CN100350971C - 用凝血酶肽衍生物刺激骨生长 - Google Patents

用凝血酶肽衍生物刺激骨生长 Download PDF

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Publication number
CN100350971C
CN100350971C CNB018158226A CN01815822A CN100350971C CN 100350971 C CN100350971 C CN 100350971C CN B018158226 A CNB018158226 A CN B018158226A CN 01815822 A CN01815822 A CN 01815822A CN 100350971 C CN100350971 C CN 100350971C
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CN
China
Prior art keywords
bone
pharmaceutical composition
amino acid
site
bone growth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB018158226A
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English (en)
Chinese (zh)
Other versions
CN1635899A (zh
Inventor
达芮尔·H·卡尼
罗杰·S·库劳泽尔
戴维·J·西蒙斯
杨金萍
威廉·R·雷丁
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Capstone Holding Corp
Original Assignee
Osorogis Ltd
The University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osorogis Ltd, The University of Texas System filed Critical Osorogis Ltd
Publication of CN1635899A publication Critical patent/CN1635899A/zh
Application granted granted Critical
Publication of CN100350971C publication Critical patent/CN100350971C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
CNB018158226A 2000-07-19 2001-07-18 用凝血酶肽衍生物刺激骨生长 Expired - Fee Related CN100350971C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21930000P 2000-07-19 2000-07-19
US60/219,300 2000-07-19

Publications (2)

Publication Number Publication Date
CN1635899A CN1635899A (zh) 2005-07-06
CN100350971C true CN100350971C (zh) 2007-11-28

Family

ID=22818711

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018158226A Expired - Fee Related CN100350971C (zh) 2000-07-19 2001-07-18 用凝血酶肽衍生物刺激骨生长

Country Status (13)

Country Link
US (3) US6914050B2 (enExample)
EP (1) EP1301196B1 (enExample)
JP (2) JP3691484B2 (enExample)
CN (1) CN100350971C (enExample)
AT (1) ATE254925T1 (enExample)
AU (2) AU7697701A (enExample)
CA (1) CA2416487A1 (enExample)
DE (1) DE60101339T2 (enExample)
DK (1) DK1301196T3 (enExample)
ES (1) ES2213707T3 (enExample)
PT (1) PT1301196E (enExample)
TR (1) TR200400260T4 (enExample)
WO (1) WO2002005836A2 (enExample)

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US5895766A (en) 1995-09-20 1999-04-20 Micron Technology, Inc. Method of forming a field effect transistor
TWI227734B (en) 1998-05-18 2005-02-11 Univ London A novel polypeptide hormone phosphatonin
TR200400260T4 (tr) 2000-07-19 2004-03-22 The Board Of Regents, The University Of Texas System Trombin peptid türevleri ile kemik büyümesinin uyarılması
DE60134864D1 (de) * 2000-08-16 2008-08-28 Acologix Inc Dentalzubereitungen enthaltend peptide, die das knochenwachstum fördern
US6911425B2 (en) 2000-08-16 2005-06-28 Acologix, Inc. Integrin binding motif containing peptides and methods of treating skeletal diseases
JP2005519067A (ja) * 2002-01-17 2005-06-30 ザ ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム トロンビンペプチド誘導体を用いた骨成長および軟骨形成の刺激
EP1539214A4 (en) * 2002-07-02 2008-01-02 Orthologic Corp Thrombin
ATE362939T1 (de) 2002-07-02 2007-06-15 Orthologic Corp Dimere von thrombinpeptidderivaten
US7169405B2 (en) * 2003-08-06 2007-01-30 Warsaw Orthopedic, Inc. Methods and devices for the treatment of intervertebral discs
JP4740532B2 (ja) * 2003-09-30 2011-08-03 雪印乳業株式会社 骨形成促進及び骨吸収抑制剤
AU2004275649A1 (en) * 2003-09-30 2005-04-07 Snow Brand Milk Products Co., Ltd. Agent for promoting osteogenesis and/or inhibiting bone resorption
AU2003272814A1 (en) 2003-10-02 2005-05-19 Ibrahim Al-Habdan Peptide for promoting healing of fractures
PL1559431T3 (pl) * 2003-12-31 2007-10-31 Orthologic Corp Kompozycja farmaceutyczna dla pochodnych peptydu trombiny
EP1928491A4 (en) 2005-07-18 2009-08-26 Acologix Inc PROTEIN FORMULATION FOR PROMOTING HARD TISSUE FORMATION
US8642060B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for osteal growth
US8642059B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for intervertebral discs
US7879027B2 (en) * 2006-04-24 2011-02-01 Warsaw Orthopedic, Inc. Controlled release devices for fusion of osteal structures
US7771414B2 (en) * 2006-04-24 2010-08-10 Warsaw Orthopedic, Inc. Controlled release devices for therapeutic treatments of spinal discs
US7888462B2 (en) 2007-01-22 2011-02-15 Acologix, Inc. Peptide composition and a method of promoting cartilage formation
WO2008100567A2 (en) * 2007-02-15 2008-08-21 Orthologic Corp. Thrombin peptide derivatives for treating fractures in osteopenic patients
CA2719940A1 (en) * 2008-03-26 2009-11-26 Orthologic Corp. Methods for treating acute myocardial infarction
US20110117075A1 (en) * 2008-03-26 2011-05-19 Orthologic Corp. Thrombin derived peptides for smooth muscle relaxation
AU2009229395A1 (en) * 2008-03-26 2009-10-01 The Board Of Regents, The University Of Texas System Method of treating degenerative diseases
WO2009120307A2 (en) * 2008-03-26 2009-10-01 Orthologic Corp. Method of treating peripheral arterial disease
WO2010033862A2 (en) * 2008-09-19 2010-03-25 The Board Of Regents, The University Of Texas System Methods for treating cancer
CN102250253A (zh) * 2010-05-17 2011-11-23 中国人民解放军军事医学科学院军事兽医研究所 一种含凝血酶片段融合肽
RU2551119C1 (ru) * 2013-11-29 2015-05-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Национальный исследовательский Томский политехнический университет" Времяпролетный спектрометр ионов
US10220078B2 (en) 2014-06-11 2019-03-05 The Board Of Regents Of The University Of Texas System Methods of using thrombin derivatives to treat medulloblastoma

