JP3989845B2 - 質量分析の方法及び装置 - Google Patents

質量分析の方法及び装置 Download PDF

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Publication number
JP3989845B2
JP3989845B2 JP2002575983A JP2002575983A JP3989845B2 JP 3989845 B2 JP3989845 B2 JP 3989845B2 JP 2002575983 A JP2002575983 A JP 2002575983A JP 2002575983 A JP2002575983 A JP 2002575983A JP 3989845 B2 JP3989845 B2 JP 3989845B2
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Japan
Prior art keywords
ions
storage device
voltage
trap
trapping
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Expired - Fee Related
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JP2002575983A
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English (en)
Japanese (ja)
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JP2005500646A5 (enExample
JP2005500646A (ja
Inventor
アレクサンダー マカロフ
マーク イー ハードマン
ジェイ シー シュワルツ
マイケル ダブリュ センコ
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Thermo Finnigan LLC
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Thermo Finnigan LLC
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Priority claimed from GB0107380A external-priority patent/GB0107380D0/en
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    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/26Mass spectrometers or separator tubes
    • H01J49/34Dynamic spectrometers
    • H01J49/42Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205Device types
    • H01J49/422Two-dimensional RF ion traps
    • H01J49/4225Multipole linear ion traps, e.g. quadrupoles, hexapoles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/26Mass spectrometers or separator tubes
    • H01J49/34Dynamic spectrometers
    • H01J49/42Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205Device types
    • H01J49/422Two-dimensional RF ion traps
    • H01J49/423Two-dimensional RF ion traps with radial ejection
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/26Mass spectrometers or separator tubes
    • H01J49/34Dynamic spectrometers
    • H01J49/42Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205Device types
    • H01J49/4245Electrostatic ion traps
    • H01J49/425Electrostatic ion traps with a logarithmic radial electric potential, e.g. orbitraps

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
JP2002575983A 2001-03-23 2002-03-20 質量分析の方法及び装置 Expired - Fee Related JP3989845B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0107380A GB0107380D0 (en) 2001-03-23 2001-03-23 Mass spectrometry method and apparatus
GB0126764A GB2378312B (en) 2001-03-23 2001-11-07 Mass spectrometry method and apparatus
PCT/GB2002/001373 WO2002078046A2 (en) 2001-03-23 2002-03-20 Mass spectrometry method and apparatus

Publications (3)

Publication Number Publication Date
JP2005500646A JP2005500646A (ja) 2005-01-06
JP2005500646A5 JP2005500646A5 (enExample) 2006-09-21
JP3989845B2 true JP3989845B2 (ja) 2007-10-10

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Family Applications (1)

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JP2002575983A Expired - Fee Related JP3989845B2 (ja) 2001-03-23 2002-03-20 質量分析の方法及び装置

Country Status (7)

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US (3) US6872938B2 (enExample)
EP (2) EP1371081B1 (enExample)
JP (1) JP3989845B2 (enExample)
AU (1) AU2002244835A1 (enExample)
CA (1) CA2441589C (enExample)
GB (1) GB2404784B (enExample)
WO (1) WO2002078046A2 (enExample)

