JP3492428B2 - 適度な脆さを有する粉末マンニトールおよびその製造方法 - Google Patents

適度な脆さを有する粉末マンニトールおよびその製造方法

Info

Publication number
JP3492428B2
JP3492428B2 JP23359994A JP23359994A JP3492428B2 JP 3492428 B2 JP3492428 B2 JP 3492428B2 JP 23359994 A JP23359994 A JP 23359994A JP 23359994 A JP23359994 A JP 23359994A JP 3492428 B2 JP3492428 B2 JP 3492428B2
Authority
JP
Japan
Prior art keywords
mannitol
particle size
microns
less
powdered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP23359994A
Other languages
English (en)
Japanese (ja)
Other versions
JPH07184590A (ja
Inventor
ミッシェル・サーペロニ
ジャン−フィリップ・ボーナエール
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roquette Freres SA
Original Assignee
Roquette Freres SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9451298&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP3492428(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roquette Freres SA filed Critical Roquette Freres SA
Publication of JPH07184590A publication Critical patent/JPH07184590A/ja
Application granted granted Critical
Publication of JP3492428B2 publication Critical patent/JP3492428B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • A23L27/34—Sugar alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/18—Polyhydroxylic acyclic alcohols
    • C07C31/26—Hexahydroxylic alcohols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Seasonings (AREA)
  • Peptides Or Proteins (AREA)
  • General Preparation And Processing Of Foods (AREA)
JP23359994A 1993-09-28 1994-09-28 適度な脆さを有する粉末マンニトールおよびその製造方法 Expired - Lifetime JP3492428B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9311513A FR2710637B1 (fr) 1993-09-28 1993-09-28 Mannitol pulvérulent de friabilité modérée et son procédé de préparation.
FR9311513 1993-09-28

Publications (2)

Publication Number Publication Date
JPH07184590A JPH07184590A (ja) 1995-07-25
JP3492428B2 true JP3492428B2 (ja) 2004-02-03

Family

ID=9451298

Family Applications (1)

Application Number Title Priority Date Filing Date
JP23359994A Expired - Lifetime JP3492428B2 (ja) 1993-09-28 1994-09-28 適度な脆さを有する粉末マンニトールおよびその製造方法

Country Status (16)

Country Link
US (1) US5573777A (el)
EP (1) EP0645096B1 (el)
JP (1) JP3492428B2 (el)
KR (1) KR100353433B1 (el)
CN (1) CN1046622C (el)
AT (1) ATE160676T1 (el)
AU (1) AU675732B2 (el)
CA (1) CA2133012C (el)
DE (1) DE69407123T2 (el)
DK (1) DK0645096T3 (el)
ES (1) ES2109635T3 (el)
FI (1) FI112356B (el)
FR (1) FR2710637B1 (el)
GR (1) GR3025720T3 (el)
HU (1) HU217453B (el)
NO (1) NO302356B1 (el)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6235947B1 (en) * 1997-04-14 2001-05-22 Takeda Chemical Industries, Ltd. D-mannitol and its preparation
CN1221398A (zh) † 1996-04-16 1999-06-30 拜尔公司 甘露糖醇及其制备
DE19615418A1 (de) * 1996-04-22 1997-10-23 Merck Patent Gmbh Polyol-Zusammensetzung
DE19617487A1 (de) † 1996-05-02 1997-11-06 Merck Patent Gmbh Geschmacksverbesserung von Arzneimittelwirkstoffen
US6024981A (en) * 1997-04-16 2000-02-15 Cima Labs Inc. Rapidly dissolving robust dosage form
GB9716432D0 (en) * 1997-08-05 1997-10-08 Cerestar Holding Bv Tableting of erythritol
DE19819012A1 (de) * 1998-04-29 1999-11-25 Dynamit Nobel Ag Feuersichere, nicht explosionsfähige, Nitroglycerin und wasserfreie Lactose enthaltende Feststoffmischungen
US6296868B1 (en) * 1998-11-19 2001-10-02 Advanced Technology Pharmaceuticals Corporation Chewable tablets containing mannitol and aspartame
FR2787110B1 (fr) * 1998-12-11 2001-02-16 Roquette Freres Sorbitol pulverulent et son procede de preparation
US20020071864A1 (en) * 1999-03-25 2002-06-13 Yuhan Corporation Rapidly disintegrable tablet for oral administration
CA2342121C (fr) * 2000-03-29 2010-05-25 Roquette Freres Mannitol pulverulent et son procede de preparation
FR2807034B1 (fr) * 2000-03-29 2002-06-14 Roquette Freres Mannitol pulverulent et son procede de fabrication
CA2428144C (en) 2000-11-07 2012-01-10 Chiron Corporation Compositions of interferon-beta stabilized with highly purified mannitol
ATE432692T1 (de) * 2001-03-06 2009-06-15 Kyowa Hakko Kirin Co Ltd Tabletten, die in der mundhöhle schnell zerfallen
DE10161402A1 (de) * 2001-12-13 2003-06-18 Merck Patent Gmbh Verfahren zur Herstellung von direkt tablettierbarem beta-Mannit
US7118765B2 (en) 2001-12-17 2006-10-10 Spi Pharma, Inc. Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms
WO2003096976A2 (en) 2002-05-14 2003-11-27 Fmc Corporation Microcrystalline cewllulose compositions
ES2199061B1 (es) * 2002-06-10 2005-02-16 Laboratorios Vita, S.A. Comprimidos bucodispersables y procedimiento para su obtencion.
US20040109889A1 (en) * 2002-12-04 2004-06-10 Bunick Frank J. Surface treatment composition for soft substrates
US7282217B1 (en) * 2003-08-29 2007-10-16 Kv Pharmaceutical Company Rapidly disintegrable tablets
JP5507840B2 (ja) * 2005-09-19 2014-05-28 ユニバーシティ・オブ・ザ・ウィットウォータースランド・ヨハネスブルグ 口腔粘膜医薬投与形態
US7879382B2 (en) * 2005-09-30 2011-02-01 Fmc Corporation Stabilizers and compositions and products comprising same
EP1965771A1 (de) * 2005-12-21 2008-09-10 ADD Advanced Drug Delivery Technologies, Ltd. Pellets enthaltend einen kern mit einem wasserlöslichen träger
WO2008057267A2 (en) * 2006-10-27 2008-05-15 Fmc Corporation Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations
GB2450498A (en) 2007-06-26 2008-12-31 Schlumberger Holdings Battery powered rotary steerable drilling system
US8895141B2 (en) 2008-08-18 2014-11-25 Mitsubishi Shoji Foodtech Co., Ltd. Excipient for compressed tablets comprising novel spherical mannitol
WO2010077878A1 (en) * 2008-12-15 2010-07-08 Fleming And Company, Pharmaceuticals Rapidly dissolving vitamin formulation and methods of using the same
FR2949462B1 (fr) * 2009-09-01 2011-12-16 Roquette Freres Poudre de cristaux de mannitol define, son procede de fabrication
FR2949296B1 (fr) 2009-09-01 2011-11-18 Roquette Freres Procede de remplacement total ou partiel du talc dans les chewing-gums
WO2012049156A1 (en) 2010-10-12 2012-04-19 Bayer Animal Health Gmbh Non-starch based soft chewables
JP6188030B2 (ja) 2011-10-05 2017-08-30 エフ エム シー コーポレーションＦｍｃ Ｃｏｒｐｏｒａｔｉｏｎ 微結晶セルロースおよびカルボキシメチルセルロースの安定化剤組成物、該組成物の製造方法並びに食品製品
CN103857739B (zh) 2011-10-05 2017-04-19 Fmc有限公司 共磨碎微晶纤维素和羧甲基纤维素的稳定剂组合物、制备方法和应用
CN104010522A (zh) 2011-12-09 2014-08-27 Fmc有限公司 共磨碎稳定剂组合物
BE1021954B1 (nl) 2014-06-05 2016-01-28 Syral Belgium Nv Samenstelling van sorbitol met lage friabiliteit
WO2016136849A1 (ja) * 2015-02-26 2016-09-01 武田薬品工業株式会社 固形製剤
FR3038836B1 (fr) * 2015-07-17 2017-07-14 Roquette Freres Granules de mannitol pour compression directe

