JP2661666B2 - 抗消化性潰瘍剤 - Google Patents
抗消化性潰瘍剤Info
- Publication number
- JP2661666B2 JP2661666B2 JP63035484A JP3548488A JP2661666B2 JP 2661666 B2 JP2661666 B2 JP 2661666B2 JP 63035484 A JP63035484 A JP 63035484A JP 3548488 A JP3548488 A JP 3548488A JP 2661666 B2 JP2661666 B2 JP 2661666B2
- Authority
- JP
- Japan
- Prior art keywords
- group
- carbon atoms
- compound
- dihydroxyhexyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000002467 anti-pepsin effect Effects 0.000 title claims description 12
- 239000003699 antiulcer agent Substances 0.000 title claims description 8
- 150000001875 compounds Chemical class 0.000 claims abstract description 47
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 12
- 239000001257 hydrogen Substances 0.000 claims abstract description 12
- 208000008469 Peptic Ulcer Diseases 0.000 claims abstract description 9
- 125000003342 alkenyl group Chemical group 0.000 claims abstract description 9
- 239000004480 active ingredient Substances 0.000 claims abstract description 8
- 208000011906 peptic ulcer disease Diseases 0.000 claims abstract description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 4
- -1 6,7-dihydroxyheptyl group Chemical group 0.000 claims description 33
- 125000004432 carbon atom Chemical group C* 0.000 claims description 29
- 125000000217 alkyl group Chemical group 0.000 claims description 18
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 10
- 229910052799 carbon Inorganic materials 0.000 claims description 10
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
- 125000005188 oxoalkyl group Chemical group 0.000 claims description 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 3
- 125000001539 acetonyl group Chemical group [H]C([H])([H])C(=O)C([H])([H])* 0.000 claims description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 125000004990 dihydroxyalkyl group Chemical group 0.000 claims description 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 10
- 229940124597 therapeutic agent Drugs 0.000 abstract description 3
- 125000006526 (C1-C2) alkyl group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 18
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 16
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- 238000002844 melting Methods 0.000 description 11
- 230000008018 melting Effects 0.000 description 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 10
- 208000025865 Ulcer Diseases 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 231100000397 ulcer Toxicity 0.000 description 9
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- 230000015572 biosynthetic process Effects 0.000 description 8
- 150000002431 hydrogen Chemical class 0.000 description 8
- 229910052757 nitrogen Inorganic materials 0.000 description 8
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- 238000000921 elemental analysis Methods 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
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- GMSNIKWWOQHZGF-UHFFFAOYSA-N 3-methyl-9H-xanthine Chemical compound O=C1NC(=O)N(C)C2=C1N=CN2 GMSNIKWWOQHZGF-UHFFFAOYSA-N 0.000 description 2
- AJBNDSREGCJZAK-UHFFFAOYSA-N 7-(5,6-dihydroxyhexyl)-1-(5-oxohexyl)-3-propylpurine-2,6-dione Chemical compound O=C1N(CCCCC(C)=O)C(=O)N(CCC)C2=C1N(CCCCC(O)CO)C=N2 AJBNDSREGCJZAK-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
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- 229930195725 Mannitol Natural products 0.000 description 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
