JP2862099B2 - Early cancer diagnostic device - Google Patents

Early cancer diagnostic device

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Publication number
JP2862099B2
JP2862099B2 JP2274921A JP27492190A JP2862099B2 JP 2862099 B2 JP2862099 B2 JP 2862099B2 JP 2274921 A JP2274921 A JP 2274921A JP 27492190 A JP27492190 A JP 27492190A JP 2862099 B2 JP2862099 B2 JP 2862099B2
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JP
Japan
Prior art keywords
image
light
wavelength
insertion portion
transmitted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2274921A
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Japanese (ja)
Other versions
JPH04150845A (en
Inventor
滝介 安達
裕久 植田
浩 佐野
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pentax Corp
Original Assignee
Asahi Kogaku Kogyo Co Ltd
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Application filed by Asahi Kogaku Kogyo Co Ltd filed Critical Asahi Kogaku Kogyo Co Ltd
Priority to JP2274921A priority Critical patent/JP2862099B2/en
Priority to DE4133493A priority patent/DE4133493A1/en
Publication of JPH04150845A publication Critical patent/JPH04150845A/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00186—Optical arrangements with imaging filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0646—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements with illumination filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6471—Special filters, filter wheel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6473—In-line geometry
    • G01N2021/6476—Front end, i.e. backscatter, geometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6447—Fluorescence; Phosphorescence by visual observation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Endoscopes (AREA)
  • Instruments For Viewing The Inside Of Hollow Bodies (AREA)

Description

【発明の詳細な説明】 〔産業上の利用分野〕 この発明は、内視鏡を利用して早期癌を診断するため
の早期癌診断装置に関する。Description: TECHNICAL FIELD The present invention relates to an early cancer diagnostic device for diagnosing early cancer using an endoscope.

〔従来の技術〕[Conventional technology]

早期癌を、通常の内視鏡検査、即ち単なる肉眼検査に
よって発見するのは容易なことではない。It is not easy to detect early cancer by ordinary endoscopy, that is, mere visual inspection.

そこで従来は、例えばヘマトポルフィリン誘導体など
の腫瘍親和性光感受性物質が癌細胞に集まり易く、レー
ザ光照射によって蛍光を発する性質を利用して、患者に
まずヘマトポルフィリン誘導体を投与しておいて、内視
鏡によりレーザ光を照射しながら蛍光を観察するように
していた。Therefore, conventionally, for example, a hematoporphyrin derivative such as a hematoporphyrin derivative is easily collected on cancer cells, and the property of emitting fluorescence by laser beam irradiation is used to first administer a hematoporphyrin derivative to a patient. The fluorescence was observed while irradiating a laser beam with an endoscope.

〔発明が解決しようとする課題〕[Problems to be solved by the invention]

しかし、ヘマトポルフィリン誘導体などは人体に対し
て副作用があるので、単なる検査のために一般の用いる
ことは好ましくない。However, hematoporphyrin derivatives and the like have side effects on the human body, and are not generally used for mere examination.

しかも、レーザ光を用いるためには、高価なレーザ光
発生装置を準備しなければならず、また、専用の内視鏡
を必要とする場合もある等、装置に莫大な費用がかか
る。In addition, in order to use laser light, an expensive laser light generator must be prepared, and a dedicated endoscope may be required, which requires enormous cost for the apparatus.

また、ヘマトポルフィリン誘導体が発生する蛍光とは
別に、癌細胞以外の正常細胞部分から発生する自家蛍光
が干渉して、必ずしも正確な診断を行うことができな
い。Further, apart from the fluorescence generated by the hematoporphyrin derivative, autofluorescence generated from normal cell parts other than cancer cells interferes, and accurate diagnosis cannot always be performed.

この発明は、従来のそのよう欠点を解消し、副作用が
なく、安価でしかも正確に早期癌の診断を行うことがで
きる早期癌診断装置を提供することを目的とする。SUMMARY OF THE INVENTION It is an object of the present invention to provide an early cancer diagnostic apparatus which solves the conventional drawbacks, has no side effects, is inexpensive, and can accurately diagnose early cancer.

