DK1301196T3 - Stimulering af knoglevækst med peptidderivater af thrombin - Google Patents

Stimulering af knoglevækst med peptidderivater af thrombin

Info

Publication number
DK1301196T3
DK1301196T3 DK01954752T DK01954752T DK1301196T3 DK 1301196 T3 DK1301196 T3 DK 1301196T3 DK 01954752 T DK01954752 T DK 01954752T DK 01954752 T DK01954752 T DK 01954752T DK 1301196 T3 DK1301196 T3 DK 1301196T3
Authority
DK
Denmark
Prior art keywords
bone growth
thrombin
stimulation
peptide derivatives
site
Prior art date
Application number
DK01954752T
Other languages
Danish (da)
English (en)
Inventor
Darrell H Carney
Roger S Crowther
David J Simmons
Jinping Yang
William R Redin
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Application granted granted Critical
Publication of DK1301196T3 publication Critical patent/DK1301196T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
DK01954752T 2000-07-19 2001-07-18 Stimulering af knoglevækst med peptidderivater af thrombin DK1301196T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21930000P 2000-07-19 2000-07-19
PCT/US2001/022641 WO2002005836A2 (en) 2000-07-19 2001-07-18 Stimulation of bone growth with thrombin peptide derivatives

Publications (1)

Publication Number Publication Date
DK1301196T3 true DK1301196T3 (da) 2004-03-29

Family

ID=22818711

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01954752T DK1301196T3 (da) 2000-07-19 2001-07-18 Stimulering af knoglevækst med peptidderivater af thrombin

Country Status (13)

Country Link
US (3) US6914050B2 (enExample)
EP (1) EP1301196B1 (enExample)
JP (2) JP3691484B2 (enExample)
CN (1) CN100350971C (enExample)
AT (1) ATE254925T1 (enExample)
AU (2) AU2001276977B2 (enExample)
CA (1) CA2416487A1 (enExample)
DE (1) DE60101339T2 (enExample)
DK (1) DK1301196T3 (enExample)
ES (1) ES2213707T3 (enExample)
PT (1) PT1301196E (enExample)
TR (1) TR200400260T4 (enExample)
WO (1) WO2002005836A2 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5895766A (en) 1995-09-20 1999-04-20 Micron Technology, Inc. Method of forming a field effect transistor
ATE354656T1 (de) 1998-05-18 2007-03-15 Univ London Von menschlichem tumor stammendes polypeptidhormon phosphatonin
ATE254925T1 (de) 2000-07-19 2003-12-15 Univ Texas Stimulierung des knochenwachstums mit peptidderivaten von thrombin
AU2002239965B2 (en) * 2000-07-19 2007-01-04 Orthologic Corp. Stimulation of bone growth and cartilage formation with thrombing peptide derivatives
ATE401350T1 (de) * 2000-08-16 2008-08-15 Acologix Inc Dentalzubereitungen enthaltend peptide, die das knochenwachstum fördern
US6911425B2 (en) 2000-08-16 2005-06-28 Acologix, Inc. Integrin binding motif containing peptides and methods of treating skeletal diseases
EP1539800B1 (en) * 2002-07-02 2007-05-23 Orthologic Corp. Thrombin peptide derivative dimers
AU2003256343B2 (en) * 2002-07-02 2006-12-21 Orthologic Corp. Thrombin peptide derivatives
US7169405B2 (en) * 2003-08-06 2007-01-30 Warsaw Orthopedic, Inc. Methods and devices for the treatment of intervertebral discs
JP4740532B2 (ja) * 2003-09-30 2011-08-03 雪印乳業株式会社 骨形成促進及び骨吸収抑制剤
KR101170852B1 (ko) * 2003-09-30 2012-08-02 유키지루시 메그밀크 가부시키가이샤 골 형성 촉진 및/또는 골 흡수 억제제
US7399826B1 (en) 2003-10-02 2008-07-15 Ali Sadat M Peptide for promoting healing of fractures
DE602004005564T2 (de) * 2003-12-31 2007-12-13 Orthologic Corp., Tempe Pharmazeutische Zusammensetzung für Thrombinpeptidderivaten
JP2009502782A (ja) 2005-07-18 2009-01-29 アコロジックス インコーポレイティッド 硬組織形成を促進するためのタンパク質製剤
US8642059B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for intervertebral discs
US7879027B2 (en) * 2006-04-24 2011-02-01 Warsaw Orthopedic, Inc. Controlled release devices for fusion of osteal structures
US7771414B2 (en) * 2006-04-24 2010-08-10 Warsaw Orthopedic, Inc. Controlled release devices for therapeutic treatments of spinal discs
US8642060B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for osteal growth
EP2117578B1 (en) 2007-01-22 2015-04-22 OrthoTrophix, Inc. A peptide composition and a method of promoting cartilage formation
WO2008100567A2 (en) * 2007-02-15 2008-08-21 Orthologic Corp. Thrombin peptide derivatives for treating fractures in osteopenic patients
AU2009229395A1 (en) * 2008-03-26 2009-10-01 The Board Of Regents, The University Of Texas System Method of treating degenerative diseases
EP2268304A2 (en) * 2008-03-26 2011-01-05 Orthologic Corp. Methods for treating acute myocardial infarction
US20110117075A1 (en) * 2008-03-26 2011-05-19 Orthologic Corp. Thrombin derived peptides for smooth muscle relaxation
WO2009120307A2 (en) * 2008-03-26 2009-10-01 Orthologic Corp. Method of treating peripheral arterial disease
US20110319340A1 (en) * 2008-09-19 2011-12-29 The Board Of Regents, The University Of Texas System Methods for treating cancer
CN102250253A (zh) * 2010-05-17 2011-11-23 中国人民解放军军事医学科学院军事兽医研究所 一种含凝血酶片段融合肽
RU2551119C1 (ru) * 2013-11-29 2015-05-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Национальный исследовательский Томский политехнический университет" Времяпролетный спектрометр ионов
US10220078B2 (en) 2014-06-11 2019-03-05 The Board Of Regents Of The University Of Texas System Methods of using thrombin derivatives to treat medulloblastoma