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- 229930006000 Sucrose Natural products 0.000 description 2
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- XRWSZZJLZRKHHD-WVWIJVSJSA-N asunaprevir Chemical compound O=C([C@@H]1C[C@H](CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)(C)C)OC1=NC=C(C2=CC=C(Cl)C=C21)OC)N[C@]1(C(=O)NS(=O)(=O)C2CC2)C[C@H]1C=C XRWSZZJLZRKHHD-WVWIJVSJSA-N 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940105329 carboxymethylcellulose Drugs 0.000 description 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 239000007931 coated granule Substances 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 229940126142 compound 16 Drugs 0.000 description 1
- 229940126086 compound 21 Drugs 0.000 description 1
- 229940125961 compound 24 Drugs 0.000 description 1
- 229940125846 compound 25 Drugs 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 230000001814 effect on stress Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229950000579 enprofylline Drugs 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 230000027119 gastric acid secretion Effects 0.000 description 1
- 230000000762 glandular Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 239000003485 histamine H2 receptor antagonist Substances 0.000 description 1
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 231100001231 less toxic Toxicity 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 229960003511 macrogol Drugs 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 238000013421 nuclear magnetic resonance imaging Methods 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940065721 systemic for obstructive airway disease xanthines Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Priority Applications (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63035484A JP2661666B2 (ja) | 1988-02-19 | 1988-02-19 | 抗消化性潰瘍剤 |
| AU28538/89A AU605669B2 (en) | 1988-02-19 | 1989-01-17 | Therapeutic agents for the treatment of peptic ulcer disease |
| ES198989102391T ES2039719T3 (es) | 1988-02-19 | 1989-02-11 | Procedimiento para preparar un agente terapeutico para el tratamiento de la enfermedad de ulcera peptica. |
| AT89102391T ATE70182T1 (de) | 1988-02-19 | 1989-02-11 | Therapeutische mittel zur behandlung von magengeschwueren. |
| DE8989102391T DE68900516D1 (de) | 1988-02-19 | 1989-02-11 | Therapeutische mittel zur behandlung von magengeschwueren. |
| EP89102391A EP0330031B1 (en) | 1988-02-19 | 1989-02-11 | Therapeutic agents for the treatment of peptic ulcer disease |
| PH38213A PH27149A (en) | 1988-02-19 | 1989-02-17 | Therapeutic agents for the treatment of peptic ulcer disease |
| HU89792A HU204702B (en) | 1988-02-19 | 1989-02-17 | Process for producing pharmaceutical compositions suitable for treating peptic ulcers and new xanthine derivatives suitable for this purpose |
| ZA891241A ZA891241B (en) | 1988-02-19 | 1989-02-17 | Therapeutic agents for the treatment of peptic ulcer disease |
| KR1019890001831A KR0133075B1 (ko) | 1988-02-19 | 1989-02-17 | 소화성 궤양 질환 치료용 치료학적 제제 |
| DK074189A DK74189A (da) | 1988-02-19 | 1989-02-17 | Laegemiddel til behandling af mavesaar |
| NZ228020A NZ228020A (en) | 1988-02-19 | 1989-02-17 | N-substituted xanthine derivatives and pharmaceutical compositions |
| US07/311,910 US5082845A (en) | 1988-02-19 | 1989-02-17 | Therapeutic xanthine derivatives for the treatment of peptic ulcer disease |
