JP3148243B2 - 総コレステロールおよび低密度リポタンパク質コレステロールの血中レベルを減少させる方法 - Google Patents

総コレステロールおよび低密度リポタンパク質コレステロールの血中レベルを減少させる方法

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Publication number
JP3148243B2
JP3148243B2 JP50826894A JP50826894A JP3148243B2 JP 3148243 B2 JP3148243 B2 JP 3148243B2 JP 50826894 A JP50826894 A JP 50826894A JP 50826894 A JP50826894 A JP 50826894A JP 3148243 B2 JP3148243 B2 JP 3148243B2
Authority
JP
Japan
Prior art keywords
hmb
cholesterol
ldl
low density
density lipoprotein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP50826894A
Other languages
English (en)
Japanese (ja)
Other versions
JPH08501777A (ja
Inventor
ニッセン、スティーヴン・エル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Iowa State University Research Foundation Inc ISURF
Original Assignee
Iowa State University Research Foundation Inc ISURF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25484425&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP3148243(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Iowa State University Research Foundation Inc ISURF filed Critical Iowa State University Research Foundation Inc ISURF
Publication of JPH08501777A publication Critical patent/JPH08501777A/ja
Application granted granted Critical
Publication of JP3148243B2 publication Critical patent/JP3148243B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP50826894A 1992-09-16 1993-09-15 総コレステロールおよび低密度リポタンパク質コレステロールの血中レベルを減少させる方法 Expired - Lifetime JP3148243B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US94640492A 1992-09-16 1992-09-16
US946,404 1992-09-16
US07/946,404 1992-09-16
PCT/US1993/008695 WO1994006417A1 (en) 1992-09-16 1993-09-15 Method of reducing blood levels of total cholesterol and low-density lipoprotein cholesterol

Publications (2)

Publication Number Publication Date
JPH08501777A JPH08501777A (ja) 1996-02-27
JP3148243B2 true JP3148243B2 (ja) 2001-03-19

Family

ID=25484425

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50826894A Expired - Lifetime JP3148243B2 (ja) 1992-09-16 1993-09-15 総コレステロールおよび低密度リポタンパク質コレステロールの血中レベルを減少させる方法

Country Status (12)

Country Link
US (1) US5360613A (cg-RX-API-DMAC7.html)
EP (1) EP0660706B1 (cg-RX-API-DMAC7.html)
JP (1) JP3148243B2 (cg-RX-API-DMAC7.html)
AU (1) AU673002B2 (cg-RX-API-DMAC7.html)
BR (1) BR9307035A (cg-RX-API-DMAC7.html)
CA (1) CA2142314C (cg-RX-API-DMAC7.html)
DE (1) DE69327468T2 (cg-RX-API-DMAC7.html)
ES (1) ES2142353T3 (cg-RX-API-DMAC7.html)
FI (1) FI951218A7 (cg-RX-API-DMAC7.html)
NO (1) NO951000D0 (cg-RX-API-DMAC7.html)
NZ (1) NZ256300A (cg-RX-API-DMAC7.html)
WO (1) WO1994006417A1 (cg-RX-API-DMAC7.html)

