JP3454824B2 - 安定な重炭酸塩溶液を製造及び貯蔵するための方法 - Google Patents
安定な重炭酸塩溶液を製造及び貯蔵するための方法Info
- Publication number
- JP3454824B2 JP3454824B2 JP52424994A JP52424994A JP3454824B2 JP 3454824 B2 JP3454824 B2 JP 3454824B2 JP 52424994 A JP52424994 A JP 52424994A JP 52424994 A JP52424994 A JP 52424994A JP 3454824 B2 JP3454824 B2 JP 3454824B2
- Authority
- JP
- Japan
- Prior art keywords
- container
- carbon dioxide
- bicarbonate
- bicarbonate solution
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 title claims abstract description 115
- 238000004519 manufacturing process Methods 0.000 title description 8
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 120
- 239000001569 carbon dioxide Substances 0.000 claims abstract description 60
- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 60
- 238000000034 method Methods 0.000 claims abstract description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 29
- 239000011343 solid material Substances 0.000 claims abstract description 13
- 230000000087 stabilizing effect Effects 0.000 claims abstract description 13
- 239000000126 substance Substances 0.000 claims abstract description 5
- 239000000243 solution Substances 0.000 claims description 88
- 239000000463 material Substances 0.000 claims description 18
- 239000002253 acid Substances 0.000 claims description 17
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 16
- 230000001954 sterilising effect Effects 0.000 claims description 13
- 239000008121 dextrose Substances 0.000 claims description 12
- 230000035699 permeability Effects 0.000 claims description 8
- 150000001413 amino acids Chemical class 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 229920000642 polymer Polymers 0.000 claims description 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 6
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 3
- UOQHWNPVNXSDDO-UHFFFAOYSA-N 3-bromoimidazo[1,2-a]pyridine-6-carbonitrile Chemical compound C1=CC(C#N)=CN2C(Br)=CN=C21 UOQHWNPVNXSDDO-UHFFFAOYSA-N 0.000 claims description 2
- 229940099563 lactobionic acid Drugs 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 239000012780 transparent material Substances 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 238000001802 infusion Methods 0.000 claims 1
- 239000008155 medical solution Substances 0.000 claims 1
- 239000012466 permeate Substances 0.000 claims 1
- 239000001384 succinic acid Substances 0.000 claims 1
- 230000006641 stabilisation Effects 0.000 abstract description 2
- 238000011105 stabilization Methods 0.000 abstract description 2
- 238000000502 dialysis Methods 0.000 description 21
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- 239000012141 concentrate Substances 0.000 description 11
- 238000004659 sterilization and disinfection Methods 0.000 description 11
- 239000007789 gas Substances 0.000 description 10
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 9
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 7
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 239000011575 calcium Substances 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical group [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
- 230000008901 benefit Effects 0.000 description 6
- 239000000872 buffer Substances 0.000 description 6
- 229910052791 calcium Inorganic materials 0.000 description 6
- 238000001631 haemodialysis Methods 0.000 description 6
- 230000000322 hemodialysis Effects 0.000 description 6
- 239000011777 magnesium Substances 0.000 description 6
- 229910052749 magnesium Inorganic materials 0.000 description 6
- 238000001556 precipitation Methods 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 5
- 239000008187 granular material Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- 208000010444 Acidosis Diseases 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000000385 dialysis solution Substances 0.000 description 4
- 238000010790 dilution Methods 0.000 description 4
- 239000012895 dilution Substances 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 239000011591 potassium Substances 0.000 description 4