| IL89324A IL89324A0 (en) | 1988-02-19 | 1989-02-17 | Therapeutic agents for the treatment of peptic ulcer disease containing xanthine derivatives |
| IE51489A IE61147B1 (en) | 1988-02-19 | 1989-02-17 | Therapeutic agents for the treatment of peptic ulcer disease |
| PT89757A PT89757B (pt) | 1988-02-19 | 1989-02-17 | Processo para a preparacao de novos derivados da xantina e de composicoes farmaceuticas que os contem, uteis no tratamento da ulcera peptica |
| GR920400270T GR3003952T3 (enExample) | 1988-02-19 | 1992-03-04 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63035484A JP2661666B2 (ja) | 1988-02-19 | 1988-02-19 | 抗消化性潰瘍剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01211524A JPH01211524A (ja) | 1989-08-24 |
| JP2661666B2 true JP2661666B2 (ja) | 1997-10-08 |
Family
ID=12443024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63035484A Expired - Lifetime JP2661666B2 (ja) | 1988-02-19 | 1988-02-19 | 抗消化性潰瘍剤 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5082845A (enExample) |
| EP (1) | EP0330031B1 (enExample) |
| JP (1) | JP2661666B2 (enExample) |
| KR (1) | KR0133075B1 (enExample) |
| AT (1) | ATE70182T1 (enExample) |
| AU (1) | AU605669B2 (enExample) |
| DE (1) | DE68900516D1 (enExample) |
| DK (1) | DK74189A (enExample) |
| ES (1) | ES2039719T3 (enExample) |
| GR (1) | GR3003952T3 (enExample) |
| HU (1) | HU204702B (enExample) |
| IE (1) | IE61147B1 (enExample) |
| IL (1) | IL89324A0 (enExample) |
| NZ (1) | NZ228020A (enExample) |
| PH (1) | PH27149A (enExample) |
| PT (1) | PT89757B (enExample) |
| ZA (1) | ZA891241B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2661666B2 (ja) * | 1988-02-19 | 1997-10-08 | ヘキスト薬品工業株式会社 | 抗消化性潰瘍剤 |
| DD298051A5 (de) * | 1989-08-16 | 1992-02-06 | ��@���������@�������k�� | Verfahren zur herstellung eines therapeutischen agens zur behandlung von verdauungskrankheiten |
| IT1240843B (it) * | 1990-05-24 | 1993-12-17 | Malesci Istituto Farmacobiologico | Derivati xantinici 1-7 sostituiti ad attivita' antiasmatica, loro sali fisiologicamente accettabili, loro composizioni farmaceutiche e procedimento per la loro preparazione. |
| JP2549480B2 (ja) * | 1991-12-10 | 1996-10-30 | ヘキストジャパン株式会社 | 排尿障害改善剤 |
| EP0570831A2 (de) * | 1992-05-20 | 1993-11-24 | Hoechst Aktiengesellschaft | Verwendung von Xanthinderivaten zur Behandlung von Nervenschädigungen nach Unterbrechung der Blutzirkulation |
| US5354756A (en) * | 1993-01-12 | 1994-10-11 | Cell Therapeutics, Inc. | Olefin-substituted long chain xanthine compounds |
| US5620676A (en) * | 1994-03-08 | 1997-04-15 | The United States Of America As Represented By The Department Of Health And Human Services | Biologically active ATP analogs |
| BRPI0908107A2 (pt) | 2008-02-29 | 2019-09-24 | Concert Pharmaceuticals Inc | composto derivado de xantina substituída, composição farmacêutica que compreende esse composto, métodos de tratamento de uma enfermidade ou condição em um paciente com necessidade do mesmo, método de tratamento de enfermidade crônica dos rins, do fígado, relacionada com diabetes e de claudicação intermitente |
| US20110053961A1 (en) | 2009-02-27 | 2011-03-03 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH608236A5 (enExample) * | 1974-01-22 | 1978-12-29 | Wuelfing J A Fa | |
| DE2432702C2 (de) * | 1974-07-08 | 1983-01-20 | Hoechst Ag, 6000 Frankfurt | Verfahren zur Herstellung von Hydroxyalkylxanthinen |
| US4207321A (en) * | 1977-04-02 | 1980-06-10 | Hoechst Aktiengesellschaft | Pharmaceutical compositions containing xanthines |
