JP3884087B2 - 質量標識結合ハイブリダイゼーションプローブ - Google Patents

質量標識結合ハイブリダイゼーションプローブ Download PDF

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Publication number
JP3884087B2
JP3884087B2 JP53394298A JP53394298A JP3884087B2 JP 3884087 B2 JP3884087 B2 JP 3884087B2 JP 53394298 A JP53394298 A JP 53394298A JP 53394298 A JP53394298 A JP 53394298A JP 3884087 B2 JP3884087 B2 JP 3884087B2
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mass
probe
mass label
label
base sequence
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Expired - Fee Related
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JP53394298A
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Japanese (ja)
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JP2001508307A5 (OSRAM
JP2001508307A (ja
Inventor
シュミット、グンテル
ヒュージン トムソン、アンドリュー
アレクサンダー ウォーカー ジョンストン、ロバート
Original Assignee
イクスツィリオン ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト
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Priority claimed from GBGB9700746.2A external-priority patent/GB9700746D0/en
Priority claimed from GBGB9718255.4A external-priority patent/GB9718255D0/en
Priority claimed from GBGB9726953.4A external-priority patent/GB9726953D0/en
Application filed by イクスツィリオン ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト filed Critical イクスツィリオン ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト
Publication of JP2001508307A publication Critical patent/JP2001508307A/ja
Publication of JP2001508307A5 publication Critical patent/JP2001508307A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6872—Methods for sequencing involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Discharge Heating (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Surgical Instruments (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
JP53394298A 1997-01-15 1998-01-15 質量標識結合ハイブリダイゼーションプローブ Expired - Fee Related JP3884087B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB9700746.2 1997-01-15
GBGB9700746.2A GB9700746D0 (en) 1996-10-04 1997-01-15 Hybridisation probes
GBGB9718255.4A GB9718255D0 (en) 1996-10-04 1997-08-28 Hybridisation probes
GB9718255.4 1997-08-28
GBGB9726953.4A GB9726953D0 (en) 1997-12-19 1997-12-19 Hybridisation probes
GB9726953.4 1997-12-19
PCT/GB1998/000127 WO1998031830A1 (en) 1997-01-15 1998-01-15 Mass label linked hybridisation probes

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2004036206A Division JP2004357697A (ja) 1997-01-15 2004-02-13 質量標識結合ハイブリダイゼーションプローブ
JP2006115777A Division JP2006208400A (ja) 1997-01-15 2006-04-19 質量標識結合ハイブリダイゼーションプローブ

Publications (3)

Publication Number Publication Date
JP2001508307A JP2001508307A (ja) 2001-06-26
JP2001508307A5 JP2001508307A5 (OSRAM) 2004-12-09
JP3884087B2 true JP3884087B2 (ja) 2007-02-21

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Family Applications (3)

Application Number Title Priority Date Filing Date
JP53394298A Expired - Fee Related JP3884087B2 (ja) 1997-01-15 1998-01-15 質量標識結合ハイブリダイゼーションプローブ
JP2004036206A Withdrawn JP2004357697A (ja) 1997-01-15 2004-02-13 質量標識結合ハイブリダイゼーションプローブ
JP2006115777A Pending JP2006208400A (ja) 1997-01-15 2006-04-19 質量標識結合ハイブリダイゼーションプローブ

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2004036206A Withdrawn JP2004357697A (ja) 1997-01-15 2004-02-13 質量標識結合ハイブリダイゼーションプローブ
JP2006115777A Pending JP2006208400A (ja) 1997-01-15 2006-04-19 質量標識結合ハイブリダイゼーションプローブ

Country Status (10)