- 229910052700 potassium Inorganic materials 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 230000007950 acidosis Effects 0.000 description 3
- 208000026545 acidosis disease Diseases 0.000 description 3
- 229920001903 high density polyethylene Polymers 0.000 description 3
- 239000004700 high-density polyethylene Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 210000004379 membrane Anatomy 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 150000007524 organic acids Chemical class 0.000 description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical group [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 description 2
- 150000002500 ions Chemical group 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 208000006443 lactic acidosis Diseases 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000003330 peritoneal dialysis fluid Substances 0.000 description 2
- 210000004303 peritoneum Anatomy 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000001103 potassium chloride Substances 0.000 description 2
- 235000011164 potassium chloride Nutrition 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 208000030090 Acute Disease Diseases 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 108010008488 Glycylglycine Proteins 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
- 206010027417 Metabolic acidosis Diseases 0.000 description 1
- 206010062237 Renal impairment Diseases 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- 239000008351 acetate buffer Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229940043257 glycylglycine Drugs 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 229910001425 magnesium ion Inorganic materials 0.000 description 1
- 230000009988 metabolic benefit Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 231100000857 poor renal function Toxicity 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000012959 renal replacement therapy Methods 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2093—Containers having several compartments for products to be mixed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
- A61M1/1656—Apparatus for preparing dialysates
- A61M1/1666—Apparatus for preparing dialysates by dissolving solids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
- A61M1/287—Dialysates therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
- A61J1/2024—Separating means having peelable seals
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- External Artificial Organs (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Carbon And Carbon Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US052,260 | 1993-04-23 | ||
| US08/052,260 US5383324A (en) | 1993-04-23 | 1993-04-23 | Method for manufacturing and storing stable bicarbonate solutions |
| PCT/US1994/002873 WO1994025084A1 (en) | 1993-04-23 | 1994-03-17 | Method for manufacturing and storing stable bicarbonate solutions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH07508678A JPH07508678A (ja) | 1995-09-28 |
| JP3454824B2 true JP3454824B2 (ja) | 2003-10-06 |
Family
ID=21976430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52424994A Expired - Fee Related JP3454824B2 (ja) | 1993-04-23 | 1994-03-17 | 安定な重炭酸塩溶液を製造及び貯蔵するための方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5383324A (enExample) |
| EP (1) | EP0647145B1 (enExample) |
| JP (1) | JP3454824B2 (enExample) |
| AT (1) | ATE161426T1 (enExample) |
| AU (1) | AU683878B2 (enExample) |
| CA (1) | CA2138665A1 (enExample) |
| DE (1) | DE69407527T2 (enExample) |
| ES (1) | ES2113645T3 (enExample) |
| GR (1) | GR3025966T3 (enExample) |
| NZ (1) | NZ263691A (enExample) |
| SG (1) | SG48702A1 (enExample) |
| TW (1) | TW266162B (enExample) |
| WO (1) | WO1994025084A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9314621D0 (en) * | 1993-07-14 | 1993-08-25 | Kodak Ltd | Material supply |
| CN1130205C (zh) * | 1994-07-01 | 2003-12-10 | 巴克斯特国际有限公司 | 生物化学平衡的腹膜透析溶液 |
| US5605934A (en) * | 1995-03-23 | 1997-02-25 | Baxter International Inc. | Method of manufacturing and storing solutions |