Families Citing this family (128)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020115056A1 (en) 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
GB2404784B (en) * 2001-03-23 2005-06-22 Thermo Finnigan Llc Mass spectrometry method and apparatus
US7265344B2 (en) * 2001-03-23 2007-09-04 Thermo Finnigan Llc Mass spectrometry method and apparatus
DE60219576T2 (de) 2001-11-22 2007-12-27 Micromass Uk Ltd. Massenspektrometer und Verfahren
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
JP5322385B2 (ja) * 2003-01-24 2013-10-23 サーモ フィニガン リミテッド ライアビリティ カンパニー 質量分析器におけるイオン集団の制御
JP4738326B2 (ja) 2003-03-19 2011-08-03 サーモ フィニガン リミテッド ライアビリティ カンパニー イオン母集団内複数親イオン種についてのタンデム質量分析データ取得
GB2402260B (en) * 2003-05-30 2006-05-24 Thermo Finnigan Llc All mass MS/MS method and apparatus
US7026613B2 (en) * 2004-01-23 2006-04-11 Thermo Finnigan Llc Confining positive and negative ions with fast oscillating electric potentials
GB2412486B (en) * 2004-03-26 2009-01-14 Thermo Finnigan Llc Fourier transform mass spectrometer and method for generating a mass spectrum therefrom
GB2414855A (en) 2004-03-30 2005-12-07 Thermo Finnigan Llc Ion fragmentation by electron capture
GB2415541B (en) 2004-06-21 2009-09-23 Thermo Finnigan Llc RF power supply for a mass spectrometer
GB0416288D0 (en) * 2004-07-21 2004-08-25 Micromass Ltd Mass spectrometer
GB0426900D0 (en) * 2004-12-08 2005-01-12 Micromass Ltd Mass spectrometer
US7166837B2 (en) * 2005-02-28 2007-01-23 Agilent Technologies, Inc. Apparatus and method for ion fragmentation cut-off
JP5306806B2 (ja) * 2005-03-29 2013-10-02 サーモ フィニガン リミテッド ライアビリティ カンパニー 質量分析計、質量分析法、コントローラ、コンピュータプログラムおよびコンピュータ可読媒体
GB0506288D0 (en) * 2005-03-29 2005-05-04 Thermo Finnigan Llc Improvements relating to mass spectrometry
GB0511083D0 (en) 2005-05-31 2005-07-06 Thermo Finnigan Llc Multiple ion injection in mass spectrometry
GB2434484B (en) 2005-06-03 2010-11-03 Thermo Finnigan Llc Improvements in an electrostatic trap
GB0513047D0 (en) * 2005-06-27 2005-08-03 Thermo Finnigan Llc Electronic ion trap
US7569811B2 (en) * 2006-01-13 2009-08-04 Ionics Mass Spectrometry Group Inc. Concentrating mass spectrometer ion guide, spectrometer and method
CA2639903C (en) * 2006-04-13 2012-01-03 Thermo Fisher Scientific (Bremen) Gmbh Ion energy spread reduction for mass spectrometer
GB0607542D0 (en) 2006-04-13 2006-05-24 Thermo Finnigan Llc Mass spectrometer
NZ549911A (en) * 2006-10-19 2009-04-30 Syft Technologies Ltd Improvements in or relating to SIFT-MS instruments
US20090283674A1 (en) * 2006-11-07 2009-11-19 Reinhold Pesch Efficient Atmospheric Pressure Interface for Mass Spectrometers and Method
US7982183B2 (en) * 2006-11-07 2011-07-19 Thermo Fisher Scientific (Bremen) Gmbh Ion transfer tube with spatially alternating DC fields
US7741600B2 (en) * 2006-11-17 2010-06-22 Thermo Finnigan Llc Apparatus and method for providing ions to a mass analyzer
GB0624679D0 (en) 2006-12-11 2007-01-17 Shimadzu Corp A time-of-flight mass spectrometer and a method of analysing ions in a time-of-flight mass spectrometer
GB0626025D0 (en) 2006-12-29 2007-02-07 Thermo Electron Bremen Gmbh Ion trap
GB2445169B (en) 2006-12-29 2012-03-14 Thermo Fisher Scient Bremen Parallel mass analysis
JP5258198B2 (ja) * 2007-01-30 2013-08-07 Msi.Tokyo株式会社 リニアイオントラップ質量分析装置
US8853622B2 (en) * 2007-02-07 2014-10-07 Thermo Finnigan Llc Tandem mass spectrometer
CA2672829A1 (en) * 2007-02-23 2008-08-28 Brigham Young University Coaxial hybrid radio frequency ion trap mass analyzer
