JP4272065B2 - Ca125の測定による敗血症の検出方法 - Google Patents
Ca125の測定による敗血症の検出方法 Download PDFInfo
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- JP4272065B2 JP4272065B2 JP2003549920A JP2003549920A JP4272065B2 JP 4272065 B2 JP4272065 B2 JP 4272065B2 JP 2003549920 A JP2003549920 A JP 2003549920A JP 2003549920 A JP2003549920 A JP 2003549920A JP 4272065 B2 JP4272065 B2 JP 4272065B2
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- sepsis
- measurement
- procalcitonin
- inflammation
- septic
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/26—Infectious diseases, e.g. generalised sepsis
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- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating And Analyzing Materials By Characteristic Methods (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Description
A.Beishuizenら, Advances in Clinical Chemistry, Vol.33, 1999, 55-131 C.Gabayら, The New England Journal of Medicine, Vol.340, No.6, 1999, 448-454 K.Reinhartら, Intensivmedizin, Georg Thieme Verlag, Stuttgart, New York, 2001, 756-760 M.Assicotら, The Lancet, Vol.341, No.8844, 1993, 515-518
CA125の測定用の商業的アッセイ(B.R.A.H.M.S Diagnostica GmbH社のKRYPTOR-CA125 II)を用いて、敗血症マーカープロカルシトニン(PCT)に高い値が見られた171人の敗血症患者の血清において、腫瘍マーカーCA125の血清濃度を測定した。68%の血清において、顕著に高いCA125濃度(32U/mlより高い)が観察された。
Claims (5)
- 敗血症および敗血症様全身性感染症の検出のための方法であって、敗血症を患った、または敗血症の疑いがある患者の生物学的流体におけるCA125の量を測定し、CA125の測定量が、敗血症の存在、予想される経過、重篤度、および/または治療のために開始された処置の成功度を示すことを特徴とする方法。
- CA125の測定が免疫検出アッセイ法によって実施されることを特徴とする、請求項1記載の方法。
- CA125に加えて、同時にさらなる敗血症パラメータのプロカルシトニンが測定されるマルチパラメータ測定法で実施され、かつ、高精度の敗血症の検出のために評価される一組の少なくとも二つの測定変数の形態の測定結果が得られることを特徴とする、請求項1または2記載の方法。
- マルチパラメータ測定法が、チップ技術法に従って操作する測定装置または免疫クロマトグラフィー測定装置による同時測定として実施されることを特徴とする、請求項3記載の方法。
- 前記測定装置を用いて得られた複数の測定結果の評価がコンピュータープログラムを用いて実施されることを特徴とする、請求項4記載の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01128848A EP1318402B1 (de) | 2001-12-04 | 2001-12-04 | Verfahren zur Diagnose von Sepsis unter Bestimmung von CA 125 |
PCT/EP2002/013391 WO2003048776A1 (de) | 2001-12-04 | 2002-11-27 | Verfahren zur diagnose von sepsis unter bestimmung von ca 125 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005512057A JP2005512057A (ja) | 2005-04-28 |
JP4272065B2 true JP4272065B2 (ja) | 2009-06-03 |
Family
ID=8179437
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003549920A Expired - Fee Related JP4272065B2 (ja) | 2001-12-04 | 2002-11-27 | Ca125の測定による敗血症の検出方法 |
Country Status (6)
Country | Link |
---|---|
US (1) | US7517518B2 (ja) |
EP (1) | EP1318402B1 (ja) |
JP (1) | JP4272065B2 (ja) |
AT (1) | ATE293794T1 (ja) |
DE (1) | DE50105971D1 (ja) |
WO (1) | WO2003048776A1 (ja) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1355159A1 (de) * | 2002-04-19 | 2003-10-22 | B.R.A.H.M.S Aktiengesellschaft | Verwendungen von Fragmenten der Carbamoylphosphat Synthetase 1 (CPS 1) für die Diagnose von Entzündungserkrankungen und Sepsis |
EP1355158A1 (de) * | 2002-04-19 | 2003-10-22 | B.R.A.H.M.S Aktiengesellschaft | Verfahren zur Diagnose von Entzündungserkrankungen und Infektionen unter Bestimmung des Phosphoproteins LASP-1 als Inflammationsmarker |
MXPA05005072A (es) | 2002-11-12 | 2005-07-22 | Becton Dickinson Co | Diagnostico de la sepsis o sirs usando perfiles de biomarcadores. |
EP1565570A4 (en) | 2002-11-12 | 2005-12-28 | Becton Dickinson Co | DIAGNOSIS OF SEPTICEMIA OR SIRS USING BIOMARKER PROFILES |
WO2006090389A2 (en) | 2005-02-24 | 2006-08-31 | Compugen Ltd. | Novel diagnostic markers, especially for in vivo imaging, and assays and methods of use thereof |
JP2008538007A (ja) | 2005-04-15 | 2008-10-02 | ベクトン,ディッキンソン アンド カンパニー | 敗血症の診断 |
JP5048838B2 (ja) * | 2007-09-07 | 2012-10-17 | ウニヴェルズィテート・ツューリヒ | ヒト敗血症を測定する方法 |
US8669113B2 (en) | 2008-04-03 | 2014-03-11 | Becton, Dickinson And Company | Advanced detection of sepsis |
US10260111B1 (en) | 2014-01-20 | 2019-04-16 | Brett Eric Etchebarne | Method of detecting sepsis-related microorganisms and detecting antibiotic-resistant sepsis-related microorganisms in a fluid sample |
