JP3691484B2 - トロンビンペプチド誘導体による骨成長の刺激 - Google Patents

トロンビンペプチド誘導体による骨成長の刺激 Download PDF

Info

Publication number
JP3691484B2
JP3691484B2 JP2002511768A JP2002511768A JP3691484B2 JP 3691484 B2 JP3691484 B2 JP 3691484B2 JP 2002511768 A JP2002511768 A JP 2002511768A JP 2002511768 A JP2002511768 A JP 2002511768A JP 3691484 B2 JP3691484 B2 JP 3691484B2
Authority
JP
Japan
Prior art keywords
gly
site
bone growth
amino acid
asp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2002511768A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004503596A5 (enExample
JP2004503596A (ja
Inventor
カーニー，ダレル，エイチ．
クローザー，ロジャー，エス．
シモンズ，デービッド，ジェイ．
ヤン，チンピン
レディン，ウィリアム，アール．
Original Assignee
ザ ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム filed Critical ザ ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム
Publication of JP2004503596A publication Critical patent/JP2004503596A/ja
Publication of JP2004503596A5 publication Critical patent/JP2004503596A5/ja
Application granted granted Critical
Publication of JP3691484B2 publication Critical patent/JP3691484B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
JP2002511768A 2000-07-19 2001-07-18 トロンビンペプチド誘導体による骨成長の刺激 Expired - Fee Related JP3691484B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21930000P 2000-07-19 2000-07-19
PCT/US2001/022641 WO2002005836A2 (en) 2000-07-19 2001-07-18 Stimulation of bone growth with thrombin peptide derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2004158162A Division JP2005053894A (ja) 2000-07-19 2004-05-27 トロンビンペプチド誘導体による骨成長の刺激

Publications (3)

Publication Number Publication Date
JP2004503596A JP2004503596A (ja) 2004-02-05
JP2004503596A5 JP2004503596A5 (enExample) 2005-01-06
JP3691484B2 true JP3691484B2 (ja) 2005-09-07

Family

ID=22818711

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002511768A Expired - Fee Related JP3691484B2 (ja) 2000-07-19 2001-07-18 トロンビンペプチド誘導体による骨成長の刺激
JP2004158162A Withdrawn JP2005053894A (ja) 2000-07-19 2004-05-27 トロンビンペプチド誘導体による骨成長の刺激

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2004158162A Withdrawn JP2005053894A (ja) 2000-07-19 2004-05-27 トロンビンペプチド誘導体による骨成長の刺激

Country Status (13)

Country Link
US (3) US6914050B2 (enExample)
EP (1) EP1301196B1 (enExample)
JP (2) JP3691484B2 (enExample)
CN (1) CN100350971C (enExample)
AT (1) ATE254925T1 (enExample)
AU (2) AU7697701A (enExample)
CA (1) CA2416487A1 (enExample)
DE (1) DE60101339T2 (enExample)
DK (1) DK1301196T3 (enExample)
ES (1) ES2213707T3 (enExample)
PT (1) PT1301196E (enExample)
TR (1) TR200400260T4 (enExample)
WO (1) WO2002005836A2 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5895766A (en) 1995-09-20 1999-04-20 Micron Technology, Inc. Method of forming a field effect transistor
TWI227734B (en) 1998-05-18 2005-02-11 Univ London A novel polypeptide hormone phosphatonin
TR200400260T4 (tr) 2000-07-19 2004-03-22 The Board Of Regents, The University Of Texas System Trombin peptid türevleri ile kemik büyümesinin uyarılması
DE60134864D1 (de) * 2000-08-16 2008-08-28 Acologix Inc Dentalzubereitungen enthaltend peptide, die das knochenwachstum fördern
US6911425B2 (en) 2000-08-16 2005-06-28 Acologix, Inc. Integrin binding motif containing peptides and methods of treating skeletal diseases
JP2005519067A (ja) * 2002-01-17 2005-06-30 ザ ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム トロンビンペプチド誘導体を用いた骨成長および軟骨形成の刺激
EP1539214A4 (en) * 2002-07-02 2008-01-02 Orthologic Corp Thrombin
ATE362939T1 (de) 2002-07-02 2007-06-15 Orthologic Corp Dimere von thrombinpeptidderivaten
US7169405B2 (en) * 2003-08-06 2007-01-30 Warsaw Orthopedic, Inc. Methods and devices for the treatment of intervertebral discs
JP4740532B2 (ja) * 2003-09-30 2011-08-03 雪印乳業株式会社 骨形成促進及び骨吸収抑制剤
AU2004275649A1 (en) * 2003-09-30 2005-04-07 Snow Brand Milk Products Co., Ltd. Agent for promoting osteogenesis and/or inhibiting bone resorption
AU2003272814A1 (en) 2003-10-02 2005-05-19 Ibrahim Al-Habdan Peptide for promoting healing of fractures
PL1559431T3 (pl) * 2003-12-31 2007-10-31 Orthologic Corp Kompozycja farmaceutyczna dla pochodnych peptydu trombiny
EP1928491A4 (en) 2005-07-18 2009-08-26 Acologix Inc PROTEIN FORMULATION FOR PROMOTING HARD TISSUE FORMATION
US8642060B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for osteal growth
US8642059B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for intervertebral discs
US7879027B2 (en) * 2006-04-24 2011-02-01 Warsaw Orthopedic, Inc. Controlled release devices for fusion of osteal structures
US7771414B2 (en) * 2006-04-24 2010-08-10 Warsaw Orthopedic, Inc. Controlled release devices for therapeutic treatments of spinal discs
US7888462B2 (en) 2007-01-22 2011-02-15 Acologix, Inc. Peptide composition and a method of promoting cartilage formation
WO2008100567A2 (en) * 2007-02-15 2008-08-21 Orthologic Corp. Thrombin peptide derivatives for treating fractures in osteopenic patients
CA2719940A1 (en) * 2008-03-26 2009-11-26 Orthologic Corp. Methods for treating acute myocardial infarction
US20110117075A1 (en) * 2008-03-26 2011-05-19 Orthologic Corp. Thrombin derived peptides for smooth muscle relaxation
AU2009229395A1 (en) * 2008-03-26 2009-10-01 The Board Of Regents, The University Of Texas System Method of treating degenerative diseases
WO2009120307A2 (en) * 2008-03-26 2009-10-01 Orthologic Corp. Method of treating peripheral arterial disease
WO2010033862A2 (en) * 2008-09-19 2010-03-25 The Board Of Regents, The University Of Texas System Methods for treating cancer
CN102250253A (zh) * 2010-05-17 2011-11-23 中国人民解放军军事医学科学院军事兽医研究所 一种含凝血酶片段融合肽
RU2551119C1 (ru) * 2013-11-29 2015-05-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Национальный исследовательский Томский политехнический университет" Времяпролетный спектрометр ионов
US10220078B2 (en) 2014-06-11 2019-03-05 The Board Of Regents Of The University Of Texas System Methods of using thrombin derivatives to treat medulloblastoma