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US5716926A (en) * 1996-07-26 1998-02-10 Paxton K. Beale Composition of pyruvate and protein and method for increasing protein concentration in a mammal
US5756469A (en) * 1996-07-26 1998-05-26 Beale; Paxton K. Composition of pyruvate and anti-cortisol compounds and method for increasing protein concentration in a mammal
US6103764A (en) * 1997-11-07 2000-08-15 Iowa State University Research Foundation, Inc. Method for increasing the aerobic capacity of muscle
US6031000A (en) * 1998-06-23 2000-02-29 Iowa State University Research Foundation, Inc. Composition comprising β-hydroxy-β-methylbutyric acid and at least one amino acid and methods of use
AU2620600A (en) * 1999-01-21 2000-08-07 Steroidogenesis Inhibitors International Composition of anti-hiv drugs and anti-cortisol compounds and method for decreasing the side effects of anti-hiv drugs in a human
CN100542525C (zh) 2001-05-18 2009-09-23 隆萨股份公司 制备3-羟基-3-甲基丁酸钠固体制剂的方法
US20040220266A1 (en) * 2002-09-09 2004-11-04 Wiley David B. Composition and method for enhancing the bioavailability of calcium and magnesium in dietary supplements and food additives
US20040048925A1 (en) * 2002-09-09 2004-03-11 Wiley David B. Composition and method for enhancing the bioavailability of calcium and magnesium in dietary supplements and food additives
US20040106678A1 (en) * 2002-09-17 2004-06-03 Dobbins Thomas A Compositions for the parenteral administration of calcium and magnesium
US6812249B2 (en) * 2003-03-04 2004-11-02 Sal Abraham Process for preparing a 3-hydroxy-3-methylbutyrate amino acid salt and method of use
EP1750527A1 (en) * 2004-03-11 2007-02-14 Wiley Organics, Inc. Compositions and method for enhancing the bioavailability of calcium and magnesium in dietary supplements and food additives
US20050215640A1 (en) 2004-03-26 2005-09-29 Baxter Jeffrey H HMB compositions and uses thereof
EP1973426A2 (en) * 2005-11-03 2008-10-01 Southwest Immunology Inc. Compositions for preventing and reducing delayed onset muscle soreness
EP1968564B1 (en) 2005-12-19 2015-09-16 Abbott Laboratories Use of beta-hydroxy-beta-methylbutyrate to modulate the imbalance in type 1 and type 2 cytokine production
US20080200422A1 (en) * 2007-01-09 2008-08-21 Cavener Douglas R Methods for reduction of adipose tissue mass
US9770424B2 (en) 2008-12-09 2017-09-26 Metabolic Technologies, Inc. Nutritional intervention for improving muscular function and strength
US9539224B2 (en) 2008-12-09 2017-01-10 Metabolic Technologies, Inc. Nutritional intervention for improving muscular function and strength
US9707241B2 (en) 2008-12-09 2017-07-18 Metabolic Technologies, Inc. Nutritional intervention for improving muscular function and strength
US11173167B2 (en) 2008-12-09 2021-11-16 Metabolic Technologies, Inc. Nutritional intervention for improving muscular function and strength
US9259430B2 (en) 2008-12-09 2016-02-16 Metabolic Technologies, Inc. Nutritional intervention for improving muscular function and strength
US8815280B2 (en) * 2008-12-09 2014-08-26 Metabolic Technologies, Inc. Nutritional intervention for improving muscular function and strength
US8538727B2 (en) * 2009-07-21 2013-09-17 George S. Cembrowski Method and apparatus for calibration and testing of scientific measurement equipment
US11042605B2 (en) 2009-07-21 2021-06-22 Ccqcc Corp. Method and apparatus for calibration and testing of scientific measurement equipment
SG182808A1 (en) 2010-01-29 2012-09-27 Abbott Lab Aseptically packaged nutritional liquids comprising hmb
WO2011094557A1 (en) 2010-01-29 2011-08-04 Abbott Laboratories Nutritional emulsions comprising calcium hmb
US9693577B2 (en) 2010-01-29 2017-07-04 Abbott Laboratories Method of preparing a nutritional powder comprising spray dried HMB
TWI526161B (zh) 2010-06-10 2016-03-21 亞培公司 包含鈣ｈｍｂ及可溶性蛋白質之實質上透明營養液
JP6158801B2 (ja) * 2011-07-15 2017-07-05 ニューサート サイエンシーズ， インコーポレイテッド 代謝経路を変調させるための組成物および方法
PH12014500329A1 (en) * 2011-08-15 2014-04-14 Abbott Laboaratories Process for manufacturing hmb and salts thereof
WO2013067485A1 (en) 2011-11-03 2013-05-10 University Of Florida Research Foundation, Inc. Nutritional supplement for weight management
WO2012140276A2 (en) * 2011-11-17 2012-10-18 Lonza Ltd Process for the preparation of 3-hydroxy-3-methylbutyric acid or its calcium salts
JP6258943B2 (ja) 2012-09-10 2018-01-10 メタボリック・テクノロジーズ，インコーポレーテッド Ｈｍｂおよびａｔｐの組成物ならびに使用方法
CA2944004C (en) 2014-03-27 2023-08-15 Roland W. Winterfield Beta-hydroxy beta-methylbutyrate for alleviating statin myopathy
DK3349745T3 (da) 2015-09-16 2024-03-18 Metabolic Tech Llc Sammensætninger og fremgangsmåder til anvendelse af beta-hydroxy-beta-methylbutyrat (hmb) til forbedret restitution efter blødvævstraume
US12208073B2 (en) 2015-09-16 2025-01-28 Metabolic Technologies, LLC Compositions and methods of use of beta-hydroxy-beta-methylbutyrate (HMB) for enhancing recovery from soft tissue trauma
TWI716495B (zh) * 2015-11-19 2021-01-21 日商協和發酵生化股份有限公司 3-羥基異戊酸之一價陽離子鹽之結晶及該結晶之製造方法
WO2017127675A1 (en) 2016-01-21 2017-07-27 Metabolic Technololgies, Inc. COMPOSITIONS AND METHODS OF USE OF β-HYDROXY-β-METHYLBUTYRATE (HMB) FOR MODULATING AUTOPHAGY AND LIPOPHAGY
CA3028608A1 (en) 2016-06-24 2017-12-28 Otsuka Pharmaceutical Factory, Inc. Crystal of amino acid salt of 3-hydroxyisovaleric acid and production method thereof
CA3041520A1 (en) 2016-10-21 2018-04-26 Metabolic Technologies, Inc. Compositions and methods of use of .beta.-hydroxy-.beta.-methylbutyrate (hmb) and probiotics

