JP2020080803A - Spice, bonito extract and kelp extract-containing composition - Google Patents

Abstract

To provide a composition that is effective in improving fatigue and/or drowsiness.SOLUTION: Provided is a composition containing ginger, Japanese pepper, jujube, fennel, ginseng, licorice, bonito extract and kelp extract. In said composition, Japanese pepper, jujube, fennel, ginseng and licorice are extract thereof.SELECTED DRAWING: None

Description

The present invention relates to a combination of spices, a composition comprising a skipjack extract and a kelp extract, and a composition thereof for improving fatigue and/or drowsiness.

Many people today feel the physical and mental fatigue caused by their work and activities. Fatigue causes various symptoms such as malaise and causes poor performance of work and activity, and may also cause various physical and mental illnesses.

In general, it is effective to take sleep/rest and to provide nutrition in order to improve fatigue. Today, various nutritional supplements and nutritional drinks as well as energy drinks for the purpose of nutritional supplementation and tonic for physical fatigue are being sold and gaining popularity.

Further, various compositions having a fatigue improving effect have been developed and reported. JP-A-2015-110536 (Patent Document 1) discloses a fatigue-reducing composition containing black ginger, black pepper, black soybean seed coat, black sesame and fermented black onion. Japanese Unexamined Patent Application Publication No. 2017-31120 (Patent Document 2) discloses a TNF-α gene expression inhibitor containing a black ginger extract as an active ingredient, and it is shown to use this as a muscle fatigue improving agent. JP-A-2007-161675 (Patent Document 3) discloses a fatigue-improving oral preparation containing one or more kinds selected from the group of crude drugs consisting of cinnamon bark, peony, licorice, oju and ginger, vitamins and amino acids. It is disclosed. Japanese Patent Publication No. 2016-515613 (Patent Document 4) discloses a composition for improving the quality of life of women, which contains a ginseng berry extract as an active ingredient, which is for improving chronic fatigue. It is shown. WO2005/087022 (Patent Document 5) discloses a food composition having an anti-stress action, which contains an extract of migratory fish such as bonito as an active ingredient, and improves the mental state of a subject who ingests the bonito extract. On the other hand, it was shown that there was no significant difference in fatigue compared with that before ingestion.

However, there remains a need in the art for new means effective in improving fatigue.

In addition, many people today have a need to control their drowsiness during work such as driving, working, studying, and in their social life. It is highly important to improve drowsiness because drowsiness causes a decrease in concentration, work efficiency may be reduced, and an unexpected accident may be caused.

Various methods for improving drowsiness have been developed and reported so far. Japanese Unexamined Patent Publication No. 2014-218483 (Patent Document 6) discloses a drowsiness preventive agent containing a gardenia extract, a pepper extract, and a ginger extract. Japanese Unexamined Patent Publication No. 2010-199571 (Patent Document 7) discloses a drowsiness inhibitor containing a capsicum extract, a ginger extract, arginine, and caffeine. JP-A-2014-113144 (Patent Document 8) contains one or more kinds selected from the group consisting of capsicum extract, ginger extract, pepper extract, pepper extract, pepper extract and allyl mustard oil. A chewing gum is disclosed and shown to be used as an anti-somnalia agent. Japanese Unexamined Patent Publication No. 2006-298829 (Patent Document 9) discloses a drowsiness preventive composition containing citral as an active ingredient.

However, there remains a long-felt need in the art for new means effective in improving drowsiness.

By the way, among natural products derived from plants, animals and minerals, those having a pharmacological action are known as “crude drugs”. For example, ginger can be used as a cold medicine, gastric digestive, antiemetic, analgesic, Sansho can be used as gastric medicine, anthelmintic, analgesic and antispasmodic, jujube is cold medicine, analgesic and antispasmodic, gastric digestive, Can be used as an antidiarrheal drug, a psychiatric drug, fennel can be used as a stomach, carminative, expectorant, diuretic, rationale, analgesic, ginseng for tonic, sever, and gastrointestinal weakness , Can be used for the purpose of improving stomach dysfunction, indigestion, vomiting, diarrhea dizziness, loss of appetite, etc. Licorice can be used for antitussive, expectorant, rheumatism, arthritis, tonsillitis, allergy, peptic ulcer, Addison's disease It is known that it can be used for treatment (Non-Patent Document 1).

The efficacy of crude drugs may be insufficient when they are derived from one crude drug, and it is generally practiced to combine and prescribe a plurality of crude drugs. However, it is usually difficult to predict what kind of crude drug will be combined with which effect.

JP, 2015-110536, A JP, 2017-31120, A JP, 2007-161675, A Japanese Patent Publication No. 2016-515613 WO2005/087022 JP, 2014-218483, A JP, 2010-195761, A JP, 2014-113144, A JP 2006-298829 A

100 Natural Medicines for Pharmacy Students/Pharmacists-Kanpo Prescriptions-Published by Tokyo Kagaku Doujinshi, March 10, 2004

An object of the present invention is to provide a new means effective in improving fatigue or improving drowsiness. In particular, the present invention aims to provide a means which is safe to be taken on a daily basis and which can exert an effect of improving fatigue or drowsiness.

