JP3168886B2 - Chemical analyzer - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a chemical analyzer,
In particular, it relates to stirring (mixing) of a sample and a reagent.

[0002]

2. Description of the Related Art Conventionally, as a chemical analyzer, there is a chemical analyzer described in US Pat. No. 4,451,433. This device consists of a colorimetric measurement unit for analyzing and quantifying proteins and ions in blood and components in urine, and an ion analysis unit for analyzing ions in blood. Therefore, a large-sized apparatus has a processing speed of 9000 tests or more. Especially in the colorimetric measurement section, in order to increase the processing speed, a large number of reaction vessels are provided on the circumference of the turntable on the top of the main body of the chemical analyzer, and a system that sequentially mixes, reacts, and measures samples by overlapping processing It is. The main components of this device are an automatic sample / reagent supply mechanism for supplying samples and reagents to the reaction vessel, an automatic stirring mechanism for stirring the samples / reagents in the reaction vessel, and a sample during or after the reaction. It has a measuring instrument for measuring the physical properties of the sample, an automatic washing mechanism for sucking and discharging the sample whose measurement has been completed, and washing the reaction vessel, and a control unit for controlling these operations. An automatic stirring mechanism for stirring the sample and the reagent is connected to a spatula for descending below the liquid level in the reaction vessel to cause a swirling flow, and a root of the spatula,
It comprises a motor for rotating the spatula, a washing vessel for washing the spatula, and a drive mechanism for moving the washing vessel and the reaction vessel back and forth.

[0003]

In the field of chemical / medical analysis, the miniaturization of liquids such as samples and reagents has become a major technical problem. That is, as the number of analysis items increases,
The amount of specimen that can be divided into single items is small, or the sample itself is valuable and cannot be prepared in large quantities.
Analysis with a small amount of sample or reagent, which has conventionally been considered as an advanced analysis, has been routinely performed. In addition, as the contents of analysis become more sophisticated, expensive reagents are generally used, and there is a demand for reducing the amount of reagents in terms of running costs. or,
In the fields of drug production and biotechnology, preparation of trace reagents and preparation of samples with trace substances are becoming important.

[0004] In the above-mentioned prior art, stirring for mixing the liquid inside the container was performed using a spatula or a screw. At this time, there is a problem that the liquid after stirring adheres to a spatula or a screw, is carried over to the inspection of the next sample, and contaminates the next sample or sample, thereby affecting analysis results.

In recent years, various other devices have been introduced into hospitals and the like in which such a chemical analyzer is installed, and further downsizing is desired.

An object of the present invention is to provide a chemical analysis device,
An object of the present invention is to prevent carryover when mixing a sample and a sample inside a container.

Another object of the present invention is to reduce the size of the chemical analyzer itself.

[0008]

The former object is to provide a reaction vessel, a sample supply means for supplying a sample from the upper opening of the reaction vessel, and a reagent supply for supplying a reagent from the upper opening of the reaction vessel. Means, and a chemical analyzer including a measuring means for measuring the physical properties of the sample during or after the reaction, provided in the outside of the reaction vessel, a sound wave generating means for generating a sound wave toward the reaction vessel Wherein the sound wave generation means is located at a distance from the reaction vessel.
The lower part is provided at a distance, and the sound wave is generated by the sound wave generator.
Occurrence occurs in a direction shifted from the center of the bottom of the reaction vessel
To be achieved.

