JP3587701B2 - Composition for moisturizing and composition for external use of skin containing the same - Google Patents
Composition for moisturizing and composition for external use of skin containing the same Download PDFInfo
- Publication number
- JP3587701B2 JP3587701B2 JP29764498A JP29764498A JP3587701B2 JP 3587701 B2 JP3587701 B2 JP 3587701B2 JP 29764498 A JP29764498 A JP 29764498A JP 29764498 A JP29764498 A JP 29764498A JP 3587701 B2 JP3587701 B2 JP 3587701B2
- Authority
- JP
- Japan
- Prior art keywords
- weight
- moisturizing
- composition
- parts
- trehalose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title claims description 62
- 230000003020 moisturizing effect Effects 0.000 title claims description 58
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 26
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 26
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 26
- 239000002537 cosmetic Substances 0.000 claims description 13
- 229930182830 galactose Natural products 0.000 claims description 13
- LKDRXBCSQODPBY-JDJSBBGDSA-N D-allulose Chemical compound OCC1(O)OC[C@@H](O)[C@@H](O)[C@H]1O LKDRXBCSQODPBY-JDJSBBGDSA-N 0.000 claims description 12
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 12
- 239000008103 glucose Substances 0.000 claims description 12
- 150000002402 hexoses Chemical class 0.000 claims description 8
- 150000002972 pentoses Chemical class 0.000 claims description 8
- 150000003625 trehaloses Chemical class 0.000 claims description 8
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims description 6
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 5
- 229910052708 sodium Inorganic materials 0.000 claims description 5
- 239000011734 sodium Substances 0.000 claims description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- 235000000346 sugar Nutrition 0.000 claims description 4
- 150000008163 sugars Chemical class 0.000 claims description 3
- 230000006698 induction Effects 0.000 claims 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 239000006210 lotion Substances 0.000 description 9
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 8
- 230000006870 function Effects 0.000 description 8
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- -1 alkylcarbonyloxy compound Chemical class 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 239000006071 cream Substances 0.000 description 6
- 235000011187 glycerol Nutrition 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 4
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 4
- 150000001720 carbohydrates Chemical class 0.000 description 4
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 4
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 4
- 229960002216 methylparaben Drugs 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 229940057995 liquid paraffin Drugs 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000004215 skin function Effects 0.000 description 3
