JP2892828B2 - 血漿プロテインの検定方法 - Google Patents

血漿プロテインの検定方法

Info

Publication number
JP2892828B2
JP2892828B2 JP2510438A JP51043890A JP2892828B2 JP 2892828 B2 JP2892828 B2 JP 2892828B2 JP 2510438 A JP2510438 A JP 2510438A JP 51043890 A JP51043890 A JP 51043890A JP 2892828 B2 JP2892828 B2 JP 2892828B2
Authority
JP
Japan
Prior art keywords
protein
thrombin
plasma
substrate
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2510438A
Other languages
English (en)
Japanese (ja)
Other versions
JPH04506603A (ja
Inventor
ローセン，ステツフエン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KUROMOIENITSUKUSU AB
Original Assignee
KUROMOIENITSUKUSU AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KUROMOIENITSUKUSU AB filed Critical KUROMOIENITSUKUSU AB
Publication of JPH04506603A publication Critical patent/JPH04506603A/ja
Application granted granted Critical
Publication of JP2892828B2 publication Critical patent/JP2892828B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/4609—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates from reptiles
    • G01N2333/4613—Snake venom
    • G01N2333/462—Snake venom from Agkistrodon sp., e.g. acutase, ACTE
    • G01N2333/4626—Snake venom from Agkistrodon sp., e.g. acutase, ACTE from Agkistrodon contortrix contortrix (copperhead snake); Protac (R)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/9645—Factor IX (3.4.21.22)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96461—Protein C (3.4.21.69)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2510438A 1989-07-14 1990-07-04 血漿プロテインの検定方法 Expired - Fee Related JP2892828B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8902532A SE464135B (sv) 1989-07-14 1989-07-14 Foerfarande foer bestaemning av funktionell aktivitet av fritt protein s eller protein c i ett plasmaprov
SE8902532-4 1989-07-14

Publications (2)

Publication Number Publication Date
JPH04506603A JPH04506603A (ja) 1992-11-19
JP2892828B2 true JP2892828B2 (ja) 1999-05-17

Family

ID=20376547

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2510438A Expired - Fee Related JP2892828B2 (ja) 1989-07-14 1990-07-04 血漿プロテインの検定方法

Country Status (13)

Country Link
US (1) US5439802A ( )
EP (1) EP0486515B1 ( )
JP (1) JP2892828B2 ( )
AT (1) ATE127853T1 ( )
AU (1) AU6053390A ( )
CA (1) CA2063564A1 ( )
DE (1) DE69022425T2 ( )
DK (1) DK0486515T3 ( )
ES (1) ES2079481T3 ( )
IE (1) IE902431A1 ( )
NO (1) NO920125D0 ( )
SE (1) SE464135B ( )
WO (1) WO1991001382A1 ( )

