JP3172575B2 - プレグナ−1,4−ジエン−3,20−ジオンのステロイド誘導体の製造法及びその中間体 - Google Patents
プレグナ−1,4−ジエン−3,20−ジオンのステロイド誘導体の製造法及びその中間体Info
- Publication number
- JP3172575B2 JP3172575B2 JP11520192A JP11520192A JP3172575B2 JP 3172575 B2 JP3172575 B2 JP 3172575B2 JP 11520192 A JP11520192 A JP 11520192A JP 11520192 A JP11520192 A JP 11520192A JP 3172575 B2 JP3172575 B2 JP 3172575B2
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- give
- agent
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0092—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9104339A FR2675146A1 (fr) | 1991-04-10 | 1991-04-10 | Nouveaux derives sterouides de la pregna-1,4-diene-3,20-dione, leur preparation, leur application a la preparation de derives 16,17-methylene dioxy substitues et nouveaux intermediaires. |
FR91-04339 | 1991-04-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH05170788A JPH05170788A (ja) | 1993-07-09 |
JP3172575B2 true JP3172575B2 (ja) | 2001-06-04 |
Family
ID=9411660
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11520192A Expired - Fee Related JP3172575B2 (ja) | 1991-04-10 | 1992-04-09 | プレグナ−1,4−ジエン−3,20−ジオンのステロイド誘導体の製造法及びその中間体 |
Country Status (7)
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2675146A1 (fr) * | 1991-04-10 | 1992-10-16 | Roussel Uclaf | Nouveaux derives sterouides de la pregna-1,4-diene-3,20-dione, leur preparation, leur application a la preparation de derives 16,17-methylene dioxy substitues et nouveaux intermediaires. |
GB9423919D0 (en) * | 1994-11-26 | 1995-01-11 | Rhone Poulenc Rorer Ltd | Chemical process |
PL327141A1 (en) * | 1995-12-20 | 1998-11-23 | Schering Corp | Method of obtaining 9,11 beta-epoxysteroides |
IT1291288B1 (it) * | 1997-04-30 | 1999-01-07 | Farmabios Srl | Processo per la preparazione di 16,17 acetali di derivati pregnanici con controllo della distribuzione epimerica al c-22. |
US6266556B1 (en) | 1998-04-27 | 2001-07-24 | Beth Israel Deaconess Medical Center, Inc. | Method and apparatus for recording an electroencephalogram during transcranial magnetic stimulation |
IT1302657B1 (it) * | 1998-10-13 | 2000-09-29 | Farmabios Srl | Processo stereoselettivo per la preparazione di budesonide nella formadi epimero 22-r. |
PL205674B1 (pl) * | 2000-11-10 | 2010-05-31 | Nycomed Gmbh | Sposób wytwarzania 16,17-[(cykloheksylometyleno) bis (oksy)]-11,21-dihydroksypregna-1,4-dieno-3,20-dionu |
CA2725008C (en) | 2008-05-28 | 2017-09-05 | Validus Biopharma, Inc. | Non-hormonal steroid modulators of nf-.kappa.b for treatment of disease |
WO2011127048A2 (en) | 2010-04-05 | 2011-10-13 | Validus Biopharma | NON-HORMONAL STEROID MODULATORS OF NF-ĸB FOR TREATMENT OF DISEASE |
WO2016120891A1 (en) | 2015-01-30 | 2016-08-04 | Coral Drugs Pvt. Ltd. | Novel process for preparation of glucocorticoid steroids |
WO2017004205A1 (en) | 2015-06-29 | 2017-01-05 | Reveragen Biopharma, Inc. | NON-HORMONAL STEROID MODULATORS OF NF-κB FOR TREATMENT OF DISEASE |
US11382922B2 (en) | 2019-03-07 | 2022-07-12 | Reveragen Biopharma, Inc. | Aqueous oral pharmaceutical suspension compositions |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2990401A (en) * | 1958-06-18 | 1961-06-27 | American Cyanamid Co | 11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids |
