JP3636363B2 - 新規デオキシガラクトノジリマイシン誘導体 - Google Patents
新規デオキシガラクトノジリマイシン誘導体 Download PDFInfo
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- JP3636363B2 JP3636363B2 JP52554194A JP52554194A JP3636363B2 JP 3636363 B2 JP3636363 B2 JP 3636363B2 JP 52554194 A JP52554194 A JP 52554194A JP 52554194 A JP52554194 A JP 52554194A JP 3636363 B2 JP3636363 B2 JP 3636363B2
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- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
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- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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| US08/102,654 | 1993-08-05 | ||
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| PCT/US1994/004974 WO1994026714A1 (en) | 1993-05-13 | 1994-05-11 | Novel deoxygalactonojirimycin derivatives |
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| JPH08510244A JPH08510244A (ja) | 1996-10-29 |
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| US5798366A (en) * | 1993-05-13 | 1998-08-25 | Monsanto Company | Method for treatment of CNS-involved lysosomal storage diseases |
| US6465488B1 (en) | 1997-12-11 | 2002-10-15 | Chancellor, Masters & Scholars Of The University Of Oxford | Inhibition of glycolipid biosynthesis |
| US6274597B1 (en) * | 1998-06-01 | 2001-08-14 | Mount Sinai School Of Medicine Of New York University | Method of enhancing lysosomal α-Galactosidase A |
| AU1734600A (en) * | 1998-11-17 | 2000-06-05 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Identification of glycosphingolipids that promote hiv-1 entry into cells |
| US6610703B1 (en) | 1998-12-10 | 2003-08-26 | G.D. Searle & Co. | Method for treatment of glycolipid storage diseases |
| GB0100889D0 (en) * | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
| US20050032841A1 (en) * | 1999-04-20 | 2005-02-10 | Steven Walkley | Therapeutic compositions and methods of treating glycolipid storage related disorders |
| GB9909066D0 (en) * | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
| ATE234626T1 (de) | 1999-07-26 | 2003-04-15 | Searle & Co | Verwendung von langkettigen n-alkyl derivaten von deoxynojirimycin mit glucocerebrosidase enzyme zur herstellung eines medikaments zur behandlung von mit glykolipiden akkumulation zusammenhängenden krankheiten |
| US7256005B2 (en) | 1999-08-10 | 2007-08-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity |
| US7816560B1 (en) | 1999-08-10 | 2010-10-19 | Thomas Jefferson University | Long chain n-alkyl compounds and oxa-derivatives thereof |
| EP1534676B1 (en) | 2002-07-17 | 2012-09-12 | Actelion Pharmaceuticals Ltd. | Piperidinetriol derivatives as inhibitors of glycosylceramide synthase |
| JP4585851B2 (ja) | 2002-07-17 | 2010-11-24 | アクテリオン ファーマシューティカルズ リミテッド | グルコシルセラミドシンターゼの阻害剤としてのピペリジントリオール誘導体 |
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| WO2004069190A2 (en) | 2003-01-31 | 2004-08-19 | Mount Sinai School Of Medicine Of New York University | Combination therapy for treating protein deficiency disorders |
| GB0313677D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compound |
| GB0313678D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compounds |
| CN1901907A (zh) * | 2003-11-12 | 2007-01-24 | 阿米库斯治疗学公司 | 用于治疗戈谢病的葡糖并咪唑和多羟基环己烯基胺衍生物 |
| US20050256168A1 (en) * | 2004-04-28 | 2005-11-17 | Block Timothy M | Compositions for oral administration for the treatment of interferon-responsive disorders |
| WO2005123055A2 (en) * | 2004-06-14 | 2005-12-29 | Musc Foundation For Research Development | Methods for treating inflammatory disorders |
| ES2572148T3 (es) | 2005-05-17 | 2016-05-30 | Amicus Therapeutics Inc | Un método para el tratamiento de la enfermedad de Pompe usando 1-desoxinojirimicina y derivados |
| GB0614947D0 (en) * | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
| EP2356990A3 (en) | 2006-08-02 | 2011-10-19 | University of Oxford | Liposome treatment of viral infections |
| WO2009118658A2 (en) * | 2008-03-26 | 2009-10-01 | University Of Oxford | Endoplasmic reticulum targeting liposomes |
| US8703744B2 (en) * | 2009-03-27 | 2014-04-22 | The Chancellor, Masters And Scholars Of The University Of Oxford | Cholesterol level lowering liposomes |
| EP2411526A4 (en) * | 2009-03-27 | 2012-09-19 | Zacharon Pharmaceuticals Inc | MODULATORS OF GANGLIOSID BIOSYNTHESIS |
| RU2609210C2 (ru) | 2010-12-23 | 2017-01-31 | Алектос Терапьютикс Инк. | Селективные ингибиторы гликозидазы и их применение |
