JP2793431B2 - 改変された補体系制御因子 - Google Patents
改変された補体系制御因子Info
- Publication number
- JP2793431B2 JP2793431B2 JP4113457A JP11345792A JP2793431B2 JP 2793431 B2 JP2793431 B2 JP 2793431B2 JP 4113457 A JP4113457 A JP 4113457A JP 11345792 A JP11345792 A JP 11345792A JP 2793431 B2 JP2793431 B2 JP 2793431B2
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- protein
- complement
- positions
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000004154 complement system Effects 0.000 title description 19
- 230000027455 binding Effects 0.000 claims description 156
- 108090000623 proteins and genes Proteins 0.000 claims description 121
- 102000004169 proteins and genes Human genes 0.000 claims description 116
- 150000001413 amino acids Chemical class 0.000 claims description 89
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 51
- 108010009575 CD55 Antigens Proteins 0.000 claims description 46
- 238000006467 substitution reaction Methods 0.000 claims description 39
- 230000000295 complement effect Effects 0.000 claims description 37
- 102000016550 Complement Factor H Human genes 0.000 claims description 31
- 108010053085 Complement Factor H Proteins 0.000 claims description 31
- 210000004027 cell Anatomy 0.000 claims description 27
- 102000034356 gene-regulatory proteins Human genes 0.000 claims description 27
- 108091006104 gene-regulatory proteins Proteins 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 23
- 102000011412 Complement 3d Receptors Human genes 0.000 claims description 16
- 108010023729 Complement 3d Receptors Proteins 0.000 claims description 16
- 230000024203 complement activation Effects 0.000 claims description 15
- 241001465754 Metazoa Species 0.000 claims description 13
- 108091008324 binding proteins Proteins 0.000 claims description 10
- 230000009261 transgenic effect Effects 0.000 claims description 10
- 102000006834 complement receptors Human genes 0.000 claims description 9
- 108010047295 complement receptors Proteins 0.000 claims description 9
- 108020004414 DNA Proteins 0.000 claims description 7
- 238000012217 deletion Methods 0.000 claims description 7
- 230000037430 deletion Effects 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 230000028327 secretion Effects 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 239000000523 sample Substances 0.000 claims description 4
- 210000004962 mammalian cell Anatomy 0.000 claims description 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 2
- 239000012472 biological sample Substances 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 108091005573 modified proteins Proteins 0.000 claims description 2
- 102000035118 modified proteins Human genes 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 102000050019 Membrane Cofactor Human genes 0.000 claims 9
- 101710146216 Membrane cofactor protein Proteins 0.000 claims 9
- 102000023732 binding proteins Human genes 0.000 claims 9
- 230000004913 activation Effects 0.000 claims 2
- 101710169105 Minor spike protein Proteins 0.000 claims 1
- 101710081079 Minor spike protein H Proteins 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 description 76
- 235000001014 amino acid Nutrition 0.000 description 62
- 230000037361 pathway Effects 0.000 description 30
- 230000000694 effects Effects 0.000 description 28
- 230000004048 modification Effects 0.000 description 24
- 238000012986 modification Methods 0.000 description 24
- 238000010494 dissociation reaction Methods 0.000 description 17
- 230000005593 dissociations Effects 0.000 description 17
- 230000005764 inhibitory process Effects 0.000 description 17
- 239000005515 coenzyme Substances 0.000 description 16
- 230000006870 function Effects 0.000 description 12
- 240000003864 Ulex europaeus Species 0.000 description 11
- 235000010730 Ulex europaeus Nutrition 0.000 description 11