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988003151A2 (en) * 1986-10-31 1988-05-05 Board Of Regents, The University Of Texas System Thrombin derived polypeptides; compositions and methods for use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4563489A (en) * 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
US4637931A (en) * 1984-10-09 1987-01-20 The United States Of America As Represented By The Secretary Of The Army Polyactic-polyglycolic acid copolymer combined with decalcified freeze-dried bone for use as a bone repair material
JPH04279520A (ja) 1990-05-31 1992-10-05 Eisai Co Ltd 骨内部埋め込み用製剤
US5563124A (en) 1991-04-22 1996-10-08 Intermedics Orthopedics/ Denver, Inc. Osteogenic product and process
US5876452A (en) 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
TW369414B (en) 1994-09-30 1999-09-11 Yamanouchi Pharma Co Ltd Bone formation transplant
JPH1033657A (ja) 1996-07-23 1998-02-10 Dainippon Ink & Chem Inc 生体内分解性材料及びその製造方法
US6001352A (en) 1997-03-31 1999-12-14 Osteobiologics, Inc. Resurfacing cartilage defects with chondrocytes proliferated without differentiation using platelet-derived growth factor
DE69714035T2 (de) 1997-08-14 2003-03-06 Sulzer Innotec Ag, Winterthur Zusammensetzung und Vorrichtung zur Reparatur von Knorpelgewebe in vivo bestehend aus Nanokapseln mit osteoinduktiven und/oder chondroinduktiven Faktoren
TR200400260T4 (tr) * 2000-07-19 2004-03-22 The Board Of Regents, The University Of Texas System Trombin peptid türevleri ile kemik büyümesinin uyarılması
DE60105772T2 (de) 2000-07-20 2006-02-16 Board of Regents, The University of Texas System, Austin Stimulation des knorpelwachstums mit agonisten des nicht-proteolytisch aktivierten thrombin rezeptors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988003151A2 (en) * 1986-10-31 1988-05-05 Board Of Regents, The University Of Texas System Thrombin derived polypeptides; compositions and methods for use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Thrombin peptide TP508 Induces differential geneexpression in fiborblasts through a nonproteolytic activationpathway.Sower L.E.et al.Exp.Cell. Res.,Vol.247 No.2. 1999 *

Also Published As

Publication number Publication date
US20020128202A1 (en) 2002-09-12
TR200400260T4 (tr) 2004-03-22
DK1301196T3 (da) 2004-03-29
EP1301196A2 (en) 2003-04-16
HK1055250A1 (en) 2004-01-02
JP2005053894A (ja) 2005-03-03
US20020182205A1 (en) 2002-12-05
CN1635899A (zh) 2005-07-06
WO2002005836A3 (en) 2002-12-19
US6894027B2 (en) 2005-05-17
ES2213707T3 (es) 2004-09-01
CA2416487A1 (en) 2002-01-24
EP1301196B1 (en) 2003-11-26
ATE254925T1 (de) 2003-12-15
JP3691484B2 (ja) 2005-09-07
AU7697701A (en) 2002-01-30
PT1301196E (pt) 2004-04-30
JP2004503596A (ja) 2004-02-05
US7304035B2 (en) 2007-12-04
DE60101339T2 (de) 2004-09-09
AU2001276977B2 (en) 2005-05-19
DE60101339D1 (de) 2004-01-08
WO2002005836A2 (en) 2002-01-24
US20050227923A1 (en) 2005-10-13
US6914050B2 (en) 2005-07-05

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: OSOLUGIAIS CO., LTD.

Free format text: FORMER OWNER: THE BOARD OF REGENTS, THE UNIV. OF TEXAS SYSTEM

Effective date: 20051223

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20051223

Address after: Arizona, USA

Applicant after: Orthologic Corp.

Address before: American Texas

Applicant before: Board of Regents of the Univ. of Texas System

C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee