JP4269144B2 - 自己免疫疾患および炎症障害の処置のためのトリプトリドアナログ - Google Patents
自己免疫疾患および炎症障害の処置のためのトリプトリドアナログ Download PDFInfo
- Publication number
- JP4269144B2 JP4269144B2 JP2002532445A JP2002532445A JP4269144B2 JP 4269144 B2 JP4269144 B2 JP 4269144B2 JP 2002532445 A JP2002532445 A JP 2002532445A JP 2002532445 A JP2002532445 A JP 2002532445A JP 4269144 B2 JP4269144 B2 JP 4269144B2
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- JP
- Japan
- Prior art keywords
- hydrogen
- cycloalkyl
- independently selected
- aryl
- natural
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 *C(C(*)C(*)(CCC1C*2)C12C1*)C1(B1)C1(*)* Chemical compound *C(C(*)C(*)(CCC1C*2)C12C1*)C1(B1)C1(*)* 0.000 description 4
- LJZVXCRGCXZEIX-AWEZNQCLSA-N CC([C@@]12OC1)=CC=C(C1CCCCC1)C2=O Chemical compound CC([C@@]12OC1)=CC=C(C1CCCCC1)C2=O LJZVXCRGCXZEIX-AWEZNQCLSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/001—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain
- C07C37/002—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain by transformation of a functional group, e.g. oxo, carboxyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23755700P | 2000-10-02 | 2000-10-02 | |
PCT/US2001/030951 WO2002028862A2 (en) | 2000-10-02 | 2001-10-02 | Triptolide analogs for the treatment of autoimmune and inflammatory disorders |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008331610A Division JP2009102371A (ja) | 2000-10-02 | 2008-12-25 | 自己免疫疾患および炎症障害の処置のためのトリプトリドアナログ |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2004525082A JP2004525082A (ja) | 2004-08-19 |
JP2004525082A5 JP2004525082A5 (de) | 2008-07-17 |
JP4269144B2 true JP4269144B2 (ja) | 2009-05-27 |
Family
ID=22894243
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002532445A Expired - Fee Related JP4269144B2 (ja) | 2000-10-02 | 2001-10-02 | 自己免疫疾患および炎症障害の処置のためのトリプトリドアナログ |
JP2008331610A Pending JP2009102371A (ja) | 2000-10-02 | 2008-12-25 | 自己免疫疾患および炎症障害の処置のためのトリプトリドアナログ |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008331610A Pending JP2009102371A (ja) | 2000-10-02 | 2008-12-25 | 自己免疫疾患および炎症障害の処置のためのトリプトリドアナログ |
Country Status (8)
Country | Link |
---|---|
US (3) | US6777441B2 (de) |
EP (2) | EP1330459B1 (de) |
JP (2) | JP4269144B2 (de) |
AT (2) | ATE469907T1 (de) |
AU (2) | AU9654201A (de) |
CA (1) | CA2424555A1 (de) |
DE (2) | DE60142313D1 (de) |
WO (1) | WO2002028862A2 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1330459B1 (de) * | 2000-10-02 | 2006-08-02 | Emory University | Triptpolidanaloge zur verendung in der behandlung von autoimmunbedingten und entzündlichen erkrankungen |
TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
US7847109B2 (en) * | 2002-05-31 | 2010-12-07 | Pharmagenesis, Inc. | Triptolide derivatives for modulation of apoptosis and immunosuppression |
AU2003272450A1 (en) * | 2002-09-13 | 2004-04-30 | C. Steven Smith | Novel composition and method for treatment of upper respiratory conditions |
US20040224876A1 (en) * | 2003-02-14 | 2004-11-11 | Jost-Price Edward Roydon | Combination therapy for the treatment of immunoinflammatory disorders |
CN102358738A (zh) * | 2003-07-30 | 2012-02-22 | 里格尔药品股份有限公司 | 2,4-嘧啶二胺化合物及其预防和治疗自体免疫疾病的用途 |
TW200522932A (en) * | 2003-09-15 | 2005-07-16 | Combinatorx Inc | Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines |
US7820834B2 (en) * | 2003-12-24 | 2010-10-26 | Pharmagenesis, Inc. | Triptolide 5,6-derivatives as immunomodulators and anticancer agents |
WO2005077008A2 (en) * | 2004-02-09 | 2005-08-25 | Pharmagenesis, Inc. | Methods for isolation of triptolide compounds from tripterygium wilfordii |
CA2557260C (en) * | 2004-03-02 | 2013-02-12 | Pharmagenesis, Inc. | Triptolide lactone ring derivatives as immunomodulators and anticancer agents |
WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
