JP3989845B2 - 質量分析の方法及び装置 - Google Patents
質量分析の方法及び装置 Download PDFInfo
- Publication number
- JP3989845B2 JP3989845B2 JP2002575983A JP2002575983A JP3989845B2 JP 3989845 B2 JP3989845 B2 JP 3989845B2 JP 2002575983 A JP2002575983 A JP 2002575983A JP 2002575983 A JP2002575983 A JP 2002575983A JP 3989845 B2 JP3989845 B2 JP 3989845B2
- Authority
- JP
- Japan
- Prior art keywords
- ions
- storage device
- voltage
- trap
- trapping
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/422—Two-dimensional RF ion traps
- H01J49/4225—Multipole linear ion traps, e.g. quadrupoles, hexapoles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/422—Two-dimensional RF ion traps
- H01J49/423—Two-dimensional RF ion traps with radial ejection
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/4245—Electrostatic ion traps
- H01J49/425—Electrostatic ion traps with a logarithmic radial electric potential, e.g. orbitraps
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Physics & Mathematics (AREA)
- Composite Materials (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Materials Engineering (AREA)
- Crystallography & Structural Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0107380A GB0107380D0 (en) | 2001-03-23 | 2001-03-23 | Mass spectrometry method and apparatus |
| GB0126764A GB2378312B (en) | 2001-03-23 | 2001-11-07 | Mass spectrometry method and apparatus |
| PCT/GB2002/001373 WO2002078046A2 (en) | 2001-03-23 | 2002-03-20 | Mass spectrometry method and apparatus |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005500646A JP2005500646A (ja) | 2005-01-06 |
| JP2005500646A5 JP2005500646A5 (enExample) | 2006-09-21 |
| JP3989845B2 true JP3989845B2 (ja) | 2007-10-10 |
Family
ID=26245890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002575983A Expired - Fee Related JP3989845B2 (ja) | 2001-03-23 | 2002-03-20 | 質量分析の方法及び装置 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US6872938B2 (enExample) |
| EP (2) | EP1371081B1 (enExample) |
| JP (1) | JP3989845B2 (enExample) |
| AU (1) | AU2002244835A1 (enExample) |
| CA (1) | CA2441589C (enExample) |
| GB (1) | GB2404784B (enExample) |
| WO (1) | WO2002078046A2 (enExample) |
Families Citing this family (128)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020115056A1 (en) | 2000-12-26 | 2002-08-22 | Goodlett David R. | Rapid and quantitative proteome analysis and related methods |
| GB2404784B (en) * | 2001-03-23 | 2005-06-22 | Thermo Finnigan Llc | Mass spectrometry method and apparatus |
| US7265344B2 (en) * | 2001-03-23 | 2007-09-04 | Thermo Finnigan Llc | Mass spectrometry method and apparatus |
| DE60219576T2 (de) | 2001-11-22 | 2007-12-27 | Micromass Uk Ltd. | Massenspektrometer und Verfahren |
| GB0305796D0 (en) | 2002-07-24 | 2003-04-16 | Micromass Ltd | Method of mass spectrometry and a mass spectrometer |
| JP5322385B2 (ja) * | 2003-01-24 | 2013-10-23 | サーモ フィニガン リミテッド ライアビリティ カンパニー | 質量分析器におけるイオン集団の制御 |
| JP4738326B2 (ja) | 2003-03-19 | 2011-08-03 | サーモ フィニガン リミテッド ライアビリティ カンパニー | イオン母集団内複数親イオン種についてのタンデム質量分析データ取得 |
| GB2402260B (en) * | 2003-05-30 | 2006-05-24 | Thermo Finnigan Llc | All mass MS/MS method and apparatus |
| US7026613B2 (en) * | 2004-01-23 | 2006-04-11 | Thermo Finnigan Llc | Confining positive and negative ions with fast oscillating electric potentials |