US2998433A (en) * | 1960-07-22 | 1961-08-29 | American Cyanamid Co | 2alpha-halo-4, 9(11), 16-pregnatriene-3, 20-diones |
US3047468A (en) * | 1961-06-06 | 1962-07-31 | American Cyanamid Co | Method of preparing delta1, 4-3-keto steroids of the pregnane series |
SE378109B (US08080257-20111220-C00005.png) * | 1972-05-19 | 1975-08-18 | Bofors Ab | |
DE2360444A1 (de) * | 1973-11-30 | 1975-06-05 | Schering Ag | Neue pregnansaeure-derivate |
US3970646A (en) * | 1974-04-24 | 1976-07-20 | Ortho Pharmaceutical Corporation | Halo-steroidal thioketals |
US4124707A (en) * | 1976-12-22 | 1978-11-07 | Schering Corporation | 7α-Halogeno-3,20-dioxo-1,4-pregnadienes, methods for their manufacture, their use as anti-inflammatory agents, and pharmaceutical formulations useful therefor |
US4267173A (en) * | 1979-11-05 | 1981-05-12 | Schering Corporation | Use of 6β-fluoro-7α-halogenocorticoids as topical anti-inflammatories and pharmaceutical formulations useful therefor |
DE3143757A1 (de) * | 1981-10-30 | 1983-05-11 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue kortikoide, ihre herstellung und verwendung |
SE8403905D0 (sv) * | 1984-07-30 | 1984-07-30 | Draco Ab | Liposomes and steroid esters |
SE8604059D0 (sv) * | 1986-09-25 | 1986-09-25 | Astra Pharma Prod | A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives |
HU203562B (en) * | 1989-03-09 | 1991-08-28 | Richter Gedeon Vegyeszet | Process for producing new steroide diols and pharmaceutical compositions containing them |
HU203769B (en) * | 1989-03-09 | 1991-09-30 | Richter Gedeon Vegyeszet | Process for producing new steroide derivatives and pharmaceutical compositions containing them |
FR2675146A1 (fr) * | 1991-04-10 | 1992-10-16 | Roussel Uclaf | Nouveaux derives sterouides de la pregna-1,4-diene-3,20-dione, leur preparation, leur application a la preparation de derives 16,17-methylene dioxy substitues et nouveaux intermediaires. |
-
1991
- 1991-04-10 FR FR9104339A patent/FR2675146A1/fr active Granted
-
1992
- 1992-04-08 HU HU9201190A patent/HU212197B/hu not_active IP Right Cessation
- 1992-04-09 EP EP92401002A patent/EP0508900B1/fr not_active Expired - Lifetime
- 1992-04-09 DE DE69227478T patent/DE69227478T2/de not_active Expired - Fee Related
- 1992-04-09 IE IE113092A patent/IE921130A1/en not_active IP Right Cessation
- 1992-04-09 JP JP11520192A patent/JP3172575B2/ja not_active Expired - Fee Related
- 1992-11-12 US US07/974,484 patent/US5310896A/en not_active Expired - Fee Related
-
1994
- 1994-02-02 US US08/190,881 patent/US5434258A/en not_active Expired - Fee Related
-
1995
- 1995-01-13 US US08/372,647 patent/US5451690A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5451690A (en) | 1995-09-19 |
FR2675146B1 (US08080257-20111220-C00005.png) | 1995-03-24 |
HU212197B (en) | 1996-03-28 |
HUT61570A (en) | 1993-01-28 |
FR2675146A1 (fr) | 1992-10-16 |
US5434258A (en) | 1995-07-18 |
IE921130A1 (en) | 1992-10-21 |
EP0508900A1 (fr) | 1992-10-14 |
US5310896A (en) | 1994-05-10 |
EP0508900B1 (fr) | 1998-11-04 |
HU9201190D0 (en) | 1992-07-28 |
DE69227478T2 (de) | 1999-06-02 |
DE69227478D1 (de) | 1998-12-10 |
JPH05170788A (ja) | 1993-07-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20010306 |
|
LAPS | Cancellation because of no payment of annual fees |