JP3899136B2 - 心血管系に活性を有する新規１７−（３−イミノ−２−アルキルプロペニル）−５β，１４β−アンドロスタン誘導体、その製法およびこれを含有する医薬組成物 - Google Patents

心血管系に活性を有する新規１７−（３−イミノ−２−アルキルプロペニル）−５β，１４β−アンドロスタン誘導体、その製法およびこれを含有する医薬組成物 Download PDF

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Publication number
JP3899136B2
JP3899136B2 JP31066995A JP31066995A JP3899136B2 JP 3899136 B2 JP3899136 B2 JP 3899136B2 JP 31066995 A JP31066995 A JP 31066995A JP 31066995 A JP31066995 A JP 31066995A JP 3899136 B2 JP3899136 B2 JP 3899136B2
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JP
Japan
Prior art keywords
methyl
androstane
propenyl
diol
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP31066995A
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English (en)
Japanese (ja)
Other versions
JPH08225591A (ja
Inventor
アルベルト・チェリ
ジュゼッペ・ビアンキ
パトリツィア・フェラーリ
ピエロ・メローニ
マリア・ルイザ・クアドリ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of JPH08225591A publication Critical patent/JPH08225591A/ja
Application granted granted Critical
Publication of JP3899136B2 publication Critical patent/JP3899136B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
JP31066995A 1994-11-29 1995-11-29 心血管系に活性を有する新規１７−（３−イミノ−２−アルキルプロペニル）−５β，１４β−アンドロスタン誘導体、その製法およびこれを含有する医薬組成物 Expired - Fee Related JP3899136B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4442486-8 1994-11-29
DE4442486A DE4442486A1 (de) 1994-11-29 1994-11-29 Neue 17-(3-Imino-2-alkylpropylen)-5ß,14ß-androstan-Derivate, die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen

Publications (2)

Publication Number Publication Date
JPH08225591A JPH08225591A (ja) 1996-09-03
JP3899136B2 true JP3899136B2 (ja) 2007-03-28

Family

ID=6534459

Family Applications (1)

Application Number Title Priority Date Filing Date
JP31066995A Expired - Fee Related JP3899136B2 (ja) 1994-11-29 1995-11-29 心血管系に活性を有する新規１７−（３−イミノ−２−アルキルプロペニル）−５β，１４β−アンドロスタン誘導体、その製法およびこれを含有する医薬組成物

Country Status (9)

Country Link
US (1) US5705662A (show.php)
EP (1) EP0714908B1 (show.php)
JP (1) JP3899136B2 (show.php)
AT (1) ATE163424T1 (show.php)
CA (1) CA2163935C (show.php)
DE (2) DE4442486A1 (show.php)
DK (1) DK0714908T3 (show.php)
ES (1) ES2112597T3 (show.php)
HK (1) HK1009334A1 (show.php)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
US6764817B1 (en) * 1999-04-20 2004-07-20 Target Discovery, Inc. Methods for conducting metabolic analyses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4222404C1 (de) * 1992-07-08 1993-12-02 Sigma Tau Ind Farmaceuti Verwendung von Iminoderivaten von Etianaldehyd zur Behandlung von Hypertonie
DE4227605C2 (de) * 1992-08-20 1995-02-16 Sigma Tau Ind Farmaceuti 17-Hydroxyiminomethyl-14beta-hydroxy-5ß-androstan-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die dieselben enthalten
DE4344236A1 (de) * 1993-12-23 1995-06-29 Sigma Tau Ind Farmaceuti Neue 17-Iminomethylalkenyl-5beta,14beta-androstan- und 17-Iminoalkyl-5beta,14beta-androstan-Derivate , die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten
DE4420501A1 (de) * 1994-06-13 1995-12-14 Sigma Tau Ind Farmaceuti Neue Hydrazino- und Hydroxyamino-14beta-hydroxyandrostanderivate mit Aktivität für das cardiovaskuläre System, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten

Also Published As

Publication number Publication date
ATE163424T1 (de) 1998-03-15
ES2112597T3 (es) 1998-04-01
EP0714908A2 (en) 1996-06-05
DK0714908T3 (da) 1998-09-28
CA2163935C (en) 2007-03-06
US5705662A (en) 1998-01-06
JPH08225591A (ja) 1996-09-03
CA2163935A1 (en) 1996-05-30
EP0714908B1 (en) 1998-02-25
DE69501660D1 (de) 1998-04-02
DE69501660T2 (de) 1998-07-09
DE4442486A1 (de) 1996-05-30
EP0714908A3 (show.php) 1996-06-19
HK1009334A1 (en) 1999-05-28

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