| GB2412486B (en) * | 2004-03-26 | 2009-01-14 | Thermo Finnigan Llc | Fourier transform mass spectrometer and method for generating a mass spectrum therefrom |
| GB2414855A (en) | 2004-03-30 | 2005-12-07 | Thermo Finnigan Llc | Ion fragmentation by electron capture |
| GB2415541B (en) | 2004-06-21 | 2009-09-23 | Thermo Finnigan Llc | RF power supply for a mass spectrometer |
| GB0416288D0 (en) * | 2004-07-21 | 2004-08-25 | Micromass Ltd | Mass spectrometer |
| GB0426900D0 (en) * | 2004-12-08 | 2005-01-12 | Micromass Ltd | Mass spectrometer |
| US7166837B2 (en) * | 2005-02-28 | 2007-01-23 | Agilent Technologies, Inc. | Apparatus and method for ion fragmentation cut-off |
| JP5306806B2 (ja) * | 2005-03-29 | 2013-10-02 | サーモ フィニガン リミテッド ライアビリティ カンパニー | 質量分析計、質量分析法、コントローラ、コンピュータプログラムおよびコンピュータ可読媒体 |
| GB0506288D0 (en) * | 2005-03-29 | 2005-05-04 | Thermo Finnigan Llc | Improvements relating to mass spectrometry |
| GB0511083D0 (en) | 2005-05-31 | 2005-07-06 | Thermo Finnigan Llc | Multiple ion injection in mass spectrometry |
| GB2434484B (en) | 2005-06-03 | 2010-11-03 | Thermo Finnigan Llc | Improvements in an electrostatic trap |
| GB0513047D0 (en) * | 2005-06-27 | 2005-08-03 | Thermo Finnigan Llc | Electronic ion trap |
| US7569811B2 (en) * | 2006-01-13 | 2009-08-04 | Ionics Mass Spectrometry Group Inc. | Concentrating mass spectrometer ion guide, spectrometer and method |
| CA2639903C (en) * | 2006-04-13 | 2012-01-03 | Thermo Fisher Scientific (Bremen) Gmbh | Ion energy spread reduction for mass spectrometer |
| GB0607542D0 (en) | 2006-04-13 | 2006-05-24 | Thermo Finnigan Llc | Mass spectrometer |
| NZ549911A (en) * | 2006-10-19 | 2009-04-30 | Syft Technologies Ltd | Improvements in or relating to SIFT-MS instruments |
| US20090283674A1 (en) * | 2006-11-07 | 2009-11-19 | Reinhold Pesch | Efficient Atmospheric Pressure Interface for Mass Spectrometers and Method |
| US7982183B2 (en) * | 2006-11-07 | 2011-07-19 | Thermo Fisher Scientific (Bremen) Gmbh | Ion transfer tube with spatially alternating DC fields |
| US7741600B2 (en) * | 2006-11-17 | 2010-06-22 | Thermo Finnigan Llc | Apparatus and method for providing ions to a mass analyzer |
| GB0624679D0 (en) | 2006-12-11 | 2007-01-17 | Shimadzu Corp | A time-of-flight mass spectrometer and a method of analysing ions in a time-of-flight mass spectrometer |
| GB0626025D0 (en) | 2006-12-29 | 2007-02-07 | Thermo Electron Bremen Gmbh | Ion trap |
| GB2445169B (en) | 2006-12-29 | 2012-03-14 | Thermo Fisher Scient Bremen | Parallel mass analysis |
| JP5258198B2 (ja) * | 2007-01-30 | 2013-08-07 | Msi.Tokyo株式会社 | リニアイオントラップ質量分析装置 |
| US8853622B2 (en) * | 2007-02-07 | 2014-10-07 | Thermo Finnigan Llc | Tandem mass spectrometer |
| CA2672829A1 (en) * | 2007-02-23 | 2008-08-28 | Brigham Young University | Coaxial hybrid radio frequency ion trap mass analyzer |
| JP4996962B2 (ja) * | 2007-04-04 | 2012-08-08 | 株式会社日立ハイテクノロジーズ | 質量分析装置 |
| DE102007024858B4 (de) | 2007-04-12 | 2011-02-10 | Bruker Daltonik Gmbh | Massenspektrometer mit einer elektrostatischen Ionenfalle |
| GB2448413B (en) * | 2007-04-12 | 2011-08-24 | Bruker Daltonik Gmbh | Mass spectrometer with an electrostatic ion trap |