The latter object is to provide a turntable in which a plurality of reaction vessels are arranged on a circumference, a sample turntable in which a plurality of sample vessels containing samples are arranged on a circumference, and a reagent-containing turntable. A plurality of reagent containers arranged on a circumference, a reagent turntable, a sample supply means for supplying a sample in the sample container from an upper opening of the reaction container, and a reagent in the reagent container. In a chemical analyzer comprising a reagent supply means for supplying from an upper opening of a reaction vessel and a measurement means for measuring physical properties of the sample during or after the reaction, the reaction vessel is provided outside the reaction vessel. Sound wave generating means for generating a sound wave toward the camera;
Raw is generated in a direction shifted from the center of the bottom of the reaction vessel.
This is achieved by:

[0010]

With respect to the former, the main cause of the carry-over in the past is that the sample and the reagent injected into the reaction vessel were mechanically stirred with a spatula or a screw. In the present invention, the sound wave generated by the sound generation means provided outside the reaction vessel is irradiated toward the reaction vessel. The sound wave acts to stir the sample and the reagent inside the container via the reaction container. Therefore, in the chemical analyzer, there is no need to mechanically stir using a spatula or a screw, so that carry-over can be prevented.

On the other hand, with respect to the latter, the configuration that controls the size of the chemical analyzer itself is mainly composed of a turntable for accommodating a plurality of reaction vessels, a sample turntable for accommodating a plurality of sample vessels, and a plurality of turntables for accommodating a plurality of sample vessels. This is the diameter of the reagent turntable that stores the reagent container.

The diameter of these turntables is a value determined by the size and the number of stored containers. Since it is difficult from the viewpoint of throughput to reduce the number measured per unit time, it is necessary to reduce the size of each container. However, since the size of each container is determined by the amount of the sample and the reagent to be put in the container, the container can no longer be made smaller.

By the way, the amounts of the sample and the reagent to be put in the container are determined not by the amount necessary for analysis and measurement but by the amount that can be mechanically stirred with a spatula or a screw. That is, if the amounts of the sample and the reagent are small, it becomes difficult to stir, so that the amount is set to an amount necessary for analysis and measurement.

In the present invention, the stirring is not performed mechanically, but is performed in contact with the object to be stirred inside the container by sound waves. In the case of a mechanical type, a certain amount of the object to be stirred is required to physically mix the object to be stirred with a spatula or the like, but in the present invention, the object to be stirred is stirred using a sound wave. Since the mixture is stirred by the flow, even a small amount of the mixture can be mixed well.

From this, the amounts of the sample and the reagent are
The amount required for analysis / measurement is sufficient, and the size of each reaction vessel can be reduced. As a result, the diameter of the turntable can be reduced.

If the amounts of the sample and the reagent to be injected into the reaction container can be reduced in this way, the sample amount and the reagent amount can be reduced, and therefore, the sample container and the reagent container can be reduced. The diameter of the turntable can be reduced.

Since the diameter of these turntables can be reduced, the overall size of the chemical analyzer can be reduced.

[0018]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS One embodiment of the present invention will be described with reference to FIGS. FIG. 1 is a perspective view showing a configuration of the chemical analyzer of the present embodiment, and FIG. 2 is a longitudinal sectional view showing a configuration of a non-invasive (non-contact) stirring device provided in the chemical analyzer shown in FIG.

A plurality of reaction vessels 301 are fixed on the circumference of the vessel fixing turntable 302. The container fixed turntable 302 is rotated in the circumferential direction by a table driving unit 303 including a motor, a rotating shaft, and the like (not shown). On the other hand, the sample has a plurality of sample cups 305
These sample cups 305 are fixed on the circumference of a sample turntable 306 which rotates by one cycle and one rotation in the circumferential direction by a table driving unit 307. The sample automatic pipetting mechanism 304 supplies the reaction container 301 with the sample in the sample cup 305 sent to a fixed position along with the rotation of the sample turntable 306 according to a predetermined sequence.
The reagents are put in a plurality of reagent bottles 309, and these reagent bottles 309 are fixed on the circumference of a reagent turntable 310 that rotates in the circumferential direction by a table driving unit 311. Also, the reagent in the reagent bottle 309 that has come to a fixed position with the rotation of the reagent turntable 310 is supplied to the reaction container 301 in accordance with a predetermined sequence. The reagent bottles 309 contain different types of reagents, and the automatic reagent pipetting mechanism 308 supplies a required amount to the reaction container 301 in a predetermined sequence.

