JP3205104B2 - Cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a derivative of chitosan, N- (3-carboxypropanoyl) -6-O- (carboxymethyl) chitosan (hereinafter referred to as "CPCM chitosan").
And an acidic mucopolysaccharide as a cosmetic component, and relates to a cosmetic having excellent moisturizing power.

[0002]

2. Description of the Related Art In recent years, cosmetics which have an excellent moisturizing effect have been desired. As substances having such an effect, hyaluronic acid, chondroitin sulfate, carboxymethyl chitin and the like, which are acidic mucopolysaccharides, are used. Have been. On the other hand, CPCM chitosan has been proposed as a substance which is inexpensive and has the same moisturizing power as hyaluronic acid (JP-A-2-105801).

[0003] However, although these substances have moderate moisturizing power, they do not have sufficient moisturizing power as moisturizers used for lotions or emulsions used under dry conditions, and development of moisturizers with high moisturizing power has been developed. Was desired by those skilled in the art.

[0004]

SUMMARY OF THE INVENTION As a result of intensive studies to solve the above problems, the present invention has found that the use of CPCM chitosan and a specific acidic mucopolysaccharide in a certain ratio increases the moisturizing power. The present invention has been completed based on this finding.

[0005]

The present invention relates to (A) a compound of the general formula (I)

[0006]

Embedded image

(Wherein M represents hydrogen or an alkali metal,
n represents an integer of 10 to 5000. )
Contains (3-carboxypropanoyl) -6-O- (carboxymethyl) chitosan and (B) acidic mucopolysaccharide
And the mixing ratio of component (A) and component (B) is
9.5: 0.5 to 0.5: 9.5, and components
The sum of (A) and component (B) is based on the total weight of the cosmetic.
Cosmetic characterized by being 0.001 to 5.0% by weight .

The CPCM chitosan used in the present invention is obtained by making the hydroxy group at the 6-position of the chitosan carboxymethylated and the amino group at the 2- position carboxypropanoyl to make it water-soluble.

As a method for producing this CPCM chitosan, as described in JP-A-2-105801, 6-O-
It is easily obtained by reacting (carboxymethyl) chitosan with succinic anhydride.

The acidic mucopolysaccharide used in the present invention is carboxymethyl chitin, hyaluronic acid, chondroitin-4-sulfate, chondroitin-6-sulfate, dermatan sulfate, keratan sulfate, and heparin.

Carboxymethyl chitin is obtained by carboxymethylating the hydroxyl group at the 6-position of chitin to make it water-soluble, and its production method is described in JP-A-59-106409.
As described in the above item, it is obtained by reacting chitin with sodium monochloroacetate. Other acidic mucopolysaccharides such as hyaluronic acid, chondroitin-4-sulfate, chondroitin-6-sulfate, dermatan sulfate, keratan sulfate, heparin and salts thereof can be easily obtained by methods known to those skilled in the art.

The blending ratio of CPCM chitosan to the specific acidic mucopolysaccharide is 9.5: 0.5 to 0.5: 9.5 by weight.
, Preferably 9.0: 1.0 to 1.0: 9.0. Except for this mixing ratio, the moisturizing effect is not sufficient.

[0013] The amount of specific acidic mucopolysaccharides and CPCM chitosan cosmetics of the present invention 0.001 to 5 percent by weight based on the total weight of the cosmetic, preferably 0.005 to%.

If the amount is less than this, the moisturizing effect is insufficient.
When the amount is more than this, stickiness is unpreferable because of stickiness.

The cosmetic of the present invention may further contain, in addition to the essential components described above, powders, oils, surfactants, antioxidants, thickeners, and organic solvents, if necessary, depending on the type of the cosmetic. Components commonly used in cosmetics, such as plasticizers, preservatives, amino acids, fragrances, and the like, can be appropriately blended as long as the effects of the present invention are not impaired.

The dosage form of the cosmetic of the present invention is arbitrary, and may be any type such as a solvent type, a solubilizing type, an emulsifying type, a powder dispersing type, and a water-oil two-layer type.

The use is optional, but typical examples include lotions, emulsions, creams, packs, hair tonics, cleansing creams, serums, foundations, soaps, facial cleansers, cleansing foams, shampoos, rinses, Body shampoo etc. can be raised.

[0018]

Next, the effect of the combination of CPCM chitosan and a specific acidic mucopolysaccharide will be described in detail with reference to Examples and Comparative Examples. In addition, the examination prescription and the measurement of the effect were based on the following methods.

<Prescription of lotion> Ethanol 10.0% Glycerin 3.0 CPCM Chitosan Amount shown in Table 1 Acid mucopolysaccharide Amount shown in Table 1 POE (50) Oleyl ether 0.5 Methyl paraben 0.2 Purified water residue Department .

<Evaluation of Moisturizing Property> A sample prepared by 10 specialized panelists was actually used, and a sensory test was conducted. The evaluation results are shown in the following display. A: Eight or more of the ten respondents answered that they were good.・ ・ ・: 6 or more respondents answered that they were good. Δ: 4 or more out of 10 responded that they were good. ×: Less than 4 out of 10 respondents answered that it was good.