WO2006012204A2 (en) * | 2004-06-25 | 2006-02-02 | Pharmagenesis, Inc. | Method for treatment of inflammatory disorders using triptolide compounds |
US8617906B2 (en) * | 2004-10-13 | 2013-12-31 | Pharmagenesis, Inc. | Identification and screening of triptolide target molecules |
CA2627242A1 (en) * | 2005-10-31 | 2007-05-10 | Rigel Pharmaceuticals, Inc. | Compositions and methods for treating inflammatory disorders |
EP2240460A4 (de) * | 2008-01-07 | 2012-02-22 | Univ Emory | Verzweigte diepoxidverbindungen zur behandlung von entzündungserkrankungen |
US9676797B2 (en) * | 2015-09-02 | 2017-06-13 | Abbvie Inc. | Anti-viral compounds |
WO2011041542A2 (en) | 2009-09-30 | 2011-04-07 | Ultimaxx, Inc. | Herbal pain killer compositions |
CN104478832B (zh) * | 2015-01-05 | 2016-04-20 | 项敬来 | 二萜化合物,含其的药物组合物及其制备方法和应用 |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
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GB1179866A (en) | 1967-09-08 | 1970-02-04 | Agfa Gevaert Nv | Photopolymerisation of Ethylenically Unsaturated Organic Compounds |
US3917652A (en) | 1968-04-29 | 1975-11-04 | Hoffmann La Roche | Juvabione and derivatives thereof |
BE789948A (fr) | 1971-10-13 | 1973-04-11 | Sandoz Sa | Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments |
US3816437A (en) | 1972-12-22 | 1974-06-11 | Sandoz Ag | Thieno(2,3-g)indazoles |
US3957816A (en) | 1973-01-31 | 1976-05-18 | Sandoz, Inc. | Substituted naphtho pyrazoles |
JPS5473766A (en) | 1977-11-21 | 1979-06-13 | Nippon Terpen Kagaku Kk | Manufacture of menthofuran |
GB2104516B (en) | 1981-07-13 | 1985-12-04 | Univ Brunel | M-alkylphenol derivatives and their use in copper extraction |
DE3219048A1 (de) | 1982-05-21 | 1983-11-24 | Basf Ag, 6700 Ludwigshafen | Thermoplastische formmassen |
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
DE3440826A1 (de) | 1983-11-10 | 1985-05-23 | Basf Ag, 6700 Ludwigshafen | 1,1-ethanoretinsaeuren und ihre c(pfeil abwaerts)1(pfeil abwaerts)-c(pfeil abwaerts)4(pfeil abwaerts)-alkylester |
JPS61197573A (ja) | 1985-02-26 | 1986-09-01 | Chugai Pharmaceut Co Ltd | 5,6−エポキシ化トランスビタミンd3 |
EP0609905B1 (de) | 1988-09-15 | 2001-06-06 | PHARMACIA & UPJOHN COMPANY | 3-(Stickstoff substituierte)phenyl-5-beta-amidomethyloxazoliden-2-one |
DE3913310A1 (de) | 1989-04-20 | 1990-10-25 | Schering Ag | Spirocyclopropane in der vitamin d-reihe |
JPH03197464A (ja) | 1989-12-16 | 1991-08-28 | Basf Ag | 置換アゾリルメチルシクロアルカノール及びこれを含有する殺菌剤 |
US5430054A (en) * | 1989-12-22 | 1995-07-04 | Jiangsu Family Planning Institute | Preparation methods of diterpene lactone compounds and application of the same to antifertility |
WO1991013627A1 (en) * | 1990-03-14 | 1991-09-19 | The Board Of Regents, The University Of Texas System | Tripterygium wilfordii hook f extracts and components thereof for immunosuppression |
US5216175A (en) | 1990-03-23 | 1993-06-01 | Sri International | Antimalarial analogs of artemisinin |
US5581004A (en) | 1991-09-23 | 1996-12-03 | Board Of Regents Of The University Of Nebraska | Preparation and use of (2-butene-1,4-diyl) magnesium complexes in organic synthesis |
WO1994002540A1 (en) | 1992-07-22 | 1994-02-03 | Lucey Michael F | Highly filled polymeric compositions |
WO1994026265A1 (en) * | 1993-05-06 | 1994-11-24 | Pharmagenesis, Inc. | 16-hydroxytriptolide composition and method for immunotherapy |
FR2707992B1 (fr) | 1993-07-21 | 1995-10-13 | Flamel Tech Sa | Nouveaux produits organiques contenant des fonctions thiols réactives, l'un de leurs procédés de préparation et les biomatériaux les contenant. |
GB9325415D0 (en) | 1993-12-13 | 1994-02-16 | Res Inst Medicine Chem | Chemical compounds |
GB9405715D0 (en) | 1994-03-23 | 1994-05-11 | Res Inst Medicine Chem | Chemical compounds |
