JP3496625B2 - Health food composition - Google Patents

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a health food composition capable of maintaining daily health and further preventing and treating lifestyle-related diseases. [0002] Conventionally, many health foods that alleviate specific symptoms or symptoms of diseases or act preventively have been known. However, there is no known health food that can increase the homeostasis of the whole body and can sufficiently promote health and prevent / treat lifestyle-related diseases. Propolis is a dendritic substance collected from honeycomb, but contains flavonoids, organic acids such as p-coumaric acid and cinnamic acid and esters thereof, various minerals, vitamins, etc. It is known to have an oxidizing action, an anticancer action and the like. Such propolis has been traditionally used for the prevention and treatment of specific diseases. [0004] Such propolis is effective against specific symptoms and diseases such as cancer,
It contributes to health promotion by improving the homeostasis of the whole body, and cannot prevent or treat lifestyle-related diseases such as hypertension, diabetes, heart disease and liver disease that are serious for modern people. [0005] By taking a combination of echinacea and propolis together, the present inventors have synergistically obtained effects that were not exhibited when each was taken alone, promoting health and life. The present inventors have obtained knowledge that prevention / treatment of habitual diseases can be achieved, and have reached the present invention. The present invention relates to propolis , echinacea and
Containing himematsutake, propolis and echinacea
Compounding ratio of 3: 1 to 1: Ru der provides a health food composition is 3. Himematsutake is its extract
Yes. The health food composition of the present invention can be made into capsules such as tablets or soft capsules. Echinacea is known to have an effect of enhancing immunity, but when taken in combination with propolis,
It is not known that it synergistically increases the homeostasis of the whole body and is effective in promoting health and preventing / treating lifestyle-related diseases. DETAILED DESCRIPTION OF THE INVENTION The present invention is described in detail below. (Propolis) The propolis used in the present invention may be an ordinary propolis or an extract thereof, and the production area, production method and the like are not particularly limited. Propolis extract is obtained from ethanol, water,
It can extract by a well-known method, using glycerol etc. as an extraction solvent. The obtained extract may be further purified by removing precipitates. Further, it may be a concentrate obtained by concentrating this extraction liquid or a dried product, or it may be mixed with an excipient such as dextrin, anhydrous crystalline maltose, starch or the like in the form of a powder. When powdered with an excipient, the ratio of the excipient to the extract (excipient: extract) is preferably 5: 1 to 1: 2. (Echinacea) The component derived from Echinacea used in the present invention is Echinaceapurpu, a chrysanthemum plant.
rea, Echinacea pallida, Echinacea angustifolia, Ec
hinacea simulata, Echinacea paradoxa or Echinacea
atrorubens whole plant or stem or root dry powder, juice or extract with various extraction solvents such as water, ethanol and the like. As in the case of the propolis extract, this extract may be further purified, concentrated and dried, or may be powdered. When an excipient is used for pulverization, the usage ratio of the excipient and the extract is the same as described above. The blending ratio of propolis and echinacea is:
Propolis: echinacea = 10: 1 to 1:10 is suitable, but desirably propolis: echinacea = 3: 1
1: 3. (Other additive components) The food composition of the present invention further includes himematsutake, ganoderma, silymarin, lactic acid bacteria,
You may mix | blend suitably other health food materials, such as a bifidobacterium, suitably. In particular, Agaricus blazei m
(urrill) fruit bodies and mycelium are extracted with hot water,
It has been reported to have antitumor activity. This extract may be purified, concentrated and dried as described above, or may be powdered. The ratio of the excipient and the extract used in pulverization is the same as described above. In the case of adding the matsutake mushroom extract, it is preferable to add the himematsutake extract in an amount of 10% by weight or more based on the total amount of the mixture of propolis and echinacea. By using this extract in combination, the immunostimulatory effect can be further enhanced and the homeostasis of the whole body can be maintained. (Encapsulation) The food composition of the present invention can be provided in various appropriate dosage forms such as tablets, capsules, beverages, troches, chewables and gums, and capsules and tablets are particularly preferred. Propolis originally emits an unpleasant odor, but it can be improved to such an extent that an unpleasant odor does not matter by processing it into a soft capsule by a known method using an appropriate film such as gelatin. In soft capsules, since the raw material does not come into direct contact with oxygen, the deterioration due to oxidation of the components is less than that of tablets, and the quality retention time after production can be extended, which is most desirable as a food form using propolis. For producing such soft capsules, a known raw material for soft capsule film (for example, gelatin: glycerol: purified water = 42: 18: 40) is used in an amount of 60 to 65.
Dissolve by warming at 0 ° C and prepare according to conventional methods. The contents of the soft capsule may be an extract liquid concentrate, a dried solid product, a powdered product, or these may be dispersed in a dispersion medium such as edible oil or beeswax. In order to prepare a soft capsule content liquid in which an active ingredient is dispersed in the dispersion medium, these raw materials are mixed and then mixed.
The mixture is heated at 5 to 75 ° C., stirred and dissolved, degassed under reduced pressure, and then cooled and prepared. Using the content liquid prepared in this way, for example, using a rotary soft capsule manufacturing apparatus, various soft capsules such as a tear mold according to a conventional method,
