JP4272066B2 - Ca19−9の測定による敗血症の検出方法 - Google Patents
Ca19−9の測定による敗血症の検出方法 Download PDFInfo
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- JP4272066B2 JP4272066B2 JP2003549921A JP2003549921A JP4272066B2 JP 4272066 B2 JP4272066 B2 JP 4272066B2 JP 2003549921 A JP2003549921 A JP 2003549921A JP 2003549921 A JP2003549921 A JP 2003549921A JP 4272066 B2 JP4272066 B2 JP 4272066B2
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- sepsis
- measurement
- procalcitonin
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- diagnosis
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/26—Infectious diseases, e.g. generalised sepsis
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Description
A.Beishuizenら, Advances in Clinical Chemistry, Vol.33, 1999, 55-131 C.Gabayら, The New England Journal of Medicine, Vol.340, No.6, 1999, 448-454 K.Reinhartら, Intensivmedizin, Georg Thieme Verlag, Stuttgart, New York, 2001, 756-760 M.Assicotら, The Lancet, Vol.341, No.8844, 1993, 515-518
CA19−9の測定用の商業的アッセイ(B.R.A.H.M.S Diagnostica GmbH社のKRYPTOR-CA19-9)を用いて、敗血症マーカープロカルシトニン(PCT)に高い値が見られた171人の敗血症患者の血清において、腫瘍マーカーCA19−9の濃度を測定した。62%の血清において、顕著に高いCA19−9濃度(20U/mlより高い)が観察された。
Claims (5)
- 敗血症および敗血症様全身性感染症の検出のための方法であって、パラメータCA19−9を患者の生物学的流体において測定し、かつ、その敗血症の存在、予想される経過、重篤度、および/または治療のために開始された処置の成功度を、前記パラメータCA19−9の存在および/または量が示すことを特徴とする方法。
- 適切な選択的抗体を用いることを特徴とする、請求項1記載の方法。
- CA19−9に加えて、プロカルシトニンの敗血症パラメータが同時に測定されるマルチパラメータ測定法で実施され、かつ、高精度の敗血症の検出のために評価される一組の測定変数の形態の測定結果が得られることを特徴とする、請求項1または2記載の方法。
- 前記マルチパラメータ測定法が、チップ技術法に従って操作する測定装置による同時測定として実施されることを特徴とする、請求項3記載の方法。
- 複数の測定結果の評価がコンピュータープログラムを用いて実施されることを特徴とする、請求項4記載の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01128850A EP1318404B1 (de) | 2001-12-04 | 2001-12-04 | Verfahren zur Diagnose von Sepsis unter Bestimmung von CA 19-9 |
PCT/EP2002/013392 WO2003048777A1 (de) | 2001-12-04 | 2002-11-27 | Verfahren zur diagnose von sepsis unter bestimmung von ca 19-9 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005512058A JP2005512058A (ja) | 2005-04-28 |
JP4272066B2 true JP4272066B2 (ja) | 2009-06-03 |
Family
ID=8179439
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003549921A Expired - Fee Related JP4272066B2 (ja) | 2001-12-04 | 2002-11-27 | Ca19−9の測定による敗血症の検出方法 |
Country Status (6)
Country | Link |
---|---|
US (1) | US7572590B2 (ja) |
EP (1) | EP1318404B1 (ja) |
JP (1) | JP4272066B2 (ja) |
AT (1) | ATE272215T1 (ja) |
DE (1) | DE50103032D1 (ja) |
WO (1) | WO2003048777A1 (ja) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1318404B1 (de) | 2001-12-04 | 2004-07-28 | B.R.A.H.M.S Aktiengesellschaft | Verfahren zur Diagnose von Sepsis unter Bestimmung von CA 19-9 |
ATE282831T1 (de) * | 2001-12-04 | 2004-12-15 | Brahms Ag | Verfahren zur diagnose von sepsis unter bestimmung löslicher cytokeratinfragmente |
DE50105971D1 (de) * | 2001-12-04 | 2005-05-25 | Brahms Ag | Verfahren zur Diagnose von Sepsis unter Bestimmung von CA 125 |
EP1355159A1 (de) * | 2002-04-19 | 2003-10-22 | B.R.A.H.M.S Aktiengesellschaft | Verwendungen von Fragmenten der Carbamoylphosphat Synthetase 1 (CPS 1) für die Diagnose von Entzündungserkrankungen und Sepsis |