As a result of repeated intensive studies to solve the above-mentioned problems, the present inventors have confirmed that the food experience information indicates that the safety and impact on the human body are plural, that is, ginger, Japanese pepper, jujube, fennel, The inventors have found that the effect of improving fatigue and/or drowsiness can be obtained by using ginseng, licorice, bonito extract, and kelp extract in combination, and completed the present invention.

That is, the present invention includes the following inventions.
[1] A composition containing ginger, pepper, jujube, fennel, ginseng, licorice, bonito extract, and kelp extract.
[2] The composition of [1], which comprises ginger, pepper, jujube, fennel, ginseng, and licorice extract.
[3] The composition of [1] or [2], which is in the form of powder or liquid.
[4] The composition according to any one of [1] to [3], which is a food or drink or a medicine.
[5] The composition according to any one of [1] to [4], which is used for improving fatigue.
[6] Furthermore, theanine, γ-aminobutyric acid, vitamins B ₁ , B ₂ , B ₆ , B ₁₂ , C, E, anthocyanins, catechins, astaxanthin, lutein, crocetin, β-cryptoxanthin, crude drugs and fruits or their extraction Substance, capsaicin, capsiate, allicin, sesamin, organic acid or salt thereof, calcium, magnesium, iron, copper, zinc, selenium, chromium, iodine, manganese, molybdenum, BCAA, L-carnitine, L-citrulline, ornithine, histidine, The composition of [5], comprising one or more selected from the group consisting of imidazole peptide, egg white peptide, royal jelly, reduced coenzyme Q10, D-ribose, and caffeine.
[7] The composition according to any one of [1] to [4], which is used for improving drowsiness.
[8] Furthermore, crude drugs and fruits or extracts thereof, capsaicin, dihydrocapsaicin, crocin, crocetin, zingerol, arginine, L-theanine, menthol, camphor, borneol, cineole, carvone, camphene, capsaicin, allyl isothiocyanate, zingerone, The composition of [7], comprising one or more selected from the group consisting of ornithine, histidine, β-alanyl leucine, β-alanyl isoleucine, citral, piperine, sanshool, allyl mustard oil, and caffeine.

According to the present invention, it is possible to provide a composition which is safe to be taken on a daily basis and which can improve fatigue and/or drowsiness.

FIG. 1 shows the results of evaluating the effect of improving fatigue (fatigue) by ingesting various test compositions. The smaller the value on the vertical axis, the higher the improvement effect. In each figure, the solid circles and solid lines show the test composition (P) containing a combination of spice extract, bonito extract and kelp extract, and the solid circles and dotted lines show the test composition containing spice extract, bonito flavour, and kelp flavor. (Q), white triangle/dotted line, test composition containing bonito extract and kelp extract (R), white square/solid line, test composition containing spice extract alone (S), black square/solid line Shows the placebo test composition (T) containing no active ingredient, respectively. (A) is a graph showing a comparison of effects by ingestion of test compositions P, Q, R, S, and T (placebo). *: P<0.1 (vs T (placebo)), t-test. (B) is a graph showing a comparison of effects by ingestion of test compositions P, Q, and S. FIG. 2 shows the results of evaluating the effect of ingesting various test compositions for improving drowsiness. The smaller the value on the vertical axis, the higher the improvement effect. In each figure, the solid circles and solid lines show the test composition (P) containing a combination of spice extract, bonito extract and kelp extract, and the solid circles and dotted lines show the test composition containing spice extract, bonito flavour, and kelp flavor. (Q), white triangle/dotted line, test composition containing bonito extract and kelp extract (R), white square/solid line, test composition containing spice extract alone (S), black square/solid line Shows the placebo test composition (T) containing no active ingredient, respectively. (A) is a graph showing a comparison of effects by ingestion of test compositions P, Q, R, S, and T (placebo). **: P<0.05, *: P<0.1 (vs T (placebo)), t-test. (B) is a graph showing a comparison of effects by ingestion of test compositions P, Q, and S. **: P<0.05 (vs S), t-test.

The composition of the present invention comprises ginger, pepper, jujube, fennel, ginseng, licorice, bonito extract, and kelp extract.

In the present invention, ginger, pepper, jujube, fennel, ginseng, and licorice may be plant organs or dried products thereof which are generally used as crude drugs and spices.

For example, ginger can use the rhizome of a plant classified as Zingiber officinale or its dried product (also referred to as ginger). The variety is not particularly limited, and examples thereof include Zingiber officinale Roscoe and its variants.

As the Japanese pepper, the pericarp of a plant classified as Zanthoxylum piperitum or a dried product thereof can be used. The variety is not particularly limited, and examples thereof include Zanthoxylum piperium De Candolle and variants thereof (Zanthoxylum piperium De Candle f. inerme Makino, etc.).

