JP4227195B2 - リポソームインフルエンザワクチンの組成物および方法 - Google Patents

リポソームインフルエンザワクチンの組成物および方法 Download PDF

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JP4227195B2
JP4227195B2 JP50263298A JP50263298A JP4227195B2 JP 4227195 B2 JP4227195 B2 JP 4227195B2 JP 50263298 A JP50263298 A JP 50263298A JP 50263298 A JP50263298 A JP 50263298A JP 4227195 B2 JP4227195 B2 JP 4227195B2
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liposome
cytokine
csf
antigen
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JP2000513352A (ja
JP2000513352A5 (enExample
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エリエゼール ケダール，
アイラン ババイ，
エチェケール バレンホルズ，
Original Assignee
イッサム リサーチ ディベロプメント カンパニー オブ ザ ヘブリュー ユニバーシティ オブ エルサレム
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A61K2039/55527—Interleukins
    • A61K2039/55533—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP50263298A 1996-06-24 1997-06-24 リポソームインフルエンザワクチンの組成物および方法 Expired - Fee Related JP4227195B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2006396P 1996-06-24 1996-06-24
US60/020,063 1996-06-24
PCT/IL1997/000210 WO1997049423A2 (en) 1996-06-24 1997-06-24 Liposomal influenza vaccine composition and method

Related Child Applications (1)

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JP2008149959A Division JP2008260779A (ja) 1996-06-24 2008-06-06 リポソームインフルエンザワクチンの組成物および方法

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JP2000513352A JP2000513352A (ja) 2000-10-10
JP2000513352A5 JP2000513352A5 (enExample) 2005-02-10
JP4227195B2 true JP4227195B2 (ja) 2009-02-18

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JP50263298A Expired - Fee Related JP4227195B2 (ja) 1996-06-24 1997-06-24 リポソームインフルエンザワクチンの組成物および方法
JP2008149959A Withdrawn JP2008260779A (ja) 1996-06-24 2008-06-06 リポソームインフルエンザワクチンの組成物および方法

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US (1) US5919480A (enExample)
EP (1) EP0954286B1 (enExample)
JP (2) JP4227195B2 (enExample)
AT (1) ATE422352T1 (enExample)
AU (1) AU731705B2 (enExample)
CA (1) CA2258878C (enExample)
DE (1) DE69739253D1 (enExample)
WO (1) WO1997049423A2 (enExample)

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AT407958B (de) 1999-02-11 2001-07-25 Immuno Ag Inaktivierte influenza-virus-vakzine zur nasalen oder oralen applikation
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AU2002236526B9 (en) * 2000-11-15 2008-05-01 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Sol-fusin: use of GP64-6His to catalyze membrane fusion
TWI228420B (en) * 2001-05-30 2005-03-01 Smithkline Beecham Pharma Gmbh Novel vaccine composition
CA2451091A1 (en) * 2001-06-25 2003-01-03 Yissum Research Development Company Of The Hebrew University In Jerusale M A method for preparation of vesicles loaded with biological material and different uses thereof
ES2329118T3 (es) * 2001-07-05 2009-11-23 Ltb4 Sweden Ab Ltb4 como adyuvante de vacuna.
US20050169979A1 (en) * 2002-07-03 2005-08-04 Dov Michaeli Liposomal vaccine
US20040247661A1 (en) * 2002-07-03 2004-12-09 Dov Michaeli Liposomal vaccine
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EP1628636A1 (de) * 2003-05-09 2006-03-01 Novosom AG Injizierbare liposomale depots zum wirkstoffdelivery
KR101280094B1 (ko) * 2003-08-11 2013-06-28 사이단호진한다이비세이부쯔뵤우겐큐우카이 점막 면역을 유도할 수 있는 보강제를 함유한 신규한 백신
CN102172397B (zh) * 2003-08-21 2013-01-30 利普泰克有限公司 树突细胞的体内靶向
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CN102056622B (zh) 2008-06-05 2016-04-06 免疫疫苗技术有限公司 包含脂质体、抗原、多核苷酸和含疏水物质的连续相的载体的组合物
WO2010007623A1 (en) * 2008-07-14 2010-01-21 Polypid Ltd. Sustained-release drug carrier composition
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CN107029229B (zh) 2009-07-06 2022-08-26 变异生物技术公司 制备囊泡的方法和由其产生的制剂
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CN102470105B (zh) 2009-07-14 2015-07-29 波利皮得有限公司 持续释放药物载体组合物
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Also Published As

Publication number Publication date
DE69739253D1 (de) 2009-03-26
JP2008260779A (ja) 2008-10-30
JP2000513352A (ja) 2000-10-10
EP0954286A2 (en) 1999-11-10
AU3188297A (en) 1998-01-14
US5919480A (en) 1999-07-06
CA2258878A1 (en) 1997-12-31
CA2258878C (en) 2008-03-18
AU731705B2 (en) 2001-04-05
ATE422352T1 (de) 2009-02-15
EP0954286B1 (en) 2009-02-11
WO1997049423A2 (en) 1997-12-31
WO1997049423A3 (en) 1998-02-19

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