- 101100365087 Arabidopsis thaliana SCRA gene Proteins 0.000 description 10
- 102100037084 C4b-binding protein alpha chain Human genes 0.000 description 10
- 101710159767 C4b-binding protein alpha chain Proteins 0.000 description 10
- 108010067641 Complement C3-C5 Convertases Proteins 0.000 description 10
- 102000016574 Complement C3-C5 Convertases Human genes 0.000 description 10
- 101150105073 SCR1 gene Proteins 0.000 description 10
- 101100134054 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) NTG1 gene Proteins 0.000 description 10
- 239000007858 starting material Substances 0.000 description 10
- 230000008859 change Effects 0.000 description 9
- 239000002299 complementary DNA Substances 0.000 description 9
- 230000001965 increasing effect Effects 0.000 description 9
- 239000003112 inhibitor Substances 0.000 description 8
- 230000002441 reversible effect Effects 0.000 description 8
- 238000003556 assay Methods 0.000 description 7
- 230000033228 biological regulation Effects 0.000 description 7
- 230000007246 mechanism Effects 0.000 description 7
- 230000001404 mediated effect Effects 0.000 description 7
- 230000002829 reductive effect Effects 0.000 description 7
- 239000012528 membrane Substances 0.000 description 6
- 239000004074 complement inhibitor Substances 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 5
- 238000001727 in vivo Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 108091026890 Coding region Proteins 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 125000000539 amino acid group Chemical group 0.000 description 4
- 201000004428 dysembryoplastic neuroepithelial tumor Diseases 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 230000002779 inactivation Effects 0.000 description 4
- 230000003834 intracellular effect Effects 0.000 description 4
- 230000009870 specific binding Effects 0.000 description 4
- 230000000451 tissue damage Effects 0.000 description 4
- 231100000827 tissue damage Toxicity 0.000 description 4
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 3
- 102000004506 Blood Proteins Human genes 0.000 description 3
- 108010017384 Blood Proteins Proteins 0.000 description 3
- 108020004635 Complementary DNA Proteins 0.000 description 3
- 229930186217 Glycolipid Natural products 0.000 description 3
- 101150039984 RCA gene Proteins 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 238000003776 cleavage reaction Methods 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 108091008053 gene clusters Proteins 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 230000002427 irreversible effect Effects 0.000 description 3
- 238000002372 labelling Methods 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 208000010125 myocardial infarction Diseases 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 230000007017 scission Effects 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 108010083822 Alternative Pathway Complement C5 Convertase Proteins 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- 108010078804 Classical Pathway Complement C5 Convertase Proteins 0.000 description 2
- 229940124073 Complement inhibitor Drugs 0.000 description 2
- 101710121996 Hexon protein p72 Proteins 0.000 description 2
- 101100007625 Homo sapiens CR1 gene Proteins 0.000 description 2
- 101000668165 Homo sapiens RNA-binding motif, single-stranded-interacting protein 1 Proteins 0.000 description 2
- 101710125418 Major capsid protein Proteins 0.000 description 2
- 102100039692 RNA-binding motif, single-stranded-interacting protein 1 Human genes 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 206010053614 Type III immune complex mediated reaction Diseases 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000004075 alteration Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 230000006037 cell lysis Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000001086 cytosolic effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 239000000539 dimer Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 238000010188 recombinant method Methods 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000014616 translation Effects 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 230000017105 transposition Effects 0.000 description 2