| US7868289B2 (en) * | 2007-04-30 | 2011-01-11 | Ionics Mass Spectrometry Group Inc. | Mass spectrometer ion guide providing axial field, and method |
| US7755040B2 (en) * | 2007-09-24 | 2010-07-13 | Agilent Technologies, Inc. | Mass spectrometer and electric field source for mass spectrometer |
| US20090134325A1 (en) | 2007-11-27 | 2009-05-28 | Goldman Mildred M | Methods for detecting estradiol by mass spectrometry |
| US7989765B2 (en) * | 2007-11-30 | 2011-08-02 | Agilent Technologies, Inc. | Method and apparatus for trapping ions |
| US8334506B2 (en) * | 2007-12-10 | 2012-12-18 | 1St Detect Corporation | End cap voltage control of ion traps |
| DE102008024297B4 (de) * | 2008-05-20 | 2011-03-31 | Bruker Daltonik Gmbh | Fragmentierung von Ionen in Kingdon-Ionenfallen |
| US7973277B2 (en) | 2008-05-27 | 2011-07-05 | 1St Detect Corporation | Driving a mass spectrometer ion trap or mass filter |
| CN102150219B (zh) | 2008-07-28 | 2015-01-28 | 莱克公司 | 在射频场中使用网的离子操纵的方法和设备 |
| US20100154568A1 (en) * | 2008-11-19 | 2010-06-24 | Roth Michael J | Analytical Instruments, Assemblies, and Methods |
| DE102009007266B4 (de) * | 2009-02-03 | 2012-04-19 | Bruker Daltonik Gmbh | Massenspektrometrische Identifizierung von Mikroorganismen in komplexen Proben |
| DE102009020886B4 (de) * | 2009-05-12 | 2012-08-30 | Bruker Daltonik Gmbh | Einspeichern von Ionen in Kíngdon-Ionenfallen |
| GB2470599B (en) * | 2009-05-29 | 2014-04-02 | Thermo Fisher Scient Bremen | Charged particle analysers and methods of separating charged particles |
| GB2470600B (en) | 2009-05-29 | 2012-06-13 | Thermo Fisher Scient Bremen | Charged particle analysers and methods of separating charged particles |
| EP3095457B1 (en) | 2009-11-05 | 2018-05-16 | Quest Diagnostics Investments Incorporated | Quantitation of insulin-like growth factor-i with high-resolution mass spectrometry |
| US8497079B2 (en) * | 2009-12-21 | 2013-07-30 | Quest Diagnostics Investments Incorporated | Glucagon detection and quantitation by mass spectrometry |
| GB2476844B (en) * | 2010-05-24 | 2011-12-07 | Fasmatech Science And Technology Llc | Improvements relating to the control of ions |
| GB2484136B (en) * | 2010-10-01 | 2015-09-16 | Thermo Fisher Scient Bremen | Method and apparatus for improving the throughput of a charged particle analysis system |
| GB2496994B (en) * | 2010-11-26 | 2015-05-20 | Thermo Fisher Scient Bremen | Method of mass separating ions and mass separator |
| US9922812B2 (en) * | 2010-11-26 | 2018-03-20 | Thermo Fisher Scientific (Bremen) Gmbh | Method of mass separating ions and mass separator |
| GB2488745B (en) | 2010-12-14 | 2016-12-07 | Thermo Fisher Scient (Bremen) Gmbh | Ion Detection |
| US8935101B2 (en) | 2010-12-16 | 2015-01-13 | Thermo Finnigan Llc | Method and apparatus for correlating precursor and product ions in all-ions fragmentation experiments |
| EP2659501B1 (en) | 2010-12-28 | 2017-09-06 | Quest Diagnostics Investments Incorporated | Quantitation of insulin by mass spectrometry |
| DE102011008713B4 (de) * | 2011-01-17 | 2012-08-02 | Bruker Daltonik Gmbh | Kingdon-Ionenfallen mit Cassini-Potentialen höherer Ordnung |
| CN107658203B (zh) | 2011-05-05 | 2020-04-14 | 岛津研究实验室(欧洲)有限公司 | 操纵带电粒子的装置 |