- 150000003385 sodium Chemical class 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 206010012438 Dermatitis atopic Diseases 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 229940121375 antifungal agent Drugs 0.000 description 2
- 201000008937 atopic dermatitis Diseases 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- ASJSAQIRZKANQN-CRCLSJGQSA-N 2-deoxy-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)CC=O ASJSAQIRZKANQN-CRCLSJGQSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 241000567240 Sporobolus stapfianus Species 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- ABJKWBDEJIDSJZ-UHFFFAOYSA-N butenafine Chemical compound C=1C=CC2=CC=CC=C2C=1CN(C)CC1=CC=C(C(C)(C)C)C=C1 ABJKWBDEJIDSJZ-UHFFFAOYSA-N 0.000 description 1
- 229960002962 butenafine Drugs 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- RBHJBMIOOPYDBQ-UHFFFAOYSA-N carbon dioxide;propan-2-one Chemical compound O=C=O.CC(C)=O RBHJBMIOOPYDBQ-UHFFFAOYSA-N 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
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- 230000004064 dysfunction Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
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- 230000014759 maintenance of location Effects 0.000 description 1
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- 239000004200 microcrystalline wax Substances 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
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- 229920001282 polysaccharide Polymers 0.000 description 1
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- 229910052700 potassium Inorganic materials 0.000 description 1
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- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
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Landscapes
- Cosmetics (AREA)
Description
【０００１】
【発明の属する技術分野】
本発明は、保湿用の組成物および化粧料などに好適な皮膚外用の組成物に関する。
【０００２】
【従来の技術】
保湿作用は、皮膚などを考える上で重要な機能の一つであり、皮膚の機能の不全などが顕在化する事項の一つに皮膚の保湿作用の低下がある。更に、皮膚機能が低下した皮膚に、優れた保湿成分を含有する化粧料などの皮膚外用剤を投与することにより、皮膚機能を改善しうることは既に古来より知られている。この為、化粧料などの皮膚外用剤に於いて、保湿剤は重要な成分となっている。この様な観点から、現代に至るまで種々の保湿剤が、保湿機能の向上を目的に開発されてきた。この様な保湿剤の例としては、例えば、抱水性の高いヒアルロン酸ナトリウム、マルチトース等の糖類、ヘパリン類似物質などの多硫酸化多糖類の塩或いはトレハロースとその誘導体などが挙げられる。
【０００３】
中でも、トレハロースは復活草に含まれる糖類であって、その保湿作用は生体構造の維持能力をも備えているので、極めてユニークなものとして注目されている。このユニークな保湿性を高める手段が種々検討され、このものの水酸基を硫酸化する事が保湿機能を高めることが見出された。この様な背景技術を元に、このトレハロース類の保湿機能を更に高め、これを化粧料などの皮膚外用の組成物に含有させ、皮膚機能の改善と低下の予防に用いる技術の開発が望まれていた。
【０００４】
一方、特定の５炭糖及び６炭糖から選ばれる３種以上とトレハロース及びその誘導体から選ばれる１種乃至は２種以上とを組み合わせて保湿用の組成物とすることも、この様な保湿用の組成物を化粧料などの皮膚外用の組成物に含有させることも全く知られていなかった。
【０００５】
【課題の解決手段】
本発明は、この様な状況下為されたものであり、トレハロース類の保湿機能を高めた保湿用の組成物およびこれを含有した皮膚外用の組成物を提供することを課題とする。
【０００６】
【課題の解決手段】
本発明者らは、この様な状況に鑑みて、トレハロース類の保湿機能を高める手段を求め、鋭意研究努力を重ねた結果、少なくともグルコース、ガラクトース及びプシコースを含む５炭糖及び６炭糖から選ばれる３種以上を共存させることにより、この様な作用が得られることを見出し、発明を完成させた。以下、本発明について、実施の形態を中心に更に詳細に説明を加える。
【０００７】
【発明の実施の形態】
（１）本発明の必須成分である５炭糖、６炭糖