Country Link
EP (2) EP1400599B1 (OSRAM)
JP (3) JP3884087B2 (OSRAM)
CN (1) CN100434531C (OSRAM)
AT (2) ATE340869T1 (OSRAM)
AU (1) AU725966B2 (OSRAM)
CA (2) CA2441655A1 (OSRAM)
DE (2) DE69838519T2 (OSRAM)
IL (1) IL130885A (OSRAM)
NZ (1) NZ336769A (OSRAM)
WO (1) WO1998031830A1 (OSRAM)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9707980D0 (en) 1997-04-21 1997-06-11 Brax Genomics Ltd Characterising DNA
AU8234898A (en) * 1997-07-11 1999-02-08 Brax Group Limited Characterising nucleic acid
CN1270598A (zh) * 1997-07-22 2000-10-18 拉普吉恩公司 用于质谱分析核酸的方法和组合物
GB9718921D0 (en) 1997-09-05 1997-11-12 Brax Genomics Ltd Catalytically generated mass labels
CA2303790A1 (en) * 1997-09-15 1999-03-25 Brax Group Limited Characterising nucleic acid by mass spectrometry
DK1036202T3 (da) * 1997-12-05 2002-08-12 Max Planck Gesellschaft Fremgangsmåde til identifikation af nucleinsyrer ved matriksassisteret laserdesorptions/ionisationsmassespektrometri
GB9815164D0 (en) * 1998-07-13 1998-09-09 Brax Genomics Ltd Compounds for mass spectrometry
GB9823646D0 (en) 1997-12-19 1998-12-23 Brax Genomics Ltd Compounds for mass spectrometry
GB9815166D0 (en) * 1998-07-13 1998-09-09 Brax Genomics Ltd Compounds for mass spectrometry
GB9815163D0 (en) * 1998-07-13 1998-09-09 Brax Genomics Ltd Compounds
EP1068216B1 (en) 1998-05-15 2003-12-10 Isis Innovation Limited Libraries of oligomers labelled with different tags
US7399844B2 (en) * 1998-07-09 2008-07-15 Agilent Technologies, Inc. Method and reagents for analyzing the nucleotide sequence of nucleic acids
US6270976B1 (en) 1998-09-15 2001-08-07 Brax Group Limited Characterizing nucleic acid by mass spectrometry
JP3668075B2 (ja) * 1999-10-12 2005-07-06 光夫 板倉 遺伝物質シーケンス決定用懸濁系、その懸濁系を用いた遺伝物質シーケンス決定方法およびその懸濁系を用いたSNPs高速スコアリング方法
US6509157B1 (en) * 1999-11-05 2003-01-21 Roche Molecular Systems, Inc 3 blocked nucleic acid amplification primers
DE19963536C2 (de) * 1999-12-20 2003-04-10 Epigenomics Ag Verfahren zur Analyse von Nukleinsäuresequenzen
JP2001204463A (ja) * 2000-01-27 2001-07-31 Toyo Kohan Co Ltd ヌクレオチド固定用担体
GB0006141D0 (en) * 2000-03-14 2000-05-03 Brax Group Ltd Mass labels
US8399383B2 (en) 2000-05-04 2013-03-19 Yale University Protein chips for high throughput screening of protein activity
WO2002014867A2 (en) * 2000-08-11 2002-02-21 Agilix Corporation Ultra-sensitive detection systems
US20040209251A1 (en) 2000-10-19 2004-10-21 Schneider Luke V Methods for determining protein and peptide terminal sequences
AU2002222614A1 (en) * 2000-12-12 2002-07-01 Chugai Seiyaku Kabushiki Kaisha Method of detecting polymorphism in dna by using mass spectroscopy
US20040121309A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
WO2004060278A2 (en) 2002-12-06 2004-07-22 Isis Pharmaceuticals, Inc. Methods for rapid identification of pathogens in humans and animals
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
JP4290003B2 (ja) 2001-09-14 2009-07-01 エレクトロフォレティクス リミテッド 質量標識体
EP1490693A1 (en) 2002-04-04 2004-12-29 Xzillion GmbH & CO.KG Method for characterising analytes
JP2004037128A (ja) * 2002-06-28 2004-02-05 Canon Inc マトリクス援助レーザー脱着/イオン化飛行時間型質量分析法による基板上の物質の解析方法
EP1579187B1 (en) 2002-10-29 2012-12-19 Target Discovery, Inc. Method for increasing ionization efficiency in mass spectroscopy
US20040219685A1 (en) 2003-01-30 2004-11-04 Applera Corporation Methods and mixtures pertaining to analyte determination using electrophilic labeling reagents
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US8242254B2 (en) 2003-09-11 2012-08-14 Ibis Biosciences, Inc. Compositions for use in identification of bacteria
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
JP2005140755A (ja) * 2003-11-10 2005-06-02 Japan Science & Technology Agency 質量分析用プローブ及びそれを用いた質量分析方法
