JP3948958B2 - メチルコバラミンの製造法 - Google Patents
メチルコバラミンの製造法 Download PDFInfo
- Publication number
- JP3948958B2 JP3948958B2 JP2001543568A JP2001543568A JP3948958B2 JP 3948958 B2 JP3948958 B2 JP 3948958B2 JP 2001543568 A JP2001543568 A JP 2001543568A JP 2001543568 A JP2001543568 A JP 2001543568A JP 3948958 B2 JP3948958 B2 JP 3948958B2
- Authority
- JP
- Japan
- Prior art keywords
- methylcobalamin
- cyanocobalamin
- hydroxocobalamin
- water
- sodium borohydride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP35068399 | 1999-12-09 | ||
| JP2000188619 | 2000-06-23 | ||
| PCT/JP2000/008675 WO2001042271A1 (fr) | 1999-12-09 | 2000-12-07 | Procede de production de methylcobalamine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP3948958B2 true JP3948958B2 (ja) | 2007-07-25 |
Family
ID=26579251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001543568A Expired - Fee Related JP3948958B2 (ja) | 1999-12-09 | 2000-12-07 | メチルコバラミンの製造法 |
Country Status (12)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002098896A1 (fr) * | 2001-06-05 | 2002-12-12 | Eisai Co., Ltd. | Procede de production de methylcobalamine |
| SG166672A1 (en) * | 2002-08-06 | 2010-12-29 | Intradigm Corp | Methods of down regulating target gene expression in vivo by introduction of interfering rna |
| ES2264374B1 (es) * | 2005-03-23 | 2007-11-01 | Ferrer Internacional, S.A. | Procedimiento de fabricacion de la metilcobalamina. |
| CN100348201C (zh) * | 2005-09-29 | 2007-11-14 | 周卓和 | 甲钴胺分散片及其制备方法 |
| WO2012165934A1 (es) * | 2011-05-30 | 2012-12-06 | Interquim, S.A. De C.V. | Proceso de síntesis de metilcobalamina |
| CN102391340A (zh) * | 2011-10-31 | 2012-03-28 | 河北玉星生物工程有限公司 | 一种甲钴胺的制备方法 |
| CN105218608A (zh) * | 2015-10-29 | 2016-01-06 | 无锡福祈制药有限公司 | 一种甲钴胺的制备方法 |
| JP6867409B2 (ja) | 2016-07-08 | 2021-04-28 | ヘルステック バイオ アクティブズ，エス．エル．ユー | メチルコバラミンの精製方法 |
| CN106349313B (zh) * | 2016-08-23 | 2019-05-14 | 宁夏泰瑞制药股份有限公司 | 一种利用氰钴胺合成甲钴胺粗品的方法 |
| CN108546278A (zh) * | 2018-03-17 | 2018-09-18 | 山东辰龙药业有限公司 | 甲钴胺的精制方法 |
| DE102018005078A1 (de) | 2018-06-26 | 2020-01-02 | Ilma biochem GmbH | Verfahren zur Herstellung und Zusammensetzung von stabilisierten Cob(II)alamin- und Cob(II)inamide-Lösungen als Ausgangszubereitungen zur Herstellung von Arzneimitteln, Medizinprodukten, Nahrungsergänzungsmitteln und Kosmetika |
| CN108948116A (zh) * | 2018-08-30 | 2018-12-07 | 上海应用技术大学 | 一种甲钴胺的绿色合成工艺 |
| CN111808158B (zh) * | 2020-07-23 | 2022-12-06 | 宁夏金维制药股份有限公司 | 一种维生素b12粗品的制备方法 |
| CN114874276A (zh) * | 2022-04-21 | 2022-08-09 | 南京工业大学 | 一种改进的合成甲钴胺的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4538059B1 (US06657057-20031202-C00006.png) * | 1967-07-27 | 1970-12-02 | ||
| BE759614A (fr) * | 1969-12-01 | 1971-06-01 | Glaxo Lab Ltd | Elimination d'ions cyanure de solutions de corrinoides |
| GB1306958A (en) | 1970-09-30 | 1973-02-14 | Pierrel Spa | Process for the preparation of substituted cobamides |
| FR2108794B1 (US06657057-20031202-C00006.png) | 1970-10-06 | 1974-04-12 | Roussel Uclaf | |
| BE789252A (fr) | 1971-11-10 | 1973-03-26 | Boige Jean | Procede de fabrication de la methylcobalamine |
| FR2240232A1 (en) | 1973-08-08 | 1975-03-07 | Boige Jean | Methylcobalamine prepn from cyanocobalamine - by reduction and methylation using methyl acid oxalate and a metal |
| US3928320A (en) | 1971-11-10 | 1975-12-23 | Jean Boige | Process for the preparation of methylcobalamine |
| US3789211A (en) | 1972-07-14 | 1974-01-29 | Marvin Glass & Associates | Decorative lighting system |
| JPS4947899A (US06657057-20031202-C00006.png) | 1972-09-18 | 1974-05-09 | ||
| JPS5729587B2 (US06657057-20031202-C00006.png) | 1973-06-14 | 1982-06-23 | ||
| JPS5038120A (US06657057-20031202-C00006.png) | 1973-08-09 | 1975-04-09 | ||
| JPH08143590A (ja) | 1994-11-24 | 1996-06-04 | Meiji Seika Kaisha Ltd | 高純度メチルコバラミンの製造方法 |
-
2000
- 2000-12-07 DK DK00979985T patent/DK1236737T3/da active
- 2000-12-07 JP JP2001543568A patent/JP3948958B2/ja not_active Expired - Fee Related
- 2000-12-07 ES ES00979985T patent/ES2257339T3/es not_active Expired - Lifetime
- 2000-12-07 US US10/130,797 patent/US6657057B2/en not_active Expired - Fee Related
- 2000-12-07 KR KR1020027006442A patent/KR100694688B1/ko not_active IP Right Cessation
- 2000-12-07 CN CNB008168857A patent/CN1170841C/zh not_active Expired - Lifetime
- 2000-12-07 WO PCT/JP2000/008675 patent/WO2001042271A1/ja active IP Right Grant
- 2000-12-07 CA CA002394155A patent/CA2394155C/en not_active Expired - Fee Related
- 2000-12-07 AT AT00979985T patent/ATE318833T1/de active
- 2000-12-07 EP EP00979985A patent/EP1236737B1/en not_active Expired - Lifetime
- 2000-12-07 DE DE60026354T patent/DE60026354T2/de not_active Expired - Lifetime
- 2000-12-08 TW TW089126254A patent/TW581770B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE318833T1 (de) | 2006-03-15 |
| KR100694688B1 (ko) | 2007-03-13 |
| CN1409723A (zh) | 2003-04-09 |
| KR20030022767A (ko) | 2003-03-17 |
| CN1170841C (zh) | 2004-10-13 |
| DE60026354T2 (de) | 2006-11-09 |
| WO2001042271A1 (fr) | 2001-06-14 |
| DE60026354D1 (de) | 2006-04-27 |
| EP1236737A1 (en) | 2002-09-04 |
| ES2257339T3 (es) | 2006-08-01 |
| CA2394155A1 (en) | 2001-06-14 |
| TW581770B (en) | 2004-04-01 |
| US20020183511A1 (en) | 2002-12-05 |
| DK1236737T3 (da) | 2006-06-19 |
| EP1236737B1 (en) | 2006-03-01 |
| US6657057B2 (en) | 2003-12-02 |
| CA2394155C (en) | 2008-01-15 |
| EP1236737A4 (en) | 2003-02-26 |
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