- 102100034088 40S ribosomal protein S4, X isoform Human genes 0.000 description 1
- 108010003529 Alternative Pathway Complement C3 Convertase Proteins 0.000 description 1
- 208000000104 Arthus reaction Diseases 0.000 description 1
- 241000228212 Aspergillus Species 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 102000015612 Complement 3b Receptors Human genes 0.000 description 1
- 108010024114 Complement 3b Receptors Proteins 0.000 description 1
- 108010034753 Complement Membrane Attack Complex Proteins 0.000 description 1
- 102000000989 Complement System Proteins Human genes 0.000 description 1
- 108010069112 Complement System Proteins Proteins 0.000 description 1
- 241000699802 Cricetulus griseus Species 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 102100040611 Endothelin receptor type B Human genes 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 101150034814 F gene Proteins 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- IECPWNUMDGFDKC-UHFFFAOYSA-N Fusicsaeure Natural products C12C(O)CC3C(=C(CCC=C(C)C)C(O)=O)C(OC(C)=O)CC3(C)C1(C)CCC1C2(C)CCC(O)C1C IECPWNUMDGFDKC-UHFFFAOYSA-N 0.000 description 1
- 102100030386 Granzyme A Human genes 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 208000004592 Hirschsprung disease Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000732165 Homo sapiens 40S ribosomal protein S4, X isoform Proteins 0.000 description 1
- 101100386242 Homo sapiens CD55 gene Proteins 0.000 description 1
- 101000967299 Homo sapiens Endothelin receptor type B Proteins 0.000 description 1
- 101001009599 Homo sapiens Granzyme A Proteins 0.000 description 1
- 101000961414 Homo sapiens Membrane cofactor protein Proteins 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- -1 MCP Proteins 0.000 description 1
- 101150047390 MCP gene Proteins 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 208000009525 Myocarditis Diseases 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- 206010063837 Reperfusion injury Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- 102000012479 Serine Proteases Human genes 0.000 description 1
- 108010022999 Serine Proteases Proteins 0.000 description 1
- 206010052779 Transplant rejections Diseases 0.000 description 1
- 208000024248 Vascular System injury Diseases 0.000 description 1
- 208000012339 Vascular injury Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 238000007818 agglutination assay Methods 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000003833 bile salt Substances 0.000 description 1
- 229940093761 bile salts Drugs 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 238000010668 complexation reaction Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 102000038379 digestive enzymes Human genes 0.000 description 1
- 108091007734 digestive enzymes Proteins 0.000 description 1
- MCWXGJITAZMZEV-UHFFFAOYSA-N dimethoate Chemical compound CNC(=O)CSP(=S)(OC)OC MCWXGJITAZMZEV-UHFFFAOYSA-N 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- IECPWNUMDGFDKC-MZJAQBGESA-N fusidic acid Chemical compound O[C@@H]([C@@H]12)C[C@H]3\C(=C(/CCC=C(C)C)C(O)=O)[C@@H](OC(C)=O)C[C@]3(C)[C@@]2(C)CC[C@@H]2[C@]1(C)CC[C@@H](O)[C@H]2C IECPWNUMDGFDKC-MZJAQBGESA-N 0.000 description 1
- 229960004675 fusidic acid Drugs 0.000 description 1
- 208000007475 hemolytic anemia Diseases 0.000 description 1
- 230000016178 immune complex formation Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000000099 in vitro assay Methods 0.000 description 1