JP4996962B2 (ja) * 2007-04-04 2012-08-08 株式会社日立ハイテクノロジーズ 質量分析装置
DE102007024858B4 (de) 2007-04-12 2011-02-10 Bruker Daltonik Gmbh Massenspektrometer mit einer elektrostatischen Ionenfalle
GB2448413B (en) * 2007-04-12 2011-08-24 Bruker Daltonik Gmbh Mass spectrometer with an electrostatic ion trap
US7868289B2 (en) * 2007-04-30 2011-01-11 Ionics Mass Spectrometry Group Inc. Mass spectrometer ion guide providing axial field, and method
US7755040B2 (en) * 2007-09-24 2010-07-13 Agilent Technologies, Inc. Mass spectrometer and electric field source for mass spectrometer
US20090134325A1 (en) 2007-11-27 2009-05-28 Goldman Mildred M Methods for detecting estradiol by mass spectrometry
US7989765B2 (en) * 2007-11-30 2011-08-02 Agilent Technologies, Inc. Method and apparatus for trapping ions
US8334506B2 (en) * 2007-12-10 2012-12-18 1St Detect Corporation End cap voltage control of ion traps
DE102008024297B4 (de) * 2008-05-20 2011-03-31 Bruker Daltonik Gmbh Fragmentierung von Ionen in Kingdon-Ionenfallen
US7973277B2 (en) 2008-05-27 2011-07-05 1St Detect Corporation Driving a mass spectrometer ion trap or mass filter
CN102150219B (zh) 2008-07-28 2015-01-28 莱克公司 在射频场中使用网的离子操纵的方法和设备
US20100154568A1 (en) * 2008-11-19 2010-06-24 Roth Michael J Analytical Instruments, Assemblies, and Methods
DE102009007266B4 (de) * 2009-02-03 2012-04-19 Bruker Daltonik Gmbh Massenspektrometrische Identifizierung von Mikroorganismen in komplexen Proben
DE102009020886B4 (de) * 2009-05-12 2012-08-30 Bruker Daltonik Gmbh Einspeichern von Ionen in Kíngdon-Ionenfallen
GB2470599B (en) * 2009-05-29 2014-04-02 Thermo Fisher Scient Bremen Charged particle analysers and methods of separating charged particles
GB2470600B (en) 2009-05-29 2012-06-13 Thermo Fisher Scient Bremen Charged particle analysers and methods of separating charged particles
EP3095457B1 (en) 2009-11-05 2018-05-16 Quest Diagnostics Investments Incorporated Quantitation of insulin-like growth factor-i with high-resolution mass spectrometry
US8497079B2 (en) * 2009-12-21 2013-07-30 Quest Diagnostics Investments Incorporated Glucagon detection and quantitation by mass spectrometry
GB2476844B (en) * 2010-05-24 2011-12-07 Fasmatech Science And Technology Llc Improvements relating to the control of ions
GB2484136B (en) * 2010-10-01 2015-09-16 Thermo Fisher Scient Bremen Method and apparatus for improving the throughput of a charged particle analysis system
GB2496994B (en) * 2010-11-26 2015-05-20 Thermo Fisher Scient Bremen Method of mass separating ions and mass separator
US9922812B2 (en) * 2010-11-26 2018-03-20 Thermo Fisher Scientific (Bremen) Gmbh Method of mass separating ions and mass separator
GB2488745B (en) 2010-12-14 2016-12-07 Thermo Fisher Scient (Bremen) Gmbh Ion Detection
US8935101B2 (en) 2010-12-16 2015-01-13 Thermo Finnigan Llc Method and apparatus for correlating precursor and product ions in all-ions fragmentation experiments
EP2659501B1 (en) 2010-12-28 2017-09-06 Quest Diagnostics Investments Incorporated Quantitation of insulin by mass spectrometry
DE102011008713B4 (de) * 2011-01-17 2012-08-02 Bruker Daltonik Gmbh Kingdon-Ionenfallen mit Cassini-Potentialen höherer Ordnung
CN107658203B (zh) 2011-05-05 2020-04-14 岛津研究实验室(欧洲)有限公司 操纵带电粒子的装置
GB2543992B (en) 2011-05-12 2017-09-06 Thermo Fisher Scient (Bremen) Gmbh Mass analyser
GB2544920B (en) 2011-05-12 2018-02-07 Thermo Fisher Scient (Bremen) Gmbh Electrostatic ion trapping with shielding conductor
US8728824B2 (en) 2011-06-22 2014-05-20 Quest Diagnostics Investments Inc. Mass spectrometric determination of fatty acids