本発明の必須成分である、５炭糖、６炭糖としては、通常皮膚外用剤で使用されている５炭糖、６炭糖であれば特段の限定なく使用する事が出来、この様な糖類としては、例えば、グルコース、ガラクトース、ラムノース、アラビノース、プシコース、リボース、デオキシリボース等が例示できる。これらについて立体は特に問わない。これらの内、最も好ましいものは、グルコース、ガラクトース及びプシコースの３者を全て含むものである。これは、この３者を含む場合の作用が特に優れ、しかも３者を組み合わせることにより相乗効果が得られるからである。即ち、この組合せのものをトレハロース類と共に存在させることにより、トレハロース類のユニークな保湿作用を非常に高めることが出来る。これら少なくともグルコース、ガラクトース及びプシコースを含む５炭糖及び６炭糖から選ばれる３種以上は、トレハロース類に対して、０．１〜１０倍量を加えて混合することにより、本発明の保湿用の組成物が得られる。
【０００８】
（２）本発明の必須成分であるトレハロース類
本発明では、上記糖類以外にトレハロース及びその誘導体から選ばれる１種乃至は２種以上を含有することを特徴とする。これは、本発明がトレハロース類のユニークな保湿性をより向上させることを目的にしているからである。本発明で言うトレハロース誘導体とは、トレハロースの構造を維持しつつ、水酸基などの変換可能な部位を化学修飾したものを意味し、この様な誘導体としては、例えば、アセチル化物、アルキルカルボニルオキシ化物等のアシル化物、硫酸化物、燐酸化物、アルキル化物、それらの生理的に許容される塩等が例示できる。これらの内、特に好ましいものは硫酸化物及び／又はその生理的に許容される塩である。これはこのものの保湿特性が特に優れているためである。ここで、生理的に許容される塩としては、例えば、ナトリウムやカリウムのようなアルカリ金属塩、カルシウムやマグネシウムなどのアルカリ土類金属塩、アンモニウム塩、有機アミン塩、リジンやアルギニン等の塩基性アミノ酸塩が好ましく例示できる。本発明の保湿用の組成物に於いては、これらトレハロース及びその誘導体から選ばれる１種乃至は２種以上を糖類に対して０．１〜１０倍量含有することが好ましい。
【０００９】
（３）本発明の保湿用の組成物
本発明の保湿用の組成物は、上記少なくともグルコース、ガラクトース及びプシコースを含む５炭糖及び６炭糖から選ばれる３種以上とトレハロース及びその誘導体から選ばれる１種乃至は２種以上とからなることを特徴とする。本発明の保湿用の組成物は、これらの必須成分を混合することにより得られる。混合は、粉体のまま混合することもできるし、水などの可溶性溶媒に溶解させて混合し、しかる後に溶媒を減圧除去しても良い。かかる組成物は、例えばそのまま培地に加え、細胞の凍結防止用として使用することもできるし、この保湿用の組成物を化粧料や皮膚外用医薬に添加することもできる。又、上記糖類とトレハロース類を個々に化粧料等の皮膚外用の組成物に加えても実質的に同じ効果が得られるので、この様な場合も化粧料に本発明の保湿用の組成物を含有させたものとみなし、本発明の保湿用の組成物の実施に含める。
【００１０】
（４）本発明の皮膚外用の組成物
本発明の皮膚外用の組成物は、上記保湿用の組成物を含有することを特徴とする。本発明の皮膚外用の組成物としては、例えば、化粧料や洗浄料や抗真菌剤、抗炎症剤、ステロイド剤等の皮膚外用医薬組成物等が例示できる。これらの内、特に好ましいものは化粧料である。これは、特に化粧料に於いて保湿機能が品質上重要な要素であるからである。本発明の保湿用の組成物の、皮膚外用の組成物に於ける好ましい含有量は、０．０１重量％〜１０重量％であり、更に好ましくは０．０５〜５重量％である。これは、少なすぎると保湿作用が発現されない場合があり、多すぎると炎症などの好ましくない反応を引き起こす原因となる場合があるからである。本発明の、皮膚外用の組成物に於いては、これら必須成分以外に、通常皮膚外用の組成物で使用される任意成分を含有することが出来る。かかる任意成分としては、例えば、ワセリンやマイクロクリスタリンワックス等のような炭化水素類、ホホバ油やゲイロウ等のエステル類、牛脂、オリーブ油等のトリグリセライド類、セタノール、オレイルアルコール等の高級アルコール類、ステアリン酸、オレイン酸等の脂肪酸、グリセリンや１，３−ブタンジオール等の多価アルコール類、非イオン界面活性剤、アニオン界面活性剤、カチオン界面活性剤、両性界面活性剤、エタノール、カーボポール等の増粘剤、防腐剤、紫外線吸収剤、抗酸化剤、色素、粉体類等が好ましく例示できる。これらの必須成分と任意成分とを常法に従って処理することにより、本発明の組成物を製造することが出来る。
【００１１】
【実施例】
以下に、実施例を挙げて本発明について更に詳細に説明を加えるが、本発明がこれら実施例にのみ限定されないことは言うまでもない。
【００１２】
＜実施例１＞
次に示す処方に従って保湿用の組成物を製造した。即ち、処方成分を乳鉢で混合し本発明の保湿用の組成物を得た。
（保湿用の組成物１）
トレハロース ５０重量部
ガラクトース ５０重量部
（保湿用の組成物２）
トレハロース ５０重量部
グルコース ５０重量部
（保湿用の組成物３）
トレハロース ５０重量部
プシコース ５０重量部
（保湿用の組成物４）
硫酸化トレハロースナトリウム ５０重量部
ガラクトース ５０重量部
（保湿用の組成物５）
硫酸化トレハロースナトリウム ５０重量部
グルコース ５０重量部
（保湿用の組成物６）
硫酸化トレハロースナトリウム ５０重量部
プシコース ５０重量部
（保湿用の組成物７）
硫酸化トレハロースナトリウム ５０重量部
ガラクトース ２５重量部
グルコース ２５重量部
（保湿用の組成物８）
硫酸化トレハロースナトリウム ５０重量部
ガラクトース ２５重量部
プシコース ２５重量部
（保湿用の組成物９）
硫酸化トレハロースナトリウム ５０重量部
ガラクトース １６重量部
グルコース １７重量部
プシコース １７重量部
【００１３】
＜実施例２＞
ヘーラ細胞を用いて、上記保湿用の組成物の形態維持性を有する保湿作用を調べた。即ち、ヘーラ細胞を１０％ＦＢＳ加イーグルの最少培地で４８時間前培養し、ＰＢＳで２回洗浄した後、１×１０5個／ｍｌになるように希釈し、これに上記保湿用の組成物を１０ｍｇ／ｍｌ加え、保存容器に充填した後、ドライアイスアセトンで２０分間冷却し、これを３７℃のお湯で一気に戻した。このものをギムザ染色し、生細胞と死細胞の数を血球板上でカウントし、生存率を求めた。対照例はなにも加えず、比較例１は硫酸化トレハロース１０ｍｇ／ｍｌ、比較例２はガラクトース１０ｍｇ／ｍｌ、比較例３はグルコース１０ｍｇ／ｍｌ、比較例４はプシコース１０ｍｇ／ｍｌ、比較例５はガラクトース３．２ｍｇ／ｍｌ、グルコース３．４ｍｇ／ｍｌ、プシコース３．４ｍｇ／ｍｌ加えたものを用いた。結果を表１に示す。これより、本発明の保湿用の組成物９を加えたものは、他の保湿用の組成物と比較しても、保湿用の組成物の形態維持性のために生存率が向上していることがわかる。
【００１４】
