JP3513859B2 - 神経糸状タンパク質遺伝子発現およびアルツハイマー病の検出 - Google Patents

神経糸状タンパク質遺伝子発現およびアルツハイマー病の検出

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Publication number
JP3513859B2
JP3513859B2 JP52355694A JP52355694A JP3513859B2 JP 3513859 B2 JP3513859 B2 JP 3513859B2 JP 52355694 A JP52355694 A JP 52355694A JP 52355694 A JP52355694 A JP 52355694A JP 3513859 B2 JP3513859 B2 JP 3513859B2
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JP
Japan
Prior art keywords
ntp
seq
nucleic acid
protein
sequence
Prior art date
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Expired - Fee Related
Application number
JP52355694A
Other languages
English (en)
Japanese (ja)
Other versions
JPH08509808A (ja
Inventor
デ・ラ・モンテ，スザンヌ・エム
ワンズ，ジャック・アール
Original Assignee
ザ・ジェネラル・ホスピタル・コーポレーション
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Publication of JPH08509808A publication Critical patent/JPH08509808A/ja
Application granted granted Critical
Publication of JP3513859B2 publication Critical patent/JP3513859B2/ja
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Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/474—Pancreatic thread protein; Reg protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Physics & Mathematics (AREA)
JP52355694A 1993-04-20 1994-04-20 神経糸状タンパク質遺伝子発現およびアルツハイマー病の検出 Expired - Fee Related JP3513859B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5055993A 1993-04-20 1993-04-20
US08/050,559 1993-04-20
PCT/US1994/004321 WO1994023756A1 (en) 1993-04-20 1994-04-20 Neural thread protein gene expression and detection of alzheimer's disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2003343063A Division JP2004097227A (ja) 1993-04-20 2003-10-01 神経糸状タンパク質遺伝子発現およびアルツハイマー病の検出

Publications (2)

Publication Number Publication Date
JPH08509808A JPH08509808A (ja) 1996-10-15
JP3513859B2 true JP3513859B2 (ja) 2004-03-31

Family

ID=21965952

Family Applications (2)

Application Number Title Priority Date Filing Date
JP52355694A Expired - Fee Related JP3513859B2 (ja) 1993-04-20 1994-04-20 神経糸状タンパク質遺伝子発現およびアルツハイマー病の検出
JP2003343063A Pending JP2004097227A (ja) 1993-04-20 2003-10-01 神経糸状タンパク質遺伝子発現およびアルツハイマー病の検出

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2003343063A Pending JP2004097227A (ja) 1993-04-20 2003-10-01 神経糸状タンパク質遺伝子発現およびアルツハイマー病の検出

Country Status (11)