At a position where the reagent automatic pipetting mechanism 308 discharges a reagent into the reaction vessel 301, a non-invasive stirring device 312 and a driver 313 for driving and controlling the non-invasive stirring device 312 are provided. Then, the sample and the reagent in the reaction container 301 that have moved to that position are stirred and mixed. Further, all the reaction vessels 301 are placed in the bathtub 40 to promote the chemical reaction between the sample and the reagent.
1 is immersed in the constant temperature water 402, and the reaction vessel 301 moves in the constant temperature water 402.

At another position in the circumferential direction of the container fixed turntable 302, a measuring unit 314 for measuring the physical properties of the reacted liquid in the container by light is provided. At another position, a cleaning mechanism 315 for sucking the reaction liquid in the container, discharging the cleaning liquid, and cleaning the reaction container 301 moved to that position is provided. At the same position as the cleaning mechanism 315, a non-invasive stirring device 316 for stirring the cleaning liquid in the container by convection to enhance the cleaning effect and a driver 317 for driving the non-invasive stirring device 316 are provided. Fixed container turntable 303, table driving units 307 and 311 and automatic sample pipetting mechanism 304, automatic reagent pipetting mechanism 308,
The drivers 313, 317, the cleaning mechanism 315, and the measuring unit 314 for the two non-invasive stirring devices are connected to the control unit 318 via a control signal line, and the sample (this program) is determined according to a predetermined sequence (program). In this case, the blood to be tested is automatically analyzed and measured.

Next, an apparatus for stirring an object to be stirred in a reaction vessel in a non-contact manner will be described with reference to FIG. When the reaction vessel 301 repeatedly rotates and stops, and stops at the position shown in the figure, the controller 313 (317, the controller 317 controls the washing stirrer 316, but their structure and operation are the non-invasive stirrer for stirring. 313
Therefore, in this specification, the noninvasive stirring device 313 and the controller 313 will be described as representatives.)
Outputs a signal to the piezoelectric element 103, and the piezoelectric element 103 outputs an ultrasonic wave, which is a high-frequency sound wave, as described in detail later. The non-invasive stirring device 312 (general name of the entire device shown in FIG. 2) is a reaction vessel 30 containing a solute (sample) 101 and a solvent (reagent) 102 as described above.
1 is fixed to the sample turntable 302. The reaction vessel 301 includes a bathtub 40 containing a constant temperature water 402.
1 dipped. The piezoelectric element 1 is provided at the bottom of the bathtub 401.
Numeral 03 is fixed to the lower part of the bathtub 401 via the position adjusting unit 106, and provided with the reaction vessel 301 via constant temperature water 402. In addition, the piezoelectric element 10 of the bathtub 401
The mounting portion 3 is provided with a seal 107 for preventing the constant temperature water 402 from flowing out. Piezoelectric element 103
Are driven at a predetermined frequency by the controller 501.

The operation of the non-invasive (contact) stirrer 312 configured as described above will be described below. Piezoelectric element 103
Is excited at a predetermined frequency by the controller 501, and the generated vibration is applied to the bathtub 40 in the direction indicated by the arrow 105.
1 propagates as a sound wave (indicated by an arrow 403) and reaches the bottom of the reaction vessel 301. This sound wave is applied to the reaction vessel 30
1 Solvent 10 passing through the bottom wall surface and being stirred in the container
2 and solute 101.

