JP4224102B2 - 脳に対する光線療法を提供するための装置及び方法 - Google Patents
脳に対する光線療法を提供するための装置及び方法 Download PDFInfo
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Description
実施例[実施例1]
神経細胞に対する光線療法の一効果、すなわち、ATP生産に対する効果を示すために、生体外実験が行われた。NHNP(Normal Human Neural Progenitor:正常ヒト神経前駆細胞)細胞は、米国メリーランド州ボルチモアのClonetics、catalog # CC−2599、から冷凍保存で入手された。NHNP細胞は、製造者の指示に従って、解凍され、細胞と共に提供された試薬を用いてPEI(ポリエチレンイミン)上で培養された。細胞は、スフェロイドとして96ウェルプレート(透明な底部を有する黒いプラスチック、米国ニュージャージー州フランクリンレークのBecton Dickinson)にプレート化されており、2週間の期間にわたり成熟した神経細胞へ分化することができた。
第2の実施例では、経頭蓋レーザ治療が、RSCEM(rabbit small clot embolic stroke model:ラビットの小凝固塞栓性脳卒中モデル)における行動欠損を治療するために低エネルギ赤外線レーザを用いて調査された。その実施例は、非特許文献5によって、より詳細に述べられており、それを参照により本明細書にそのすべてを組み込む。
20 脳
30 頭皮
40 光源
40a 光源
40b 光源
41 出力放射領域
50 エレメント
60 キャップ
110 光放射ブランケット
112 電力通路インターフェース、光パワーインターフェース
114 光ファイバ
120 ストラップ
126 制御装置
140 手持形プローブ
200 制御回路
310 治療装置
340 光源
342 レーザダイオード
346 ミラー
370 照射パターン
370’ 照射パターン
372 照光領域
372’ 照光領域
374 非照光領域
374’ 非照光領域
410 光源
430 キャップ
Claims (28)
- 患者の脳を治療するための治療装置であって、
有効な電力密度及び光の波長を用いて、前記脳の一部分を照射するように配置された出力放射領域を有する光源であって、前記有効な電力密度が、硬膜の下の約2センチメートルの深さで約0.01mW/cm 2 〜約100mW/cm 2 である前記光源と、
前記光源と前記患者の頭皮との間に介在し、前記光によって生じた前記頭皮における温度上昇を抑制するように適合されているエレメントと、
を備えている前記治療装置において、
前記エレメントは、前記頭皮の少なくとも一部分に圧力を加え、それにより、前記頭皮の少なくとも一部分を白化させて、前記頭皮中の血液による前記光の吸収を減少させることを特徴とする治療装置。 - 前記光が、前記頭皮に到達する前に前記エレメントを通過することを特徴とする請求項1に記載の治療装置。
- 前記エレメントが前記患者の頭皮に接触していることを特徴とする請求項1に記載の治療装置。
- 前記エレメントが、前記光源に取り付けられており、前記頭皮に対する前記光源の位置決めを行うように前記頭皮に適合するように構成されていることを特徴とする請求項3に記載の治療装置。
- 前記エレメントが、前記頭皮に対して前記光生成装置の位置を調整するために、機械的に調整可能であることを特徴とする請求項4に記載の治療装置。
- 前記エレメントが、前記頭皮に前記治療装置を適応させるために機械的に調整可能である、請求項4に記載の治療装置。
- 前記エレメントが、前記頭皮の輪郭に適合する材料を含むバッグを備えることを特徴とする請求項6に記載の治療装置。
- 前記エレメントの少なくとも一部分が、前記光源から前記頭皮への光路内に存在することを特徴とする請求項4に記載の治療装置。
- 前記エレメントが、前記波長において実質的に光学的な透過性があり、前記光の後方反射を低減するように適合されていることを特徴とする請求項8に記載の治療装置。
- 前記エレメントは、前記光の前記光路中における、前記頭皮と前記エレメントとの間の空隙を実質的に低減するために、前記頭皮に適応するように構成されていることを特徴とする請求項9に記載の治療装置。
- 前記エレメントが、前記頭皮の屈折率と実質的に一致する屈折率を有する材料を含むことを特徴とする請求項9に記載の治療装置。
- 前記材料がグリセロールを含むことを特徴とする請求項11に記載の治療装置。
- 前記材料がシリカゲルを含むことを特徴とする請求項11に記載の治療装置。
- 前記エレメントが、前記頭皮から熱を除去することによって前記頭皮を冷却するように適合していることを特徴とする請求項1に記載の治療装置。
- 前記エレメントが、前記頭皮の近くの通路を通じて流れ、前記頭皮によって加熱され、前記頭皮から流れ出る冷却液を含むように適合された前記通路を備えることを特徴とする請求項14に記載の治療装置。
- 前記冷却液が、前記エレメントと熱伝導装置との間を循環し、それにより、前記冷却液が前記頭皮によって加熱され、また前記熱伝導装置によって冷却されることを特徴とする請求項15に記載の治療装置。