- 238000005462 in vivo assay Methods 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 230000002101 lytic effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 229940126619 mouse monoclonal antibody Drugs 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 206010028417 myasthenia gravis Diseases 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 235000013930 proline Nutrition 0.000 description 1
- 125000001500 prolyl group Chemical class [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 108020001580 protein domains Proteins 0.000 description 1
- 230000007026 protein scission Effects 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 230000006337 proteolytic cleavage Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008521 reorganization Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 102220201851 rs143406017 Human genes 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 238000012868 site-directed mutagenesis technique Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 230000003966 vascular damage Effects 0.000 description 1
- 239000012905 visible particle Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000002689 xenotransplantation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Environmental Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69551491A | 1991-05-03 | 1991-05-03 | |
| US695,514 | 1991-05-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0616696A JPH0616696A (ja) | 1994-01-25 |
| JP2793431B2 true JP2793431B2 (ja) | 1998-09-03 |
Family
ID=24793320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4113457A Expired - Fee Related JP2793431B2 (ja) | 1991-05-03 | 1992-05-06 | 改変された補体系制御因子 |
Country Status (5)
| Country | Link |
|---|---|
| US (6) | US6897290B1 (enExample) |
| EP (2) | EP0512733A2 (enExample) |
| JP (1) | JP2793431B2 (enExample) |
| AU (1) | AU657751B2 (enExample) |
| CA (1) | CA2067653C (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6482404B1 (en) | 1989-10-12 | 2002-11-19 | David James White | Transplantation of tissue comprising a DNA sequence encoding a homologous complement restriction factor |
| EP0512733A2 (en) * | 1991-05-03 | 1992-11-11 | Washington University | Modified complement system regulator |
| US5856300A (en) * | 1994-05-12 | 1999-01-05 | T Cell Sciences, Inc. | Compositions comprising complement related proteins and carbohydrates, and methods for producing and using said compositions |
| PT730608E (pt) | 1993-05-17 | 2002-09-30 | Avant Immunotherapeutics Inc | Composicoes compreendendo hidratos de carbono e proeinas relacionadas pelo complemento e metodos para produzir e utilizar as referidas composicoes |
| US5976540A (en) * | 1993-05-17 | 1999-11-02 | T Cell Sciences, Inc. | Compositions comprising complement related proteins and carbohydrates, and methods for producing and using said compositions |
| US5679546A (en) * | 1993-09-24 | 1997-10-21 | Cytomed, Inc. | Chimeric proteins which block complement activation |
| EP1493446A1 (en) * | 1993-09-24 | 2005-01-05 | Washington University | Modified truncated complement system regulators |
| ATE265221T1 (de) * | 1993-09-24 | 2004-05-15 | Univ Washington | Modifizierte, verkürzte regulatoren des komplementsystems |
| US5866402A (en) * | 1995-05-05 | 1999-02-02 | Chiron Corporation | Chimeric MCP and DAF proteins with cell surface localizing domain |
| GB9604518D0 (en) * | 1996-03-02 | 1996-05-01 | Smithkline Beecham Plc | Novel compounds |
| GB9624731D0 (en) * | 1996-11-28 | 1997-01-15 | Univ Leicester | Complement inhibitor |
| GB9704519D0 (en) | 1997-03-05 | 1997-04-23 | Smithkline Beecham Plc | Compounds |
| WO1998039659A1 (en) * | 1997-03-06 | 1998-09-11 | Bion Diagnostic Sciences, Inc. | Screening and treatment using complement regulator or receptor proteins |