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4006634A1 (de) * 1990-03-03 1991-09-05 Behringwerke Ag Funktioneller test zur bestimmung der protein s-aktivitaet
ES2115679T3 (es) * 1991-10-04 1998-07-01 Dade Behring Inc Preparacion de reactivos de tiempo de protrombina a partir de factor de tejido humano recombinante y de fosfolipidos sinteticos y naturales purificados.
AU2870992A (en) * 1991-10-04 1993-05-03 Board Of Regents Of The University Of Nebraska, The A soluble thrombomodulin-based one-stage assay for vitamin k-dependent coagulation-inhibiting proteins
US5716795A (en) * 1991-10-04 1998-02-10 Matschiner; John T. Thrombomodulin-based coagulometric assay of the protein C system
SE470274B (sv) * 1991-11-13 1993-12-20 Bjoern Dahlbaeck Användning av en in vitro-metod för diagnos av blodkoagulationssjukdomar
ATE132909T1 (de) * 1991-11-13 1996-01-15 Bjoern Dahlbaeck Vefahren zur diagnose von störungen der blutgerinnung
US5308756A (en) * 1991-11-20 1994-05-03 Baxter Diagnostics Inc. Protein S chromogenic assay
DE4229933A1 (de) * 1992-09-08 1994-03-10 Max Planck Gesellschaft Verfahren zur Bestimmung von Thrombose verursachenden Lupus-anticoagulant-Antikörpern
JPH08506181A (ja) 1993-01-29 1996-07-02 ダールベック，ビョルン 新規抗凝固性補助因子活性
DE59410041D1 (de) * 1993-12-03 2002-03-21 Baxter Ag Test zur Bestimmung der Empfindlichkeit gegenüber aktiviertem Protein C
AUPM731394A0 (en) * 1994-08-05 1994-09-01 Life Therapeutics Limited Improved activated protein c resistance test
DE4427785A1 (de) * 1994-08-08 1996-02-15 Behringwerke Ag Verfahren zum Nachweis von Störungen des Protein C/Protein S-Systems
SE9403833D0 (sv) * 1994-11-08 1994-11-08 Global Hemostasis Inst Mgr Ab Analysförfarande och kit
US5780255A (en) * 1995-06-09 1998-07-14 Instrumentation Laboratory, S.P.A. Protein C pathway screening test
US5766869A (en) * 1995-11-30 1998-06-16 Ahs Hospital Corp. Factor V ratio blood test for susceptibility to thromboembolism
US6379975B1 (en) 1996-11-27 2002-04-30 T.A.C. Thrombosis And Coagulation Aktiebolag Methods and reagents for determining protein S
SE9701228D0 (sv) * 1997-04-03 1997-04-03 Bjoern Dahlbaeck Rekombinanta protein-C-och protein-S-varianter
AUPP159698A0 (en) * 1998-02-02 1998-02-26 Life Therapeutics Limited Improved blood coagulation test
ES2162361T3 (es) 1998-03-19 2001-12-16 Instrumentation Lab Spa Metodos, kits y reactivos mejorados para el muestreo de defectos de la coagulacion sanguinea.
US6855509B2 (en) * 2000-12-19 2005-02-15 Instrumentation Laboratory Company Protein S functional assay and kit therefor
JP5839256B2 (ja) 2011-03-14 2016-01-06 学校法人九州文化学園 総プロテインｓ異常症の検出方法において用いる試薬
CN106153612A (zh) * 2015-12-04 2016-11-23 上海贞元诊断用品科技有限公司 抗凝血酶活性检测试剂及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657894A (en) * 1983-03-31 1987-04-14 Scripps Clinic & Research Foundation New factor VIII coagulant polypeptides
DE3516579A1 (de) * 1984-11-19 1986-05-22 Boehringer Mannheim Gmbh, 6800 Mannheim Gerinnungstest auf teststreifen
US4775624A (en) * 1985-02-08 1988-10-04 Eli Lilly And Company Vectors and compounds for expression of human protein C
DE3607559A1 (de) * 1986-03-07 1987-09-10 Boehringer Mannheim Gmbh Verfahren zur photometrischen bestimmung der protein c- und/oder protein s-aktivitaet
US4908314A (en) * 1987-07-02 1990-03-13 American National Red Cross Protein C activator
DE3724443A1 (de) * 1987-07-23 1989-02-02 Max Planck Gesellschaft Funktioneller test zur bestimmung der protein s-aktivitaet
JP2739050B2 (ja) * 1988-01-28 1998-04-08 ヘキスト薬品工業株式会社 抗血液凝固剤
US5051357A (en) * 1989-07-14 1991-09-24 Board Of Trustees Operating Michigan State University Method and assay using inactivation of factors Va and VIIIa by activated Protein C to diagnose thrombic disease or assay for Protein C and kit therefor

Also Published As

Publication number Publication date
WO1991001382A1 (en) 1991-02-07
DE69022425T2 (de) 1996-05-02
EP0486515B1 (en) 1995-09-13
ATE127853T1 (de) 1995-09-15
SE8902532L (sv) 1991-01-15
NO920125L (no) 1992-01-09
DE69022425D1 (de) 1995-10-19
AU6053390A (en) 1991-02-22
CA2063564A1 (en) 1991-01-15
SE464135B (sv) 1991-03-11
EP0486515A1 (en) 1992-05-27
ES2079481T3 (es) 1996-01-16
IE902431A1 (en) 1991-06-19
JPH04506603A (ja) 1992-11-19
US5439802A (en) 1995-08-08
DK0486515T3 (da) 1996-01-29
NO920125D0 (no) 1992-01-09
SE8902532D0 (sv) 1989-07-14

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Legal Events

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