US8866077B2 (en) * 2011-10-20 2014-10-21 Shimadzu Corporation Mass spectrometer
GB201118270D0 (en) 2011-10-21 2011-12-07 Shimadzu Corp TOF mass analyser with improved resolving power
DE102011118052A1 (de) * 2011-11-08 2013-07-18 Bruker Daltonik Gmbh Züchtung von Obertönen in Schwingungs- Massenspektrometern
US20130131998A1 (en) 2011-11-18 2013-05-23 David A. Wright Methods and Apparatus for Identifying Mass Spectral Isotope Patterns
WO2013112677A2 (en) 2012-01-24 2013-08-01 Thermo Finnigan Llc Multinotch isolation for ms3 mass analysis
US8933397B1 (en) * 2012-02-02 2015-01-13 University of Northern Iowa Research Foundati Ion trap mass analyzer apparatus, methods, and systems utilizing one or more multiple potential ion guide (MPIG) electrodes
US9347917B2 (en) * 2012-03-28 2016-05-24 Dh Technologies Development Pte. Ltd. Mass spectrometry systems and methods for analyses on lipid and other ions using a unique workflow
CN103367094B (zh) * 2012-03-31 2016-12-14 株式会社岛津制作所 离子阱分析器以及离子阱质谱分析方法
US10840073B2 (en) 2012-05-18 2020-11-17 Thermo Fisher Scientific (Bremen) Gmbh Methods and apparatus for obtaining enhanced mass spectrometric data
US20150260684A1 (en) * 2012-11-16 2015-09-17 Dh Technologies Development Pte. Ltd. Method and apparatus for ion mobility spectrometry
RU2542722C2 (ru) * 2012-11-16 2015-02-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Рязанский государственный радиотехнический университет" Способ времяпролетного масс-анализа и устройство для его осуществления
EP2741224A1 (en) 2012-11-20 2014-06-11 Thermo Finnigan LLC Methods for generating local mass spectral libraries for interpreting multiplexed mass spectra
US20140138531A1 (en) 2012-11-20 2014-05-22 David A. Wright Use of Neutral Loss Mass to Reconstruct MS-2 Spectra in All Ions Fragmentation
US20140142865A1 (en) 2012-11-20 2014-05-22 David A. Wright Automatic Reconstruction of MS-2 Spectra from all Ions Fragmentation to Recognize Previously Detected Compounds
EP2939024B1 (en) 2012-12-26 2021-04-28 Quest Diagnostics Investments Incorporated C peptide detection by mass spectrometry
US20140252218A1 (en) 2013-03-05 2014-09-11 David A. Wright Methods and Apparatus for Decomposing Tandem Mass Spectra Generated by All-Ions Fragmentation
WO2014164198A1 (en) 2013-03-11 2014-10-09 David Rafferty Automatic gain control with defocusing lens
EP2973653B1 (en) 2013-03-13 2018-10-03 Micromass UK Limited Toroidal trapping geometry pulsed ion source
US8969794B2 (en) 2013-03-15 2015-03-03 1St Detect Corporation Mass dependent automatic gain control for mass spectrometer
US8921770B1 (en) * 2013-07-05 2014-12-30 Bruker Daltonics, Inc. Reduction of cross-talk between RF components in a mass spectrometer
CN110718442B (zh) 2015-01-23 2022-08-16 加州理工学院 整合的混合nems质谱测定法
US9536723B1 (en) * 2015-02-06 2017-01-03 Agilent Technologies, Inc. Thin field terminator for linear quadrupole ion guides, and related systems and methods
US10324082B2 (en) 2015-03-03 2019-06-18 Quest Diagnostics Investments Llc Methods for quantitation of insulin levels by mass spectrometry
EP3086353A1 (en) 2015-04-24 2016-10-26 Thermo Fisher Scientific (Bremen) GmbH A method of producing a mass spectrum
GB2538075B (en) 2015-05-05 2019-05-15 Thermo Fisher Scient Bremen Gmbh Method and apparatus for injection of ions into an electrostatic ion trap
US9524860B1 (en) 2015-09-25 2016-12-20 Thermo Finnigan Llc Systems and methods for multipole operation
GB2551110B (en) 2016-05-23 2020-03-11 Thermo Fisher Scient Bremen Gmbh Ion injection to an electrostatic trap