| US6221621B1 (en) | 1997-03-06 | 2001-04-24 | Bard Diagnostic Sciences, Inc. | Methods of screening for colorectal cancers in which a complement Factor I or related protein is associated |
| AU4452100A (en) * | 1999-04-09 | 2000-11-14 | Washington University | Modified complement system regulators |
| US20090054330A1 (en) * | 1999-05-25 | 2009-02-26 | Kotwal Girish J | Novel Therapeutic Use of Viral Inflammation Modulatory Protein in Blocking Xenograft Rejection |
| HK1045456B (en) * | 1999-05-25 | 2006-09-08 | King Faisal Specialist Hospital & Research Centre | Novel therapeutic use of viral inflammation modulatory protein in blocking xenograft rejection |
| US6820011B2 (en) | 2001-04-11 | 2004-11-16 | The Regents Of The University Of Colorado | Three-dimensional structure of complement receptor type 2 and uses thereof |
| JP2004529945A (ja) * | 2001-05-17 | 2004-09-30 | ラ ホヤ ファーマシューティカル カンパニー | Ｃｄ２１を阻害する薬剤を使用して抗体媒介性病理を処置する方法 |
| CA2505601C (en) * | 2002-11-15 | 2014-10-28 | Musc Foundation For Research Development | Complement receptor 2 targeted complement modulators |
| DE10343620A1 (de) * | 2003-09-20 | 2005-04-28 | Leibrock Maschinenfabrik Im Un | Verfahren und Vorrichtung zum Erfassen der zum Rauen bestimmten Seitenbereiche von auf Leisten aufgebrachten Schuhschäften |
| US8124097B2 (en) | 2004-01-21 | 2012-02-28 | Case Western Reserve University | Hybrid and chimeric polypeptides that regulate activation of complement |
| JP5137053B2 (ja) * | 2004-02-10 | 2013-02-06 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイト | 抗ｂ因子抗体もしくはその抗原結合性フラグメント、それを含む組成物、抗原結合性ポリペプチド、および治療薬 |
| US8043609B2 (en) | 2004-10-08 | 2011-10-25 | Potentia Pharmaceuticals, Inc. | Viral complement control proteins for eye disorders |
| WO2006042252A2 (en) * | 2004-10-08 | 2006-04-20 | Potentia Pharmeceuticals, Inc. | Viral complement control proteins for eye disorders |
| JP5707024B2 (ja) * | 2005-05-26 | 2015-04-22 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ | 外傷性脳損傷、脊髄損傷および関連状態を治療するために補体副経路を阻害する作用剤 |
| US20070004625A1 (en) * | 2005-06-30 | 2007-01-04 | Li Liang-Man | Use of complement inhibitory proteins to treat spinal cord injury |
| EP1738763A1 (en) * | 2005-06-30 | 2007-01-03 | AVANT Immunotherapeutics, Inc. | Use of complement inhibitory proteins to treat spinal cord injury |
| DK1951279T3 (en) | 2005-10-08 | 2017-07-31 | Apellis Pharmaceuticals Inc | COMPSTATIN AND ANALOGUES THEREOF FOR EYE DISEASES |
| US8168584B2 (en) | 2005-10-08 | 2012-05-01 | Potentia Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration by compstatin and analogs thereof |
| PL2044111T3 (pl) | 2006-06-21 | 2015-02-27 | Musc Found For Res Dev | Celowanie czynnika H dopełniacza do leczenia chorób |
| EP2479284B1 (en) | 2006-07-13 | 2017-09-20 | University of Iowa Research Foundation | Methods and reagents for treatment and diagnosis of vascular disorders and age-related macular degeneration |
| BRPI0808227A2 (pt) * | 2007-03-14 | 2014-07-08 | Taligen Therapeutics Inc | Anticorpo humanizado anti-fator b |
| US20110092446A1 (en) * | 2007-07-20 | 2011-04-21 | Cedric Francois | Compositions and methods for treatment of trauma |
| EP2278987A4 (en) * | 2008-03-28 | 2012-08-22 | Apellis Ag | MODULATION AND REPLY / IMPROVEMENT OF THE COMPLEMENTARY SYSTEM IN THE TREATMENT OF TRAUMATISM |
| WO2011003098A1 (en) | 2009-07-02 | 2011-01-06 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
| NZ600393A (en) | 2009-11-05 | 2014-08-29 | Alexion Cambridge Corp | Treatment of paroxysmal nocturnal hemoglobinuria, hemolytic anemias and disease states involving intravascular and extravascular hemolysis |
| KR20130080443A (ko) | 2010-05-14 | 2013-07-12 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 개선된 보체 수용체 ２(ｃｒ２) 표적 그룹들 |
| MX2012014975A (es) | 2010-06-22 | 2013-03-12 | Univ Colorado Regents | Anticuerpos al fragmento c3d de componente 3 de complemento. |
