JP2988803B2 - Skin aging prevention cosmetic composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an anti-skin aging effect containing an extract of a plant belonging to the birch genus Birch or Alder genus of the birch family (promoting proliferation and differentiation of epidermal cells, turnover of stratum corneum) Skin aging preventive cosmetics which are excellent in promotion, keratin improvement, and beautiful skin effect.

[0002]

2. Description of the Related Art In aging skin, the cell activity of the epidermis and the dermis is reduced, and as a result, dry skin due to a decrease in the function of the stratum corneum and inelastic skin due to a decrease in the function of the dermal fibroblasts are obtained. . In order to restore the activity of such aging skin, a cell activator has been searched for, and substances having a growth promoting effect on dermal fibroblasts have been proposed (placenta extract, whey extract, etc.). However, the composition containing these compounds is not sufficiently effective as a skin aging preventive cosmetic, and the search for more effective components has been a problem.

[0003]

[Means for Solving the Problems] The present inventors have continued to search for activators of epidermal cells, and surprisingly, the extract of plants belonging to the birch genus and alder genus of the birch family has remarkably increased the proliferation of epidermal cells. Have been found to have an accelerating effect, and as a result of diligent studies, the extract improves the function of the stratum corneum, and further comprises an extract of a plant belonging to the birch genus of the birch family, alder genus. Skin cosmetics promote the turnover of aging skin, exhibit a remarkable effect on skin roughening and keratin improvement, and provide beautiful skin effects (moist, smooth, firm, supple and glossy) ) Was also confirmed, and the present invention was completed. That is, the present invention is a skin aging preventive cosmetic comprising an extract of a plant belonging to the birch genus and alder genus of the birch family.

The birch of the birch genus of the birch family used in the present invention is a known plant that is present in the highlands of Takayama in the central and northern parts of Japan. Alder, a plant belonging to the genus Alnus in the same family, is also a known plant existing in Japan. The plant extract to be incorporated in the skin cosmetic of the present invention is an extract belonging to the birch genus of the birch family, alder genus, and the extraction solvent is not particularly limited, but benzene, ethyl ether, chloroform, methylene chloride, and ethyl acetate. , Butyl acetate, acetone, methanol, ethanol,
1,3-butylene glycol or water is preferred, and chloroform, ethanol or water is particularly preferred. These extraction solvents can be used as a mixture of two or more kinds. The extraction operation is performed by a conventional method. That is, the xylem, bark, roots, leaves, etc. of these plants are dried or crushed finely as they are and immersed in a desired extraction solvent. The immersion temperature is not particularly limited. After immersion, the solvent is filtered off,
The extract can be obtained by concentration by a method such as concentration under reduced pressure.
The amount of the extract of the plant belonging to the birch genus birch or alder is from 0.001 to 2.0.
Preferably, it is weight%. The amount is 0.001.
If the amount is less than 10% by weight, the intended effect of preventing skin aging cannot be sufficiently exhibited. On the other hand, if the content exceeds 2.0% by weight, the effect corresponding to the increase cannot be improved. These extracts of plants belonging to the birch genus Birch, belonging to the genus Alnus improve skin function, repair or improve the function originally provided by the skin, keep the skin healthy, and especially apply to aging skin. In this case, a remarkable effect is observed. The skin cosmetic of the present invention may be appropriately blended with known components (base, pigment, fragrance, preservative, surfactant, pigment, antioxidant, etc.) according to the type thereof, as long as the performance is not impaired. it can.

[0005]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail based on Reference Examples and Examples. [Preparation of Extract Extract] Reference Example 1: 100 g of birch bark was extracted twice with 1 liter of water. Next, the extract was concentrated twice under reduced pressure and then dried to obtain 1.4 g of an extract. (Yield 1.4
%) Reference Example 2: 100 g of birch bark was extracted twice with 1 liter of ethanol. Then, the extract was concentrated twice under reduced pressure and then dried to obtain 22 g of extract. (Yield: 22%) Reference Example 3: 100 g of birch bark was extracted twice with 1 liter of chloroform. Next, the extract was concentrated twice under reduced pressure and then dried to obtain 23 g of an extract. (23% yield)

Reference Example 4: 100 g of alder bark was added to 1
Extracted twice with 1 liter of water. Next, the extract was concentrated twice under reduced pressure and then dried to obtain 1.0 g of an extract.
(Yield 1.0%) Reference Example 5 100 g of alder bark was extracted twice with 1 liter of ethanol. Next, the two extracts were concentrated under reduced pressure and then dried to obtain 18 g of an extract. (Yield 18%) Reference Example 6 100 g of alder bark was extracted twice with 1 liter of chloroform. Next, the extract was concentrated twice under reduced pressure and then dried to obtain 23 g of an extract. (23% yield)