GB201613988D0 (en) 2016-08-16 2016-09-28 Micromass Uk Ltd And Leco Corp Mass analyser having extended flight path
US10192730B2 (en) 2016-08-30 2019-01-29 Thermo Finnigan Llc Methods for operating electrostatic trap mass analyzers
WO2018087634A1 (en) * 2016-11-11 2018-05-17 Dh Technologies Development Pte. Ltd. Spatial, mass and energy focused ion injection method and device
WO2018142265A1 (en) * 2017-02-01 2018-08-09 Dh Technologies Development Pte. Ltd. Fourier transform mass spectrometer
EP4220157B1 (en) 2017-03-31 2025-05-14 Quest Diagnostics Investments LLC Methods for quantitation of insulin and c-peptide
US10957527B2 (en) 2017-04-04 2021-03-23 Atonarp Inc. Mass analyzer
GB2567794B (en) 2017-05-05 2023-03-08 Micromass Ltd Multi-reflecting time-of-flight mass spectrometers
GB2563571B (en) 2017-05-26 2023-05-24 Micromass Ltd Time of flight mass analyser with spatial focussing
CN111164731B (zh) 2017-08-06 2022-11-18 英国质谱公司 进入多通道质谱分析仪的离子注入
US11049712B2 (en) 2017-08-06 2021-06-29 Micromass Uk Limited Fields for multi-reflecting TOF MS
WO2019030471A1 (en) 2017-08-06 2019-02-14 Anatoly Verenchikov ION GUIDE INSIDE PULSED CONVERTERS
EP3662502A1 (en) 2017-08-06 2020-06-10 Micromass UK Limited Printed circuit ion mirror with compensation
WO2019030472A1 (en) 2017-08-06 2019-02-14 Anatoly Verenchikov IONIC MIRROR FOR MULTI-REFLECTION MASS SPECTROMETERS
US11817303B2 (en) 2017-08-06 2023-11-14 Micromass Uk Limited Accelerator for multi-pass mass spectrometers
WO2019030475A1 (en) 2017-08-06 2019-02-14 Anatoly Verenchikov MASS SPECTROMETER WITH MULTIPASSAGE
US10199207B1 (en) 2017-09-07 2019-02-05 California Institute Of Technology Determining isotope ratios using mass spectrometry
US10236168B1 (en) 2017-11-21 2019-03-19 Thermo Finnigan Llc Ion transfer method and device
GB201806507D0 (en) 2018-04-20 2018-06-06 Verenchikov Anatoly Gridless ion mirrors with smooth fields
GB201807626D0 (en) 2018-05-10 2018-06-27 Micromass Ltd Multi-reflecting time of flight mass analyser
GB201807605D0 (en) 2018-05-10 2018-06-27 Micromass Ltd Multi-reflecting time of flight mass analyser
GB201808530D0 (en) 2018-05-24 2018-07-11 Verenchikov Anatoly TOF MS detection system with improved dynamic range
GB201810573D0 (en) 2018-06-28 2018-08-15 Verenchikov Anatoly Multi-pass mass spectrometer with improved duty cycle
US10600632B2 (en) 2018-08-23 2020-03-24 Thermo Finnigan Llc Methods for operating electrostatic trap mass analyzers
GB201901411D0 (en) 2019-02-01 2019-03-20 Micromass Ltd Electrode assembly for mass spectrometer
GB201903779D0 (en) 2019-03-20 2019-05-01 Micromass Ltd Multiplexed time of flight mass spectrometer
GB2583758B (en) * 2019-05-10 2021-09-15 Thermo Fisher Scient Bremen Gmbh Improved injection of ions into an ion storage device
GB201907211D0 (en) * 2019-05-22 2019-07-03 Thermo Fisher Scient Bremen Gmbh A mass spectrometer
GB2584129B (en) * 2019-05-22 2022-01-12 Thermo Fisher Scient Bremen Gmbh Ion trap with elongated electrodes
EP4012747A1 (en) 2020-12-10 2022-06-15 Thermo Fisher Scientific (Bremen) GmbH Methods and systems for processing mass spectra
CN112488117B (zh) * 2020-12-11 2022-09-27 南京理工大学 一种基于方向诱导卷积的点云分析方法
EP4102509A1 (en) 2021-06-07 2022-12-14 MSAID GmbH Method and apparatus for identifying molecular species in a mass spectrum
US11581180B2 (en) * 2021-06-23 2023-02-14 Thermo Finnigan Llc Apparatus and methods for injecting ions into an electrostatic trap
CN114867182B (zh) * 2022-01-14 2024-07-30 天津大学 一种用于带电粒子储存的紧凑型静电储存环装置