【表１】
＜参考例１〜８及び実施例３＞
以下に示す処方に従って、化粧水を作成した。即ち、処方成分を室温で攪拌可溶化し化粧水を得た。このものを１群５匹の雄性モルモットのテープストリッピングした背部に０．０２ｍｌ塗布し、３日後の皮膚の状態を観察し、＋＋（評点２）：痂皮形成、＋（評点１）：炎症を認める、±（評点０．５）：僅かに炎症を認める、−（評点０）：正常の基準で評価した。この結果を平均評点として表２に示す。これより、本発明の保湿用の組成物９を配合した実施例３の化粧水は、他の保湿組成物を配合した参考例１〜８の化粧水と比較して、保湿作用により、損傷面を保護する作用に優れることがわかる。
１，３−ブタンジオール ７ 重量部
グリセリン ３ 重量部
エタノール １０ 重量部
ＰＯＥ（６０）硬化ひまし油 ０．１重量部
メチルパラベン ０．２重量部
保湿用の組成物＊ １ 重量部
水 ７８．７重量部
【００１６】
【表２】
＜実施例４＞
実施例３の化粧水を用いて、肌荒れに悩む人を対象に使用テストを行った。比較例として、比較例６、１０の化粧水を用いた。３０名の全パネラーは無作為に１０名づつ３群に群分けし、第１群には実施例３の化粧水を、第２群には比較例６の化粧水を、第３群には比較例１０の化粧水をそれぞれ１カ月使用してもらい、肌荒れの改善を＋＋：非常に改善、＋：明らかに改善、±：僅かに改善、−：改善なしの基準で評価してもらった。結果を出現例数として、表３に示す。これより、本発明の化粧料は肌荒れの改善作用に優れることがわかる。
【００１８】
【表３】
＜実施例５＞
下記に示す処方に従って、クリームを作成した。即ち、イ、ロ、ハ、ニのそれぞれの成分を７０℃に加熱し、イとロを混合し、良く混練りし、これをハを加えて希釈し、これにニを徐々に加え乳化し、攪拌冷却し、クリームを得た。このものは、アトピー性皮膚炎に優れた作用を示した。
イ
７０％マルチトース水溶液 ５ 重量部
グリセリン ３ 重量部
保湿用の組成物９ ０．５重量部
・ ３−ブタンジオール ５ 重量部
メチルパラベン ０．２重量部
ロ
トリグリセリンジイソステアレート ４ 重量部
ソルビタンセスキオレート ０．５重量部
ハ
軽質イソパラフィン １０ 重量部
流動パラフィン １０ 重量部
グリセリルトリイソオクタネート ５ 重量部
ニ
水 ５６．３重量部
硫酸化トレハロース ０．５重量部
【００２０】
＜実施例６＞
下記に示す処方に従って、クリームを作成した。即ち、イ、ロ、ハ、ニのそれぞれの成分を７０℃に加熱し、イとロを混合し、良く混練りし、これをハを加えて希釈し、これにニを徐々に加え乳化し、攪拌冷却し、クリームを得た。このものは、アトピー性皮膚炎に優れた作用を示した。
イ
７０％マルチトース水溶液 ５ 重量部
グリセリン ３ 重量部
保湿用の組成物９ ０．５ 重量部
１，３−ブタンジオール ５ 重量部
メチルパラベン ０．２ 重量部
インドメタシン １ 重量部
ロ
トリグリセリンジイソステアレート ４ 重量部
ソルビタンセスキオレート ０．５ 重量部
ハ
軽質イソパラフィン １０ 重量部
流動パラフィン １０ 重量部
グリセリルトリイソオクタネート ５ 重量部
ニ
水 ５５．３ 重量部
硫酸化トレハロース ０．５ 重量部
【００２１】
＜実施例７＞
下記に示す処方に従って、クリームを作成した。即ち、イ、ロ、ハ、ニのそれぞれの成分を７０℃に加熱し、イとロを混合し、良く混練りし、これをハを加えて希釈し、これにニを徐々に加え乳化し、攪拌冷却し、クリームを得た。このものは、抗真菌症の治療効果のみならず、真菌により爛れた皮膚を修復する作用をも有していた。
イ
７０％マルチトース水溶液 ５ 重量部
グリセリン ３ 重量部
保湿用の組成物９ ０．５重量部
１，３−ブタンジオール ５ 重量部
メチルパラベン ０．２重量部
ブテナフィン １ 重量部
ロ
トリグリセリンジイソステアレート ４ 重量部
ソルビタンセスキオレート ０．５重量部
ハ
軽質イソパラフィン １０ 重量部
流動パラフィン １０ 重量部
グリセリルトリイソオクタネート ５ 重量部
ニ
水 ５５．３重量部
硫酸化トレハロース ０．５重量部
【００２２】
【発明の効果】
本発明によれば、トレハロース類の保湿機能を高めた保湿用の組成物およびこれを含有した皮膚外用の組成物を提供することができる。[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to compositions and cosmetic, etc. In the preferred composition for outer skin moisturizing.
[0002]
[Prior art]
The moisturizing effect is one of the important functions in considering the skin and the like, and one of the items where the dysfunction of the skin becomes apparent is a decrease in the moisturizing effect of the skin. Furthermore, it has been known from ancient times that skin function can be improved by administering a skin external preparation such as a cosmetic containing an excellent moisturizing component to skin with reduced skin function. For this reason, humectants are important components in skin external preparations such as cosmetics. From such a viewpoint, various moisturizing agents have been developed for the purpose of improving the moisturizing function up to the present day. Examples of such humectants include sugars such as sodium hyaluronate and maltose, which have high hydration, salts of polysulfated polysaccharides such as heparin-like substances, and trehalose and its derivatives.
[0003]