| GB2543992B (en) | 2011-05-12 | 2017-09-06 | Thermo Fisher Scient (Bremen) Gmbh | Mass analyser |
| GB2544920B (en) | 2011-05-12 | 2018-02-07 | Thermo Fisher Scient (Bremen) Gmbh | Electrostatic ion trapping with shielding conductor |
| US8728824B2 (en) | 2011-06-22 | 2014-05-20 | Quest Diagnostics Investments Inc. | Mass spectrometric determination of fatty acids |
| US8866077B2 (en) * | 2011-10-20 | 2014-10-21 | Shimadzu Corporation | Mass spectrometer |
| GB201118270D0 (en) | 2011-10-21 | 2011-12-07 | Shimadzu Corp | TOF mass analyser with improved resolving power |
| DE102011118052A1 (de) * | 2011-11-08 | 2013-07-18 | Bruker Daltonik Gmbh | Züchtung von Obertönen in Schwingungs- Massenspektrometern |
| US20130131998A1 (en) | 2011-11-18 | 2013-05-23 | David A. Wright | Methods and Apparatus for Identifying Mass Spectral Isotope Patterns |
| WO2013112677A2 (en) | 2012-01-24 | 2013-08-01 | Thermo Finnigan Llc | Multinotch isolation for ms3 mass analysis |
| US8933397B1 (en) * | 2012-02-02 | 2015-01-13 | University of Northern Iowa Research Foundati | Ion trap mass analyzer apparatus, methods, and systems utilizing one or more multiple potential ion guide (MPIG) electrodes |
| US9347917B2 (en) * | 2012-03-28 | 2016-05-24 | Dh Technologies Development Pte. Ltd. | Mass spectrometry systems and methods for analyses on lipid and other ions using a unique workflow |
| CN103367094B (zh) * | 2012-03-31 | 2016-12-14 | 株式会社岛津制作所 | 离子阱分析器以及离子阱质谱分析方法 |
| US10840073B2 (en) | 2012-05-18 | 2020-11-17 | Thermo Fisher Scientific (Bremen) Gmbh | Methods and apparatus for obtaining enhanced mass spectrometric data |
| US20150260684A1 (en) * | 2012-11-16 | 2015-09-17 | Dh Technologies Development Pte. Ltd. | Method and apparatus for ion mobility spectrometry |
| RU2542722C2 (ru) * | 2012-11-16 | 2015-02-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Рязанский государственный радиотехнический университет" | Способ времяпролетного масс-анализа и устройство для его осуществления |
| EP2741224A1 (en) | 2012-11-20 | 2014-06-11 | Thermo Finnigan LLC | Methods for generating local mass spectral libraries for interpreting multiplexed mass spectra |
| US20140138531A1 (en) | 2012-11-20 | 2014-05-22 | David A. Wright | Use of Neutral Loss Mass to Reconstruct MS-2 Spectra in All Ions Fragmentation |
| US20140142865A1 (en) | 2012-11-20 | 2014-05-22 | David A. Wright | Automatic Reconstruction of MS-2 Spectra from all Ions Fragmentation to Recognize Previously Detected Compounds |
| EP2939024B1 (en) | 2012-12-26 | 2021-04-28 | Quest Diagnostics Investments Incorporated | C peptide detection by mass spectrometry |
| US20140252218A1 (en) | 2013-03-05 | 2014-09-11 | David A. Wright | Methods and Apparatus for Decomposing Tandem Mass Spectra Generated by All-Ions Fragmentation |
| WO2014164198A1 (en) | 2013-03-11 | 2014-10-09 | David Rafferty | Automatic gain control with defocusing lens |
| EP2973653B1 (en) | 2013-03-13 | 2018-10-03 | Micromass UK Limited | Toroidal trapping geometry pulsed ion source |
| US8969794B2 (en) | 2013-03-15 | 2015-03-03 | 1St Detect Corporation | Mass dependent automatic gain control for mass spectrometer |