| WO2011163394A2 (en) | 2010-06-22 | 2011-12-29 | Apellis Pharmaceuticals, Inc. | Compstatin analogs for treatment of neuropathic pain |
| AU2011295715B9 (en) | 2010-09-03 | 2017-02-23 | Abbvie Stemcentrx Llc | Novel modulators and methods of use |
| WO2012078968A2 (en) | 2010-12-10 | 2012-06-14 | Lifeline Scientific, Inc. | Machine perfusion with complement inhibitors |
| US10125171B2 (en) | 2011-05-11 | 2018-11-13 | Apellis Pharmaceuticals, Inc. | Cell-reactive, long-acting, or targeted compstatin analogs and uses thereof |
| BR112013033272A2 (pt) | 2011-06-22 | 2020-11-10 | Apellis Pharmaceuticals, Inc. | composição farmaceutica compreendendo um inibidor do complemento e um agente anti-th17, e usos dos mesmos |
| EP2557089A2 (en) * | 2011-07-15 | 2013-02-13 | Fundació Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Compositions and methods for immunomodulation |
| WO2013177035A2 (en) | 2012-05-24 | 2013-11-28 | Alexion Pharmaceuticals, Inc. | Humaneered anti-factor b antibody |
| WO2014028865A1 (en) | 2012-08-17 | 2014-02-20 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for detecting complement activation |
| US10413620B2 (en) | 2012-08-17 | 2019-09-17 | The Regents Of The University Of Colorado, A Body Corporate | Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging |
| ES2879430T3 (es) | 2012-11-15 | 2021-11-22 | Apellis Pharmaceuticals Inc | Análogos de compstatina de acción prolongada y composiciones y métodos relacionados |
| WO2014152391A1 (en) | 2013-03-15 | 2014-09-25 | Apellis Pharmaceuticals, Inc. | Cell-penetrating compstatin analogs and uses thereof |
| US20160168237A1 (en) | 2014-12-12 | 2016-06-16 | Alexion Pharmaceuticals, Inc. | Method for treating a complement mediated disorder caused by an infectious agent in a patient |
| EP3328885A1 (en) | 2015-09-11 | 2018-06-06 | Bruce Andrien | Recombinant glycosylated eculizumab and eculizumab variants |
| FI3359555T3 (fi) | 2015-10-07 | 2024-03-20 | Apellis Pharmaceuticals Inc | Annostusohjeet |
| US11203634B2 (en) | 2015-10-07 | 2021-12-21 | Alexion Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration in a patient comprising administering an anti-C5a antibody |
| MX2019000059A (es) * | 2016-06-28 | 2020-09-07 | Univ Ulm | Inhibidores de complementos y usos de los mismos. |
| US11828683B2 (en) | 2016-10-19 | 2023-11-28 | Alexion Pharmaceuticals, Inc. | Method of quantitating unbound C5a in a sample |
| WO2018075758A1 (en) | 2016-10-19 | 2018-04-26 | Alexion Pharmaceuticals, Inc. | A method of quantitating unbound c5 in a sample |
| JP2020516607A (ja) | 2017-04-07 | 2020-06-11 | アペリス・ファーマシューティカルズ・インコーポレイテッドＡｐｅｌｌｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 投与レジメンならびに関連組成物および方法 |
| WO2019118938A1 (en) | 2017-12-15 | 2019-06-20 | Apellis Pharmaceuticals, Inc. | Dosing regimens and related compositions and methods |
| WO2020232319A1 (en) | 2019-05-15 | 2020-11-19 | Insideoutbio, Inc. | Modular therapeutics for the treatment of inflammatory diseases and cancer |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5212071A (en) | 1988-04-01 | 1993-05-18 | The Johns Hopkins University | Nucleic acids encoding a human C3b/C4b receptor (CR1) |
| US5109113A (en) * | 1986-05-02 | 1992-04-28 | Genentech, Inc. | Membrane anchor fusion polypeptides |
| JPH0742235B2 (ja) * | 1985-11-08 | 1995-05-10 | 三共株式会社 | 自己免疫性疾病の予防・治療剤 |
| US4935233A (en) * | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
| US5256642A (en) * | 1988-04-01 | 1993-10-26 | The Johns Hopkins University | Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof |
| IL89790A (en) | 1988-04-01 | 2002-05-23 | Johns Hopking University | Nucleic acid sequences that encode and cells that produce cr1 protein and methods of production and purification |
| EP0483247A4 (en) * | 1989-07-21 | 1992-12-09 | Washington University | Recombinantly produced human membrane cofactor protein (mcp) |
