JP3056525B2 - 肺の界面活性タンパク質の単離および精製 - Google Patents

肺の界面活性タンパク質の単離および精製

Info

Publication number
JP3056525B2
JP3056525B2 JP3512939A JP51293991A JP3056525B2 JP 3056525 B2 JP3056525 B2 JP 3056525B2 JP 3512939 A JP3512939 A JP 3512939A JP 51293991 A JP51293991 A JP 51293991A JP 3056525 B2 JP3056525 B2 JP 3056525B2
Authority
JP
Japan
Prior art keywords
rsp
fusion protein
mixture
inclusion body
chromatography
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP3512939A
Other languages
English (en)
Japanese (ja)
Other versions
JPH05502888A (ja
Inventor
ジェイ． ベンソン，ブラッドリー
バックリー，ダグラス
レシカー，デイビッド
ナイドゥ，エイシャ
バプティ シルバネス，カティ
Original Assignee
バイク グルデン ロンバーグ ケミッシェ ファブリク ゲーエムベーハー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by バイク グルデン ロンバーグ ケミッシェ ファブリク ゲーエムベーハー filed Critical バイク グルデン ロンバーグ ケミッシェ ファブリク ゲーエムベーハー
Publication of JPH05502888A publication Critical patent/JPH05502888A/ja
Application granted granted Critical
Publication of JP3056525B2 publication Critical patent/JP3056525B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/848—Lungs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP3512939A 1990-07-10 1991-07-10 肺の界面活性タンパク質の単離および精製 Expired - Lifetime JP3056525B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US551,524 1990-07-10
US07/551,524 US5258496A (en) 1990-07-10 1990-07-10 Isolation and purification of lung surfactant protein

Publications (2)

Publication Number Publication Date
JPH05502888A JPH05502888A (ja) 1993-05-20
JP3056525B2 true JP3056525B2 (ja) 2000-06-26

Family

ID=24201618

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3512939A Expired - Lifetime JP3056525B2 (ja) 1990-07-10 1991-07-10 肺の界面活性タンパク質の単離および精製

Country Status (11)

Country Link
US (2) US5258496A (enExample)
EP (1) EP0491033B1 (enExample)
JP (1) JP3056525B2 (enExample)
AT (1) ATE159534T1 (enExample)
CA (1) CA2065323C (enExample)
DE (1) DE69128022T2 (enExample)
DK (1) DK0491033T3 (enExample)
ES (1) ES2111570T3 (enExample)
GR (1) GR3025929T3 (enExample)
HK (1) HK1004336A1 (enExample)
WO (1) WO1992000993A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69133617D1 (de) * 1990-04-04 2009-07-23 Novartis Vaccines & Diagnostic Protease von Hepatitis C Virus
US5258496A (en) * 1990-07-10 1993-11-02 Scios Nova Inc. Isolation and purification of lung surfactant protein
AU667438B2 (en) * 1993-04-30 1996-03-21 Mitsubishi-Tokyo Pharmaceuticals, Inc. Method of purifying hydrophobic polypeptide
CA2206848A1 (en) * 1994-12-07 1996-06-13 Bionebraska, Inc. Production of peptides using recombinant fusion protein constructs
AU4415796A (en) * 1994-12-07 1996-06-26 Bionebraska, Inc. Production of c-terminal amidated peptides from recombinant protein constructs
US6031075A (en) * 1996-02-05 2000-02-29 Children's Hospital Medical Center Mature alveolar SP-B and a process for producing the same
US6020307A (en) * 1997-04-25 2000-02-01 Ony, Inc. Compositions and methods for isolating lung surfactant hydrophobic proteins SP-B and SP-C
AU2815297A (en) * 1996-04-26 1997-11-19 Ony, Inc. Compositions and methods for isolating lung surfactant hydrophobic proteins sp-b and sp-c
ATE301674T1 (de) * 1996-05-15 2005-08-15 Altana Pharma Ag Verfahren zur trennung und bestimmung von hydrophoben proteinen durch dünnschichtchromatographie
PL341293A1 (en) * 1997-12-23 2001-04-09 Lilly Co Eli Beta-lypothropin and application thereof
JPH11335392A (ja) 1998-05-26 1999-12-07 Hsp Kenkyusho:Kk 可溶性タンパク質の回収方法
US20100273983A1 (en) * 2007-04-05 2010-10-28 The University Of Queensland Method of purifying peptides by selective precipitation
WO2009035395A1 (en) 2007-09-14 2009-03-19 Marcus Larsson A lung-surfactant product

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987002037A1 (en) * 1985-09-26 1987-04-09 Genetics Institute, Inc. Pulmonary surfactant proteins
US4882422A (en) * 1985-10-24 1989-11-21 Genetics Institute, Inc. Pulmonary surfactant proteins
US4918161A (en) * 1985-09-26 1990-04-17 Genetics Institute, Inc. Low molecular weight pulmonary surfactant proteins
US4734362A (en) * 1986-02-03 1988-03-29 Cambridge Bioscience Corporation Process for purifying recombinant proteins, and products thereof
US5013720A (en) * 1986-05-06 1991-05-07 Abbott Laboratories SAP-6-Val proteins and methods
JPS63503222A (ja) * 1986-05-06 1988-11-24 サイオス　ノバ　インコーポレイテッド 肺の疎水性界面活性物質に結合した分子量６，０００ダルトンのタンパク質及びその多量体
JPH01501282A (ja) * 1986-12-08 1989-05-11 ホイツトセツト，ジエフリー　エイ． 肺胞疎水性界面活性物質関連タンパク質
WO1988005820A1 (en) * 1987-01-29 1988-08-11 California Biotechnology, Inc. Recombinant alveolar surfactant protein
AU622860B2 (en) * 1987-05-11 1992-04-30 Novartis Vaccines And Diagnostics, Inc. Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
US4931543A (en) * 1987-05-11 1990-06-05 Cetus Corporation Process for recovering microbially produced interleukin-2
ATE163013T1 (de) * 1987-11-04 1998-02-15 Byk Gulden Lomberg Chem Fab Alveolare oberflächenaktive proteine
JPH02501488A (ja) * 1987-11-12 1990-05-24 ユニリーバー・ナームローゼ・ベンノートシヤープ 自動皿洗い機用液体洗剤の物理的安定性の改良
CH677879A5 (enExample) * 1988-07-22 1991-07-15 Pentapharm Ag
SE8803713D0 (sv) * 1988-10-18 1988-10-18 Kabigen Ab Biologically active lipoprotein and its use
JPH04506809A (ja) * 1989-07-11 1992-11-26 ジェネンテク，インコーポレイテッド 界面活性剤組成物および方法
US5258496A (en) * 1990-07-10 1993-11-02 Scios Nova Inc. Isolation and purification of lung surfactant protein

Also Published As

Publication number Publication date
US5258496A (en) 1993-11-02
US5403915A (en) 1995-04-04
EP0491033A4 (enExample) 1994-03-30
JPH05502888A (ja) 1993-05-20
CA2065323A1 (en) 1992-01-11
EP0491033A1 (en) 1992-06-24
DE69128022D1 (de) 1997-11-27
HK1004336A1 (en) 1998-11-20
DK0491033T3 (da) 1998-07-20
EP0491033B1 (en) 1997-10-22
CA2065323C (en) 2003-06-10
ATE159534T1 (de) 1997-11-15
WO1992000993A1 (en) 1992-01-23
DE69128022T2 (de) 1998-05-20
GR3025929T3 (en) 1998-04-30
ES2111570T3 (es) 1998-03-16

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