The transmitted vibration wave propagates vertically upward in the solvent as a sound wave. A steady stream called an acoustic straight stream indicated by an arrow 203 is generated in the propagation direction. The cause of this steady flow is described in the document "Physical Acoustics" page
As described in 265-330, when a sound wave propagates through a fluid such as a solvent in the vibration direction, the sound wave is absorbed by the influence of the viscosity and bulk viscosity of the fluid, and the absorption causes the sound wave to propagate in the propagation direction. It is considered that a pressure gradient is generated due to the energy difference of The solute 101 is lifted vertically above the solvent 102 by the acoustic straight flow 203, and forms a vertical convection that reaches the vicinity of the liquid surface and then descends again around.
Therefore, the solvent 102 and the solute 101 are agitated without inserting an intervening object such as a spatula into the container.
The flow velocity of the acoustic straight stream 203 is the sound absorption coefficient of the solvent 102,
According to the experimental results, the condition in which the acoustic straight flow is remarkably generated in the reaction vessel 301 is a condition in which the vibration speed of the piezoelectric element 103 is at least 0.1 mm / s or more. Turned out to be necessary.

This sound wave causes an acoustic straight stream 203 in a fluid such as the solvent 102 to promote the movement of the solute 101 to perform stirring. In the figure, the reaction vessel 301 and the piezoelectric element 1
Although the constant temperature water 402 is interposed between the piezoelectric element 103 and the piezoelectric element 103, the stirring can be performed even when the piezoelectric element 103 is brought into contact with the reaction vessel 301.

As described above, according to the present embodiment shown in FIGS. 1 and 2, the stirring of the solute and the solvent in the reaction vessel 301 is not performed without using a contact-type stirring means such as a spatula. The object to be stirred attached to the spatula does not enter the other reaction vessel 301 (carry over) and does not affect the analysis / measurement result.

In addition, there is a demand for reducing the size of the entire chemical analyzer. To reduce the size, the number of the reaction vessels 301 mounted on the vessel fixed turntable 302 can be reduced to reduce the diameter. Although this can be achieved, it is not preferable because the throughput is reduced as a chemical analyzer.
By the way, in the contact type stirring means, there is a problem that stirring cannot be performed when the amount of the object to be stirred is less than the lower limit value due to its structure, which is larger than the amount required for analysis / measurement. The volume had to be increased, and as a result, the diameter of the container fixed turntable 302 was increased. Further, in order to satisfy the liquid amount required for stirring, the amount of the sample and the reagent is large, and the sample cup 305 and the reagent bottle 309 have large sizes. For this reason, the sample turntable 30
4 and the diameter of the reagent turntable 310 could not be reduced, which hindered miniaturization of the entire chemical analyzer.

According to this embodiment, since the stirring of the object to be stirred in the reaction vessel is of a non-contact type, the amount of the object to be stirred (sample or reagent) can be set to the amount required for analysis and measurement. As a result, the size of the reaction vessel 301 can be reduced, and at least the diameter of the vessel fixed turntable 302 can be reduced accordingly. Therefore, the size of the entire chemical analyzer can be reduced while maintaining the throughput of the chemical analyzer. Furthermore, if miniaturization is desired, the amount of sample and reagent required for the reaction is also reduced, so that these containers can also be miniaturized. As a result, the sample turntable 304 and the reagent turntable 310 Since the diameter can be reduced, the overall size of the chemical analyzer can be reduced. If the size of the reagent bottle 309 is kept as it is, and the amount of the reagent is the same as the conventional amount, the amount of replacement of the reagent with respect to the number of times of replacing the sample is reduced even if the size of the apparatus is somewhat sacrificed. There is an effect of doing.

By the way, although not a chemical analyzer, a method described in the following literature is known as a method of mixing using ultrasonic waves.

JP-A-57-28182 discloses that, in order to mix a liquid crystal and a polychromatic dye, a container containing the liquid crystal and the polychromatic dye is covered, and then ultrasonic waves are applied to the container to vibrate the container with high frequency. Is described.

Also, The Acoustical Society of Japan, Vol. 45, No. 1 (198
9) "Promotion of heat transfer by acoustic streaming" describes the use of a rectilinear acoustic flow having the same action as a forced flow from outside to promote heat transfer of a heated object.