As the jujube, fruits of plants classified as Ziziphus jujuba or dried products thereof can be used. The cultivar is not particularly limited, but may be Zyiffus jujuba Miller var. Inermis Rehder and its variants.

As the fennel, fruits of plants classified as Foeniculum vulgare or dried products thereof can be used. The variety is not particularly limited, and examples thereof include Foeniculum vulgare Miller and its variants.

For ginseng, the roots of plants classified as Panax ginseng or dried products thereof can be used. The variety is not particularly limited, but Panax ginseng C. A. Examples include Meyer and its variants.

As the licorice, the roots of plants classified as Glycyrrrhiza uralensis or Glycyrrhiza glabra, stron or a dried product thereof can be used. Stron refers to a stalk that hangs in the ground as a vine and takes roots and stems out of the nodes and propagates. The variety is not particularly limited, and examples thereof include Glycyrrhiza uralensis Fischer or Glycyrrhiza glabra Linne and variants thereof.

In the present specification, the above-mentioned plant organ used in the present invention or a dried product thereof may be simply referred to as “spice”.

These spices may be in the original form, cut into appropriate sizes or shapes, or crushed, ground, or ground. For example, spices can be in the form of powder, granules, etc. obtained by crushing, crushing, or grinding.

Also, these spices may be in the form of extracts. Examples of the "extract" of spice include squeezed juice, an extract, or a mixture thereof, or a concentrate or a dried product obtained by concentrating or drying the juice, the extract or a mixture thereof.

"Squeezed juice" can be prepared by crushing and squeezing spices to separate a liquid fraction from a solid fraction such as cell walls, and obtaining a liquid fraction. The liquid fraction and the solid fraction can be separated by an ordinary solid-liquid separation means such as centrifugation, filtration (for example, diatomaceous earth filtration, membrane filtration).

The “extract” can be prepared by subjecting spices to an extraction operation using an extraction medium. As the extraction medium, organic solvents, solvents such as water and hot water, and supercritical fluids such as supercritical carbon dioxide can be used, and solvents are particularly preferable. As the solvent, water or hot water, alcohol such as ethanol, hexane, an organic solvent such as acetone, or a mixed solvent thereof can be used, preferably water or hot water, ethanol, or a mixture thereof, or acetone. is there. When the extract is produced by solvent extraction, the spice is immersed in an appropriate amount of a solvent (for example, 0.5 to 20 times the weight of the spice on a weight basis), and the mixture is appropriately stirred or left still to dissolve the solvent in the solvent. Elute soluble components. The extraction time is not particularly limited, but may be 5 minutes to 120 minutes, for example, 15 minutes to 30 minutes. The extraction temperature is not particularly limited, but may be 0°C to 125°C, for example, 25°C to 125°C. After the extraction, the solvent fraction containing the solvent-soluble component and the solid fraction such as the cell wall are separated by the above-mentioned solid-liquid separation means to obtain the solvent fraction as an extract. The obtained extract is further subjected to solvent fractionation, chromatography (column chromatography, gas chromatography, high performance liquid chromatography (HPLC), supercritical fluid chromatography, etc.) and/or recrystallization, if necessary. It may be attached to a purification means. The shape of the spice used for extraction may be the original shape, a shape cut into an appropriate size or shape, a crushed, crushed or ground form, or a juice form.

The "concentrate or dried product" can be produced by concentrating or drying the above-mentioned juice or extract or a mixture thereof. Here, the concentration means reducing the liquid (water and/or extraction solvent) in the squeezed or extracted liquid or a mixture thereof, and preferably making the final sugar concentration 50% or more. The sugar concentration can be measured with a commercially available sugar meter. As the concentration method, for example, vacuum evaporation concentration and membrane concentration can be adopted. Vacuum evaporation concentration is generally called vacuum concentration. The degree of vacuum at the time of concentration can be selected within a range where the liquid (water and/or extraction solvent) in the final product can be reduced, and preferably, the sugar content of the final product can be 50% or more, and is not particularly limited. The membrane concentration can be performed using a membrane such as a reverse osmosis membrane (RO) or an ultrafiltration membrane (UF). The type of the membrane to be used can be selected within a range capable of reducing the liquid (water and/or extraction solvent) in the final product, and preferably the sugar content of the final product can be 50% or more, and is not particularly limited. Drying can be carried out by drying the above-mentioned squeezed or extracted liquid or a mixture thereof using an ordinary drying means (freeze drying, reduced pressure drying, heat drying, air drying, etc.). At the time of concentrating or drying, the squeezed juice, the extract, or the concentrate and other components such as an excipient may be combined and concentrated or dried.

The spice extract may be prepared by mixing the extracts obtained by treating each spice separately, or may be used, or after mixing the spices together, It may be an extract obtained by subjecting to an extraction treatment. An "extract" of spice is sometimes referred to as an "extract" of spice.

