JP2879596B2 - Hair cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention contains an amine oxide, has an excellent effect of imparting moist and smooth hair, and prevents hair loss,
The present invention relates to a hair cosmetic composition having an excellent hair nourishing effect.

[Prior art] Conventionally, causes of baldness and hair loss include (1) activation of androgens in organs such as hair roots and sebaceous glands, (2) decrease in blood flow to hair follicles, and (3) excessive secretion of sebum. ,
Abnormalities of the scalp due to the production of peroxide, etc., are considered.

For this reason, a compound having an action of eliminating or reducing the above-mentioned causes is generally added to conventional hair restorations.

For example, vitamins such as vitamin E, vasodilators such as assembly extract, anti-inflammatory agents such as hinokitiol,
It contains a female hormone such as estradiol, a skin function enhancer such as cepharanthin, and the like, and is used for the prevention and treatment of alopecia.

However, the mechanism of hair loss and hair growth is very complex, and the inhibition of male hormone activation and the increase in blood flow of hair follicles by conventional hair growth materials alone are not enough to prevent hair loss and to have the effect of hair growth. I was not able to admit.

The present applicant has found that hair cosmetics containing an amine oxide having an alkyl group or an alkenyl group having 8 to 24 carbon atoms have the effects of preventing hair loss and improving hair growth, and have found the effects of Japanese Patent Application No.
Filed as 249132.

[Problems to be Solved by the Invention] However, although the above hair cosmetics are excellent in hair loss prevention and hair nourishing effects, they lack the effect of imparting moistness and smoothness to hair, and as hair cosmetics It was unsatisfactory.

In view of the above circumstances, the present inventor has moisturized hair,
As a result of exploring hair cosmetics having the effect of imparting smoothness, preventing hair loss, and having an effective action on hair growth, hair cosmetics containing a specific amine oxide satisfy the above requirements. And completed the present invention.

[Means for Solving the Problems] That is, the present invention provides a hair cosmetic characterized by blending a specific amine oxide.
Hereinafter, the configuration of the present invention will be described in detail.

The following are examples of the amine oxide used in the present invention.

(1) Dimethylalkylamine oxide represented by the general formula (A) (In the formula, R represents a linear or branched alkyl group or alkenyl group having 26 to 36 carbon atoms.) (2) Dihydroxyethylalkylamine oxide represented by the general formula (B) (In the formula, R represents a linear or branched alkyl group or alkenyl group having 26 to 36 carbon atoms.) (3) Dimethylalkylpolyoxyethyleneamine oxide represented by the general formula (C) (In the formula, R represents a linear or branched alkyl group or alkenyl group having 26 to 36 carbon atoms, and n represents an integer of 1 to 5.) The amine of the above (i), (ii) and (iii) One or more oxides are used.

Specific examples of the amine oxide of the present invention include, for example, N, N-dimethyl-2-dodecylhexadecylamine oxide, N, N-dimethyl-2-tetradecylstearylamine oxide, N, N-dihydroxy Ethyl-2
-Dodecylhexadecylamine oxide, dimethyloctacosylpolyoxyethylene (3 mol) amine oxide, dimethylhexacosylpolyoxyethylene (1.5 mol) amine oxide, and the like.

The compounding amount of the above amine oxide is in the hair cosmetic of the present invention.
The range is preferably 0.0001 to 20% by weight, more preferably
0.005 to 10% by weight. If the amount is less than 0.0001% by weight, sufficient hair loss prevention, hair-growth effect and excellent usability such as moistness and smoothness of the hair cannot be obtained. It is not preferable from above.

In the hair cosmetic composition according to the present invention, in addition to one or more of the amine oxides of the present invention, vitamin B ₆ , vitamin E and its derivatives, vitamins such as biotin, pantothenic acid and its derivatives, glycyrrhetinic acid And nicotinic acid esters such as benzyl nicotinate, cyclosporins, carpronium chloride, cepharanthin, oxendron, diazoxide, minoxidil, ethinyl estradiol, and the like. Further, additives usually used for hair cosmetics, for example, antibacterial agents such as hinokitiol, hexachlorophen, phenol, benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, trichlorocarbanilide and bithionol, refreshing agents such as menthol,
Drugs such as salicylic acid, zinc and its derivatives, lactic acid and its alkyl esters, organic acids such as citric acid, amino acids such as arginine, chelating agents such as edetic acid or its salts, olive oil, squalane, liquid paraffin, isopropyl myristate Oils such as higher fatty acids and higher alcohols, polyhydric alcohols such as glycerin and propylene glycol, nonionic surfactants, cationic surfactants, anionic surfactants, fragrances, antioxidants, ultraviolet absorbers, pigments, Ethanol, water, a humectant, a thickener, a chelating agent, a buffer, and the like can be appropriately compounded within a range that does not impair the effects of the present invention.

The properties of the hair cosmetic composition of the present invention may be any properties that can be applied to the outer skin, such as liquids, emulsions, and ointments.

[Examples] Next, the present invention will be described in more detail with reference to examples.
The present invention is not limited by this. The compounding amount is% by weight.

Examples 1-4 A lotion having the composition shown in Table 1 was prepared.

(Production method) A hydrogenated castor oil ethylene oxide (40 mol) adduct and a fragrance are dissolved in 95% ethanol, and then purified water is added. Then, an amine oxide and a dye shown in Table 1 are added, and the mixture is stirred and dissolved. A liquid hair cosmetic was obtained.