Further, 1991 IEEE, pp. 277-282, "Ultrasonically Induced Microtransp.
Ort "describes that a piezoelectric thin film is provided on the bottom wall surface of the tank as a fluid moving means to generate a traveling wave of a transverse wave.

The following problem arises when an acoustic stream is used as a stirring mechanism of a chemical analyzer. That is, in the chemical analyzer, there is a step of first injecting a sample into a reaction vessel, injecting a reagent, and stirring, so that the upper part of the reaction vessel must be open. At this time, it has been found that there is a problem that the object to be stirred is blown out from the upper opening portion when the ultrasonic wave is given unnecessarily.

In an embodiment described below to solve this problem, when an ultrasonic wave for generating an acoustic straight flow is applied, the relative position between the piezoelectric element and the reaction vessel is appropriately adjusted, so that the object to be stirred is provided. By preventing ultrasonic waves having the same intensity from being applied uniformly to the object, it is possible to prevent the object to be stirred from moving upward and blowing out at the same time. That is, blowing is prevented by causing a flow of the object to be stirred inside the container. Hereinafter, FIG.
This will be described with reference to FIGS. In these figures, the same reference numerals as those in FIGS. 1 and 2 indicate the same parts.

3 differs from the embodiment shown in FIG. 2 in that the position of the piezoelectric element 103 is shifted from the center of the bottom of the reaction vessel 301. Since this position has an optimum position with respect to the reaction vessel stop position, some adjustment is required at the time of manufacturing. Therefore, a position adjusting unit 106 for adjusting the position of the piezoelectric element 103 attached to the bottom of the bathtub 401 is provided. Was. Since the piezoelectric element 103 is arranged in this manner, the ultrasonic waves generated by the piezoelectric element 103 travel through the constant temperature water 401 as shown by an arrow 105,
Reaching the bottom of the reaction vessel 301, an acoustic straight stream 203 is generated inside the reaction vessel. The location where the acoustic straight stream 203 is generated occurs near the wall surface of the reaction vessel 301 because the piezoelectric element 103 is displaced from the center. For this reason, the object to be stirred rises near the wall surface together with the acoustic straight flow 203, and the circulating flow 10 descends from the opposite wall surface.
It becomes 8, and it promotes internal stirring. Thus, the circulation flow 1
The reason why 08 occurs is that a difference is provided in the energy intensity distribution in a plane perpendicular to the propagation direction of the sound wave. In this case, the piezoelectric element 103 was arranged so that the energy intensity near the wall surface of the reaction vessel 301 was the highest. If the acoustic straight stream 203 occurs in the propagation direction of the ultrasonic wave,
Is uniform in a plane perpendicular to the propagation direction of the sound wave, there is no relative velocity difference in the acoustic straight stream 203 in the reaction vessel 301, so that not only the circulation flow does not occur, but also the aforementioned As described above, the object to be stirred is ejected from the upper opening from the reaction vessel 301.

According to this embodiment, there is an effect that stirring can be efficiently performed in a short time while preventing ejection.

Another embodiment will be described with reference to FIG. FIG.
The difference from the embodiment shown in FIG.
01 is provided not on the bottom but on the side. Reaction vessel 3
Ultrasonic waves are applied obliquely (angle adjustment is performed by the angle adjustment unit 109) to part (bottom and side surfaces) or all (side surfaces) of the side surfaces of the reaction vessel 01, and the inside of the reaction vessel 301 is operated by the same operation as described above. An acoustic straight stream 108 is generated that proceeds obliquely toward the wall opposite to the wall to be irradiated. The flow that collides with the opposite wall becomes a circulating flow 108 that diverges up and down due to the angle and returns.

According to this embodiment, since the circulating flow is divided as described above, the upward flow vector is smaller than in the embodiment shown in FIG. 3, and the possibility of ejecting the object to be stirred is reduced. In addition to the above effect, since the piezoelectric element is attached to the side surface of the bathtub 401, there is an effect that the angle can be easily adjusted at the time of manufacturing or the like.