The amount of each spice contained in the composition of the present invention may vary depending on the form of each spice and the dosage form and form of the composition, but each spice should be contained in an amount selected from the following range. Yes, but not limited to these amounts. In addition, the said weight shows the dry substance raw material weight of each spice, and when each spice is in the form of an extract, it means the amount equivalent to the drug substance.
Ginger: 50 mg to 1200 mg, preferably 100 mg to 800 mg, more preferably 200 mg to 500 mg.
Japanese pepper: 20 mg to 500 mg, preferably 40 mg to 350 mg, more preferably 100 mg to 200 mg.
Jujube: 20 mg to 500 mg, preferably 40 mg to 350 mg, more preferably 100 mg to 200 mg.
Fennel: 10 mg to 300 mg, preferably 20 mg to 200 mg, more preferably 40 mg to 120 mg.
Ginseng: 10 mg to 300 mg, preferably 20 mg to 200 mg, more preferably 40 mg to 120 mg.
Licorice: 5 mg to 100 mg, preferably 10 mg to 60 mg, more preferably 20 mg to 40 mg.

In the present invention, the “bonito extract” means an extract (also sometimes referred to as “extract”) extracted from raw bonito and/or bonito section. In the present invention, the term “bonito” refers to bonito (also referred to as bonito, also known as matsutsuo) (Katsuwonus peramis) and hagatsuo (Sarda orientalis), as well as bonito (Eutynus azuz az aux). rochei rochei)) and the like (not particularly limited), and one or more of them and variants thereof can be used in combination. In the present invention, the "bonito" is preferably a bonito (Hontu bonito, Magatsuo), soda bonito, Hagatsuo, which is generally used as a raw material for bonito flakes, and particularly preferably bonito (Hon bonito, Magatsuo). The bonito extract may include crushed bonito flakes for the purpose of seasoning.

Katsuobushi is produced by a conventionally known method, that is, sliced or molded fish meat is boiled, dried and dried (Ara-bushi), if necessary, with mold. It is possible to use dried ones (a dried node, main dried node).

In the present invention, the “kelp extract” means an extract (sometimes referred to as “extract”) extracted from kelp. Examples of the kelp include Saccharina japonica var. (It is not particularly limited), and one or more of them and variants thereof can be used in combination. Particularly preferred is mackerel. As the kelp, raw one can be used, but preferably dried kelp is used. The kelp extract may include crushed kelp dried for the purpose of seasoning.

The bonito extract and the kelp extract can be prepared by subjecting an extraction operation using an extraction medium to a raw bonito and/or bonito section, and a kelp, respectively. As the extraction medium, those commonly used in the production of an extract called "Japanese-style dashi", "dashi" or the like using raw bonito and/or bonito flakes or kelp can be used, for example, water or hot water. , Alcohol such as ethanol, organic solvent such as hexane and acetone, or a mixed solvent thereof can be used, and water or hot water, ethanol, a mixture thereof, or acetone is preferable. When solvent extraction is carried out, raw skipjack and/or skipjack tuna and kelp are each in an appropriate amount of solvent (for example, 0.5 to 100 times by weight based on the weight of each raw bonito and/or bonito pieces and kelp). Then, the solvent-soluble component is eluted in the solvent by appropriately stirring or standing still. The extraction time is not particularly limited, but can be 5 minutes to 120 minutes, for example, 10 minutes to 30 minutes. The extraction temperature is not particularly limited, but may be 0°C to 125°C, for example, 25°C to 125°C. After the extraction, the solvent fraction containing the solvent-soluble component and the solid fraction are separated by the solid-liquid separation means described above, and the solvent fraction is obtained as a skipjack extract or a kelp extract. Alternatively/ additionally, the raw skipjack and/or skipjack sections, and the kelp may be subjected to other extraction operations, respectively. For example, raw bonito and/or bonito flakes and kelp are subjected to a supercritical extraction method using supercritical carbon dioxide as a medium, a steam distillation method, a compression method, a gas-liquid countercurrent catalytic distillation method, an enzymatic decomposition method, or the like. Skipjack extract and kelp extract may be prepared. The obtained skipjack extract and kelp extract may be further subjected to solvent fractionation, chromatography (column chromatography, gas chromatography, high performance liquid chromatography (HPLC), supercritical fluid chromatography, etc.) and/or recrystallization. May be subjected to further purification means such as. The shape of the raw skipjack and/or bonito knot and the kelp used for the extraction can be cut, flaked or crushed, ground or ground to an appropriate size or shape.

The bonito extract and the kelp extract may be prepared by separately mixing the raw bonito and/or the bonito section, and the extract obtained by subjecting the kelp to the extraction treatment, respectively, or alternatively, the raw bonito and/or After the bonito flakes and the kelp are mixed, they may be prepared by subjecting them to an extraction treatment together.