| EP0157098A1 (en) * | 1980-06-21 | 1985-10-09 | Beecham Wuelfing GmbH & Co KG | Xanthine derivatives, pharmaceuticals compositions containing them and a process for their preparation |
| DE3138397A1 (de) * | 1981-09-26 | 1983-04-07 | Hoechst Ag, 6230 Frankfurt | "arzneimittel, darin enthaltene vicinale dihydroxyalkylxanthine und herstellungsverfahren fuer diese xanthinverbindungen" |
| US4636507A (en) * | 1984-04-30 | 1987-01-13 | Hoechst-Roussel Pharmaceuticals Inc. | Host defense mechanism enhancement |
| GB8418430D0 (en) * | 1984-07-19 | 1984-08-22 | Beecham Wuelfing Gmbh & Co Kg | Treatment |
| DE3508097A1 (de) * | 1984-07-21 | 1986-02-06 | Hoechst Ag, 6230 Frankfurt | Kombinationspraeparat aus xanthinderivaten und o-acetylsalicylsaeure bzw. deren pharmakologisch vertraeglichen salzen und dessen verwendung |
| DE3525801A1 (de) * | 1985-07-19 | 1987-01-22 | Hoechst Ag | Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung |
| US4772607A (en) * | 1986-05-20 | 1988-09-20 | Warner-Lambert Company | Dialkenyl derivatives of xanthine, pharmaceutical compositions and methods of use therefor |
| JPS63225317A (ja) * | 1986-10-06 | 1988-09-20 | Hoechst Japan Kk | 抗消化性潰瘍剤 |
| JP2661666B2 (ja) * | 1988-02-19 | 1997-10-08 | ヘキスト薬品工業株式会社 | 抗消化性潰瘍剤 |
-
1988
- 1988-02-19 JP JP63035484A patent/JP2661666B2/ja not_active Expired - Lifetime
-
1989
- 1989-01-17 AU AU28538/89A patent/AU605669B2/en not_active Ceased
- 1989-02-11 EP EP89102391A patent/EP0330031B1/en not_active Expired - Lifetime
- 1989-02-11 AT AT89102391T patent/ATE70182T1/de not_active IP Right Cessation
- 1989-02-11 DE DE8989102391T patent/DE68900516D1/de not_active Expired - Lifetime
- 1989-02-11 ES ES198989102391T patent/ES2039719T3/es not_active Expired - Lifetime
- 1989-02-17 DK DK074189A patent/DK74189A/da not_active Application Discontinuation
- 1989-02-17 US US07/311,910 patent/US5082845A/en not_active Expired - Fee Related
- 1989-02-17 ZA ZA891241A patent/ZA891241B/xx unknown
- 1989-02-17 IL IL89324A patent/IL89324A0/xx not_active IP Right Cessation
- 1989-02-17 HU HU89792A patent/HU204702B/hu not_active IP Right Cessation
- 1989-02-17 NZ NZ228020A patent/NZ228020A/en unknown
- 1989-02-17 IE IE51489A patent/IE61147B1/en not_active IP Right Cessation
- 1989-02-17 KR KR1019890001831A patent/KR0133075B1/ko not_active Expired - Fee Related
- 1989-02-17 PH PH38213A patent/PH27149A/en unknown
- 1989-02-17 PT PT89757A patent/PT89757B/pt not_active IP Right Cessation
-
1992
- 1992-03-04 GR GR920400270T patent/GR3003952T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0330031B1 (en) | 1991-12-11 |
| JPH01211524A (ja) | 1989-08-24 |
| HU204702B (en) | 1992-02-28 |
| PT89757A (pt) | 1989-10-04 |
| EP0330031A1 (en) | 1989-08-30 |
| KR890012652A (ko) | 1989-09-18 |
| ES2039719T3 (es) | 1993-10-01 |
| DE68900516D1 (de) | 1992-01-23 |
| IE61147B1 (en) | 1994-10-05 |
| IE890514L (en) | 1989-08-19 |
| ATE70182T1 (de) | 1991-12-15 |
| IL89324A0 (en) | 1989-09-10 |
| NZ228020A (en) | 1991-07-26 |
| US5082845A (en) | 1992-01-21 |
| KR0133075B1 (ko) | 1998-04-17 |
| AU605669B2 (en) | 1991-01-17 |
| PT89757B (pt) | 1994-03-31 |
| AU2853889A (en) | 1989-08-24 |
| DK74189D0 (da) | 1989-02-17 |
| PH27149A (en) | 1993-04-02 |
| HUT49283A (en) | 1989-09-28 |
| DK74189A (da) | 1989-08-20 |
| GR3003952T3 (enExample) | 1993-03-16 |
| ZA891241B (en) | 1989-10-25 |
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