US8163895B2 (en) 2003-12-05 2012-04-24 Ibis Biosciences, Inc. Compositions for use in identification of orthopoxviruses
US20050148087A1 (en) 2004-01-05 2005-07-07 Applera Corporation Isobarically labeled analytes and fragment ions derived therefrom
US7355045B2 (en) 2004-01-05 2008-04-08 Applera Corporation Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof
US20050148771A1 (en) 2004-01-05 2005-07-07 Applera Corporation. Active esters of N-substituted piperazine acetic acids, including isotopically enriched versions thereof
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
CA2557997C (en) 2004-03-01 2012-01-31 Applera Corporation Determination of analyte characteristics based upon binding properties
ES2641832T3 (es) 2004-05-24 2017-11-14 Ibis Biosciences, Inc. Espectrometría de masas con filtración de iones selectiva por establecimiento de umbrales digitales
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
US20070048752A1 (en) 2004-07-12 2007-03-01 Applera Corporation Mass tags for quantitative analyses
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
US20060024722A1 (en) 2004-07-30 2006-02-02 Mark Fischer-Colbrie Samples for detection of oncofetal fibronectin and uses thereof
US20060183238A1 (en) 2005-02-09 2006-08-17 Applera Corporation Amine-containing compound analysis methods
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
US20060205040A1 (en) 2005-03-03 2006-09-14 Rangarajan Sampath Compositions for use in identification of adventitious viruses
EP1904655A2 (en) 2005-07-21 2008-04-02 Isis Pharmaceuticals, Inc. Methods for rapid identification and quantitation of nucleic acid variants
GB0515323D0 (en) 2005-07-26 2005-08-31 Electrophoretics Ltd Mass labels
GB0518585D0 (en) * 2005-09-12 2005-10-19 Electrophoretics Ltd Mass labels
US8975404B2 (en) 2006-01-24 2015-03-10 Dh Technologies Development Pte. Ltd. Labeling reagents for analyte determination and methods and compounds used in making the same
EP2010679A2 (en) 2006-04-06 2009-01-07 Ibis Biosciences, Inc. Compositions for the use in identification of fungi
EP2054540B1 (en) 2006-05-26 2014-11-26 DH Technologies Development Pte. Ltd. Tagging reagents and methods for hydroxylated compounds
US11098345B2 (en) 2006-06-05 2021-08-24 California Institute Of Technology Methods for detecting target analytes
US7906341B2 (en) 2006-06-30 2011-03-15 Dh Technologies Development Pte, Ltd. Methods, mixtures, kits and compositions pertaining to analyte determination
US8362242B2 (en) 2006-06-30 2013-01-29 Dh Technologies Development Pte. Ltd. Analyte determination utilizing mass tagging reagents comprising a non-encoded detectable label
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US8048626B2 (en) 2006-07-28 2011-11-01 California Institute Of Technology Multiplex Q-PCR arrays
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
AU2007353877B2 (en) 2006-09-14 2012-07-19 Ibis Biosciences, Inc. Targeted whole genome amplification method for identification of pathogens
JP5680304B2 (ja) 2007-02-23 2015-03-04 アイビス バイオサイエンシズ インコーポレイティッド 迅速な法医学的dna分析法
GB0704764D0 (en) 2007-03-12 2007-04-18 Electrophoretics Ltd Isobarically labelled reagents and methods of their use
US9598724B2 (en) 2007-06-01 2017-03-21 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
CN101519698B (zh) * 2008-03-10 2013-05-22 周国华 一种利用序列标签定量测定核酸的方法
WO2010033627A2 (en) 2008-09-16 2010-03-25 Ibis Biosciences, Inc. Sample processing units, systems, and related methods
EP2349549B1 (en) 2008-09-16 2012-07-18 Ibis Biosciences, Inc. Mixing cartridges, mixing stations, and related kits, and system
US8534447B2 (en) 2008-09-16 2013-09-17 Ibis Biosciences, Inc. Microplate handling systems and related computer program products and methods