Another embodiment will be described with reference to FIG. FIG.
3 is different from the embodiment shown in FIG. 3 in that the piezoelectric element 103 is shifted in the direction along the bottom of the bathtub 401 so that the ultrasonic irradiation position is shifted from the center of the bottom surface of the reaction vessel 301. However, in the present embodiment, the ultrasonic irradiation position was near the center of the bottom of the reaction vessel 301, and the piezoelectric element 1
The difference is that a circulating flow is formed inside the reaction vessel 301 by appropriately setting the distance between the reaction vessel 03 and the bottom of the reaction vessel 301. The ultrasonic wave generated from the piezoelectric element 103 has a portion where the energy intensity is sharpened in a plane perpendicular to the propagation direction. By adjusting the bottom of the reaction vessel 301 to this sharpened portion, that is, the position where the energy converges, a sharpened acoustic straight stream 203 is generated near the center of the inside of the reaction vessel 301, thereby rising from the center, A circulating flow 108 descending from the surroundings is created. This sharpened portion can be found by adjusting the piezoelectric element 103 in the vertical direction by the distance adjusting unit.

According to the present embodiment, the object to be stirred which is settled particularly at the center of the bottom of the reaction vessel can be levitated, so that the stirring can be performed in a short time.

FIG. 6 shows an embodiment in which the energy intensity is further sharpened in the embodiment shown in FIG. Piezoelectric element 1
The point that the acoustic lens 601 is provided in the radiation direction of the vibration wave 03 is different from the embodiment shown in FIG. The acoustic lens 601 has a function of converging the vibration wave, and the ultrasonic wave that has exited the acoustic lens 601 passes through the bottom of the reaction vessel 301 and is focused on the vicinity of the solvent 102 or the solute 101.
As a result, a strong sound field is formed vertically upward in the vicinity of the solute 101, so that an acoustic straight stream 203 sufficient to levitate the solute 101 is generated. In particular, this is effective when a solute having a large specific gravity or viscosity or a case where rapid stirring is desired. In this embodiment, the following operation can be performed. The vibration wave emitted from the piezoelectric element 103 is partially reflected after hitting the solute 101. This time is detected by the piezoelectric element 103, and the position of the solute 10l is specified by the controller 313. Acoustic lens 60
The device 1 receives a position information signal indicating the position of the solute 101 from the controller 313, operates to converge the vibration wave to the position of the solute 101, and efficiently generates an acoustic straight stream sufficient to levitate the solute 101. give.

The chemical analyzer of the type in which the turntable is rotated to perform the automatic analysis has been described above.
Examples of the number of reaction vessels is less semi-automatic chemical analyzer will be described with reference to FIG.

The chemical analyzer according to the present embodiment measures the sample automatic pipetting mechanism 304, the reagent automatic pipetting mechanism 308, the reaction vessel 301, the piezoelectric element 103 provided at the bottom of the reaction vessel 301, and the properties of the sample. And a tube 324 for introducing a sample from the bottom of the container into the sensor 322 and a pump 323 for moving the sample. When the automatic sample pipetting mechanism 304 and the automatic reagent pipetting mechanism 301 operate, the reaction vessel 301
A predetermined amount of sample and reagent are discharged into the inside. The piezoelectric element 103 starts vibrating in synchronization with the ejection timing, and as a result,
Reagents and samples are mixed in a relatively short period of time to induce acoustic streaming. The mixed sample is moved to the sensor unit 322 by the operation of the pump 323 and guided to be measured.

The installation position and configuration of the piezoelectric element 103 may be configured as shown in FIGS.

In particular, the trouble of inserting the stirring means into the container,
Since time for washing the stirring means can be saved, time-efficient analysis can be performed.

Further, by using this mixing reaction device, the liquids can be mixed and reacted without coming into contact with the liquid in the tank. Particularly, it is suitable for mixing a small amount of reagent, mixing a precious sample, or performing mixing for avoiding contamination with impurities through a spatula or the like.