Country Link
EP (2) EP1564293B9 (enExample)
JP (2) JP3513859B2 (enExample)
KR (1) KR100392244B1 (enExample)
AT (2) ATE406444T1 (enExample)
CA (1) CA2161097A1 (enExample)
DE (2) DE69435136D1 (enExample)
DK (2) DK0697893T3 (enExample)
ES (2) ES2255054T3 (enExample)
NZ (1) NZ266072A (enExample)
PT (1) PT1564293E (enExample)
WO (1) WO1994023756A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5804560A (en) * 1995-01-06 1998-09-08 Sibia Neurosciences, Inc. Peptide and peptide analog protease inhibitors
US5936078A (en) * 1995-12-12 1999-08-10 Kyowa Hakko Kogyo Co., Ltd. DNA and protein for the diagnosis and treatment of Alzheimer's disease
AU1110297A (en) * 1995-12-12 1997-07-03 Kyowa Hakko Kogyo Co. Ltd. Novel dnas, novel polypeptides and novel antibodies
AU749348B2 (en) 1997-02-26 2002-06-27 General Hospital Corporation, The Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's disease
US7226730B1 (en) 1997-02-26 2007-06-05 The General Hospital Corporation Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's Disease
JP2001514663A (ja) 1997-03-12 2001-09-11 エスモンド，ロバート ダブリュー． アルツハイマー病を処置または予防するための方法
EP1541166B1 (en) * 2001-05-16 2007-12-19 Nymox Corporation Preventing cell death using segments of neural thread proteins
JP2004529179A (ja) 2001-05-16 2004-09-24 ナイモックス コーポレーション 神経線維タンパク質のセグメントを使用する細胞死の予防法
US6770797B2 (en) 2001-06-01 2004-08-03 Rhode Island Hospital Non-Transgenic nonhuman model for Alzheimer's Disease using a AD7c-NTP nucleic acid
EP1714979A3 (en) * 2001-11-16 2007-04-25 Nymox Corporation Peptides effective in the treatment of tumors and other conditions requiring the removal or destruction of cells
US7317077B2 (en) 2001-11-16 2008-01-08 Nymox Pharmaceutical Corporation Peptides effective in the treatment of tumors and other conditions requiring the removal or destruction of cells
PL1994152T3 (pl) * 2006-02-28 2013-05-31 Nymox Corp Peptydy skuteczne w leczeniu nowotworów i innych stanów wymagających usunięcia lub zniszczenia komórek
US20080027005A1 (en) * 2006-07-31 2008-01-31 Paul Averback Peptides effective in the treatment of tumors and other conditions requiring the removal or destruction of cells
US11628202B2 (en) 2015-07-24 2023-04-18 Nymox Corporation Methods of reducing the need for surgery in patients suffering from benign prostatic hyperplasia
US10183058B2 (en) 2016-06-17 2019-01-22 Nymox Corporation Method of preventing or reducing the progression of prostate cancer
US10172910B2 (en) 2016-07-28 2019-01-08 Nymox Corporation Method of preventing or reducing the incidence of acute urinary retention
US10532081B2 (en) 2016-09-07 2020-01-14 Nymox Corporation Method of ameliorating or preventing the worsening or the progression of symptoms of BPH
US10335453B2 (en) 2017-03-01 2019-07-02 Nymox Corporation Compositions and methods for improving sexual function
JP2025516554A (ja) * 2022-05-10 2025-05-30 エフ． ホフマン－ラ ロシュ アーゲー Ｃｆｐ－ｅｌｋ１遺伝子間領域を標的とするアンチセンスオリゴヌクレオチド
WO2024227045A1 (en) * 2023-04-27 2024-10-31 Siemens Healthcare Diagnostics Inc. High-sensitivity assay for serum neurofilament light chain cross reference to related applications

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0378924B1 (en) * 1988-12-21 1996-11-13 The General Hospital Corporation Detection of neurological disease or dysfunction

Also Published As

Publication number Publication date
PT1564293E (pt) 2008-12-02
EP1564293A1 (en) 2005-08-17
EP0697893B1 (en) 2005-12-07
ES2255054T3 (es) 2006-06-16
EP1564293B9 (en) 2009-08-19
EP0697893A4 (en) 1996-12-18
JP2004097227A (ja) 2004-04-02
EP0697893A1 (en) 1996-02-28
AU6666994A (en) 1994-11-08
ES2312913T3 (es) 2009-03-01
WO1994023756A1 (en) 1994-10-27
AU674581B2 (en) 1997-01-02
DE69434844D1 (de) 2006-10-19
DE69435136D1 (de) 2008-10-09
DE69434844T2 (de) 2006-12-14
DK0697893T3 (da) 2006-02-20
EP1564293B1 (en) 2008-08-27
DK1564293T3 (da) 2009-01-12
ATE312348T1 (de) 2005-12-15
JPH08509808A (ja) 1996-10-15
KR100392244B1 (ko) 2003-11-28
CA2161097A1 (en) 1994-10-27
NZ266072A (en) 1997-07-27
ATE406444T1 (de) 2008-09-15

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