The obtained skipjack extract and/or kelp extract can be concentrated or dried to give a concentrate or a dried product. The concentration can be performed by reducing the liquid (water and/or extraction solvent) in the extract, and can be performed, for example, by the above-mentioned vacuum evaporation concentration and membrane concentration. Drying can be carried out by drying the extract using an ordinary drying means (freeze drying, reduced pressure drying, heat drying, air drying, etc.). Upon concentration or drying, the extract and other components such as an excipient may be combined and concentrated or dried.

The skipjack extract may include an extract of either raw bonito or bonito section, and preferably contains at least an extract of raw bonito. It is not necessary to include both the bonito extract and the bonito extract, but it is possible to include the bonito extract and the bonito extract from the viewpoint of imparting a bonito-specific good flavor to the composition. preferable. If the bonito extract contains both an extract of bonito and an extract of bonito, each extract is based on the weight of solids (ie, “dry weight”): bonito extract: bonito extract= It can be combined in an amount of about 1-100:1, for example about 10-80:1, preferably about 20-60:1.

The amounts of skipjack extract and kelp extract contained in the composition of the present invention may vary depending on their respective forms and the dosage form and form of the composition, but each is included in an amount selected from the following range. (But not limited to these amounts). In addition, the said weight shows the weight (namely, "dry weight") of the solid content obtained by drying a skipjack extract and a kelp extract. In the present specification, "bonito extract" and "kelp extract" consist only of extracts extracted from bonito and/or bonito section and kelp respectively, and are added for the purpose of improving fluidity and storability, and increasing the amount. It does not mean that it contains other components such as dextrin and sugar.
Skipjack extract: 50 mg to 5000 mg, preferably 50 mg to 1500 mg, more preferably 100 mg to 1000 mg, and further preferably 200 mg to 600 mg.
Comb extract: 20 mg to 1500 mg, preferably 20 mg to 500 mg, more preferably 40 mg to 350 mg, further preferably 100 mg to 200 mg.

The mixture of skipjack extract and kelp extract may be referred to as "dashi" or "Japanese-style dashi". In the present invention, a commercially available “dashi” or “Japanese-style dashi” containing bonito extract and kelp extract can also be used.

In the composition of the present invention, spice extract, bonito extract and kelp extract, spice, raw bonito and / or bonito section, and spice extract obtained by subjecting the kelp to the extraction treatment separately, bonito extract. The kelp extract and the kelp extract may then be mixed, or alternatively, the spice, the raw bonito and/or bonito bonito, and the kelp may be mixed and then prepared together by an extraction treatment.

The composition of the present invention includes ginger, pepper, jujuba, fennel, ginseng, licorice, bonito extract, and kelp extract, and further, an excipient, a disintegrating agent, and a lubricant acceptable as pharmaceuticals or foods and drinks. , Other components such as a binder, etc. can be included, and a desired dosage form or form can be produced.

Examples of the excipient include glucose, starch, pregelatinized starch, dextrin, D-mannitol, D-sorbitol, lactose, corn starch, crystalline cellulose, low-substituted hydroxypropyl cellulose, sodium carboxymethyl cellulose, gum arabic, sucrose, pullulan. , Light anhydrous silicic acid, synthetic aluminum silicate, magnesium aluminometasilicate, and the like.

Examples of the disintegrant include starch, lactose, carboxymethyl cellulose, carboxymethyl cellulose calcium, croscarmellose sodium, carboxymethyl starch sodium, sucrose, light anhydrous silicic acid, low-substituted hydroxypropyl cellulose and the like.

Examples of the lubricant include sugar esters such as sucrose fatty acid ester and glycerin fatty acid ester, calcium stearate, magnesium stearate, stearic acid, stearyl alcohol, hardened oil such as powdered vegetable oil and fat, waxes such as salix beeswax, Examples thereof include talc, silicic acid and silicon.

Examples of the binder include sucrose, pregelatinized starch, gelatin, dextrin, gum arabic, methylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, crystalline cellulose, sucrose, D-mannitol, trehalose, pullulan, hydroxypropylcellulose, hydroxypropylmethylcellulose. , Polyvinylpyrrolidone and the like.

The composition of the present invention further comprises a diluent, buffer, suspending agent, coating agent, preservative, ordinarily used in the production of pharmaceuticals (including quasi drugs) or foods and drinks, if necessary. Preservatives, antioxidants, colorants, anti-agglomeration agents, absorption promoters, solvents, solubilizers, isotonic agents, stabilizers, flavoring agents, pH adjusting agents, flavors, sweeteners, taste components, Other components such as acidulant and baking soda can be appropriately selected and blended according to the dosage form and form desired in the composition.