In the above-described embodiments, the blood analyzer has been described as an example, but the present invention is not limited to this.

Although ultrasonic waves are used to stir an object to be stirred in a non-contact manner, denaturation of proteins such as blood can be prevented by adjusting the intensity and irradiation time. However, it goes without saying that if the object to be stirred is not invaded by the ultrasonic waves, it is not necessary to consider the denaturation.

[0049]

As described above, according to the chemical analyzer of the present invention, carry-over can be prevented and the size of the chemical analyzer can be reduced.

[Brief description of the drawings]

FIG. 1 is a perspective view of a chemical analyzer according to one embodiment of the present invention.

FIG. 2 is a configuration diagram of a non-invasive stirring device mounted on a chemical analysis device.

FIG. 3 is a diagram showing a non-invasive stirring device according to an embodiment of the present invention.

FIG. 4 is a view showing a non-invasive stirring apparatus according to another embodiment of the present invention.

FIG. 5 is a view showing a non-invasive stirring apparatus according to another embodiment of the present invention.

FIG. 6 is a view showing a non-invasive stirring apparatus according to another embodiment of the present invention.

FIG. 7 is a perspective view of a chemical analyzer according to another embodiment of the present invention.

[Explanation of symbols]

101: solute, 102: solvent, 103: piezoelectric element, 30
DESCRIPTION OF SYMBOLS 1 ... Reaction container, 203 ... Acoustic straight stream, 313 ... Controller, 601 ... Acoustic lens, 304 ... Sample automatic pipetting mechanism, 308 ... Reagent automatic pipetting mechanism, 312, 316 ... Non-invasive stirring device, 314 ... Measurement part, 315: cleaning mechanism, 318: control unit.

──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Hideo Eno 502 Kandachicho, Tsuchiura-shi, Ibaraki Pref. Machinery Research Laboratory, Hitachi, Ltd. In the Machinery Division (56) References JP-A 56-106834 (JP, U) JP-A 62-40564 (JP, U) JP-A 56-161569 (JP, U) (58) Fields surveyed (Int. Cl ^7, DB name) G01N 35/00 -. 35/10 B01F 11/02

Claims (10)