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4563489A (en) * 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
US4637931A (en) * 1984-10-09 1987-01-20 The United States Of America As Represented By The Secretary Of The Army Polyactic-polyglycolic acid copolymer combined with decalcified freeze-dried bone for use as a bone repair material
US5352664A (en) 1986-10-31 1994-10-04 Board Of Regents, The University Of Texas System Thrombin derived polypeptides; compositions and methods for use
JPH04279520A (ja) 1990-05-31 1992-10-05 Eisai Co Ltd 骨内部埋め込み用製剤
US5563124A (en) 1991-04-22 1996-10-08 Intermedics Orthopedics/ Denver, Inc. Osteogenic product and process
US5876452A (en) 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
TW369414B (en) 1994-09-30 1999-09-11 Yamanouchi Pharma Co Ltd Bone formation transplant
JPH1033657A (ja) 1996-07-23 1998-02-10 Dainippon Ink & Chem Inc 生体内分解性材料及びその製造方法
US6001352A (en) 1997-03-31 1999-12-14 Osteobiologics, Inc. Resurfacing cartilage defects with chondrocytes proliferated without differentiation using platelet-derived growth factor
DE69714035T2 (de) 1997-08-14 2003-03-06 Sulzer Innotec Ag, Winterthur Zusammensetzung und Vorrichtung zur Reparatur von Knorpelgewebe in vivo bestehend aus Nanokapseln mit osteoinduktiven und/oder chondroinduktiven Faktoren
TR200400260T4 (tr) * 2000-07-19 2004-03-22 The Board Of Regents, The University Of Texas System Trombin peptid türevleri ile kemik büyümesinin uyarılması
DE60105772T2 (de) 2000-07-20 2006-02-16 Board of Regents, The University of Texas System, Austin Stimulation des knorpelwachstums mit agonisten des nicht-proteolytisch aktivierten thrombin rezeptors

Also Published As

Publication number Publication date
US20020128202A1 (en) 2002-09-12
TR200400260T4 (tr) 2004-03-22
DK1301196T3 (da) 2004-03-29
EP1301196A2 (en) 2003-04-16
HK1055250A1 (en) 2004-01-02
JP2005053894A (ja) 2005-03-03
US20020182205A1 (en) 2002-12-05
CN1635899A (zh) 2005-07-06
WO2002005836A3 (en) 2002-12-19
US6894027B2 (en) 2005-05-17
ES2213707T3 (es) 2004-09-01
CA2416487A1 (en) 2002-01-24
EP1301196B1 (en) 2003-11-26
ATE254925T1 (de) 2003-12-15
AU7697701A (en) 2002-01-30
PT1301196E (pt) 2004-04-30
JP2004503596A (ja) 2004-02-05
US7304035B2 (en) 2007-12-04
DE60101339T2 (de) 2004-09-09
AU2001276977B2 (en) 2005-05-19
DE60101339D1 (de) 2004-01-08
WO2002005836A2 (en) 2002-01-24
US20050227923A1 (en) 2005-10-13
CN100350971C (zh) 2007-11-28
US6914050B2 (en) 2005-07-05

Similar Documents

Publication Publication Date Title
EP1301196B1 (en) Stimulation of bone growth with thrombin peptide derivatives
AU2001276977A1 (en) Stimulation of bone growth with thrombin peptide derivatives
EP0608313B1 (en) Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
KR102751476B1 (ko) 자가 골 이식편 대체재
US11596712B2 (en) Autologous bone graft substitute composition
CA2491052A1 (en) Thrombin peptide derivatives
AU2002239965B2 (en) Stimulation of bone growth and cartilage formation with thrombing peptide derivatives
AU2002239965A1 (en) Stimulation of bone growth and cartilage formation with thrombing peptide derivatives
HK1055250B (en) Stimulation of bone growth with thrombin peptide derivatives
HK1078264A (en) Stimulation of bone growth and cartilage formation with thrombing peptide derivatives

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20031119

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20040331

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20040527

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20040610

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20040714

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20050113

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050120

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20050607

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20050615

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20090624

Year of fee payment: 4

LAPS Cancellation because of no payment of annual fees