filed Critical
Publication of JP2005502656A publication Critical patent/JP2005502656A/ja
Publication of JP2005502656A5 publication Critical patent/JP2005502656A5/ja
Application granted granted Critical
Publication of JP4299666B2 publication Critical patent/JP4299666B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2003520749A 2001-08-14 2002-08-14 Ｄｎａプロテインキナーゼ阻害剤としてのチオピラン−４−オン類 Expired - Fee Related JP4299666B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0119863.9A GB0119863D0 (en) 2001-08-14 2001-08-14 DNA-PK inhibitors
PCT/GB2002/003740 WO2003015790A1 (en) 2001-08-14 2002-08-14 Thiopyrane-4-ones as dna protein kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2005502656A JP2005502656A (ja) 2005-01-27
JP2005502656A5 true JP2005502656A5 (https=) 2005-12-22
JP4299666B2 JP4299666B2 (ja) 2009-07-22

Family

ID=9920418

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003520749A Expired - Fee Related JP4299666B2 (ja) 2001-08-14 2002-08-14 Ｄｎａプロテインキナーゼ阻害剤としてのチオピラン−４−オン類

Country Status (8)

Country Link
US (1) US7105518B2 (https=)
EP (1) EP1416936B1 (https=)
JP (1) JP4299666B2 (https=)
AT (1) ATE296633T1 (https=)
DE (1) DE60204468T2 (https=)
ES (1) ES2243750T3 (https=)
GB (1) GB0119863D0 (https=)
WO (1) WO2003015790A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0119865D0 (en) * 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
GB0209891D0 (en) * 2002-04-30 2002-06-05 Glaxo Group Ltd Novel compounds
AU2004265149A1 (en) * 2003-08-13 2005-02-24 Kudos Pharmaceuticals Limited Aminopyrones and their use as ATM inhibitors
BRPI0515498A (pt) * 2004-09-20 2008-07-29 Kudos Pharm Ltd inibidores de dna-pk
EP1848712A1 (en) * 2005-02-09 2007-10-31 Kudos Pharmaceuticals Ltd Atm inhibitors
AR053358A1 (es) * 2005-04-15 2007-05-02 Cancer Rec Tech Ltd Inhibidores de adn - pk
US20090035394A1 (en) * 2005-05-26 2009-02-05 Graeme Cameron Murray Smith Use of dna-pk inhibition to sensitise atm deficient cancers to dna-damaging cancer therapies
UY31232A1 (es) * 2007-07-19 2009-03-02 Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones
CN112566905B (zh) * 2019-05-10 2024-07-30 上海海雁医药科技有限公司 取代的苯基丙烯基吡啶类衍生物，其制法与医药上的用途

Family Cites Families (38)

* Cited by examiner, † Cited by third party
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US5284856A (en) 1988-10-28 1994-02-08 Hoechst Aktiengesellschaft Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives
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US5302613A (en) 1990-06-29 1994-04-12 The Upjohn Company Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
US5252735A (en) 1990-06-29 1993-10-12 The Upjohn Company Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
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US5378725A (en) 1993-07-19 1995-01-03 The Arizona Board Of Regents Inhibition of phosphatidylinositol 3-kinase with wortmannin and analogs thereof
US5441947A (en) 1993-08-25 1995-08-15 Eli Lilly And Company Methods of inhibiting vascular restenosis
US5504103A (en) 1993-08-25 1996-04-02 Eli Lilly And Company Inhibition of phosphatidylinositol 3-kinase with 17 β-hydroxywortmannin and analogs thereof
US5468773A (en) 1993-08-25 1995-11-21 Eli Lilly And Company Methods for inhibiting bone loss and cartilage degradation using wortmannin and its analogs
CA2133815A1 (en) 1993-10-12 1995-04-13 Jeffrey Alan Dodge Inhibition of phosphatidylinositol 3-kinase with viridin, demethoxyviridin, viridiol, demethoxyviridiol, virone, wortmannolone, and analogs thereof
US6632789B1 (en) 1994-04-29 2003-10-14 The United States Of America As Represented By The Secretary Of The Navy Methods for modulating T cell responses by manipulating intracellular signal transduction
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WO1998055602A1 (en) 1997-06-06 1998-12-10 Mayo Foundation For Medical Education And Research Screening for phosphatidylinositol related-kinase inhibitors
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FR2776291B1 (fr) 1998-03-18 2000-06-16 Pf Medicament Nouveaux derives bis-benzamides, leur procede de fabrication, les compositions pharmaceutiques les contenant et leur utilisation comme medicament
US6348311B1 (en) 1999-02-10 2002-02-19 St. Jude Childre's Research Hospital ATM kinase modulation for screening and therapies
US6387640B1 (en) 1999-02-10 2002-05-14 St. Jude Children's Research Hospital ATM kinase modulation for screening and therapies
CN1891693A (zh) 2000-01-24 2007-01-10 基纳西亚股份有限公司 用于治疗的吗啉代基取代的化合物
WO2002020500A2 (en) 2000-09-01 2002-03-14 Icos Corporation Materials and methods to potentiate cancer treatment
DE60203260T2 (de) 2001-01-16 2006-02-02 Glaxo Group Ltd., Greenford Pharmazeutische kombination, die ein 4-chinazolinamin und paclitaxel, carboplatin oder vinorelbin enthält, zur behandlung von krebs
GB0119865D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
WO2003035618A2 (en) 2001-10-24 2003-05-01 Iconix Pharmaceuticals, Inc. Modulators of phosphoinositide 3-kinase
AU2002357667A1 (en) 2001-10-24 2003-05-06 Iconix Pharmaceuticals, Inc. Modulators of phosphoinositide 3-kinase
BR0307944A (pt) 2002-02-25 2005-02-01 Kudos Pharm Ltd Piranonas úteis como inibidores de atm
US7049313B2 (en) 2002-02-25 2006-05-23 Kudos Pharmaceuticals Ltd. ATM inhibitors
DE60335359D1 (de) 2002-04-30 2011-01-27 Kudos Pharm Ltd Phthalazinonderivate

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