Test Example of Hair Usability Effect (1) Test Method In order to evaluate the moistness and smoothness of the hair of the hair cosmetic composition of the present invention, sensory evaluation was performed by 10 specialized panels, and the average score was given.

◎ (2) It is quite moist and smooth.

○ (1) Moist and smooth.

× (0) Moist, not smooth.

(2) Result As is clear from Table 2, the hair cosmetic composition according to the present invention has an excellent effect of imparting moist and smooth hair.

Example of hair loss prevention effect test (1) Test method Judgment was made based on the change in the number of hair loss during hair washing before and after sample use. The number of subjects was eight in each group of Examples and Comparative Examples. The test period was six months, the first two months were the period of no sample application, and the second four months were the sample application period. During the sample application period, 2 to 4 ml of the sample was applied to the scalp twice a day. During the test period, the hair was washed every other day to collect the removed hair, and the number of hair having a thickness of 50 μm or more was counted. For the number of hair removals in each period, the data for the two months without sample application and the data for the number of hair removals for the latter two months of the hair restoration application period are summarized for each period, and the average rate of change in the number of hair removals per day for each subject (Average number of hair removed during hair application period 毛 Average number of hair removed during no application period × 100) was expressed in%.

(2) Result As is evident from Table 3, the hair removal effect of the hair cosmetic composition of the present invention containing an amine oxide is extremely excellent.

Test Example of Hair Restoring Effect (1) Test Method In order to examine the hair restoring action of the hair cosmetic composition of the present invention, a tricogram test was performed. The number of subjects was eight in each group of Examples and Comparative Examples. The sample application period is 4 months,
During this time, 2 to 4 ml of the sample was applied to the scalp twice a day. Immediately before the application and immediately after the end of the application, 50 hairs were removed from the crown of each subject, and the roots of the removed hairs were observed under a microscope. The growth of hair, regression, and resting period were determined based on the form of the hair root. Was determined, and the hair root telogen rate was calculated. The hair nourishing effect of each sample was compared by increasing and decreasing the rest period before and after sample application.

(2) Result As is evident from Table 4, the hair cosmetic composition according to the present invention has a reduced hair rest period and has an excellent hair-growing effect.

Example 5 A lotion having the following composition was prepared.

95% ethanol 90.0 N, N-dimethyl-2-dodecylhexadecylamine oxide 0.0003 dihydrocyethylhexacosylamine oxide 0.0002 sodium lauryl sulfate 0.1 hydrogenated castor oil ethylene oxide (40 mol) adduct 0.5 purified water residue perfume and dye Method) Dissolve the hydrogenated castor oil ethylene oxide (40 mol) adduct and perfume in 95% ethanol, then add purified water, then add the above amine oxide and dye,
The mixture was stirred and dissolved to obtain a clear liquid hair cosmetic.

Example 6 (A phase) N, N-dimethyl-2-hexadecyleicosylamine oxide 10.0 liquid paraffin 5.0 cetostearyl alcohol 5.5 glyceryl monostearate 3.0 dihydroxyethylhexacosylamine oxide 0.002 dimethyloctacosyl polyoxyethylene (3 Mol) Amine oxide 0.003 Vitamin E acetate 0.05 Propyl paraben 0.3 Fragrance 0.05 (B phase) Glycerin 7.0 Dipropylene glycol 20.0 Polyethylene glycol 4000 5.0 Sodium hexametaphosphate 0.005 Purified water Residue (Production method) Heat and dissolve A phase and B phase respectively The mixture was mixed and emulsified with a homomixer to obtain an ointment-like hair cosmetic.

Example 7 (Phase A) N, N-dimethyl-2-tetradecylstearylamine oxide 8.0 N, N-dimethyl-2-hexadecyleicosylamine oxide 2.0 N, N-dihydroxyethyl-2-dodecylhexadecylamine Oxide 2.0 Cetanol 5.5 Vaseline 3.0 Polyoxyethylene (10 mole addition) Monostearate 2.0 Sorbitan monooleate 1.0 Fragrance 0.1 (B phase) Glycerin 10.0 20% Chlorhexidine gluconate solution 0.1 Purified water Residue (Production method) A phase and B phase Each was heated and dissolved, and mixed and emulsified with a homomixer to obtain an emulsion hair cosmetic.

[Effects of the Invention] The hair cosmetic composition according to the present invention has an excellent effect of imparting moistness and smoothness to hair, reduces hair root telogen, and is extremely excellent in hair nourishing effect and hair loss preventing effect. I have.

Claims (1)

(57) [Claims] 1. A hair cosmetic comprising one or more amine oxides represented by the following general formulas (i), (ii) and (iii): (i) a general formula (A) Dimethylalkylamine oxide represented by (In the formula, R represents a linear or branched alkyl group or alkenyl group having 26 to 36 carbon atoms.) (Ii) Dihydroxyethylalkylamine oxide represented by the general formula (B) (In the formula, R represents a linear or branched alkyl group or alkenyl group having 26 to 36 carbon atoms.) (Iii) Dimethylalkylpolyoxyethyleneamine oxide represented by the general formula (C) (In the formula, R represents a linear or branched alkyl group or alkenyl group having 26 to 36 carbon atoms, and n represents an integer of 1 to 5.)