[0021]

[Table 1]

From the results shown in Table 1, it can be seen that the cosmetic of the present invention is excellent in moisture retention.

Example 9 A hair brushing agent composition shown below was prepared and its performance was evaluated. As a result, this hair brushing agent composition 1 showed an excellent moist feeling. (Composition) Cocoyl arginine ethyl ester / PCA salt 0.5% CPCM chitosan 0.3 Hyaluronic acid 0.2 Ethyl alcohol 5.0 Methyl paraben 0.1 Perfume 0.1 Purified water Remainder.

Example 10 A hair treatment composition shown below was prepared and its performance was evaluated. As a result, the hair treatment composition showed an excellent moist feeling. (Composition) Cetostearyltrimethylammonium chloride 3.0% CPCM chitosan 0.1 Sodium chondroitin sulfate 0.05 Cetostearyl alcohol 2.5 Liquid paraffin 1.5 POE (5) Stearyl ether 1.0 Glycerin 5.0 Preservative 0 .1 purified water remaining part.

Example 11 The following emulsion was prepared and its performance was evaluated.
This emulsion showed an excellent moist feeling. (Composition) Liquid paraffin 10.0% Squalane 2.0 Vaseline 2.0 Sorbitan sesquioleate 0.9 Polyoxyethylene oleyl ether 1.2 Glycerin 3.0 Ethanol 3.0 Carboxyvinyl polymer 0.2 Potassium hydroxide 0.1 CPCM chitosan 0.05 carboxymethyl chitin 0.03 PCA soda 1.0 luffa extract 0.5 purified water balance section 1.0 preservative.

Example 12 The following hair rinse composition was prepared, and its performance was evaluated. As a result, the hair rinse composition showed an excellent moist feeling. (Composition) Stearyltrimethylammonium chloride 1.5% Distearyldimethylammonium chloride 1.5 Cetanol 3.5 Jojoba oil 2.0 Lipophilic glyceryl monostearate 1.0 Polyethylene glycol (8EO) 0.3 1.3 butylene glycol 5.0 CPCM chitosan 1.0 0.2 carboxymethyl chitin 0.5 amino-modified silicone polymer 0.5 preservative 0.3 purified water balance unit hyaluronic acid.

Example 13 A hair shampoo composition shown below was prepared and its performance was evaluated. The hair shampoo composition showed an excellent moist feeling. (Composition) Sodium polyoxyethylene (3) lauryl ether sulfate (25%) 10.0% Sodium lauroylmethyl-β-alanine (30%) 15.0 Amidopropyl betaine laurate (30%) 15.0 N-cocoyl -L- glutamate Monotorieta Noruamin (30%) 10.0 lauric acid diethanolamide 3.0 CPCM chitosan 1.5 sodium chondroitin sulfate 0.2 carboxymethyl chitin 0.3 edetate sodium 0.2 preservative 0.3 purified water the remaining part.

Example 14 The following lotion composition was prepared and its performance was evaluated. As a result, this lotion showed an excellent moist feeling. (Composition) Ethanol 10.0% Glycerin 5.0 CPCM chitosan 0.0005 0.0005 Methylparaben 0.1 Sodium edetate 0.1 Purified water balance unit hyaluronic acid.

Example 15 The following hair essence composition was prepared and its performance was evaluated. The hair essence showed an excellent moist feeling. (Composition) 20.0% CPCM chitosan 0.009 carboxymethyl chitin 0.001 Methylparaben 0.1 Sodium 0.1 Purified water balance unit edetate ethanol.

[0030]

EFFECT OF THE INVENTION By using CPCM chitosan and a specific acidic mucopolysaccharide as a humectant, a cosmetic having excellent moisturizing properties can be obtained.

──────────────────────────────────────────────────続 き Continuation of front page (72) Inventor Eiji Kobayashi 4-1-6 Chitose-cho, Noboribetsu-shi, Hokkaido (56) References JP-A-2-105801 (JP, A) JP-A-2-101008 (JP, A) JP-A-63-230614 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61K ^7/ 00-7/50 CA (STN) REGISTRY (STN)

Claims (2)

(57) [Claims] (A) General formula (I) (Wherein, M represents hydrogen or an alkali metal, and n is 10 to 5)
Represents an integer of 000. )) And N- (3-carboxypropanoyl) -6-O- (carboxymethyl) chitosan; and (B) an acidic mucopolysaccharide ;
The compounding ratio of the component (B) is 9.5: 0.5 by weight.
0.5: 9.5 and the ratio of component (A) to component (B)
The sum is 0.001 to 5.0 weight based on the total weight of the cosmetic.
% Cosmetics. 2. The cosmetic according to claim 1, wherein the acidic mucopolysaccharide of the component (B) is at least one selected from carboxymethyl chitin, hyaluronic acid, chondroitin sulfate, dermatan sulfate, keratan sulfate and heparin.