EP2396803A4 (en) 2009-02-12 2016-10-26 Ibis Biosciences Inc IONIZATION PROBE ASSEMBLIES
US9719083B2 (en) 2009-03-08 2017-08-01 Ibis Biosciences, Inc. Bioagent detection methods
US8486712B2 (en) 2009-03-10 2013-07-16 University Of Maryland, College Park Deuterium isobaric tag reagents for quantitative analysis
US9393564B2 (en) 2009-03-30 2016-07-19 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
EP2454000A4 (en) 2009-07-17 2016-08-10 Ibis Biosciences Inc SYSTEMS FOR IDENTIFYING BIOLOGICAL SUBSTANCES
US8950604B2 (en) 2009-07-17 2015-02-10 Ibis Biosciences, Inc. Lift and mount apparatus
WO2011014811A1 (en) 2009-07-31 2011-02-03 Ibis Biosciences, Inc. Capture primers and capture sequence linked solid supports for molecular diagnostic tests
EP3098325A1 (en) 2009-08-06 2016-11-30 Ibis Biosciences, Inc. Non-mass determined base compositions for nucleic acid detection
EP2957641B1 (en) 2009-10-15 2017-05-17 Ibis Biosciences, Inc. Multiple displacement amplification
US9758840B2 (en) 2010-03-14 2017-09-12 Ibis Biosciences, Inc. Parasite detection via endosymbiont detection
WO2012003478A2 (en) 2010-07-02 2012-01-05 Ventana Medical Systems, Inc. Detecting targets using mass tags and mass spectrometry
US8492163B2 (en) 2011-01-31 2013-07-23 Dh Technologies Development Pte. Ltd. Methods, mixtures, kits and compositions pertaining to analyte determination
US9708647B2 (en) * 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
US20170089915A1 (en) * 2015-09-30 2017-03-30 Agilent Technologies, Inc. Methods of analyte derivatization and enhanced soft ionization
EP3400444A4 (en) * 2016-01-04 2019-10-16 QuantuMDx Group Limited DESIGN, SYNTHESIS AND USE OF SYNTHETIC NUCLEOTIDES WITH LOADING MASS MARKINGS
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
JP7687957B2 (ja) 2019-03-14 2025-06-03 インシリクサ, インコーポレイテッド 時間ゲート蛍光ベースの検出のための方法およびシステム
WO2022098819A1 (en) * 2020-11-06 2022-05-12 Waters Technologies Corporation Methods and compositions useful for nucleic acid analysis
EP4368984A4 (en) * 2021-07-08 2024-11-13 Shimadzu Corporation METHOD OF MASS SPECTROMETRY OF MICROORGANISMS
CN116496335B (zh) * 2023-03-21 2024-03-08 中国药科大学 一种修饰核苷酸及其应用
CN118980740B (zh) * 2024-09-19 2025-01-24 常州越泰检测科技有限公司 一种磁粉检测用喷照一体装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2153387A1 (en) * 1993-01-07 1994-07-21 Hubert Koester Dna sequencing by mass spectrometry
GB9315847D0 (en) * 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
DE69621507T2 (de) * 1995-03-28 2003-01-09 Japan Science And Technology Corp., Kawaguchi Verfahren zur molekularen Indexierung von Genen unter Verwendung von Restriktionsenzymen
JPH11503611A (ja) * 1995-04-11 1999-03-30 トラスティーズ・オブ・ボストン・ユニバーシティ 生体高分子の固相配列決定法
DE69739465D1 (de) * 1996-01-23 2009-07-30 Operon Biotechnologies Inc Methoden zur Analyse von Nukleinsäure-Molekülen mittels Techniken zur Grössen-bestimmung
GB9618544D0 (en) * 1996-09-05 1996-10-16 Brax Genomics Ltd Characterising DNA

Also Published As

Publication number Publication date
DE69838519T2 (de) 2008-07-03
EP0979305A1 (en) 2000-02-16
EP1400599A1 (en) 2004-03-24
NZ336769A (en) 2001-01-26
AU725966B2 (en) 2000-10-26
CA2277786A1 (en) 1998-07-23
ATE340869T1 (de) 2006-10-15
EP0979305B1 (en) 2006-09-27
JP2004357697A (ja) 2004-12-24
CN100434531C (zh) 2008-11-19
ATE374836T1 (de) 2007-10-15
EP1400599B1 (en) 2007-10-03
WO1998031830A1 (en) 1998-07-23
IL130885A (en) 2005-05-17
DE69836013D1 (de) 2006-11-09
AU5570098A (en) 1998-08-07
JP2001508307A (ja) 2001-06-26
DE69838519D1 (de) 2007-11-15
JP2006208400A (ja) 2006-08-10
CN1250483A (zh) 2000-04-12
CA2441655A1 (en) 1998-07-23
DE69836013T2 (de) 2007-05-24
IL130885A0 (en) 2001-01-28

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