In addition, the composition of the present invention may further contain other components known to be effective in improving fatigue. Such other components include, for example, theanine, γ-aminobutyric acid (GABA), vitamins (vitamins B ₁ , B ₂ , B ₆ , B ₁₂ , C, E, etc.), polyphenols (anthocyanin, catechin, etc.). ), carotenoids (astaxanthin, lutein, crocetin, β-cryptoxanthin, etc.), crude drugs and fruits (Eleuthero, turmeric, kanju communis, kumazasa, blueberries, bilberries, cassis, guarana, etc.) or extracts thereof, capsaicin, capsiate. , Allicin, sesamin, organic acids (citric acid, etc.) or salts thereof, minerals (calcium, magnesium, iron, copper, zinc, selenium, chromium, iodine, manganese, molybdenum, etc.), amino acids (branched chain amino acids (BCAA), L -Carnitine, L-citrulline, ornithine, histidine, etc.), peptides (imidazole peptide, egg white peptide, etc.), royal jelly, reduced coenzyme Q10, D-ribose, caffeine, and the like (but not limited thereto). One or more selected may be included in the composition of the invention. Examples of the crude drug or fruit extract include squeezed juice, an extract, or a mixture thereof, or a concentrate or a dried product obtained by concentrating or drying the juice, the extract or a mixture thereof. Each form is as defined above.

In addition, the composition of the present invention can further contain other components known to be effective in improving drowsiness. Examples of such other components include crude drugs and fruits (capsicum, gardenia, rosemary, coffee, zedoary, coryder, lemongrass, pepper, pepper, wasabi, mustard, radish, etc.) or extracts thereof, capsaicin, dihydrocapsaicin, Crocin, crocetin, zingerol, arginine, L-theanine, menthol, camphor, borneol, cineole, carvone, camphene, capsaicin, allyl isothiocyanate, zingerone, ornithine, histidine, β-alanyl leucine, β-alanyl isoleucine, citral, Examples include, but are not limited to, piperine, sanshool, allyl mustard oil, caffeine, and the like, and one or more selected from these can be included in the composition of the present invention. Examples of the crude drug or fruit extract include squeezed juice, an extract, or a mixture thereof, or a concentrate or a dried product obtained by concentrating or drying the juice, the extract or a mixture thereof. Each form is as defined above.

The composition of the present invention can be provided in the form of a drug (including a quasi drug) or a food or drink.

The form of the drug is not particularly limited, but it is preferably a form suitable for oral administration. For example, solid compositions for oral administration (solid pharmaceutical preparations) may be in the form of tablets (including sugar-coated tablets), pills, capsules, fine granules, granules, troches, chewable drops, and the like. The liquid composition for oral administration (liquid pharmaceutical preparation) can be in the form of emulsion, solution, suspension, syrup and the like. In these preparations, ginger, which is an active ingredient, pepper, jujube, fennel, ginseng, licorice, bonito extract, and kelp extract, in addition to the above-mentioned other ingredients depending on the dosage form, it is usually mixed. It can be formulated according to the method.

Food and drink include tablets, tablets, chewable tablets, tablets, powders, powders, capsules, granules, soft drinks, powdered soft drinks, jelly drinks, sports drinks, confectionery (for example, biscuits, cookies), dried soup, etc. It can take the form. In these foods and drinks, ginger which is an active ingredient, Japanese pepper, jujube, fennel, ginseng, licorice, bonito extract, and kelp extract, in addition to the above-mentioned other ingredients depending on its form, are usually blended. It can be manufactured according to the law.

Foods and drinks include general foods and drinks, foods with health claims (foods with specified health uses (including foods with specified health benefits with conditions), foods with nutrient function claims, foods with functional claims, and health foods (supplements, nutrition Supplements, dietary supplements, nutritional supplements, etc.) are included.

The composition of the present invention has an effect of improving fatigue and can be used for the purpose of improving fatigue.

"Fatigue" refers to a decline in physical function resulting from continued activities such as work or exercise, or a condition associated therewith (eg, fatigue, particularly general fatigue). “Ameliorating” means reducing the deterioration of the physical function or a condition associated therewith (for example, fatigue, particularly general fatigue).

By administering or ingesting the composition of the present invention to a subject, fatigue in the subject can be improved as compared with the case where the composition is not administered or ingested, and for example, fatigue and other conditions can be improved.

Further, the composition of the present invention has an effect of improving drowsiness, and can be used for the purpose of improving drowsiness.

"Drowsiness" means the feeling of falling asleep and is one manifestation of the physiological phenomenon in humans. “Improvement of drowsiness” means promoting wakefulness and reducing or eliminating drowsiness.

By administering or ingesting the composition of the present invention to a subject, it is possible to improve drowsiness in the subject, as compared with the case where the subject is not administered or ingested.

Administration or ingestion of the composition of the present invention can be performed by oral administration or ingestion, and can be performed by any means depending on the form of the composition.