| US8921770B1 (en) * | 2013-07-05 | 2014-12-30 | Bruker Daltonics, Inc. | Reduction of cross-talk between RF components in a mass spectrometer |
| CN110718442B (zh) | 2015-01-23 | 2022-08-16 | 加州理工学院 | 整合的混合nems质谱测定法 |
| US9536723B1 (en) * | 2015-02-06 | 2017-01-03 | Agilent Technologies, Inc. | Thin field terminator for linear quadrupole ion guides, and related systems and methods |
| US10324082B2 (en) | 2015-03-03 | 2019-06-18 | Quest Diagnostics Investments Llc | Methods for quantitation of insulin levels by mass spectrometry |
| EP3086353A1 (en) | 2015-04-24 | 2016-10-26 | Thermo Fisher Scientific (Bremen) GmbH | A method of producing a mass spectrum |
| GB2538075B (en) | 2015-05-05 | 2019-05-15 | Thermo Fisher Scient Bremen Gmbh | Method and apparatus for injection of ions into an electrostatic ion trap |
| US9524860B1 (en) | 2015-09-25 | 2016-12-20 | Thermo Finnigan Llc | Systems and methods for multipole operation |
| GB2551110B (en) | 2016-05-23 | 2020-03-11 | Thermo Fisher Scient Bremen Gmbh | Ion injection to an electrostatic trap |
| GB201613988D0 (en) | 2016-08-16 | 2016-09-28 | Micromass Uk Ltd And Leco Corp | Mass analyser having extended flight path |
| US10192730B2 (en) | 2016-08-30 | 2019-01-29 | Thermo Finnigan Llc | Methods for operating electrostatic trap mass analyzers |
| WO2018087634A1 (en) * | 2016-11-11 | 2018-05-17 | Dh Technologies Development Pte. Ltd. | Spatial, mass and energy focused ion injection method and device |
| WO2018142265A1 (en) * | 2017-02-01 | 2018-08-09 | Dh Technologies Development Pte. Ltd. | Fourier transform mass spectrometer |
| EP4220157B1 (en) | 2017-03-31 | 2025-05-14 | Quest Diagnostics Investments LLC | Methods for quantitation of insulin and c-peptide |
| US10957527B2 (en) | 2017-04-04 | 2021-03-23 | Atonarp Inc. | Mass analyzer |
| GB2567794B (en) | 2017-05-05 | 2023-03-08 | Micromass Ltd | Multi-reflecting time-of-flight mass spectrometers |
| GB2563571B (en) | 2017-05-26 | 2023-05-24 | Micromass Ltd | Time of flight mass analyser with spatial focussing |
| CN111164731B (zh) | 2017-08-06 | 2022-11-18 | 英国质谱公司 | 进入多通道质谱分析仪的离子注入 |
| US11049712B2 (en) | 2017-08-06 | 2021-06-29 | Micromass Uk Limited | Fields for multi-reflecting TOF MS |
| WO2019030471A1 (en) | 2017-08-06 | 2019-02-14 | Anatoly Verenchikov | ION GUIDE INSIDE PULSED CONVERTERS |
| EP3662502A1 (en) | 2017-08-06 | 2020-06-10 | Micromass UK Limited | Printed circuit ion mirror with compensation |
| WO2019030472A1 (en) | 2017-08-06 | 2019-02-14 | Anatoly Verenchikov | IONIC MIRROR FOR MULTI-REFLECTION MASS SPECTROMETERS |
| US11817303B2 (en) | 2017-08-06 | 2023-11-14 | Micromass Uk Limited | Accelerator for multi-pass mass spectrometers |
| WO2019030475A1 (en) | 2017-08-06 | 2019-02-14 | Anatoly Verenchikov | MASS SPECTROMETER WITH MULTIPASSAGE |
| US10199207B1 (en) | 2017-09-07 | 2019-02-05 | California Institute Of Technology | Determining isotope ratios using mass spectrometry |
| US10236168B1 (en) | 2017-11-21 | 2019-03-19 | Thermo Finnigan Llc | Ion transfer method and device |
| GB201806507D0 (en) | 2018-04-20 | 2018-06-06 | Verenchikov Anatoly | Gridless ion mirrors with smooth fields |
| GB201807626D0 (en) | 2018-05-10 | 2018-06-27 | Micromass Ltd | Multi-reflecting time of flight mass analyser |