Among them, trehalose is a saccharide contained in the resurrection grass, and its moisturizing action also has the ability to maintain the biological structure, and thus has been attracting attention as an extremely unique substance. Various means for enhancing this unique moisturizing property have been studied, and it has been found that sulfating a hydroxyl group of the means enhances the moisturizing function. Based on such background technology, it is desired to develop a technique for further enhancing the moisturizing function of the trehalose, including the trehalose in a composition for external use of the skin such as cosmetics, and improving and preventing the skin function from decreasing. I was
[0004]
On the other hand, a composition for moisturizing may be prepared by combining three or more selected from specific pentose and hexose and one or two or more selected from trehalose and its derivatives. It has not been known at all to include a composition for skin use in a composition for external use such as cosmetics.
[0005]
[Means for solving the problem]
The present invention has been made under such circumstances, and it is an object of the present invention to provide a moisturizing composition having an enhanced moisturizing function of trehalose and an external skin composition containing the same.
[0006]
[Means for solving the problem]
In view of such circumstances, the present inventors have sought a means for enhancing the moisturizing function of trehalose, and as a result of intensive research efforts, selected from pentose and hexose containing at least glucose, galactose and psicose. by the coexistence of 3 or more elements, it found that such effect is obtained, thereby completing the invention. Hereinafter, the present invention will be described in more detail focusing on embodiments.
[0007]
BEST MODE FOR CARRYING OUT THE INVENTION
(1) Pentose and hexose which are essential components of the present invention The pentose and hexose which are essential components of the present invention include pentose and hexose which are commonly used in skin external preparations. Any sugar can be used without any particular limitation. Examples of such sugars include glucose, galactose, rhamnose, arabinose, psicose, ribose, deoxyribose and the like. These stereoscopic is not a particular limitation. Of these, most preferred are those containing glucose and 3 who galactose and psicose all. This effect is particularly excellent in the case of including the three parties, yet because synergistic effects are obtained by combining the three parties. That is, the unique moisturizing action of the trehalose can be greatly enhanced by the presence of this combination together with the trehalose. At least three kinds selected from pentose and hexose containing glucose, galactose and psicose are added to the trehalose in an amount of 0.1 to 10 times and mixed to obtain the moisturizing agent of the present invention. Is obtained.