| WO1991018097A1 (en) * | 1990-05-11 | 1991-11-28 | University Of Melbourne | Cd46 variants |
| AU655182B2 (en) * | 1990-05-11 | 1994-12-08 | Austin Research Institute, The | CD46 variants |
| EP0512733A2 (en) * | 1991-05-03 | 1992-11-11 | Washington University | Modified complement system regulator |
| JPH05271288A (ja) | 1992-02-21 | 1993-10-19 | Mochida Pharmaceut Co Ltd | 新規な薬理学的特性を有する蛋白質 |
-
1992
- 1992-04-28 EP EP92303826A patent/EP0512733A2/en not_active Ceased
- 1992-04-28 EP EP20030024658 patent/EP1413587A2/en not_active Withdrawn
- 1992-04-29 AU AU15902/92A patent/AU657751B2/en not_active Ceased
- 1992-04-30 CA CA002067653A patent/CA2067653C/en not_active Expired - Fee Related
- 1992-05-06 JP JP4113457A patent/JP2793431B2/ja not_active Expired - Fee Related
-
1993
- 1993-09-24 US US08/126,505 patent/US6897290B1/en not_active Expired - Fee Related
-
1994
- 1994-03-18 US US08/210,266 patent/US5545619A/en not_active Expired - Lifetime
-
1995
- 1995-06-07 US US08/477,860 patent/US6010873A/en not_active Expired - Fee Related
-
1996
- 1996-07-30 US US08/688,675 patent/US5719127A/en not_active Expired - Fee Related
-
1999
- 1999-12-02 US US09/453,835 patent/US6521450B1/en not_active Expired - Lifetime
-
2004
- 2004-11-23 US US10/997,454 patent/US20080119400A1/en not_active Abandoned
Non-Patent Citations (1)
| Title |
|---|
| Ｊ．ＥＸＰ．ＭＥＤ．，ＶＯＬ．１６８，Ｐ．１６９９−１７１７（１９８８） |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0616696A (ja) | 1994-01-25 |
| US20080119400A1 (en) | 2008-05-22 |
| EP0512733A3 (enExample) | 1994-08-03 |
| US5719127A (en) | 1998-02-17 |
| US6521450B1 (en) | 2003-02-18 |
| US6010873A (en) | 2000-01-04 |
| EP0512733A2 (en) | 1992-11-11 |
| CA2067653C (en) | 2001-02-13 |
| CA2067653A1 (en) | 1992-11-04 |
| US6897290B1 (en) | 2005-05-24 |
| EP1413587A2 (en) | 2004-04-28 |
| AU1590292A (en) | 1992-11-05 |
| US5545619A (en) | 1996-08-13 |
| AU657751B2 (en) | 1995-03-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2793431B2 (ja) | 改変された補体系制御因子 | |
| CA1340544C (en) | Human tissue factor related dna segments, polypeptides and antibodies | |
| US5110730A (en) | Human tissue factor related DNA segments | |
| US6551595B1 (en) | Smallpox inhibitor of complement enzymes (SPICE) protein and methods of inhibiting complement activation | |
| US6001978A (en) | Human tissue factor related DNA segments polypeptides and antibodies | |
| JP2000513934A (ja) | 改変された第▲ｖｉｉｉ▼因子 | |
| JP3805358B2 (ja) | フォン・ウィルブランド因子の治療用ドメイン | |
| WO1997017987A9 (en) | C9 complement inhibitor | |
| WO1997017987A1 (en) | C9 complement inhibitor | |
| AU691525B2 (en) | Modified truncated complement system regulators | |
| RU2183214C2 (ru) | Природный и рекомбинантный ингибиторы тромбина, их получение и применение | |
| CA2046925A1 (en) | Pregnancy specific proteins applications | |
| WO1992014834A1 (en) | Insulin-like growth factor binding protein | |
| HK1065552A (en) | Modified complement system regulator | |
| WO1991003251A1 (en) | Cr2 ligand compositions and methods for modulating immune cell functions | |
| WO2000061752A2 (en) | Modified complement system regulators | |
| EP1493446A1 (en) | Modified truncated complement system regulators | |
| DK176220B1 (da) | Monoklonalt antistof, som binder human vævsfaktor-protein, samt dets anvendelse | |
| HK1072725A (en) | Modified truncated complement system regulators | |
| IE20040562A1 (en) | Human tissue factor related DNA segments, polypeptides and antibodies. | |
| HK1060578A (en) | Human tissue factor related dna segments, polypeptides and antibodies | |
| IE83847B1 (en) | Human tissue factor related DNA segments, polypeptides and antibodies |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 19980521 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20080619 Year of fee payment: 10 |
|
| LAPS | Cancellation because of no payment of annual fees |