〔課題を解決するための手段〕[Means for solving the problem]

上記の目的を達成するため、本発明の早期癌診断装置
は、内視鏡の照明用光源から送られてきた照明光を挿入
部先端に形成された照明窓から被写体に照射して、その
被写体の像を上記挿入部先端に設けられた対物光学系に
よって結像させ、その像を、像伝送手段によって上記挿
入部外に伝送して上記挿入部外で観察できるようにした
ものにおいて、生体が蛍光を発生する波長の励起光を透
過する第１の波長選択透過フィルタを、上記光源と上記
被写体との間の照明光路中に設けると共に、上記第１の
波長選択透過フィルタが透過する波長の光は透過せず、
上記蛍光は透過する第２の波長選択透過フィルタを、上
記被写体と上記挿入部外との間の観察光路中に設けたこ
とを特徴とする。In order to achieve the above object, an early cancer diagnostic apparatus of the present invention irradiates a subject with illumination light sent from an illumination light source of an endoscope through an illumination window formed at the distal end of the insertion section, and The image is formed by an objective optical system provided at the distal end of the insertion portion, and the image is transmitted outside the insertion portion by image transmission means so that the image can be observed outside the insertion portion. A first wavelength selective transmission filter that transmits excitation light having a wavelength that generates fluorescence is provided in an illumination optical path between the light source and the subject, and a light having a wavelength that is transmitted by the first wavelength selective transmission filter. Does not pass through,
A second wavelength selective transmission filter that transmits the fluorescence is provided in an observation optical path between the subject and the outside of the insertion section.

〔作用〕[Action]

生体組織に、可視光の短波長の光や紫外線などを照射
すると、生体組織が蛍光を発生することが、近年知られ
てきた。この生体組織自身の蛍光を自家蛍光と呼ぶ。こ
の自家蛍光は、生体組織全体から発生するが、癌細胞の
部分からはあまり発生しない。In recent years, it has been known that when a living tissue is irradiated with short-wavelength light of visible light, ultraviolet light, or the like, the living tissue generates fluorescence. This fluorescence of the living tissue itself is called autofluorescence. This autofluorescence is generated from the whole living tissue, but is not generated so much from the part of the cancer cells.

本発明の照明用光源で発生した照明光は、第１の波長
選択透過フィルタを透過する波長の光（励起光）だけが
被写体（生体組織面）に照射され、その励起光によって
被写体が蛍光（自家蛍光）を発生する。In the illumination light generated by the illumination light source according to the present invention, only light (excitation light) having a wavelength transmitted through the first wavelength selective transmission filter is applied to the subject (living tissue surface), and the excitation light causes the subject to emit fluorescence (excitation light). (Autofluorescence).

そして、その蛍光は対物光学系と像伝送手段を介し
て、内視鏡の挿入部外で観察される。しかし、励起光
は、第２の波長選択透過フィルタによってカットされ、
挿入部外の観察部に達しないので、そこでは、励起光に
干渉されることなく自家蛍光だけを観察することができ
る。Then, the fluorescence is observed outside the insertion portion of the endoscope via the objective optical system and the image transmission means. However, the excitation light is cut by the second wavelength selective transmission filter,
Since the light does not reach the observation part outside the insertion part, only the autofluorescence can be observed there without being interfered by the excitation light.

したがって、被写体内に早期癌細胞があれば、そこだ
けが自家蛍光が弱くて、暗く観察される。Therefore, if there is an early cancer cell in the subject, only that portion has weak auto-fluorescence and is observed dark.

〔実施例〕〔Example〕

図面を参照して実施例を説明する。 Embodiments will be described with reference to the drawings.

第１図は、本発明の第１の実施例を示している。図
中、10は内視鏡、30は光源装置である。FIG. 1 shows a first embodiment of the present invention. In the figure, 10 is an endoscope, and 30 is a light source device.