| JP2872643B2 (ja) * | 1996-05-03 | 1999-03-17 | バクスター・インターナショナル・インコーポレイテッド | 腹膜透析システム、腹膜透析液のパッケージングシステムおよびパッケージ形成方法 |
| KR100304846B1 (ko) * | 1996-06-17 | 2001-09-24 | 오쓰카 요시미쓰 | 중탄산염 함유 약액 용기 포장체 및 피에이치인디케이터ㅔ |
| US5881879A (en) * | 1997-02-07 | 1999-03-16 | Baxter International Inc. | System for preserving and delivering gas-containing solutions |
| IT1307734B1 (it) * | 1999-01-29 | 2001-11-19 | Bieffe Medital Spa | Cartuccia per dialisi contenente bicarbonato di sodio. |
| HK1040369A1 (zh) | 1999-03-03 | 2002-06-07 | Eli Lilly And Company | 制备药物口服ecb配方和组合物的方法 |
| WO2000057833A1 (en) * | 1999-03-25 | 2000-10-05 | Gambro Lundia Ab | Method and supply bag for providing a medical solution |
| US6309673B1 (en) | 1999-09-10 | 2001-10-30 | Baxter International Inc. | Bicarbonate-based solution in two parts for peritoneal dialysis or substitution in continuous renal replacement therapy |
| US7122210B2 (en) * | 2002-01-11 | 2006-10-17 | Baxter International Inc. | Bicarbonate-based solutions for dialysis therapies |
| ITMI20020516A1 (it) * | 2002-03-12 | 2003-09-12 | Gambro Lundia Ab | Liquidi per dialisi peritoneale emodialisi e reintegrazione |
| US7445801B2 (en) * | 2002-06-07 | 2008-11-04 | Baxter International Inc. | Stable bicarbonate-based solution in a single container |
| US6991800B2 (en) | 2002-06-13 | 2006-01-31 | Vicuron Pharmaceuticals Inc. | Antifungal parenteral products |
| TWI319984B (en) * | 2003-06-06 | 2010-02-01 | Sterile combined preparation | |
| US7159374B2 (en) * | 2003-11-10 | 2007-01-09 | Inoflate, Llc | Method and device for pressurizing containers |
| US7935070B2 (en) | 2005-01-28 | 2011-05-03 | Fresenius Medical Care North America | Systems and methods for dextrose containing peritoneal dialysis (PD) solutions with neutral pH and reduced glucose degradation product |
| US7857977B2 (en) * | 2005-07-12 | 2010-12-28 | Rockwell Medical Technologies, Inc. | Packaging of ferric pyrophosphate for dialysis |
| US8162917B2 (en) * | 2008-05-21 | 2012-04-24 | Onpharma, Inc. | Methods and apparatus for buffering anesthetics |
| US20110005958A1 (en) * | 2009-07-09 | 2011-01-13 | Onpharma, Inc. | METHODS AND SYSTEMS FOR ADJUSTING THE pH OF MEDICAL BUFFERING SOLUTIONS |
| US8303566B2 (en) | 2009-07-09 | 2012-11-06 | Onpharma, Inc. | Methods and apparatus for buffering parenteral solutions |
| US8585963B2 (en) * | 2009-07-09 | 2013-11-19 | Onpharma, Inc. | Methods and devices for sterilizing and holding buffering solution cartridges |
| CN102574085B (zh) | 2009-07-09 | 2015-04-15 | 昂法玛公司 | 用于灭菌和容纳缓冲溶液药筒的方法和装置 |
| US9051098B2 (en) * | 2009-10-19 | 2015-06-09 | Inoflate, Llc | Method for pressurizing containers with nitrogen |
| US9056446B2 (en) | 2010-06-30 | 2015-06-16 | Paper-Pak Industries | Absorbent food pad |
| US9585810B2 (en) | 2010-10-14 | 2017-03-07 | Fresenius Medical Care Holdings, Inc. | Systems and methods for delivery of peritoneal dialysis (PD) solutions with integrated inter-chamber diffuser |
| CN103402482B (zh) | 2010-11-15 | 2016-08-17 | 昂法玛公司 | 用于隔绝流体转移期间所排出的流体的装置与方法 |
| US9757401B2 (en) | 2011-11-11 | 2017-09-12 | Nova Neura, Llc | Method for relieving neurogenic pain |
| US10478381B2 (en) | 2014-07-08 | 2019-11-19 | Fenwal, Inc. | Minimization of air ingress in solution containers |
| GR1009074B (el) * | 2016-04-20 | 2017-07-07 | Βερμα Ντραγκς - Verma Drugs Abee | Φυσιγγα διττανθρακικου νατριου με ανυδρο κιτρικο οξυ ως σταθεροποιητη του ρη |
| GR1009075B (el) * | 2016-04-20 | 2017-07-07 | Βερμα Ντραγκς - Verma Drugs Abee | Σακος διττανθρακικου νατριου με ανυδρο κιτρικο οξυ ως σταθεροποιητη του ρη |
| US10882295B2 (en) | 2018-03-09 | 2021-01-05 | Novipax Llc | Absorbent fluff and tissue laminate pads for food packaging |
| US11925703B1 (en) | 2022-07-29 | 2024-03-12 | Xellia Pharmaceuticals Aps | Liquid composition comprising glucose |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3878664A (en) * | 1972-11-27 | 1975-04-22 | Cybersol | Process for producing a therapeutic composition |