FR2733498B1 (fr) | 1995-04-27 | 1997-05-30 | Adir | Nouveaux composes cyclohexaniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US5723632A (en) | 1996-08-08 | 1998-03-03 | Mgi Pharma, Inc. | Total synthesis of antitumor acylfulvenes |
IT1287174B1 (it) | 1996-11-15 | 1998-08-04 | Angelini Ricerche Spa | Diaril-ciclometilenpirazoli farmacologicamente attivi,procedimento per prepararli e composizioni farmaceutiche che li contengono |
US5972998A (en) * | 1997-05-23 | 1999-10-26 | Hoechst Marion Roussel, Inc. | Triptolide derivatives useful in the treatment of autoimmune diseases |
NZ503966A (en) | 1997-10-14 | 2002-10-25 | Scripps Research Inst | iso -CBI and iso -CI analogs of CC-1065 and the duocarmycins |
IL136489A0 (en) | 1997-12-08 | 2001-06-14 | Scripps Research Inst | Synthesis of cc-1065/duocarmycin analogs |
DE19855859A1 (de) | 1998-12-03 | 2000-06-08 | Degussa | Katalysatoren für die enantioselektive Epoxidierung von C=C-Doppelbindungen |
FR2787451B1 (fr) | 1998-12-18 | 2001-01-26 | Adir | Nouveaux composes imidazoliniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
AR023071A1 (es) | 1998-12-23 | 2002-09-04 | Syngenta Participations Ag | Compuestos de piridincetona, compuestos intermediarios, composicion herbicida e inhibidora del crecimiento de plantas, metodo para controlar la vegetacion indeseada, metodo para inhibir el crecimiento de las plantas, y uso de la composicion para controlar el crecimiento indeseado de plantas. |
US6331642B1 (en) | 1999-07-12 | 2001-12-18 | Hoffmann-La Roche Inc. | Vitamin D3 analogs |
EP1330459B1 (de) | 2000-10-02 | 2006-08-02 | Emory University | Triptpolidanaloge zur verendung in der behandlung von autoimmunbedingten und entzündlichen erkrankungen |
US20040204394A1 (en) | 2003-04-11 | 2004-10-14 | Aderis Pharmaceuticals, Inc. | Triptolide analogues |
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2001
- 2001-10-02 EP EP01977423A patent/EP1330459B1/de not_active Expired - Lifetime
- 2001-10-02 DE DE60142313T patent/DE60142313D1/de not_active Expired - Lifetime
- 2001-10-02 US US09/970,089 patent/US6777441B2/en not_active Expired - Lifetime
- 2001-10-02 AU AU9654201A patent/AU9654201A/xx active Pending
- 2001-10-02 AT AT05077239T patent/ATE469907T1/de not_active IP Right Cessation
- 2001-10-02 EP EP05077239A patent/EP1659125B1/de not_active Expired - Lifetime
- 2001-10-02 CA CA002424555A patent/CA2424555A1/en not_active Abandoned
- 2001-10-02 WO PCT/US2001/030951 patent/WO2002028862A2/en active Search and Examination
- 2001-10-02 JP JP2002532445A patent/JP4269144B2/ja not_active Expired - Fee Related
- 2001-10-02 AU AU2001296542A patent/AU2001296542B2/en not_active Ceased
- 2001-10-02 DE DE60121986T patent/DE60121986T2/de not_active Expired - Lifetime
- 2001-10-02 AT AT01977423T patent/ATE334986T1/de not_active IP Right Cessation
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2004
- 2004-08-17 US US10/919,824 patent/US7557139B2/en not_active Expired - Fee Related
-
2008
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JP2004525082A (ja) | 2004-08-19 |
ATE469907T1 (de) | 2010-06-15 |
EP1330459B1 (de) | 2006-08-02 |
CA2424555A1 (en) | 2002-04-11 |
AU9654201A (en) | 2002-04-15 |
US7557139B2 (en) | 2009-07-07 |
EP1659125B1 (de) | 2010-06-02 |
US20090234000A1 (en) | 2009-09-17 |
US20030027806A1 (en) | 2003-02-06 |
WO2002028862A2 (en) | 2002-04-11 |
JP2009102371A (ja) | 2009-05-14 |
AU2001296542B2 (en) | 2007-10-25 |
DE60121986D1 (de) | 2006-09-14 |
US8193249B2 (en) | 2012-06-05 |
US6777441B2 (en) | 2004-08-17 |
EP1330459A2 (de) | 2003-07-30 |
ATE334986T1 (de) | 2006-08-15 |
US20060040907A1 (en) | 2006-02-23 |
DE60121986T2 (de) | 2007-07-26 |
AU2001296542B9 (en) | 2002-04-15 |
EP1659125A1 (de) | 2006-05-24 |
DE60142313D1 (de) | 2010-07-15 |
WO2002028862A3 (en) | 2002-09-12 |
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