[Keratinocyte proliferation promotion test] Cultured cells: As keratinocytes, SV40 transform human keratinocytes which have been established as cultured cells were used. Test method: In a clean bench, put 2.5 ml of sterilized bovine fetal serum, 75 ml of keratinocyte basic medium, and 0.8 ml of antibiotic, and spread 1.6 × 10 ⁶ keratinocytes into a 6-well plate. Dispense 3 ml at a time in a carbon dioxide incubator under an atmosphere containing 5% carbon dioxide.
Incubated at ℃. After 24 hours, the culture was removed, and 1.5 ml of keratinocyte basic medium, 1.5 ml of Dulbecco's modified Eagle minimal nutrient medium, 3 μg of linoleic acid, 3 μg of potassium chloride, 30 μg of antibiotics, and 30 μg / ml of fatty acid-free bovine serum albumin were added. The substance is brought to a final concentration of 0.
It was added to 1 μg / ml and cultured for one week. After the culture, the culture solution was removed, and a Dulbecco's phosphoric acid buffer solution containing 0.02% EDTA and then 0.25% trypsin was added, followed by stripping. Then, these were removed, 1 ml of Dulbecco's phosphate buffer solution was added to each well, suspended, and the number of cells was counted using a hemocytometer. Based on the number of cells in a blank test using distilled water instead of the plant extract, the growth ratio was calculated by the following formula and shown in Table 1.

[0008]

(Equation 1)

[0009]

[Table 1]

[Sensory test (Beautiful skin effect test)] Test method: 20% of female subjects (30 to 40s) complaining of rough skin, wrinkles, dry skin, etc. were blended with 2.0% of the birch extract of Example 2 The applied cream and birch extract-free cream (cream B) were applied twice a day (morning and evening) for three consecutive months, and the effect after three months was evaluated. The test results were indicated by the number of persons who answered in five steps for each item of skin wettability, flexibility, elasticity, and gloss.

[0011]

[Table 2]

Test Results: As is clear from the results in Table 2, it was recognized that the birch extract of the present invention exhibited a beautiful skin effect (giving a moist feeling, a smooth feeling, firmness, and gloss to the skin). .

Embodiment 1 Lotion Component amount (% by weight) Birch extract (Reference Example 2) 0.05 Glycerin 6.0 Ethanol 8.0 Polyoxyethylene hydrogenated castor oil 0.8 Methyl paraoxybenzoate 0.05 Citric acid 0.05 Citric acid Sodium acid 0.07 Fragrance 0.1 Purified water Remainder Total 100 Dissolve glycerin, citric acid and sodium citrate in purified water. Separately, birch extract, polyoxyethylene hydrogenated castor oil (60E.O), methylparaben, and flavor were dissolved in ethanol, added to the purified aqueous solution, solubilized, and filtered to obtain a lotion.

Embodiment 2 Cream Ingredients Blended amount (% by weight) Ingredient (A) Birch extract (Reference Example 1) 2.0 Ascorbyl stearate 1.0 Red beeswax 4.0 Cetanol 2.0 Stearic acid 1.0 Isopropyl myristate 5.0 Lanolin 2.0 Liquid paraffin 9.0 Self-emulsifying glyceryl monostearate 3.0 Monostearic acid Polyoxyethylene sorbitan (20E.O) 1.5 Propyl parahydroxybenzoate 0.1 Component (B) Methyl paraoxybenzoate 0. 2 Propylene glycol 5.0 Perfume 0.2 Purified water Remainder Total 100 Heat and dissolve component (A) and maintain at 80 ° C. Separately, the component (B) excluding the fragrance was heated and dissolved and kept at 80 ° C., and the component (A) was added thereto with stirring, cooled, the fragrance was added, and further cooled to obtain a cream.

Embodiment 3 Cosmetic Oil Ingredients Blended Birch Extract (Reference Example 3) 1.0 Cholesteryl stearate 1.0 Olive oil 2.0 Squalene Remainder Total 100 Other components are uniformly dissolved in squalane to make cosmetic oil Obtained.

Instead of the birch extract of Examples 1 to 3, cosmetics containing the extract of alder shown in Reference Examples 4 to 6 can be similarly formulated. These cosmetics are used for female subjects who complain of rough skin, wrinkles, dry skin, etc.
In each case, favorable evaluations were obtained for each item of skin wettability, flexibility, elasticity, and gloss.

[0017]

The skin cosmetic of the present invention has the effects of promoting the proliferation and differentiation of epidermal cells, promoting the turnover of the stratum corneum, improving the stratum corneum, improving the skin beautifulness, etc., improving the skin function and aging the skin. It has an excellent effect on prevention.

Continuation of the front page (58) Field surveyed (Int.Cl. ⁶ , DB name) A61K 7/48 A61K 7/00 A61K 35/78

Claims (3)

(57) [Claims] 1. A skin aging prevention cosmetic composition comprising one or more extracts of a plant belonging to the birch or alder genus of the birch family. 2. The plant belonging to the genus Birch is birch (Be
The skin aging preventive cosmetic composition according to claim 1, wherein the plant belonging to the genus Alnus tula platyphylla) is alder (Alnus japonica). 3. The extraction extract is selected from the group consisting of benzene, ethyl ether, chloroform, methylene chloride, ethyl acetate, butyl acetate, acetone, methanol, ethanol, 1,3-butylene glycol and water.
The cosmetic composition for preventing skin aging according to claim 1 or 2, which is prepared by using one or more kinds of solvents.