The dose or intake of the composition of the present invention may vary depending on factors such as the form of the components, the age and weight of the subject, the number of administrations/intakes, the administration/ingestion method, the degree of fatigue and drowsiness, It is preferable to administer or ingest the composition of the present invention in an amount such that each component can be administered/ingested in an amount selected from the following range per day. In addition, the weight of spice shows the dry substance raw material weight, and when the spice is in the form of an extract, it means the amount equivalent to the original drug. In addition, skipjack extract and kelp extract show dry weight.
Ginger: 50 mg to 1200 mg, preferably 100 mg to 800 mg, more preferably 200 mg to 500 mg.
Japanese pepper: 20 mg to 500 mg, preferably 40 mg to 350 mg, more preferably 100 mg to 200 mg.
Jujube: 20 mg to 500 mg, preferably 40 mg to 350 mg, more preferably 100 mg to 200 mg.
Fennel: 10 mg to 300 mg, preferably 20 mg to 200 mg, more preferably 40 mg to 120 mg.
Ginseng: 10 mg to 300 mg, preferably 20 mg to 200 mg, more preferably 40 mg to 120 mg.
Licorice: 5 mg to 100 mg, preferably 10 mg to 60 mg, more preferably 20 mg to 40 mg.
Skipjack extract: 50 mg to 5000 mg, preferably 50 mg to 1500 mg, more preferably 100 mg to 1000 mg, and further preferably 200 mg to 600 mg.
Comb extract: 20 mg to 1500 mg, preferably 20 mg to 500 mg, more preferably 40 mg to 350 mg, further preferably 100 mg to 200 mg.

The composition of the present invention can be administered or ingested in the above-mentioned amount once or several times a day (for example, 2-3 times).

As one embodiment, the composition of the present invention has a powdery form, ginger: 300 mg-600 mg, Japanese pepper: 120 mg-240 mg, jujube: 120 mg-240 mg, fennel: 60 mg-120 mg, ginseng: 60 mg-120 mg, Licorice: 15 mg to 30 mg, skipjack extract: 360 mg to 720 mg, kelp extract: 120 mg to 240 mg (the weight of each spice represents the dry substance raw material weight, and when the spice is in the form of an extract, it is converted into a crude drug. In addition, bonito extract and kelp extract represent dry weight.) In administration or ingestion, 100 mL to 150 mL of water, preferably hot water, is added at once or for a short time (for example, 2 times). Time or less, 1 hour or less, 30 minutes or less, 20 minutes or less, 10 minutes or less, or 5 minutes or less) can be continuously administered or ingested in multiple times.

The composition of the present invention can provide an effect of improving fatigue or improving drowsiness immediately (for example, within 3 hours, within 2 hours, within 1 hour, or within 30 minutes) after administration or ingestion. However, it can be administered or ingested over a long period of time. For example, the composition of the present invention may be used for 2 days or more, 3 days or more, 5 days or more, 1 week or more, 2 weeks or more, 3 weeks or more, 1 month or more, 2 months or more, or more according to the above-mentioned dosage. Can be continuously administered or ingested over the period.

As another embodiment of the composition of the present invention, ginger, Japanese pepper, jujuba, fennel, ginseng, and one or more spices selected from the group consisting of licorice, and bonito extract and kelp extract. A composition comprising. Here, "two or more" means a combination of two, three, four, five or six spices. For example, the composition includes the following as spices, along with bonito extract and kelp extract:
(I) Any one of ginger, pepper, jujube, fennel, ginseng, or licorice, such as ginger or pepper;
(Ii) either Japanese pepper, jujube, fennel, ginseng, or licorice, and two ginger, for example, Japanese pepper and ginger;
(Iii) jujube, fennel, ginseng, or licorice, and Japanese pepper;
(Iv) Two of jujube, fennel, or licorice, and ginseng;
(V) either fennel or licorice, and jujube;
(Vi) Fennel and licorice.
In the present composition, each spice, and bonito extract and kelp extract can be included in the above amount, and can be used for improving fatigue or for improving sleepiness. it can.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited to these Examples.

Example 1: Preparation of test composition

1. Preparation of Spice Extract Hot water was added to a mixture of various crushed spices (ginger, Japanese pepper, jujube, fennel, ginseng, and licorice), and extraction was performed at 95° C. with stirring. After completion of the extraction step, the obtained extract was centrifuged to separate a water-soluble substance and a water-insoluble substance, and a water-soluble substance (supernatant) was recovered. The obtained supernatant was dried under vacuum conditions to obtain a mixed extract derived from a mixture of various spices. The obtained mixed extract was ground into powder and used as an extract of spice in the preparation of the following test composition.

2. Skipjack extract-containing composition Skipjack extract (powder and pure soup stock (Ariaque Japan Co., Ltd.) containing an extract extracted from raw skipjack fillets cut into appropriate sizes and an extract extracted from crushed skipjack sections , And other raw materials such as excipients were mixed and prepared at the ratio shown in Table 1 below, and used as a skipjack extract-containing composition in the following test composition.

3. Comb Extract-Containing Composition Comb extract (Kombu extract powder (Niken Food Co., Ltd.)) containing an extract extracted from crushed dry kelp was mixed with other raw materials such as excipients in the proportions shown in Table 2 below. Was prepared and used for the preparation of the following test composition as a composition containing kelp extract.