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4563489A (en) * 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
US4637931A (en) * 1984-10-09 1987-01-20 The United States Of America As Represented By The Secretary Of The Army Polyactic-polyglycolic acid copolymer combined with decalcified freeze-dried bone for use as a bone repair material
US5352664A (en) * 1986-10-31 1994-10-04 Board Of Regents, The University Of Texas System Thrombin derived polypeptides; compositions and methods for use
JPH04279520A (ja) 1990-05-31 1992-10-05 Eisai Co Ltd 骨内部埋め込み用製剤
US5563124A (en) 1991-04-22 1996-10-08 Intermedics Orthopedics/ Denver, Inc. Osteogenic product and process
US5876452A (en) 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
TW369414B (en) 1994-09-30 1999-09-11 Yamanouchi Pharma Co Ltd Bone formation transplant
JPH1033657A (ja) 1996-07-23 1998-02-10 Dainippon Ink & Chem Inc 生体内分解性材料及びその製造方法
US6001352A (en) 1997-03-31 1999-12-14 Osteobiologics, Inc. Resurfacing cartilage defects with chondrocytes proliferated without differentiation using platelet-derived growth factor
ATE220564T1 (de) 1997-08-14 2002-08-15 Sulzer Innotec Ag Zusammensetzung und vorrichtung zur reparatur von knorpelgewebe in vivo bestehend aus nanokapseln mit osteoinduktiven und/oder chondroinduktiven faktoren
ATE254925T1 (de) 2000-07-19 2003-12-15 Univ Texas Stimulierung des knochenwachstums mit peptidderivaten von thrombin
CN1458974A (zh) 2000-07-20 2003-11-26 德克萨斯系统大学董事会 用非蛋白质水解激活的凝血酶受体的激动剂刺激软骨生长

Also Published As

Publication number Publication date
EP1301196A2 (en) 2003-04-16
AU2001276977B2 (en) 2005-05-19
HK1055250A1 (en) 2004-01-02
US6894027B2 (en) 2005-05-17
ATE254925T1 (de) 2003-12-15
AU7697701A (en) 2002-01-30
CA2416487A1 (en) 2002-01-24
DE60101339T2 (de) 2004-09-09
EP1301196B1 (en) 2003-11-26
US7304035B2 (en) 2007-12-04
JP2004503596A (ja) 2004-02-05
US6914050B2 (en) 2005-07-05
US20020128202A1 (en) 2002-09-12
ES2213707T3 (es) 2004-09-01
CN100350971C (zh) 2007-11-28
PT1301196E (pt) 2004-04-30
JP3691484B2 (ja) 2005-09-07
US20050227923A1 (en) 2005-10-13
CN1635899A (zh) 2005-07-06
DE60101339D1 (de) 2004-01-08
WO2002005836A3 (en) 2002-12-19
US20020182205A1 (en) 2002-12-05
JP2005053894A (ja) 2005-03-03
WO2002005836A2 (en) 2002-01-24
TR200400260T4 (tr) 2004-03-22

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