11は、可撓管からなる挿入部であり、その基端側には
操作部12が連結されている。13は、操作部12に取りつけ
られた接眼部である。Reference numeral 11 denotes an insertion portion formed of a flexible tube, and an operation portion 12 is connected to a proximal end thereof. Reference numeral 13 denotes an eyepiece attached to the operation unit 12.

挿入部11の先端には、被写体100を照明するための照
明窓15と、被写体100を観察するための観察窓16とが並
んで設けられている。At the tip of the insertion section 11, an illumination window 15 for illuminating the subject 100 and an observation window 16 for observing the subject 100 are provided side by side.

そして、照明窓15の内側には、照明用ライトガイドフ
ァイババンドル21の出射端が配置されている。観察窓16
の内側には観察光学系の対物レンズ22が配置されてい
て、その対物レンズ22による被写体100の結像位置に
は、像伝送用のイメージガイドファイババンドル23の入
射端が配置されている。The emission end of the illumination light guide fiber bundle 21 is arranged inside the illumination window 15. Observation window 16
An objective lens 22 of the observation optical system is arranged inside the image forming apparatus, and an incident end of an image guide fiber bundle 23 for image transmission is arranged at a position where the objective lens 22 forms an image of the subject 100.

ライトガイドファイババンドル21の入射端21aは光源
装置30に接続されていて、光源ランプ31で発生した照明
光が、コンデンサレンズ32によって集光されて、ライト
ガイドファイババンドル21の入射端21aに入射する。The incident end 21a of the light guide fiber bundle 21 is connected to the light source device 30, and the illumination light generated by the light source lamp 31 is collected by the condenser lens 32 and is incident on the incident end 21a of the light guide fiber bundle 21. .

光源ランプ31とコンデンサレンズ32との間の照明光路
中には、400nmないし500nmの波長の光だけを透過する第
１の波長選択透過フィルタ１が設けられている。したが
って、ライトガイドファイババンドル21を通って照明窓
15から被写体100に照射される照明光は、この400nmない
し500nmの波長の光に限られる。In the illumination light path between the light source lamp 31 and the condenser lens 32, a first wavelength selective transmission filter 1 that transmits only light having a wavelength of 400 nm to 500 nm is provided. Therefore, the illumination window through the light guide fiber bundle 21
The illumination light emitted from 15 to the object 100 is limited to light having a wavelength of 400 nm to 500 nm.

第２図に示されるように、この波長域の光を正常な生
体組織に照射すると、生体組織自体が励起されて、500n
mないし600nmの波長の蛍光（自家蛍光）が発生する。As shown in FIG. 2, when light in this wavelength range is irradiated on normal living tissue, the living tissue itself is excited, and 500 n
Fluorescence (autofluorescence) with a wavelength of m to 600 nm is generated.

第１図に戻って、イメージガイドファイババンドル23
の出射端は、接眼部13内に設けられた接眼レンズ25によ
る拡大観察位置に配置されている。また、接眼部13の外
端部には,500nmないし600nmの波長の光だけを透過する
第２の波長選択透過フィルタ２が取り付けられている。Returning to FIG. 1, the image guide fiber bundle 23
Is disposed at an enlarged observation position by an eyepiece 25 provided in the eyepiece 13. A second wavelength selective transmission filter 2 that transmits only light having a wavelength of 500 nm to 600 nm is attached to the outer end of the eyepiece 13.

したがって、観察窓16、対物レンズ22からイメージガ
イドファイババンドル23を通って接眼部13外から観察さ
れる被写体100の像は、第２の波長選択透過フィルタ２
が透過する500nmないし600nmの波長の光だけに限られ
る。Therefore, the image of the subject 100 observed from outside the eyepiece 13 through the observation window 16 and the objective lens 22 through the image guide fiber bundle 23 is transmitted to the second wavelength selective transmission filter 2.
Is limited to only light having a wavelength of 500 nm to 600 nm transmitted through.

このように構成された早期癌診断装置を使用する際に
は、内視鏡10の挿入部11を、例えば人体の気管支や消化
器内などに挿入し、その部位の生体組織が被写体100に
なる。When using the early cancer diagnostic apparatus configured as described above, the insertion section 11 of the endoscope 10 is inserted into, for example, a bronchus or a digestive organ of a human body, and the living tissue at the site becomes the subject 100. .