4. Preparation of Test Composition Spice extract, skipjack extract-containing composition, and kelp extract-containing composition were mixed with other raw materials (excipient, sugar, salt, etc.) in the amounts shown in Table 3 below, Each test composition was prepared. Each raw material in the table is shown by the amount (g) contained per serving (2.3 g).
Furthermore, as a skipjack extract, a skipjack spice flavor (Katsuo Dashi Flavor (Hasegawa Fragrance Co., Ltd.)) that is an extract of the flavor portion of the skipjack tuna, and as a kelp extract, a kelp flavor (Kombuda flavor) (Hasegawa Koryo Co., Ltd.) was also used to prepare a test composition.

The obtained test composition (2.3 g per serving) contains various spices in the amounts shown in Table 4 below in terms of herbal medicine.

Example 2: Effect of test composition Test method

(1) Test subjects Eight test subjects with a constitutional disposition (4 men in their 20s to 50s and 4 women in their 20s to 50s)

(2) Ingestion method The test composition (2.3 g) was dissolved in 120 mL of hot water at about 90°C and ingested at 2:00 pm. The intake order of the test composition was random, each test was conducted at least one day apart, and each test was conducted on the same day of work so that the fatigue conditions were the same.
The following items are prohibited: Ingestion of medicines and foods that improve fatigue.

(3) Evaluation method For the test subject, before the start of the test (before intake), immediately after intake, 1 hour after intake (3:00 pm), and 2 hours after intake (4:00 pm), fatigue (fatigue), and We conducted a questionnaire on drowsiness items.
In the questionnaire, each test subject was asked to fill in the self-assessment results by the VAS method regarding fatigue (fatigue) and drowsiness.
The VAS (Visual Analog Scale) method is a test that digitizes and evaluates the degree of subjective symptoms. This is a straight line method in which the highest possible state is the right end and the lowest is the left end, and the degree of one's condition is shown on the line segment. It is also widely used in clinical medicine for subjective evaluation, and is especially used for comparing the pre- and post-administration states of the same subject.

(4) Test results Regarding fatigue (fatigue):
The effect of each test composition on malaise is shown in FIG.
When a composition (P) containing a combination of an extract of spice, a bonito extract, and a kelp extract is taken as an active ingredient, the effect of improving fatigue is higher after 2 hours than when other test compositions are taken. It was confirmed that the effect was higher than that of the composition (S) containing the spice extract alone as the active ingredient (FIG. 1(B)).

About drowsiness:
The effect of each test composition on sleepiness is shown in FIG.
When a composition (P) containing a combination of a spice extract, a bonito extract, and a kelp extract as an active ingredient was ingested, an effect of improving drowsiness was observed immediately after ingestion, and after 2 hours, another test composition was added. A higher sleepiness-improving effect than when ingested was observed, and in particular, it was confirmed that the effect was higher than that of the composition (S) containing the spice extract alone as the active ingredient (Fig. 2( B)).
It was also confirmed that the skipjack extract and the composition (Q) containing an aroma component as a kelp extract were used in combination with the spice extract to improve the drowsiness (FIG. 2(B)). ..

From the above results, the composition of the present invention has an effect of improving fatigue and drowsiness, and the effect is a synergistic effect of a combination of a spice extract, a skipjack extract, and a kelp extract. Was confirmed.

Claims (8)

A composition containing ginger, Japanese pepper, jujube, fennel, ginseng, licorice, bonito extract, and kelp extract. The composition according to claim 1, wherein the ginger comprises an extract of Japanese pepper, jujube, fennel, ginseng, and licorice. The composition according to claim 1 or 2, which is in the form of powder or liquid. The composition according to any one of claims 1 to 3, which is a food or drink or a medicine. The composition according to any one of claims 1 to 4, which is used for improving fatigue. Furthermore, theanine, γ-aminobutyric acid, vitamins B ₁ , B ₂ , B ₆ , B ₁₂ , C, E, anthocyanins, catechins, astaxanthin, lutein, crocetin, β-cryptoxanthin, herbal medicines or fruits or extracts thereof, capsaicin. , Capsiate, allicin, sesamin, organic acids or salts thereof, calcium, magnesium, iron, copper, zinc, selenium, chromium, iodine, manganese, molybdenum, BCAA, L-carnitine, L-citrulline, ornithine, histidine, imidazole peptide, The composition according to claim 5, comprising one or more selected from the group consisting of egg white peptide, royal jelly, reduced coenzyme Q10, D-ribose, and caffeine. The composition according to any one of claims 1 to 4, which is used for improving drowsiness. Furthermore, crude drugs and fruits or extracts thereof, capsaicin, dihydrocapsaicin, crocin, crocetin, zingerol, arginine, L-theanine, menthol, camphor, borneol, cineole, carvone, camphene, capsaicin, allyl isothiocyanate, zingerone, ornithine, histidine. The composition according to claim 7, comprising one or more selected from the group consisting of, β-alanyl leucine, β-alanyl isoleucine, citral, piperine, sanshool, allyl mustard oil, and caffeine.