EP1355158A1 (de) * | 2002-04-19 | 2003-10-22 | B.R.A.H.M.S Aktiengesellschaft | Verfahren zur Diagnose von Entzündungserkrankungen und Infektionen unter Bestimmung des Phosphoproteins LASP-1 als Inflammationsmarker |
CN1742087A (zh) | 2002-11-12 | 2006-03-01 | 贝克顿迪金森公司 | 使用生物标记谱诊断脓毒或者sirs |
MXPA05005031A (es) | 2002-11-12 | 2005-11-17 | Becton Dickinson Co | Diagnostico de la sepsis o sirs usando perfiles de biomarcadores. |
EP1869463A4 (en) | 2005-04-15 | 2010-05-05 | Becton Dickinson Co | SEPSIS DIAGNOSIS |
US8435755B2 (en) * | 2007-09-07 | 2013-05-07 | Universitaet Zuerich | Method for assaying sepsis in humans |
WO2009123737A2 (en) | 2008-04-03 | 2009-10-08 | Becton, Dickinson And Company | Advanced detection of sepsis |
US20150293131A1 (en) * | 2012-04-02 | 2015-10-15 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of sepsis |
US10260111B1 (en) | 2014-01-20 | 2019-04-16 | Brett Eric Etchebarne | Method of detecting sepsis-related microorganisms and detecting antibiotic-resistant sepsis-related microorganisms in a fluid sample |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5660994A (en) * | 1986-11-10 | 1997-08-26 | Progen Biotechnik Gmbh | Method of detecting tissue-specific, insoluble cytoskeletal proteins |
DE4227454C1 (de) * | 1992-08-19 | 1994-02-03 | Henning Berlin Gmbh | Verfahren zur Früherkennung, zur Erkennung des Schweregrads sowie zur therapiebegleitenden Verlaufsbeurteilung einer Sepsis sowie Mittel zur Durchführung des Verfahrens |
JPH10500210A (ja) * | 1994-05-06 | 1998-01-06 | スロットマン,ガス・ジェイ | 全身性炎症状態の危険にある患者の同定及び監視方法 |
DE19847690A1 (de) | 1998-10-15 | 2000-04-20 | Brahms Diagnostica Gmbh | Verfahren und Substanzen für die Diagnose und Therapie von Sepsis und sepsisähnlichen systemischen Infektionen |
DE10119804A1 (de) | 2001-04-23 | 2002-10-24 | Brahms Ag | Entzündungsspezifische Peptide und deren Verwendungen |
DE10130985B4 (de) | 2001-06-27 | 2004-03-18 | B.R.A.H.M.S Ag | Verfahren zur Diagnose von Sepsis und schweren Infektionen unter Bestimmung löslicher Cytokeratin-1-Fragmente |
DE10131922A1 (de) | 2001-07-02 | 2003-01-30 | Brahms Ag | Verwendung des Calcineurin B Homologen Proteins (CHP) für die Diagnose und Therapie von Entzündungserkrankungen und Sepsis |
EP1318404B1 (de) | 2001-12-04 | 2004-07-28 | B.R.A.H.M.S Aktiengesellschaft | Verfahren zur Diagnose von Sepsis unter Bestimmung von CA 19-9 |
-
2001
- 2001-12-04 EP EP01128850A patent/EP1318404B1/de not_active Expired - Lifetime
- 2001-12-04 DE DE50103032T patent/DE50103032D1/de not_active Expired - Lifetime
- 2001-12-04 AT AT01128850T patent/ATE272215T1/de active
-
2002
- 2002-11-27 US US10/496,250 patent/US7572590B2/en not_active Expired - Fee Related
- 2002-11-27 JP JP2003549921A patent/JP4272066B2/ja not_active Expired - Fee Related
- 2002-11-27 WO PCT/EP2002/013392 patent/WO2003048777A1/de active Application Filing
Also Published As
Publication number | Publication date |
---|---|
JP2005512058A (ja) | 2005-04-28 |
WO2003048777A1 (de) | 2003-06-12 |
US7572590B2 (en) | 2009-08-11 |
EP1318404A1 (de) | 2003-06-11 |
US20050059104A1 (en) | 2005-03-17 |
DE50103032D1 (de) | 2004-09-02 |
EP1318404B1 (de) | 2004-07-28 |
ATE272215T1 (de) | 2004-08-15 |
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