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3145146A (en) * 1961-10-31 1964-08-18 Warner Lambert Pharmaceutical Modified mannitol for pharmaceutical tablets
US3341415A (en) * 1964-02-12 1967-09-12 Warner Lambert Pharmaceutical Pharmaceutical tablet excipients of solid particles of a binary solid solution of mannitol with a sugar
JPS5536646A (en) * 1978-09-06 1980-03-14 Arai Pump Mfg Co Ltd Double mechanical seal
US4293570A (en) * 1979-04-02 1981-10-06 Chimicasa Gmbh Process for the preparation of sweetener containing product
FR2571046B1 (fr) * 1984-10-03 1987-10-16 Roquette Freres Procede de preparation de mannitol granulaire directement compressible
FR2571045B1 (fr) * 1984-10-03 1987-12-11 Roquette Freres Mannitol granulaire directement compressible et son procede de fabrication
JPS6185330A (ja) * 1984-10-04 1986-04-30 Fuji Kagaku Kogyo Kk 直打用賦形薬の製造法
JPS6185331A (ja) * 1984-10-04 1986-04-30 Fuji Kagaku Kogyo Kk 直打用賦形薬の製造法
DK0487774T3 (da) * 1990-11-29 1994-11-21 Wei Ming Pharmaceutical Mfg Co Hjælpestof til direkte tablettering
JPH06185330A (ja) * 1992-12-16 1994-07-05 Nissan Motor Co Ltd エンジンのオイルポンプ支持構造

Also Published As

Publication number Publication date
NO302356B1 (no) 1998-02-23
HU9402773D0 (en) 1994-12-28
ES2109635T3 (es) 1998-01-16
CA2133012A1 (en) 1995-03-29
US5573777A (en) 1996-11-12
NO943586L (no) 1995-03-29
KR100353433B1 (ko) 2002-12-11
FI112356B (fi) 2003-11-28
HUT70804A (en) 1995-11-28
DE69407123D1 (de) 1998-01-15
KR950008457A (ko) 1995-04-17
DE69407123T2 (de) 1998-04-23
JPH07184590A (ja) 1995-07-25
CA2133012C (en) 2006-01-31
EP0645096B1 (fr) 1997-12-03
HU217453B (hu) 2000-01-28
GR3025720T3 (en) 1998-03-31
AU7423994A (en) 1995-04-13
FI944464A (fi) 1995-03-29
ATE160676T1 (de) 1997-12-15
CN1107516A (zh) 1995-08-30
NO943586D0 (no) 1994-09-27
FR2710637B1 (fr) 1995-12-08
DK0645096T3 (da) 1998-05-04
FR2710637A1 (fr) 1995-04-07
EP0645096A1 (fr) 1995-03-29
FI944464A0 (fi) 1994-09-27
AU675732B2 (en) 1997-02-13
CN1046622C (zh) 1999-11-24

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