JP3981407B2 - 置換された０▲上６▼−ベンジルグアニン - Google Patents

置換された０▲上６▼−ベンジルグアニン Download PDF

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Publication number
JP3981407B2
JP3981407B2 JP50669496A JP50669496A JP3981407B2 JP 3981407 B2 JP3981407 B2 JP 3981407B2 JP 50669496 A JP50669496 A JP 50669496A JP 50669496 A JP50669496 A JP 50669496A JP 3981407 B2 JP3981407 B2 JP 3981407B2
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Japan
Prior art keywords
alkyl
amino
benzyl
group
hydroxy
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Expired - Lifetime
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JP50669496A
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English (en)
Japanese (ja)
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JPH10508288A (ja
Inventor
スィー． モシェル、ロバート
イー． ペッグ、アンソニー
ドラン、エム．アイリーン
ツェ、ミ−ヨン
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Government of the United States of America
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Government of the United States of America
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP50669496A 1994-08-01 1995-07-31 置換された０▲上６▼−ベンジルグアニン Expired - Lifetime JP3981407B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US283,953 1994-08-01
US08/283,953 US5525606A (en) 1994-08-01 1994-08-01 Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines
PCT/US1995/009702 WO1996004281A1 (en) 1994-08-01 1995-07-31 Substituted o6-benzylguanines and 6(4)-benzyloxypyrimidines

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2006273447A Division JP2007077157A (ja) 1994-08-01 2006-10-04 ６（４）−ベンジルオキシピリミジンおよび他の化合物

Publications (2)

Publication Number Publication Date
JPH10508288A JPH10508288A (ja) 1998-08-18
JP3981407B2 true JP3981407B2 (ja) 2007-09-26

Family

ID=23088285

Family Applications (2)

Application Number Title Priority Date Filing Date
JP50669496A Expired - Lifetime JP3981407B2 (ja) 1994-08-01 1995-07-31 置換された０▲上６▼−ベンジルグアニン
JP2006273447A Pending JP2007077157A (ja) 1994-08-01 2006-10-04 ６（４）−ベンジルオキシピリミジンおよび他の化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2006273447A Pending JP2007077157A (ja) 1994-08-01 2006-10-04 ６（４）−ベンジルオキシピリミジンおよび他の化合物

Country Status (10)

Country Link
US (8) US5525606A (https=)
EP (3) EP1518854A1 (https=)
JP (2) JP3981407B2 (https=)
AT (2) ATE286054T1 (https=)
CA (2) CA2195856C (https=)
DE (2) DE69533900T2 (https=)
DK (2) DK0775142T3 (https=)
ES (2) ES2167451T3 (https=)
PT (2) PT775142E (https=)
WO (1) WO1996004281A1 (https=)

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Also Published As

Publication number Publication date
DE69533900T2 (de) 2005-12-29
ATE286054T1 (de) 2005-01-15
JP2007077157A (ja) 2007-03-29
US5753668A (en) 1998-05-19
EP0775142A1 (en) 1997-05-28
EP1142893A1 (en) 2001-10-10
CA2632452A1 (en) 1996-02-15
US5525606A (en) 1996-06-11
DE69523462D1 (de) 2001-11-29
PT1142893E (pt) 2005-04-29
US6303604B1 (en) 2001-10-16
DE69533900D1 (de) 2005-02-03
DE69523462T2 (de) 2002-07-11
ES2233513T3 (es) 2005-06-16
ATE207490T1 (de) 2001-11-15
EP0775142B1 (en) 2001-10-24
CA2195856A1 (en) 1996-02-15
WO1996004281A1 (en) 1996-02-15
DK0775142T3 (da) 2002-02-18
EP1142893B1 (en) 2004-12-29
DK1142893T3 (da) 2005-03-29
ES2167451T3 (es) 2002-05-16
US6436945B2 (en) 2002-08-20
AU702711B2 (en) 1999-03-04
US6172070B1 (en) 2001-01-09
US6333331B1 (en) 2001-12-25
JPH10508288A (ja) 1998-08-18
CA2195856C (en) 2008-09-30
US5916894A (en) 1999-06-29
PT775142E (pt) 2002-04-29
EP1518854A1 (en) 2005-03-30
US5958932A (en) 1999-09-28
US20020013299A1 (en) 2002-01-31
AU3207995A (en) 1996-03-04

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