[0008]
(2) Trehalose which is an essential component of the present invention The present invention is characterized in that it contains one or two or more selected from trehalose and derivatives thereof in addition to the above saccharide. This is because the object of the present invention is to further improve the unique moisturizing properties of trehalose. The trehalose derivative referred to in the present invention means a compound obtained by chemically modifying a convertible site such as a hydroxyl group while maintaining the structure of trehalose. Examples of such a derivative include an acetylated product, an alkylcarbonyloxy compound and the like. Acylated, sulfated, phosphoric, alkylated, and physiologically acceptable salts thereof. Of these, particularly preferred are sulfates and / or their physiologically acceptable salts. This is because the moisturizing properties are particularly excellent. Here, physiologically acceptable salts include, for example, alkali metal salts such as sodium and potassium, alkaline earth metal salts such as calcium and magnesium, ammonium salts, organic amine salts, and basic salts such as lysine and arginine. Preferred examples are amino acid salts. In the composition for moisturizing of the present invention, it is preferable that one or two or more selected from these trehalose and derivatives thereof are contained in an amount of 0.1 to 10 times the amount of the saccharide.
[0009]
(3) Moisturizing composition of the present invention The moisturizing composition of the present invention is selected from trehalose and its derivatives, at least three of pentose and hexose containing at least glucose, galactose and psicose. And one or more of the above. The moisturizing composition of the present invention can be obtained by mixing these essential components. The powder may be mixed as it is, or may be dissolved in a soluble solvent such as water and mixed, and then the solvent may be removed under reduced pressure. Such compositions, for example, as it is added to the medium, to as a freezing prevention of cell can be used, can also be added to the composition for the moisturizing in cosmetics and skin external medicines. Also, the same effect can be obtained by adding the above saccharide and trehalose individually to a composition for external use such as a cosmetic, so that in such a case, the composition for moisturizing of the present invention is added to the cosmetic. And included in the practice of the moisturizing composition of the present invention.
[0010]
(4) The composition for external use of the skin of the present invention The composition for external use of the skin of the present invention contains the above-mentioned composition for moisturizing. Examples of the composition for external use of the skin of the present invention include cosmetic compositions and cleaning agents, and pharmaceutical compositions for external use of the skin such as antifungal agents, anti-inflammatory agents, and steroid agents. Of these, cosmetics are particularly preferred. This is because the moisturizing function is an important factor in quality, especially in cosmetics. The preferred content of the moisturizing composition of the present invention in the composition for external use on the skin is from 0.01% by weight to 10% by weight, more preferably from 0.05 to 5% by weight. This is because if the amount is too small, the moisturizing effect may not be exhibited, and if the amount is too large, it may cause an undesirable reaction such as inflammation. In the composition for external use of the skin of the present invention, in addition to these essential components, optional components usually used in the composition for external use of the skin can be contained. Such optional components include, for example, hydrocarbons such as petrolatum and microcrystalline wax, esters such as jojoba oil and gay wax, triglycerides such as tallow, olive oil, higher alcohols such as cetanol and oleyl alcohol, and stearic acid. Fatty acids such as oleic acid, polyhydric alcohols such as glycerin and 1,3-butanediol, nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, ethanol, carbopol, etc. Preferred examples include a tackifier, a preservative, an ultraviolet absorber, an antioxidant, a pigment, and powders. And these essential components and optional components by processing according to a conventional method, it is possible to produce a composition of the present invention.
[0011]
【Example】
Hereinafter, the present invention will be described in more detail with reference to Examples, but it goes without saying that the present invention is not limited to these Examples.
[0012]
<Example 1>
A moisturizing composition was produced according to the following formulation. That is, the ingredients were mixed in a mortar to obtain the moisturizing composition of the present invention.