前述したように、被写体100には、400nmないし500nm
の光だけが照射され、それによって被写体100から、500
nmないし600nmの自家蛍光が発生する。As described above, the subject 100 has a wavelength of 400 nm to 500 nm.
Light from the subject 100
Autofluorescence of nm to 600 nm is generated.

そして、接眼部13外からは、500nmないし600nmの蛍光
像だけが観察される。しかし、被写体100に癌細胞があ
ると、その部分は蛍光が弱くて暗く観察され、正常部は
明るく観察される。Then, from the outside of the eyepiece 13, only a fluorescent image of 500 nm to 600 nm is observed. However, if there is a cancer cell in the subject 100, that part has weak fluorescence and is observed dark, and the normal part is observed bright.

なお、蛍光の明るさが充分に得られない場合には、接
眼部13をイメージインテンシファイア（暗視野スコー
プ）などに接続して、観察像の明るさを増幅させて観察
すればよい。If the brightness of the fluorescence cannot be sufficiently obtained, the eyepiece unit 13 may be connected to an image intensifier (dark field scope) or the like to amplify the brightness of the observation image for observation.

また、第１の波長選択透過フィルタ１は光源ランプ31
と被写体100との間の照明光路中のどこに設けてもよ
く、また、第２の波長選択透過フィルタ２は被写体100
と接眼部13外との間の観察光路中のどこに設けてもよ
い。Further, the first wavelength selective transmission filter 1 includes a light source lamp 31.
The second wavelength selective transmission filter 2 may be provided anywhere in the illumination optical path between the object 100 and the object 100.
It may be provided anywhere in the observation optical path between the camera and the outside of the eyepiece 13.

第３図は、本発明の第２の実施例を示しており、観察
像を伝送するために、イメージガイドファイババンドル
23に代えて固体撮像素子41を用いた例を示しており、第
２の波長選択透過フィルタ２は、対物レンズ22と固体撮
像素子41との間に配置されている。42は、固体撮像素子
41から送られてくる画像信号を処理するためのビデオプ
ロセッサ。43は、画像を表示するためのモニタである。FIG. 3 shows a second embodiment of the present invention, in which an image guide fiber bundle is used for transmitting an observation image.
An example in which a solid-state imaging device 41 is used instead of 23 is shown, and the second wavelength selective transmission filter 2 is disposed between the objective lens 22 and the solid-state imaging device 41. 42 is a solid-state image sensor
Video processor for processing image signals sent from 41. 43 is a monitor for displaying an image.

〔発明の効果〕〔The invention's effect〕

本発明の早期癌診断装置によれば、ヘマトポルフィリ
ン誘導体などの薬品や化学物質類を一切用いる必要がな
いので、副作用のおそれが全くなく、また、レーザ装置
などを必要とせず、通常の内視鏡装置に２枚の波長選択
透過フィルタを付加するだけで済むので、装置コストが
極めて低く非常に経済的である。According to the early cancer diagnostic device of the present invention, since there is no need to use any drug or chemical substance such as a hematoporphyrin derivative, there is no risk of side effects, and there is no need for a laser device or the like. Since only two wavelength selective transmission filters need to be added to the mirror device, the cost of the device is extremely low and the cost is very low.

しかも、生体が発する自家蛍光だけを観察することが
できるので、他の励起光や蛍光などの影響を受けず、早
期癌を正確に診断することができる。Moreover, since only the autofluorescence emitted by the living body can be observed, early cancer can be diagnosed accurately without being affected by other excitation light, fluorescence, or the like.