| GB201807605D0 (en) | 2018-05-10 | 2018-06-27 | Micromass Ltd | Multi-reflecting time of flight mass analyser |
| GB201808530D0 (en) | 2018-05-24 | 2018-07-11 | Verenchikov Anatoly | TOF MS detection system with improved dynamic range |
| GB201810573D0 (en) | 2018-06-28 | 2018-08-15 | Verenchikov Anatoly | Multi-pass mass spectrometer with improved duty cycle |
| US10600632B2 (en) | 2018-08-23 | 2020-03-24 | Thermo Finnigan Llc | Methods for operating electrostatic trap mass analyzers |
| GB201901411D0 (en) | 2019-02-01 | 2019-03-20 | Micromass Ltd | Electrode assembly for mass spectrometer |
| GB201903779D0 (en) | 2019-03-20 | 2019-05-01 | Micromass Ltd | Multiplexed time of flight mass spectrometer |
| GB2583758B (en) * | 2019-05-10 | 2021-09-15 | Thermo Fisher Scient Bremen Gmbh | Improved injection of ions into an ion storage device |
| GB201907211D0 (en) * | 2019-05-22 | 2019-07-03 | Thermo Fisher Scient Bremen Gmbh | A mass spectrometer |
| GB2584129B (en) * | 2019-05-22 | 2022-01-12 | Thermo Fisher Scient Bremen Gmbh | Ion trap with elongated electrodes |
| EP4012747A1 (en) | 2020-12-10 | 2022-06-15 | Thermo Fisher Scientific (Bremen) GmbH | Methods and systems for processing mass spectra |
| CN112488117B (zh) * | 2020-12-11 | 2022-09-27 | 南京理工大学 | 一种基于方向诱导卷积的点云分析方法 |
| EP4102509A1 (en) | 2021-06-07 | 2022-12-14 | MSAID GmbH | Method and apparatus for identifying molecular species in a mass spectrum |
| US11581180B2 (en) * | 2021-06-23 | 2023-02-14 | Thermo Finnigan Llc | Apparatus and methods for injecting ions into an electrostatic trap |
| CN114867182B (zh) * | 2022-01-14 | 2024-07-30 | 天津大学 | 一种用于带电粒子储存的紧凑型静电储存环装置 |
| GB2629681A (en) | 2022-05-09 | 2024-11-06 | Thermo Fisher Scient Bremen Gmbh | Charge detection for ion accumulation control |
| AU2024247888A1 (en) | 2023-03-31 | 2025-10-09 | Quest Diagnostics Investments Llc | Methods for quantitation of adiponectin by mass spectrometry |
| DE112024002304T5 (de) | 2023-05-26 | 2026-03-19 | California Institute Of Technology | Methode zum Betrieb eines Massenspektrometers mit einer Ionenfalle |
| GB202319611D0 (en) | 2023-12-20 | 2024-01-31 | Thermo Fisher Scient Bremen Gmbh | Systems and methods of analysis of isobaric tagging experiments |
| CN117554533A (zh) * | 2024-01-11 | 2024-02-13 | 安益谱(苏州)医疗科技有限公司 | 一种气相色谱混合质谱联用仪及联用方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4540884A (en) | 1982-12-29 | 1985-09-10 | Finnigan Corporation | Method of mass analyzing a sample by use of a quadrupole ion trap |
| US5179278A (en) | 1991-08-23 | 1993-01-12 | Mds Health Group Limited | Multipole inlet system for ion traps |
| US6011259A (en) * | 1995-08-10 | 2000-01-04 | Analytica Of Branford, Inc. | Multipole ion guide ion trap mass spectrometry with MS/MSN analysis |
| US5689111A (en) | 1995-08-10 | 1997-11-18 | Analytica Of Branford, Inc. | Ion storage time-of-flight mass spectrometer |
| US5420425A (en) * | 1994-05-27 | 1995-05-30 | Finnigan Corporation | Ion trap mass spectrometer system and method |
| US5572022A (en) * | 1995-03-03 | 1996-11-05 | Finnigan Corporation | Method and apparatus of increasing dynamic range and sensitivity of a mass spectrometer |