| FR2468400A1 (fr) * | 1979-11-01 | 1981-05-08 | Baxter Travenol Lab | Procede et dispositif pour le melange de solutions hypernutritives |
| CA1166966A (en) * | 1980-05-09 | 1984-05-08 | Albert L. Babb | System for bicarbonate dialysate |
| US4489535A (en) * | 1980-10-02 | 1984-12-25 | Veltman Preston Leonard | Materials and method for preparing dialysis solutions containing bicarbonate ions |
| US4397392A (en) * | 1981-01-08 | 1983-08-09 | Intensive Technology, Inc. | Contained blood gas control |
| US4465488A (en) * | 1981-03-23 | 1984-08-14 | Baxter Travenol Laboratories, Inc. | Collapsible multi-chamber medical fluid container |
| US4396383A (en) * | 1981-11-09 | 1983-08-02 | Baxter Travenol Laboratories, Inc. | Multiple chamber solution container including positive test for homogenous mixture |
| US4584176A (en) * | 1984-03-19 | 1986-04-22 | Oliver James C | Method and apparatus for storing bicarbonate dialysate |
| IT1214872B (it) * | 1984-04-06 | 1990-01-18 | Mariano Feriani | Sacca contenente due o piu'sostanze per infusione ad uso medicale, poste in scomparti separati, comprendente mezzi atti a consentire la miscelazione di tali sostanze solo al momento dell'uso. |
| EP0209607B1 (en) * | 1985-05-31 | 1989-12-20 | Hans Dr. Dietl | Hemodialysis liquid feed system |
| GR870129B (en) * | 1987-01-27 | 1987-02-04 | Giatzidis Ippokratis | Stable bicarbonate - glycylglycine dialysate for hemodialysis and peritoneal dialysis |
| US4784495A (en) * | 1987-02-06 | 1988-11-15 | Gambro Ab | System for preparing a fluid intended for a medical procedure by mixing at least one concentrate in powder form with water |
| US5092838A (en) * | 1989-11-30 | 1992-03-03 | Baxter International Inc. | Histidine buffered peritoneal dialysis solution |
| AU627309B2 (en) * | 1989-05-26 | 1992-08-20 | Terumo Kabushiki Kaisha | Preparation for blood dialysis and method for production thereof |
| DE3917251A1 (de) * | 1989-05-26 | 1990-11-29 | Fresenius Ag | Natriumbicarbonat enthaltendes konzentrat sowie verfahren zur herstellung einer dialysierfluessigkeit |
| US5071558A (en) * | 1989-08-11 | 1991-12-10 | Nikkiso Co., Ltd. | Sodium bicarbonate dialysate |
| DE59101623D1 (de) * | 1990-01-12 | 1994-06-23 | Nephro Medica Pharma | Bicarbonat und Calcium enthaltende Infusions- und Dialysierlösung. |
| SE505967C2 (sv) * | 1990-10-15 | 1997-10-27 | Gambro Ab | Förfarande respektive anläggning för beredning av en medicinsk lösning, t ex en dialyslösning |
-
1993
- 1993-04-23 US US08/052,260 patent/US5383324A/en not_active Expired - Fee Related
-
1994
- 1994-03-16 TW TW83102278A patent/TW266162B/zh active
- 1994-03-17 AT AT94912244T patent/ATE161426T1/de not_active IP Right Cessation
- 1994-03-17 CA CA 2138665 patent/CA2138665A1/en not_active Abandoned
- 1994-03-17 EP EP94912244A patent/EP0647145B1/en not_active Expired - Lifetime
- 1994-03-17 ES ES94912244T patent/ES2113645T3/es not_active Expired - Lifetime
- 1994-03-17 WO PCT/US1994/002873 patent/WO1994025084A1/en not_active Ceased
- 1994-03-17 AU AU64473/94A patent/AU683878B2/en not_active Ceased
- 1994-03-17 DE DE69407527T patent/DE69407527T2/de not_active Expired - Fee Related
- 1994-03-17 SG SG1995002031A patent/SG48702A1/en unknown
- 1994-03-17 JP JP52424994A patent/JP3454824B2/ja not_active Expired - Fee Related
- 1994-03-17 NZ NZ263691A patent/NZ263691A/en unknown
-
1998
- 1998-01-21 GR GR980400136T patent/GR3025966T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU683878B2 (en) | 1997-11-27 |
| CA2138665A1 (en) | 1994-11-10 |
| EP0647145B1 (en) | 1997-12-29 |
| SG48702A1 (en) | 1998-05-18 |
| US5383324A (en) | 1995-01-24 |
| AU6447394A (en) | 1994-11-21 |
| DE69407527D1 (de) | 1998-02-05 |
| ATE161426T1 (de) | 1998-01-15 |
| WO1994025084A1 (en) | 1994-11-10 |
| TW266162B (enExample) | 1995-12-21 |
| ES2113645T3 (es) | 1998-05-01 |
| JPH07508678A (ja) | 1995-09-28 |
| EP0647145A1 (en) | 1995-04-12 |
| NZ263691A (en) | 1996-11-26 |
| GR3025966T3 (en) | 1998-04-30 |
| DE69407527T2 (de) | 1998-07-16 |
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