- 前記冷却液が、水を含むことを特徴とする請求項15に記載の治療装置。
- 前記冷却液が、空気を含むことを特徴とする請求項15に記載の治療装置。
- 前記エレメントが、前記頭皮と熱的に結合された非流体材料を含むことを特徴とする請求項14に記載の治療装置。
- 前記非流体材料が、前記脳の治療前に事前に冷却されていることを特徴とする請求項19に記載の治療装置。
- 前記非流体材料がゲルを含むことを特徴とする請求項19に記載の治療装置。
- 前記エレメントが、前記頭皮に到達する前に前記光を拡散させるように適合していることを特徴とする請求項1に記載の治療装置。
- 前記脳の前記照射された部分が全体の脳を含むことを特徴とする請求項1に記載の治療装置。
- 前記装置が同時の複数日にわたり着用可能であることを特徴とする請求項1に記載の治療装置。
- 脳組織を治療するための治療装置であって、
有効な量の光が前記脳組織に到達するように頭蓋骨に浸透する波長及び電力密度を有している光を用いて、前記患者の頭の少なくとも一部を照射するように配置されている光源であって、前記光が、前記患者の硬膜の下の約2センチメートルの深さで約0.01mW/cm 2 〜約100mW/cm 2 である前記光源と、
前記頭における温度上昇を抑制するように適合されている要素であって、前記頭に接触し、且つ、前記患者の前記頭の少なくとも照射された部分に圧力を作用させるように適合され、これにより前記照射された部分を白化させる前記要素と、
を備えていることを特徴とする治療装置。 - 前記光源は、前記頭の所定の領域を照射するように適合されていることを特徴とする請求項25に記載の治療装置。
- 前記頭の所定領域は、前記頭の全領域の一部であることを特徴とする請求項26に記載の治療装置。
- 患者の脳を治療するための治療装置であって、
有効な電力密度及び光の波長を用いて、前記脳の少なくとも一部分に照射するように適合されている光源であって、前記有効な電力密度が、硬膜の下の約2センチメートルの深さで約0.01mW/cm 2 〜約100mW/cm 2 である前記光源と、
頭皮における温度上昇を抑制するように適合されており、前記頭皮の少なくとも一部分に圧力を作用させることによって前記頭皮の少なくとも一部分を白化させるエレメントであって、前記エレメントの少なくとも一部が前記光源から前記頭皮に至る光路内に存在している前記エレメントと、
を備えていることを特徴とする治療装置。
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PCT/US2004/029724 WO2005025672A1 (en) | 2003-01-24 | 2004-09-10 | Device and method for providing phototherapy to the brain |
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JP2007504909A JP2007504909A (ja) | 2007-03-08 |
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EP (2) | EP2266663A1 (ja) |
JP (1) | JP4224102B2 (ja) |
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US20100010594A1 (en) | 2010-01-14 |
US20060253177A1 (en) | 2006-11-09 |
EP1663392A1 (en) | 2006-06-07 |
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US10758743B2 (en) | 2020-09-01 |
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US20050107851A1 (en) | 2005-05-19 |
JP2007504909A (ja) | 2007-03-08 |
US20100010592A1 (en) | 2010-01-14 |
US20100094384A1 (en) | 2010-04-15 |
CA2537370A1 (en) | 2005-03-24 |
US7309348B2 (en) | 2007-12-18 |
US20040138727A1 (en) | 2004-07-15 |
US10653889B2 (en) | 2020-05-19 |
US10857376B2 (en) | 2020-12-08 |
EP2266663A1 (en) | 2010-12-29 |
US20080004565A1 (en) | 2008-01-03 |
WO2005025672A1 (en) | 2005-03-24 |
US20100105977A1 (en) | 2010-04-29 |
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