GB2629681A (en) 2022-05-09 2024-11-06 Thermo Fisher Scient Bremen Gmbh Charge detection for ion accumulation control
AU2024247888A1 (en) 2023-03-31 2025-10-09 Quest Diagnostics Investments Llc Methods for quantitation of adiponectin by mass spectrometry
DE112024002304T5 (de) 2023-05-26 2026-03-19 California Institute Of Technology Methode zum Betrieb eines Massenspektrometers mit einer Ionenfalle
GB202319611D0 (en) 2023-12-20 2024-01-31 Thermo Fisher Scient Bremen Gmbh Systems and methods of analysis of isobaric tagging experiments
CN117554533A (zh) * 2024-01-11 2024-02-13 安益谱(苏州)医疗科技有限公司 一种气相色谱混合质谱联用仪及联用方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540884A (en) 1982-12-29 1985-09-10 Finnigan Corporation Method of mass analyzing a sample by use of a quadrupole ion trap
US5179278A (en) 1991-08-23 1993-01-12 Mds Health Group Limited Multipole inlet system for ion traps
US6011259A (en) * 1995-08-10 2000-01-04 Analytica Of Branford, Inc. Multipole ion guide ion trap mass spectrometry with MS/MSN analysis
US5689111A (en) 1995-08-10 1997-11-18 Analytica Of Branford, Inc. Ion storage time-of-flight mass spectrometer
US5420425A (en) * 1994-05-27 1995-05-30 Finnigan Corporation Ion trap mass spectrometer system and method
US5572022A (en) * 1995-03-03 1996-11-05 Finnigan Corporation Method and apparatus of increasing dynamic range and sensitivity of a mass spectrometer
DE19511333C1 (de) * 1995-03-28 1996-08-08 Bruker Franzen Analytik Gmbh Verfahren und Vorrichtung für orthogonalen Einschuß von Ionen in ein Flugzeit-Massenspektrometer
GB9506695D0 (en) * 1995-03-31 1995-05-24 Hd Technologies Limited Improvements in or relating to a mass spectrometer
US5569917A (en) 1995-05-19 1996-10-29 Varian Associates, Inc. Apparatus for and method of forming a parallel ion beam
DE19523860A1 (de) * 1995-06-30 1997-01-02 Bruker Franzen Analytik Gmbh Ionenfallen-Massenspektrometer mit vakuum-externer Ionenerzeugung
US5729014A (en) * 1996-07-11 1998-03-17 Varian Associates, Inc. Method for injection of externally produced ions into a quadrupole ion trap
GB2324906B (en) 1997-04-29 2002-01-09 Masslab Ltd Ion source for a mass analyser and method of providing a source of ions for analysis
US5880466A (en) 1997-06-02 1999-03-09 The Regents Of The University Of California Gated charged-particle trap
CA2312806A1 (en) 1997-12-05 1999-06-17 University Of British Columbia Method of analyzing ions in an apparatus including a time of flight mass spectrometer and a linear ion trap
US6545268B1 (en) * 2000-04-10 2003-04-08 Perseptive Biosystems Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis
US6627883B2 (en) * 2001-03-02 2003-09-30 Bruker Daltonics Inc. Apparatus and method for analyzing samples in a dual ion trap mass spectrometer
GB2404784B (en) * 2001-03-23 2005-06-22 Thermo Finnigan Llc Mass spectrometry method and apparatus

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US20040108450A1 (en) 2004-06-10
AU2002244835A1 (en) 2002-10-08
US20050121609A1 (en) 2005-06-09
US6998609B2 (en) 2006-02-14
WO2002078046A3 (en) 2003-02-13
GB0421715D0 (en) 2004-11-03
EP1371081A2 (en) 2003-12-17
EP1371081B1 (en) 2012-12-12
GB2404784A (en) 2005-02-09
WO2002078046A2 (en) 2002-10-03
US6872938B2 (en) 2005-03-29
US20050167585A1 (en) 2005-08-04
CA2441589A1 (en) 2002-10-03
EP2442351B1 (en) 2015-07-29
EP2442351A2 (en) 2012-04-18
EP2442351A3 (en) 2012-04-25
US6995364B2 (en) 2006-02-07
GB2404784B (en) 2005-06-22
CA2441589C (en) 2010-05-18
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