Other capsules can be produced. Examples of edible oils and fats used for the dispersion medium include safflower oil, soybean oil, sesame oil and the like, and safflower oil is particularly preferable. The compounding amount of the active ingredient in the capsule content is 1
It is 5 to 40% by weight, preferably 20 to 35% by weight.
In addition, the total content of propolis and echinacea in one capsule is 40 to 160 mg, preferably 80 to
120 mg. (Tablets) In the food composition of the invention, it is desirable to tablet each of the powdered components or, if necessary, granulated components, and take them without chewing them in the mouth. Since propolis has a peculiar smell that is unpleasant, tablets are preferably provided with a shellac coat or sugar coating. Alternatively, only a strong odor propolis component may be processed into a microcapsule and then processed into a tablet. Any known tableting method may be used to make the health food composition of the present invention into a tablet form. That is, propolis powder and echinacea powder, and if necessary, himematsutake powder, further excipients, sweeteners,
Appropriate additive components such as a fragrance, a colorant, and a lubricant are added, and a health food composition in the form of a tablet can be obtained using a known tableting machine. The compounding amount of the active ingredient in such tablets is 20-8.
0% by weight, preferably 40 to 60% by weight. As the excipient, powdered reduced maltose, lactose, crystalline cellulose and the like are used, and the excipient content in the tablet is 20 to 80% by weight, preferably 40 to 60% by weight. A lubricant is usually used for the tablet, and a sucrose fatty acid ester is generally used as the lubricant. The blending amount of the lubricant in the tablet is 1 to 5% by weight, preferably 2 to 4% by weight. Next, the present invention will be described more specifically with reference to examples. [Example 1] A questionnaire survey was conducted with 30 volunteers taking the soft capsule samples shown in Table 1 (4 capsules daily) for one year. The results are shown in Table 2. [Table 1] [Table 2] [Example 2] Table 3 shows the composition of the contents of the soft capsules used in the test. The raw materials were mixed uniformly while heating, and processed into a capsule shape with a gelatin film. [Table 3] Thirty healthy adults are randomly divided into three groups,
For two months from December in winter, the test products B, C, and D were each ingested by 6 capsules of 6 capsules per day. After the test, we conducted a questionnaire survey about the epidemic cold,
The results of Table 4 were obtained. [Table 4] The results are shown in terms of the total number of applicable items.
As shown in Table 4, it was confirmed that the test product B combining propolis and echinacea had fewer people who complained of symptoms of epidemic cold than the test product C using propolis alone or the test product D using echinacea alone. [Example 3] The results of examining the antihypertensive effect are shown. Twenty-four 15-week-old male hypertensive rats (SHR) were preliminarily raised for one week using a standard diet, and then body weight and blood pressure were measured. . The standard feed used was SP manufactured by Funabashi Farm. Table 5 shows the results of ingesting the experimental feed for each group for 8 weeks and examining the blood pressure every 2 weeks. [Table 5] There were no significant differences in food intake or body weight between the groups. The blood pressure was measured using a tail artery pressure measuring device (UR1000, UEDA) without anesthesia. At 6th and 8th weeks, significant suppression of blood pressure increase was observed in the propolis / echinacea combination group. [Example 4] The raw materials shown in Table 6 were uniformly mixed and processed into tablets using a tableting machine. Tableting may be performed after granulation as necessary, and shellac coat or sugar coating may be applied to the tablet. [Table 6] [Example 5] Table 7 shows the results of examining the leukemia inhibitory effect. Sixty 5-week-old AKR / J mice that spontaneously develop leukemia associated with thymic lymphoma formation were preliminarily raised on a standard diet for 1 week, and then divided into 5 groups as 12 mice per group so that their body weights were equal. After ingesting experimental samples in each group, the number of dead individuals was observed over 48 weeks. Each feed was fed ad libitum. [Table 7] The mortality rate of 100% was 4 weeks later in the propolis group than in the control group, and 6% in the echinacea group.
Late in the week, 10 weeks later in the propolis / echinacea combination group, 12 in the propolis / echinacea / himematsutake group
The result was a week later. From these results, propolis /
It can be seen that the combination of echinacea or the combination of propolis / echinacea / himematsutake has the effect of delaying the onset of leukemia. [Example 6] The results of examining the effect of improving liver function are shown in Table 9 below. Twelve volunteers who were in the course of observing the progress of liver function were continuously ingested 6 tablets a day for 2 months with the tablet test products shown in Table 8 containing propolis extract powder, echinacea extract powder, and himematsutake extract powder. Blood was collected before and after ingestion, and the effect of improving the liver function index in serum was examined (Table 9). AST and ALT were measured by ultraviolet absorption photometry, and γ-GTP was measured by L-γ-glutamyl-p-nitroanilide substrate method. [Table 8] [Table 9] A significant decrease in AST and ALT of the liver function index was observed, and a tendency for γ-GTP to decrease was observed. The health food of the present invention contributes to the promotion of health by increasing the homeostasis of the whole body, and the lifestyle-related diseases such as hypertension, diabetes, heart disease and liver disease that are serious for modern people. Widely prevent and treat.

Continuation of front page (56) References JP 7-274896 (JP, A) JP 10-234319 (JP, A) Registered utility model 3059321 (JP, U) (58) Fields surveyed (Int. Cl ⁷ , DB name) A23L 1/30 A23L 1/076 A61K 35/78 JSTPlus (JOIS)

Claims (1)

(57) [Claims] [Claim 1] Propolis , Echinacea and Himematsu
The blend ratio of propolis and echinacea
A health food composition that is 3: 1 to 1: 3 .