(57) [Claims] 1. A reaction vessel, sample supply means for supplying a sample from an upper opening of the reaction vessel, reagent supply means for supplying a reagent from an upper opening of the reaction vessel, during or after the reaction. In a chemical analysis device provided with measuring means for measuring physical properties of the sample, a sound wave generating means provided outside the reaction vessel and generating a sound wave toward the reaction vessel, and a position of the sound wave generating means are determined.
Chemical analyzer with a mechanism for adjusting 2. A reaction vessel, sample supply means for supplying a sample from the upper opening of the reaction vessel, reagent supply means for supplying a reagent from the upper opening of the reaction vessel, and during or after the reaction. A chemical analyzer provided with measuring means for measuring the physical properties of the sample, provided with a sound wave generating means provided outside the reaction vessel and generating a sound wave toward the reaction vessel, wherein the sound wave generating means A chemical analyzer provided at a lower portion of the reaction vessel at a distance from the vessel, wherein the generation of the sound wave by the sound wave generation means is generated in a direction shifted from the center of the bottom surface of the reaction vessel. 3. A reaction vessel, sample supply means for supplying a sample from the upper opening of the reaction vessel, reagent supply means for supplying a reagent from the upper opening of the reaction vessel, and during or after the reaction. A chemical analyzer provided with measuring means for measuring the physical properties of the sample, provided with a sound wave generating means provided outside the reaction vessel and generating a sound wave toward the reaction vessel, wherein the sound wave generating means A chemical analyzer provided at a lower portion of the reaction vessel at a distance from the vessel, wherein the sound wave is generated by the sound wave generation means so that the energy intensity of the sound wave converges near the center of the bottom surface of the reaction vessel. 4. The chemical analyzer according to claim 3, wherein the convergence of the energy intensity of the sound wave is performed by an acoustic lens. 5. A reaction vessel, sample supply means for supplying a sample from an upper opening of the reaction vessel, reagent supply means for supplying a reagent from an upper opening of the reaction vessel, and during or after the reaction. In a chemical analysis apparatus comprising: a measuring unit for measuring physical properties of the sample, a sound wave generating unit is provided outside the reaction vessel, and generates a sound wave toward the reaction vessel. A chemical analyzer that generates sound waves toward the side of the reaction vessel. 6. A turntable in which a plurality of reaction vessels are arranged on a circumference, a sample turntable in which a plurality of sample vessels containing samples are arranged on a circumference, and a plurality of reagents containing reagents. A reagent turntable in which containers are arranged on a circumference, sample supply means for supplying a sample in the sample container from an upper opening of the reaction container, and a reagent opening in the reagent container in an upper opening of the reaction container In a chemical analyzer having a reagent supply unit supplied from the unit and a measurement unit for measuring physical properties of the sample during or after the reaction, the chemical analysis device is provided outside the reaction container, and emits a sound wave toward the reaction container. A chemical analyzer having a sound wave generating means for generating a sound and a mechanism for determining a position of the sound wave generating means. 7. A turntable in which a plurality of reaction vessels are arranged on a circumference, a sample turntable in which a plurality of sample vessels containing samples are arranged on a circumference, and a plurality of reagents containing reagents. A reagent turntable in which containers are arranged on a circumference, sample supply means for supplying a sample in the sample container from an upper opening of the reaction container, and a reagent opening in the reagent container in an upper opening of the reaction container A chemical analyzer comprising: a reagent supply unit supplied from a unit; and a measurement unit for measuring physical properties of the sample during or after the reaction, provided outside the reaction container, and applying a sound wave toward the reaction container. A sound wave generating means for generating the sound wave, wherein the sound wave generating means is provided at a lower portion of the reaction vessel at a distance from the reaction vessel; A chemical analyzer generated in a direction shifted from the center of the surface. 8. A turntable in which a plurality of reaction vessels are arranged on a circumference, a sample turntable in which a plurality of sample vessels containing samples are arranged on a circumference, and a plurality of reagents containing reagents. A reagent turntable in which containers are arranged on a circumference, sample supply means for supplying a sample in the sample container from an upper opening of the reaction container, and a reagent opening in the reagent container in an upper opening of the reaction container A chemical analyzer comprising: a reagent supply unit supplied from a unit; and a measurement unit for measuring physical properties of the sample during or after the reaction, provided outside the reaction container, and applying a sound wave toward the reaction container. A sound wave generating means for generating the sound wave, wherein the sound wave generating means is provided at a lower portion of the reaction vessel at a distance from the reaction vessel; A chemical analyzer which is generated so that the energy intensity of a sound wave converges in the vicinity of the center of the surface. 9. The chemical analyzer according to claim 8, wherein the convergence of the energy intensity of the sound wave is performed by an acoustic lens. 10. A turntable in which a plurality of reaction vessels are arranged on a circumference, a sample turntable in which a plurality of sample vessels containing samples are arranged on a circumference, and a plurality of reagents containing reagents. A reagent turntable in which containers are arranged on a circumference, sample supply means for supplying a sample in the sample container from an upper opening of the reaction container, and a reagent opening in the reagent container in an upper opening of the reaction container In a chemical analyzer having a reagent supply unit supplied from the unit and a measurement unit for measuring physical properties of the sample during or after the reaction, the chemical analysis device is provided outside the reaction container, and emits a sound wave toward the reaction container. A chemical analyzer, wherein a sound wave generating means for generating the sound wave is provided, and the sound wave generating means generates a sound wave toward a side surface of the reaction vessel.