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3629449A (en) * 1968-04-22 1971-12-21 Majid Siddiqi Process of combatting hypercholesterolemia
US4760090A (en) * 1986-03-11 1988-07-26 Iowa State University Research Foundation, Inc. Method of feeding ketoisocaproate to cattle and sheep
US4764531A (en) * 1986-03-11 1988-08-16 Iowa State University Research Foundation, Inc. Method of feeding ketoisocaproate to laying chickens
US5087472A (en) * 1990-01-30 1992-02-11 Iowa State University Research Foundation, Inc. Feed compositions for domestics animals containing hydroxymethylbutyrate
US5028440A (en) * 1990-01-30 1991-07-02 Iowa State University Research Foundation, Inc. Method of raising meat producing animals to increase lean tissue development
US4992470A (en) * 1990-02-08 1991-02-12 Iowa State University Research Foundation, Inc. Method of enhancing immune response of mammals

Also Published As

Publication number Publication date
DE69327468D1 (de) 2000-02-03
US5360613A (en) 1994-11-01
NO951000L (no) 1995-03-15
ES2142353T3 (es) 2000-04-16
NO951000D0 (no) 1995-03-15
CA2142314C (en) 1999-06-01
FI951218A0 (fi) 1995-03-15
DE69327468T2 (de) 2000-05-11
AU4922593A (en) 1994-04-12
NZ256300A (en) 1997-06-24
FI951218L (fi) 1995-03-15
AU673002B2 (en) 1996-10-24
EP0660706B1 (en) 1999-12-29
WO1994006417A1 (en) 1994-03-31
EP0660706A1 (en) 1995-07-05
CA2142314A1 (en) 1994-03-31
EP0660706A4 (cg-RX-API-DMAC7.html) 1995-07-26
JPH08501777A (ja) 1996-02-27
BR9307035A (pt) 1999-06-29
FI951218A7 (fi) 1995-03-15

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