| WO2012129651A1 (en) | 2011-03-31 | 2012-10-04 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| US9701693B2 (en) | 2011-06-27 | 2017-07-11 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| EP2890676B1 (en) | 2012-08-31 | 2018-12-05 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
| US9522883B2 (en) * | 2012-08-31 | 2016-12-20 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
| EP2890675A4 (en) | 2012-08-31 | 2016-01-13 | Alectos Therapeutics Inc | GLYCOSIDASE INHIBITORS AND USES THEREOF |
| KR20150079711A (ko) | 2012-10-31 | 2015-07-08 | 알렉토스 테라퓨틱스 인크. | 글리코시다아제 저해제 및 이의 용도 |
| ES2779006T3 (es) * | 2013-01-09 | 2020-08-13 | Amicus Therapeutics Inc | Composiciones de DNJ parenterales estables |
| AU2018278247B2 (en) | 2017-06-01 | 2022-07-28 | Idorsia Pharmaceuticals Ltd | Crystalline form of N-butyldeoxygalactonojirimycin |
| EP4034256B1 (en) | 2019-09-25 | 2025-11-19 | Assia Chemical Industries Ltd. | Solid state forms of lucerastat salts and process for preparation thereof |
| WO2022132992A1 (en) | 2020-12-16 | 2022-06-23 | Amicus Therapeutics, Inc. | Highly purified batches of pharmaceutical grade 1-deoxygalactonojirimycin compounds |
| US11623916B2 (en) | 2020-12-16 | 2023-04-11 | Amicus Therapeutics, Inc. | Highly purified batches of pharmaceutical grade migalastat and methods of producing the same |
| WO2025017212A1 (en) | 2023-07-20 | 2025-01-23 | Katholieke Universiteit Leuven | Udp-glucose ceramide glucosyltransferase synthase (ugcg) inhibitors in the treatment of cancer |
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| GB1555654A (en) | 1977-06-25 | 1979-11-14 | Exxon Research Engineering Co | Agricultural burner apparatus |
| US4065562A (en) | 1975-12-29 | 1977-12-27 | Nippon Shinyaku Co., Ltd. | Method and composition for reducing blood glucose levels |
| NO154918C (no) | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
| GB2020278B (en) | 1978-05-03 | 1983-02-23 | Nippon Shinyaku Co Ltd | Moranoline dervitives |
| EP0252962B1 (en) | 1985-12-23 | 1995-08-23 | Fred Hutchinson Cancer Research Center | Regulating retroviral replication, infection, and pathogenesis |
| US4849430A (en) | 1988-03-09 | 1989-07-18 | Monsanto Company | Method of inhibiting virus |
| US5011829A (en) * | 1989-06-02 | 1991-04-30 | G. D. Searle & Co. | Pharmaceutical composition and method of inhibiting virus |
| US5030638A (en) | 1990-02-26 | 1991-07-09 | G. D. Searle & Co. | Method of antiviral enhancement |
| WO1992000277A1 (en) | 1990-06-29 | 1992-01-09 | Nippon Shinyaku Co., Ltd. | Piperidine derivative |
| US5128347A (en) * | 1990-10-18 | 1992-07-07 | Monsanto Company | Glycosidase inhibiting 1,4-dideoxy-4-fluoronojirimycin |
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1993
- 1993-08-05 US US08/102,654 patent/US6291657B1/en not_active Expired - Lifetime
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1994
- 1994-05-11 EP EP94916021A patent/EP0698012B1/en not_active Expired - Lifetime
- 1994-05-11 WO PCT/US1994/004974 patent/WO1994026714A1/en not_active Ceased
- 1994-05-11 DK DK94916021.2T patent/DK0698012T3/da active
- 1994-05-11 AT AT94916021T patent/ATE148456T1/de not_active IP Right Cessation
- 1994-05-11 JP JP52554194A patent/JP3636363B2/ja not_active Expired - Fee Related
- 1994-05-11 DE DE69401658T patent/DE69401658T2/de not_active Expired - Fee Related
- 1994-05-11 AU AU67832/94A patent/AU6783294A/en not_active Abandoned
- 1994-05-11 CA CA002159988A patent/CA2159988C/en not_active Expired - Fee Related
- 1994-05-11 ES ES94916021T patent/ES2097653T3/es not_active Expired - Lifetime
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- 1995-03-01 US US08/396,989 patent/US5580884A/en not_active Expired - Lifetime
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- 1996-01-17 US US08/588,027 patent/US5786368A/en not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| US5786368A (en) | 1998-07-28 |
| JPH08510244A (ja) | 1996-10-29 |
| CA2159988A1 (en) | 1994-11-24 |
| DE69401658T2 (de) | 1997-06-12 |
| EP0698012B1 (en) | 1997-01-29 |
| CA2159988C (en) | 2007-01-09 |
| ATE148456T1 (de) | 1997-02-15 |
| DE69401658D1 (de) | 1997-03-13 |
| GR3022554T3 (en) | 1997-05-31 |
| US5580884A (en) | 1996-12-03 |
| US6291657B1 (en) | 2001-09-18 |
| DK0698012T3 (enExample) | 1997-02-17 |
| EP0698012A1 (en) | 1996-02-28 |
| AU6783294A (en) | 1994-12-12 |
| WO1994026714A1 (en) | 1994-11-24 |
| ES2097653T3 (es) | 1997-04-01 |
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