(Composition 1 for moisturizing)
Trehalose 50 parts by weight Galactose 50 parts by weight (moisturizing composition 2)
Trehalose 50 parts by weight Glucose 50 parts by weight (composition 3 for moisturizing)
Trehalose 50 parts by weight Psicose 50 parts by weight (composition 4 for moisturizing)
50 parts by weight of sulfated trehalose sodium 50 parts by weight of galactose (moisturizing composition 5)
50 parts by weight of sulfated trehalose sodium 50 parts by weight of glucose (composition 6 for moisturizing)
Sulfated sodium trehalose 50 parts by weight Psicose 50 parts by weight (moisturizing composition 7)
50 parts by weight of sulfated sodium trehalose 25 parts by weight of galactose 25 parts by weight of glucose (composition 8 for moisturizing)
Sulfated sodium trehalose 50 parts by weight Galactose 25 parts by weight Psicose 25 parts by weight (moisturizing composition 9)
Sodium sulfated trehalose 50 parts by weight galactose 16 parts by weight glucose 17 parts by weight psicose 17 parts by weight
<Example 2>
Using a Hera cell, the moisturizing effect of the above moisturizing composition having a shape-maintaining property was examined. That is, the Hera cells were pre-cultured for 48 hours in the minimum medium of Eagle supplemented with 10% FBS, washed twice with PBS, and then diluted to 1 × 10 5 cells / ml. Was added to a storage container, and the mixture was cooled with dry ice acetone for 20 minutes, and returned at a stretch with hot water at 37 ° C. This was stained with Giemsa, and the number of live cells and dead cells was counted on a blood cell plate to determine the survival rate. No control was added, Comparative Example 1 was 10 mg / ml sulfated trehalose, Comparative Example 2 was 10 mg / ml galactose, Comparative Example 3 was 10 mg / ml glucose, Comparative Example 4 was 10 mg / ml psicose, and Comparative Example 5 Used 3.2 mg / ml of galactose, 3.4 mg / ml of glucose, and 3.4 mg / ml of psicose. Table 1 shows the results. From this, the addition of the moisturizing composition 9 of the present invention has an improved survival rate due to the form retention of the moisturizing composition, as compared with other moisturizing compositions . You can see that.
[0014]
[Table 1]
< Reference Examples 1 to 8 and Example 3 >
A lotion was prepared according to the following prescription. That is, the ingredients were stirred and solubilized at room temperature to obtain a lotion. 0.02 ml of this was applied to the back of a group of 5 male guinea pigs tape-stripped, and the state of the skin after 3 days was observed. ++ (score 2): crust formation, + (score 1): inflammation Recognized, ± (score 0.5): slight inflammation was observed,-(score 0): evaluated based on normal criteria. The results are shown in Table 2 as average scores. Accordingly, the lotion of Example 3 in which the moisturizing composition 9 of the present invention was blended was compared with the lotions of Reference Examples 1 to 8 in which the other moisturizing compositions were blended, by the moisturizing action, the damaged surface was damaged. It can be seen that it is excellent in the effect of protecting.
1,3-butanediol 7 parts by weight glycerin 3 parts by weight ethanol 10 parts by weight POE (60) hydrogenated castor oil 0.1 part by weight Methyl paraben 0.2 part by weight Composition for moisturizing * 1 part by weight Water 78.7 parts by weight [ 0016
[Table 2]
<Example 4 >
Using the lotion of Example 3 , a use test was conducted for persons suffering from rough skin. As comparative examples, the lotions of Comparative Examples 6 and 10 were used. All 30 panelists were randomly divided into 3 groups of 10 persons, the first group containing the lotion of Example 3 , the second group the lotion of Comparative Example 6, and the third group. Each of the lotions of Comparative Example 10 was used for one month, and the improvement of the rough skin was evaluated on the basis of ++: extremely improved, +: clearly improved, ±: slightly improved,-: no improvement. Table 3 shows the results as the number of appearance cases. This indicates that the cosmetic of the present invention is excellent in the effect of improving skin roughness.
[0018]
[Table 3]
<Example 5 >
A cream was prepared according to the following recipe. That is, each component of A, B, C, and D is heated to 70 ° C., and B and B are mixed and kneaded well, and the mixture is diluted by adding C, and D is gradually added and emulsified. After stirring and cooling, a cream was obtained. This showed an excellent effect on atopic dermatitis.