【図面の簡単な説明】[Brief description of the drawings]

第１図は、本発明の第１の実施例の構成図、 第２図は、励起光と自家蛍光の特性線図、 第３図は、本発明の第２の実施例の構成図である。 １……第１の波長選択透過フィルタ、２……第２の波長
選択透過フィルタ、10……内視鏡、11……挿入部、13…
…接眼部、15……照明窓、16……観察窓、21……ライト
ガイドファイババンドル、22……対物レンズ、23……イ
メージガイドファイババンドル、31……光源ランプ、41
……固体撮像素子。FIG. 1 is a configuration diagram of a first embodiment of the present invention, FIG. 2 is a characteristic diagram of excitation light and autofluorescence, and FIG. 3 is a configuration diagram of a second embodiment of the present invention. . DESCRIPTION OF SYMBOLS 1 ... 1st wavelength selection transmission filter, 2 ... 2nd wavelength selection transmission filter, 10 ... Endoscope, 11 ... Insertion part, 13 ...
... Eyepiece, 15 ... Illumination window, 16 ... Observation window, 21 ... Light guide fiber bundle, 22 ... Objective lens, 23 ... Image guide fiber bundle, 31 ... Light source lamp, 41
.... Solid-state imaging device.

───────────────────────────────────────────────────── フロントページの続き (72)発明者 佐野 浩 東京都板橋区前野町２丁目36番９号 旭 光学工業株式会社内 (56)参考文献 特開 昭60−246733（ＪＰ，Ａ) 特開 昭62−217216（ＪＰ，Ａ) 特開 昭63−29615（ＪＰ，Ａ) (58)調査した分野(Int.Cl.6，ＤＢ名) A61B 10/00──────────────────────────────────────────────────続 き Continuation of front page (72) Inventor Hiroshi Sano 2-36-9 Maeno-cho, Itabashi-ku, Tokyo Asahi Optical Industry Co., Ltd. (56) References JP-A-60-246733 (JP, A) 62-217216 (JP, A) JP-A-63-29615 (JP, A) (58) Fields investigated (Int. Cl. 6 , DB name) A61B 10/00

Claims (1)

(57)【特許請求の範囲】(57) [Claims] 【請求項１】内視鏡の照明用光源から送られてきた照明
光を挿入部先端に形成された照明窓から被写体に照射し
て、その被写体の像を上記挿入部先端に設けられた対物
光学系によって結像させ、その像を、像伝送手段によっ
て上記挿入部外に伝送して上記挿入部外で観察できるよ
うにしたものにおいて、 生体が蛍光を発生する400nm〜500nmの波長の励起光だけ
を透過する第１の波長選択透過フィルタを、上記光源と
上記被写体との間の照明光路中に設けると共に、 上記第１の波長選択透過フィルタが透過する波長の光は
透過せず、500nm〜600nmの波長の光だけを透過する第２
の波長選択透過フィルタを、上記被写体と上記挿入部外
との間の観察光路中に設け、 さらに、上記像伝送手段によって上記挿入部外に伝送さ
れた像の明るさを増幅させるための増幅手段を設けたこ
とを 特徴とする早期癌診断装置。An illumination light transmitted from an illumination light source of an endoscope is illuminated on an object from an illumination window formed at the distal end of an insertion portion, and an image of the object is provided at the distal end of the insertion portion. An image is formed by an optical system, and the image is transmitted outside the insertion portion by an image transmission means so that the image can be observed outside the insertion portion. A first wavelength selective transmission filter that transmits only the light is provided in the illumination light path between the light source and the subject, and light having a wavelength transmitted by the first wavelength selective transmission filter is not transmitted. The second that transmits only light with a wavelength of 600 nm
A wavelength selective transmission filter is provided in an observation optical path between the subject and the outside of the insertion portion, and an amplification means for amplifying the brightness of an image transmitted outside the insertion portion by the image transmission means. An early-stage cancer diagnostic device characterized by comprising:
JP2274921A 1990-10-12 1990-10-12 Early cancer diagnostic device Expired - Lifetime JP2862099B2 (en)

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JP2274921A JP2862099B2 (en) 1990-10-12 1990-10-12 Early cancer diagnostic device
DE4133493A DE4133493A1 (en) 1990-10-12 1991-10-09 Endoscopic diagnostic device for detecting cancer cells - filters examination light beam to provoke fluorescence of living tissue

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JP2274921A JP2862099B2 (en) 1990-10-12 1990-10-12 Early cancer diagnostic device

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