| DE19511333C1 (de) * | 1995-03-28 | 1996-08-08 | Bruker Franzen Analytik Gmbh | Verfahren und Vorrichtung für orthogonalen Einschuß von Ionen in ein Flugzeit-Massenspektrometer |
| GB9506695D0 (en) * | 1995-03-31 | 1995-05-24 | Hd Technologies Limited | Improvements in or relating to a mass spectrometer |
| US5569917A (en) | 1995-05-19 | 1996-10-29 | Varian Associates, Inc. | Apparatus for and method of forming a parallel ion beam |
| DE19523860A1 (de) * | 1995-06-30 | 1997-01-02 | Bruker Franzen Analytik Gmbh | Ionenfallen-Massenspektrometer mit vakuum-externer Ionenerzeugung |
| US5729014A (en) * | 1996-07-11 | 1998-03-17 | Varian Associates, Inc. | Method for injection of externally produced ions into a quadrupole ion trap |
| GB2324906B (en) | 1997-04-29 | 2002-01-09 | Masslab Ltd | Ion source for a mass analyser and method of providing a source of ions for analysis |
| US5880466A (en) | 1997-06-02 | 1999-03-09 | The Regents Of The University Of California | Gated charged-particle trap |
| CA2312806A1 (en) | 1997-12-05 | 1999-06-17 | University Of British Columbia | Method of analyzing ions in an apparatus including a time of flight mass spectrometer and a linear ion trap |
| US6545268B1 (en) * | 2000-04-10 | 2003-04-08 | Perseptive Biosystems | Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis |
| US6627883B2 (en) * | 2001-03-02 | 2003-09-30 | Bruker Daltonics Inc. | Apparatus and method for analyzing samples in a dual ion trap mass spectrometer |
| GB2404784B (en) * | 2001-03-23 | 2005-06-22 | Thermo Finnigan Llc | Mass spectrometry method and apparatus |
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2001
- 2001-11-07 GB GB0421715A patent/GB2404784B/en not_active Expired - Fee Related
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2002
- 2002-03-20 WO PCT/GB2002/001373 patent/WO2002078046A2/en not_active Ceased
- 2002-03-20 CA CA2441589A patent/CA2441589C/en not_active Expired - Lifetime
- 2002-03-20 AU AU2002244835A patent/AU2002244835A1/en not_active Abandoned
- 2002-03-20 EP EP02713044A patent/EP1371081B1/en not_active Expired - Lifetime
- 2002-03-20 US US10/472,917 patent/US6872938B2/en not_active Expired - Lifetime
- 2002-03-20 EP EP11175216.8A patent/EP2442351B1/en not_active Expired - Lifetime
- 2002-03-20 JP JP2002575983A patent/JP3989845B2/ja not_active Expired - Fee Related
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2004
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Also Published As
| Publication number | Publication date |
|---|---|
| US20040108450A1 (en) | 2004-06-10 |
| AU2002244835A1 (en) | 2002-10-08 |
| US20050121609A1 (en) | 2005-06-09 |
| US6998609B2 (en) | 2006-02-14 |
| WO2002078046A3 (en) | 2003-02-13 |
| GB0421715D0 (en) | 2004-11-03 |
| EP1371081A2 (en) | 2003-12-17 |
| EP1371081B1 (en) | 2012-12-12 |
| GB2404784A (en) | 2005-02-09 |
| WO2002078046A2 (en) | 2002-10-03 |
| US6872938B2 (en) | 2005-03-29 |
| US20050167585A1 (en) | 2005-08-04 |
| CA2441589A1 (en) | 2002-10-03 |
| EP2442351B1 (en) | 2015-07-29 |
| EP2442351A2 (en) | 2012-04-18 |
| EP2442351A3 (en) | 2012-04-25 |
| US6995364B2 (en) | 2006-02-07 |
| GB2404784B (en) | 2005-06-22 |
| CA2441589C (en) | 2010-05-18 |
| JP2005500646A (ja) | 2005-01-06 |
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