A 70% maltose aqueous solution 5 parts by weight glycerin 3 parts by weight Moisturizing composition 9 0.5 part by weight 3-butanediol 5 parts by weight methyl paraben 0.2 parts by weight rotriglycerin diisostearate 4 parts by weight sorbitan sesquiolate 0 0.5 parts by weight Light isoparaffin 10 parts by weight Liquid paraffin 10 parts by weight glyceryl triisooctanoate 5 parts by weight Dish water 56.3 parts by weight Sulfated trehalose 0.5 parts by weight
<Example 6 >
A cream was prepared according to the following recipe. That is, each component of A, B, C, and D is heated to 70 ° C., and B and B are mixed and kneaded well, and the mixture is diluted by adding C, and D is gradually added and emulsified. After stirring and cooling, a cream was obtained. This showed an excellent effect on atopic dermatitis.
A 70% maltose aqueous solution 5 parts by weight glycerin 3 parts by weight Moisturizing composition 9 0.5 parts by weight 1,3-butanediol 5 parts by weight methyl paraben 0.2 parts by weight indomethacin 1 part by weight rotriglycerin diisostearate 4 parts by weight Parts by weight sorbitan sesquiolate 0.5 parts by weight light isoparaffin 10 parts by weight liquid paraffin 10 parts by weight glyceryl triisooctate 5 parts by weight 55.3 parts by weight sulfated trehalose 0.5 parts by weight
<Example 7 >
A cream was prepared according to the following recipe. That is, each component of A, B, C, and D is heated to 70 ° C., and B and B are mixed and kneaded well, and the mixture is diluted by adding C, and D is gradually added and emulsified. After stirring and cooling, a cream was obtained. This product not only has an antifungal therapeutic effect, but also has an effect of repairing the skin that has been soaked by fungi.
A 70% aqueous solution of maltose 5 parts by weight glycerin 3 parts by weight Composition 9 for moisturizing 9 0.5 parts by weight 1,3-butanediol 5 parts by weight methyl paraben 0.2 parts by weight butenafine 1 part by weight rotriglycerin diisostearate 4 parts by weight Parts by weight Sorbitan sesquiolate 0.5 parts by weight Light isoparaffin 10 parts by weight Liquid paraffin 10 parts by weight Glyceryl triisooctate 5 parts by weight Dish water 55.3 parts by weight Sulfated trehalose 0.5 parts by weight
【The invention's effect】
ADVANTAGE OF THE INVENTION According to this invention, the composition for moisturizing which improved the moisturizing function of trehalose, and the composition for external use of the skin containing this can be provided.
Claims (4)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29764498A JP3587701B2 (en) | 1998-10-05 | 1998-10-05 | Composition for moisturizing and composition for external use of skin containing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29764498A JP3587701B2 (en) | 1998-10-05 | 1998-10-05 | Composition for moisturizing and composition for external use of skin containing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000109419A JP2000109419A (en) | 2000-04-18 |
| JP3587701B2 true JP3587701B2 (en) | 2004-11-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP29764498A Expired - Lifetime JP3587701B2 (en) | 1998-10-05 | 1998-10-05 | Composition for moisturizing and composition for external use of skin containing the same |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4034509B2 (en) * | 2000-10-30 | 2008-01-16 | 株式会社資生堂 | Skin cosmetics |
| JP2002161031A (en) * | 2000-11-27 | 2002-06-04 | Noevir Co Ltd | Skin care preparation |
| DE10124475A1 (en) * | 2001-05-19 | 2002-11-21 | Beiersdorf Ag | Cosmetic or dermatological composition containing ketohexose, useful for treating e.g. inflammation, pigment disorders, and skin aging, promotes barrier function |
| EP2364710B1 (en) * | 2002-05-22 | 2018-11-28 | National University Corporation Kagawa University | Therapeutic use of D-allose |
| JP2004026770A (en) * | 2002-06-28 | 2004-01-29 | Milbon Co Ltd | First agent for correcting curly hair and method for correcting treatment of curly hair using the same |
| JP7076695B2 (en) * | 2015-08-12 | 2022-05-30 | 株式会社セレーネ | Skin function improving composition containing D-psicose as an active ingredient |
| KR102282246B1 (en) | 2020-10-27 | 2021-07-27 | 쿼럼바이오 주식회사 | Composition for preventing, alleviating, or treating atopic dermatitis |
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1998
- 1998-10-05 JP JP29764498A patent/JP3587701B2/en not_active Expired - Lifetime
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| JP2000109419A (en) | 2000-04-18 |
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