MD3515487T2 (ro) * | 2016-09-23 | 2023-11-30 | Regeneron Pharma | Anticorpi bispecifici anti-MUC16-CD3 și conjugate anticorp anti-MUC16-medicament |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5660994A (en) * | 1986-11-10 | 1997-08-26 | Progen Biotechnik Gmbh | Method of detecting tissue-specific, insoluble cytoskeletal proteins |
US5366866A (en) * | 1991-07-25 | 1994-11-22 | Duke University | Method of diagnosing ovarian and endometrial cancer with monoclonal antibodies OXA and OXB |
DE4227454C1 (de) * | 1992-08-19 | 1994-02-03 | Henning Berlin Gmbh | Verfahren zur Früherkennung, zur Erkennung des Schweregrads sowie zur therapiebegleitenden Verlaufsbeurteilung einer Sepsis sowie Mittel zur Durchführung des Verfahrens |
JPH10500210A (ja) * | 1994-05-06 | 1998-01-06 | スロットマン,ガス・ジェイ | 全身性炎症状態の危険にある患者の同定及び監視方法 |
US5536382A (en) * | 1994-05-23 | 1996-07-16 | Advanced Molecular Systems, Inc. | Capillary electrophoresis assay method useful for the determination of constituents of a clinical sample |
US20040010121A1 (en) * | 2001-03-16 | 2004-01-15 | Birse Charles E. | 7 Human ovarian and ovarian cancer associated proteins |
US20040253637A1 (en) * | 2001-04-13 | 2004-12-16 | Biosite Incorporated | Markers for differential diagnosis and methods of use thereof |
DE10130985B4 (de) * | 2001-06-27 | 2004-03-18 | B.R.A.H.M.S Ag | Verfahren zur Diagnose von Sepsis und schweren Infektionen unter Bestimmung löslicher Cytokeratin-1-Fragmente |
DE50103032D1 (de) * | 2001-12-04 | 2004-09-02 | Brahms Ag | Verfahren zur Diagnose von Sepsis unter Bestimmung von CA 19-9 |
ATE282831T1 (de) * | 2001-12-04 | 2004-12-15 | Brahms Ag | Verfahren zur diagnose von sepsis unter bestimmung löslicher cytokeratinfragmente |
DE50103030D1 (de) * | 2001-12-04 | 2004-09-02 | Brahms Ag | Verfahren zur Diagnose von Sepsis unter Bestimmung von S100B |
DE50108027D1 (de) * | 2001-12-04 | 2005-12-15 | Brahms Ag | Verwendung der Glycin-N-Acyl-Transferase (GNAT) für die Diagnose von Entzündungserkrankungen und Sepsis |
EP1318407B1 (de) * | 2001-12-07 | 2004-09-29 | B.R.A.H.M.S Aktiengesellschaft | Verwendungen der Aldose-1-Epimerase (Mutarotase) für die Diagnose von Entzündungserkrankungen und Sepsis |
EP1355158A1 (de) * | 2002-04-19 | 2003-10-22 | B.R.A.H.M.S Aktiengesellschaft | Verfahren zur Diagnose von Entzündungserkrankungen und Infektionen unter Bestimmung des Phosphoproteins LASP-1 als Inflammationsmarker |
EP1355159A1 (de) * | 2002-04-19 | 2003-10-22 | B.R.A.H.M.S Aktiengesellschaft | Verwendungen von Fragmenten der Carbamoylphosphat Synthetase 1 (CPS 1) für die Diagnose von Entzündungserkrankungen und Sepsis |
EP1369693A1 (de) * | 2002-06-04 | 2003-12-10 | B.R.A.H.M.S Aktiengesellschaft | Verfahren zur Sepsisdiagnose und zur Kontrolle von Spenderblut durch Bestimmung von anti-Asialo-Gangliosid-Antikörpern |
ES2271674T3 (es) * | 2002-11-20 | 2007-04-16 | B.R.A.H.M.S Aktiengesellschaft | Inmunoensayo tipo sandwich para la determinacion de peptidos parciales proanp. |
-
2001
- 2001-12-04 AT AT01128848T patent/ATE293794T1/de active
- 2001-12-04 DE DE50105971T patent/DE50105971D1/de not_active Expired - Lifetime
- 2001-12-04 EP EP01128848A patent/EP1318402B1/de not_active Expired - Lifetime
-
2002
- 2002-11-27 WO PCT/EP2002/013391 patent/WO2003048776A1/de active Application Filing
- 2002-11-27 US US10/496,173 patent/US7517518B2/en not_active Expired - Fee Related
- 2002-11-27 JP JP2003549920A patent/JP4272065B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO2003048776A1 (de) | 2003-06-12 |
US20050074811A1 (en) | 2005-04-07 |
EP1318402A1 (de) | 2003-06-11 |
DE50105971D1 (de) | 2005-05-25 |
US7517518B2 (en) | 2009-04-14 |
ATE293794T1 (de) | 2005-05-15 |
JP2005512057A (ja) | 2005-04-28 |
EP1318402B1 (de) | 2005-04-20 |
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